Nonapeptide-1(tseem hu ua Jiushengpeptide) yog ib qho me me active peptide uas muaj cuaj amino acids. CAS 158563-45-2, Molecular formula C61H87N15O9S. Nws cov txheej txheem ntawm kev ua yog yooj yim heev, uas yog ua kom tsis muaj zog ntawm melanocytes hauv cov leeg nqaij los ntawm inhibiting cov haujlwm ntawm tyrosinase. Yooj yim muab tso, nws ua tiav cov xim dawb thiab qhov chaw fading los ntawm inhibiting zus tau tej cov melanin. Raws li biostructural mimetic peptide tshwj xeeb rau alpha MSH, nws yog homologous rau alpha MSH thiab muaj kev sib raug zoo nrog MC1-R (melanocortin receptor-1) ntawm melanocytes. Nws tuaj yeem tiv thaiv kev khi ntawm alpha MSH rau MC1-R receptors, inhibit qhov kev qhia ntawm MITF transcription yam, thiab thaiv kev ua kom melanin synthesis txoj hauv kev thiab tyrosinase hauv melanocytes los ntawm qhov chaw, yog li thaiv melanin synthesis thiab ua tiav cov nyhuv ntawm whitening thiab lightening me ntsis.
Palmitoyl Tripeptide-1 COA
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| Certificate of Analysis | ||
| Compound npe | Palmitoyl Tripeptide-1 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 623172-56-5 | |
| Ntau | 80g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090067 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.58% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.49% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.68% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 140 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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| Chemical Formula: | C61H87N15O9S |
| Exact Mass: | 1206 |
| Molecular Luj: | 1207 |
| m/z: | 1206 (100.0%), 1207 (66.0%), 1208 (21.4%), 1207 (5.2%), 1209 (4.6%), 1208 (4.5%), 1208 (3.7%), 1209 (3.0%), 1208 (1.8%), 1209 (1.2%), 1209 (1.2%), 1207 (1.0%) |
| Elemental Analysis: | C, 60.73; H, 7.27; N, 17.41; O, 11.93; S, 2.66 |
NonapeptideSiv
Whitening thiab brightening - txo melanin ntau lawm los ntawm qhov chaw
Qhov no yog qhov feem ntau paub tab thiab dav siv daim ntawv thov scenario.
1. inhibit basal melanin synthesis
Nonapeptide-1(20 μ M, 3 hnub) tuaj yeem inhibit basal melanin synthesis hauv tib neeg epidermal melanocytes (HEM hlwb) thiab HaCaT hlwb, thiab thim rov qab UVA induced melanin nce. Qhov no txhais tau hais tias nws tuaj yeem tsis tsuas yog tiv thaiv kev tsim cov melanin tshiab, tab sis kuj kho cov xim uas twb muaj lawm photodamage pigmentation.
Cov ntaub ntawv hauv vitro kuaj pom tau hais tias lub hom phiaj MC1 receptor thev naus laus zis tuaj yeem txo qis melanin synthesis teeb liab kis tau tus mob los ntawm 63%, thiab piv rau cov khoom xyaw tshuaj dawb, txo melanin ntau lawm los ntawm 41.6%.
2. Clinically pom daim tawv nqaij brightening
Cov ntaub ntawv tshawb fawb soj ntsuam kom pom tseeb tias tom qab siv cov khoom tu tawv nqaij uas muaj nws rau 14 hnub, kev txhim kho ntawm cov tawv nqaij sib xws tuaj yeem pom.
Thiab tom qab 28 hnub (ib lub voj voog ntawm daim tawv nqaij ua kom tiav), cov tawv nqaij ua kom pom tseeb. Lwm qhov kev kuaj mob pom tau tias 28.7% kev txhim kho ntawm daim tawv nqaij sib xws tom qab 28 hnub.
Lub logic whitening tsis yog superficial npog, tab sis theej txo qis hauv kev tsim tawm hauv melanocytes - txo cov synthesis thiab activation ntawm tyrosinase, txo qis tag nrho cov melanin tsim, thiab txo nws txoj kev thauj mus rau stratum corneum los ntawm inhibiting qhov diffusion ntawm melanosomes, thaum kawg ua tiav whitening ".
