Nyob rau hauv pem hauv ntej ntawm anti-aging science, ib tug hluavtaws peptide hu uaEpitalon hmoovyog garnering nce kev mloog. Nws cov txiaj ntsig tseem ceeb nyob hauv kev muab txoj hauv kev tshiab cog lus los tiv thaiv cov txheej txheem kev laus los ntawm kev siv ntau yam thiab sib koom ua ke lom neeg. Kev tshawb fawb qhia tias Epitalon tsis tsuas yog lub hom phiaj thiab ua kom telomerase kom ruaj khov lossis txawm tias ntev telomeres -" moos molecular" ntawm cellular lub neej-tab sis kuj tseem ua haujlwm ntau lub luag haujlwm tseem ceeb, suav nrog kev tswj hwm cov kab mob neuroendocrine thiab muab cov txiaj ntsig zoo antioxidant. Nws yog qhov tseeb qhov kev sib koom ua ke thoob plaws ntau txoj hauv kev uas tau pom tseeb qhov cuam tshuam hauv ntau yam qauv kev sim hauv lub cev, qhia txog kev ncua sij hawm tseem ceeb thiab ncua kev laus -txog phenotypes. Txawm hais tias txoj kev taug kev los ntawm chav kuaj mus rau qhov kev thov dav dav tseem nyob ntev, kev tshawb fawb uas twb muaj lawm tau pib qhia txog lub zeem muag zoo: Epitalon yuav tsis yog tus yuam sij rau kev ua neej ntev, tab sis kuj yog tus neeg sib tw tseem ceeb rau kev ua tiav kev noj qab haus huv txuas ntxiv thiab siab - kev laus zoo - qhov kawg ntawm tib neeg lub siab nyiam. Hauv qab no, peb yuav delve rau hauv lub hauv paus kev tshawb fawb, cov txheej txheem ntawm kev ua, thiab kev cia siab yav tom ntej ntawm cov molecule no.
Peb cov khoom Description
epithalon hmoov
txhaj tshuaj epitalon
epitalon tshuaj ntsiav
tshuaj epitalon
epitalon qhov ntswg tsuag
Epithalon COA
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| Certificate of Analysis | ||
| Compound npe | Epitalon | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 307297-39-8 | |
| Ntau | 1g | |
| Ntim txheem | 1g / hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090066 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |  |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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Raws li ib tug pioneering multi- lub hom phiaj molecule rau intervening nyob rau hauv kev laus, tus nqi tseem ceeb ntawmEpitalon hmoovlus dag nyob rau hauv nws synergistic multi-mechanistic ua: nws tsis tsuas yog txuas telomeres los ntawm activating telomerase tab sis kuj muaj ntau yam txiaj ntsig, nrog rau kev tswj cov kab mob