3. Lub hom phiaj zoo rau hom tawv nqaij Asian
Cov neeg Esxias muaj ntau dua qhov tseeb melanin hauv lawv cov tawv nqaij, thiab lawv cov kev txwv tsis pub muaj tyrosinase txoj hauv kev ua rau lawv tshwj xeeb hauv kev txhim kho jaundice thiab brightening ntawm daim tawv nqaij. Ntau qhov kev tshawb fawb tau pom tsis tu ncua tias nws muaj txiaj ntsig zoo rau cov tawv nqaij Esxias.
Spot lightening thiab tshem tawm qhov chaw - ntau qhov xwm txheej ntawm cov xim pigmentation
Daim ntawv thov nyob rau hauv daim teb ntawm pigmentation npog yuav luag txhua hom pigmentation teeb meem.
1. Sunburn thiab Freckles
Ultraviolet hluav taws xob yog thawj tus tsav tsheb ntawm pigmentation. Los ntawm inhibiting qhov nce ntawm melanin tshwm sim los ntawm ultraviolet hluav taws xob, nws tuaj yeem cuam tshuam ncaj qha rau kev tsim cov txheej txheem ntawm hnub ci thiab freckles. Nws yog qhia meej ntxiv rau cov khoom xws li tshuaj pleev qhov chaw tshem tawm (sunspots, freckles). Los ntawm inhibiting MSH (melanocyte stimulating hormone), txo melanin ntau lawm, thiab tiv thaiv melanin ntau lawm.
2. Melasma
Kev tsim ntawm melasma yog ze ze rau qhov overactivation ntawm MC1R signaling pathway. Los ntawm kev sib tw inhibiting ntawm - MSH qhov chaw khi thiab txo qis kev qhia ntawm TYR thiab TRP-1 cov noob, kev thaiv ntau qhov los ntawm cov teeb liab tuaj yeem ua tiav.
Nws "triple mechanism ntawm kev txiav txim" - kev sib tw inhibition ntawm alpha MSH khi qhov chaw, downregulation ntawm tyrosinase kev ua, thiab inhibition ntawm melanosome diffusion - muab nws lub hom phiaj cov teebmeem ntawm tawv ncauj pigmentation.
3. Tsaus pob txuv nti (post inflammatory pigmentation, PIH)
Cov tawv nqaij o yog qhov ua txhaum ntawm "post inflammatory pigmentation". Nonapeptide tuaj yeem tswj cov kab mob ntsig txog kev taw qhia txoj hauv kev thiab txo qis melanin ntau dhau los ua rau mob. Qhov no yog qhov tshwj xeeb tshaj yog rau cov teeb meem xws li pob txuv nti, rhiab ntawm daim tawv nqaij, thiab tom qab phais tas. Nws tuaj yeem tiv thaiv qhov tshwm sim ntawm post inflammatory pigmentation thiab dilute inflammatory pigmentation uas twb muaj lawm.
4. Cov tawv nqaij tsis sib xws thiab dullness hauv zos
Nonapeptide txhim kho cov tawv nqaij tsis sib xws los ntawm kev txo qis melanin ntau dhau ntawm cov tawv nqaij. Nws tsis zoo ib yam 'bleach' tag nrho lub ntsej muag, tab sis theej rov zoo li qub rau cov cheeb tsam uas tsim melanin ntau dhau, yog li ua tiav lub ntuj thiab txawm tias tawv nqaij.
Los tiv thaiv UV pigmentation - tus khub dawb ntawm cov khoom siv tshuaj pleev thaiv hnub
1. inhibit UVA induced melanin nce
UVA yog lub ntsiab ultraviolet band uas ua rau sib sib zog nqus pigmentation thiab photoaging. Nonapeptide (20 μ M, 3 hnub) tuaj yeem thim rov qab qhov nce ntawm melanin hauv tib neeg epidermal melanocytes ntxias los ntawm UVA. Qhov no ua rau nws yog ib qho zoo tagnrho "cov khoom xyaw ua kom dawb huv" hauv cov khoom siv tshuaj pleev thaiv hnub - cov tshuaj pleev thaiv hnub thaiv cov kab hluav taws xob ultraviolet thiab blocks melanin synthesis signals tshwm sim los ntawm cov hluav taws xob ultraviolet nyob rau theem cellular.
2. Xim tswj nyob rau tom qab hnub kho
NtxivNonapeptide-1tom qab lub hnub kho cov khoom tuaj yeem txo qis tom qab hnub tsaus ntuj thiab tawv nqaij liab, thiab ua kom tawv nqaij rov qab zoo.
Nws ob qhov kev cuam tshuam los ntawm kev tiv thaiv - cov khoom ua kom mob thiab inhibition ntawm melanin synthesis ua rau lub hnub kho tom qab tsis txwv rau soothing, tab sis tib lub sijhawm daws ob qhov teeb meem loj ntawm "sunburn" thiab "tanning".
3. Synergistic synergy nrog tshuaj pleev thaiv hnub formulations
tuaj yeem sib xyaw nrog tshuaj pleev thaiv hnub los tiv thaiv UV induced pigmentation. Kev tshawb fawb tau pom tias nws tuaj yeem ua kom muaj kev sib koom ua ke ntawm NRF2 antioxidant txoj hauv kev, txo qhov tso tawm ntawm cov kab mob inflammatory tshwm sim los ntawm ultraviolet hluav taws xob, thiab txo qis qhov liab ntawm cov nqaij ntshiv los ntawm 19.3%, ua tiav cov txiaj ntsig zoo ntawm kev ua kom dawb thiab kho.
Anti-inflammatory mediated melanin inhibition - underestimated thib ob battlefield
Qhov no yog qhov feem ntau saib tsis tau tab sis tseem ceeb heev daim ntawv thov qhov ntev rau inhibiting melanin.
1. Kev tawm tswv yim zoo voj ntawm qhov mob thiab melanin
Cov tawv nqaij o tso tawm ntau yam inflammatory yam, uas tuaj yeem ncaj qha txhawb kev loj hlob ntawm melanocytes thiab melanin synthesis, ua rau lub voj voog vicious ntawm "mob → pigmentation → ntau o". Nws tuaj yeem cuam tshuam cov tawv nqaij o thiab txiav tawm cov lus pom zoo no los ntawm qhov chaw.
2. Txo UV induced ntawm daim tawv nqaij liab
UV irradiation tsis tsuas yog txhawb cov melanin, tab sis kuj ua rau muaj kev mob tshwm sim.
Cov tshuaj tiv thaiv -cov khoom ua rau mob ua rau nws muaj nuj nqis dual hauv cov khoom siv kho mob tom qab hnub ci: nws inhibits melanin thiab soothes liab. Los ntawm kev tswj cov kab mob ntsig txog kev mob, peb tuaj yeem txo qhov ntau ntawm melanin tshwm sim los ntawm kev mob.
3. Txoj hauv kev nyab xeeb rau cov tawv nqaij tawv tawv
Cov khoom xyaw tshuaj pleev ib ce xws li niacin thiab arbutin tuaj yeem ua rau cov tawv nqaij rhiab heev kom liab thiab sting. Nonapeptide muab txoj hauv kev tsis ua kom tawv nqaij dawb rau cov tawv nqaij rhiab los ntawm thawj zaug thaiv cov teeb liab MC1R thiab tom qab ntawd kho qhov mob. Ntau cov kev tshawb fawb toxicological tau pom tias nws tsis yog khaus thiab tsis ua xua rau ntawm daim tawv nqaij, thiab tau dhau los ntawm thoob ntiaj teb ECARF daim ntawv pov thawj kev nyab xeeb ntawm daim tawv nqaij.
Compound Efficiency Enhancement - Ntau lub hom phiaj Synergistic Inhibition ntawm melanin
Tsis tshua muaj kev sib ntaus sib tua ib leeg, nws lub hwj chim tiag tiag nyob hauv kev sib koom ua ke nrog lwm cov khoom xyaw ua kom dawb los tsim "ntau- phiaj xwm, ntau-channel" melanin inhibition matrix. Synergistic mechanism ntawm compound cov khoom xyaw, melanin inhibition nyhuv, thiab ntxiv
Niacinamide inhibits melanin synthesis thiab blocks melanin thauj mus rau keratinocytes, ho txhim kho whitening efficiency.
3-O-ethyl ascorbic acid (VC derivative) VC inhibits tyrosinase thiab suppresses ob qho tib si sab sauv thiab qis qis ntawm MC1R teeb liab
Chuanming acid inhibits txoj hauv kev plasmin, txo UV induced pigmentation, thiab muaj ob yam kev tiv thaiv - inflammatory thiab whitening.
Arbutin ncaj qha inhibits tyrosinase kev ua si thiab dual inhibition ntawm txoj kev taw qhia.
Salicylic acid accelerates keratinocyte metabolism, pab nyob rau hauv shedding metabolism ntawm generated melanin, thiab inhibits ob leeg.
Centella asiatica glycoside muaj cov tshuaj tiv thaiv - mob thiab kho cov teebmeem, txo cov xim tsaus thiab soothing tom qab o, thiab ua kom dawb huv.
Lub tswv yim ntawm "txhim kho tag nrho cov saw hlau los ntawm cov teeb liab mus rau enzyme, thauj mus rau cov metabolism" yog cov ntsiab lus tseem ceeb ntawm cov khoom lag luam whitening thoob ntiaj teb tam sim no, thiab nws yog qhov tseem ceeb ntawm "cov teeb liab blocker" ntawm lawv.
Cov cuab yeej tshawb fawb tshawb fawb - cov cuab yeej muaj zog rau kev tshuaj xyuas cov txheej txheem ntawm melanin
Hauv chav kuaj, nws yog ib qho cuab yeej tseem ceeb rau kev kawm txog cov txheej txheem ntawm daim tawv nqaij pigmentation.
1. Kev tshawb fawb ntawm daim tawv nqaij Pigmentation
Raws li ib qho kev xaiv antagonist ntawm MC1R (Ki: 40 nM), nws tau dav siv los tshawb xyuas lub luag haujlwm tshwj xeeb ntawm - MSH/MC1R/cAMP signaling pathway hauv melanin synthesis. Cov kws tshawb fawb siv nws los "kaw" txoj hauv kev no thiab saib cov kev hloov pauv hauv qab MITF, tyrosinase, thiab TRP1 / TRP2 los qhia txog cov txheej txheem molecular ntawm pigmentation.
2. Kev tshawb fawb txog kev tswj hwm ntawm adrenal steroidogenesis
MC1R tsis tsuas yog muaj nyob rau ntawm melanocytes, tab sis kuj nyob rau hauv adrenal cortex hlwb.Nonapeptide-1muab ib qho tseem ceeb pharmacological cuab yeej rau kev tshawb fawb hauv daim teb no.
3. Kev tshawb fawb ntawm daim tawv nqaij
Vim lub shielding nyhuv ntawm melanin ntawm ultraviolet hluav taws xob, inhibiting melanin synthesis theoretically tsub kom lub rhiab heev ntawm daim tawv nqaij rau UV hluav taws xob. Tab sis qhov sib txawv, los ntawm inhibiting txoj hauv kev ntawm melanin synthesis, nws tuaj yeem pab qhia txog kev sib raug zoo ntawm kev loj hlob ntawm melanocytes thiab qog nqaij hlav ntawm daim tawv nqaij, muab qhov kev xav tshiab rau kev tshawb fawb los tiv thaiv kab mob qog noj ntshav.
Cov ntaub ntawv
[1] Sohu Nonapeptide-1; H-Met-Pro-D-Ph-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂; Muaj D-Phe thiab D-Trp-action_of_melanin 2026-03-03.
[3] Sohu Nonapeptide-1; H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Var-NH2_Skin Repaired Structural Formula-0202-3.
[6] Sohu Daim ntawv thov ntau yam ntawm nonapeptide-1 hauv tshuaj pleev ib ce 2025-03-10.
[9] Peptide Biology 【New Breakthrough in Targeted Whitening】 Peptide-1: Los ntawm MC1 receptor blockade technology, nws inhibits melanin ntau lawm signaling txoj kev ntawm qhov chaw 2025-05-05.
FAQ
Puas yog palmitoyl tripeptide 1 muaj kev nyab xeeb rau daim tawv nqaij?
Palmitoyl tripeptide-1 yog ib qho hluavtaws fatty acid-linked peptide uas tuaj yeem pab kho qhov pom ntawm daim tawv nqaij puas thiab ntxiv dag zog rau cov tawv nqaij hauv qab cov ntsiab lus txhawb nqa.
Nonapeptide 1 siv rau dab tsi?
NONAPEPTIDE-1 siv rau dab tsi? Nonapeptide-1 muaj txiaj ntsig zoo hauv cov tshuaj pleev ib ce rau inhibiting melanin ntau lawm los ntawm kev txo qis kev ua haujlwm ntawm enzyme tyrosinase, pab kom pom kev hyperpigmentation, tsaus me ntsis, thiab cov tawv nqaij tsis sib xws.
Cim npe nrov: Tuam Tshoj nonapeptide-1 manufacturers, lwm tus neeg
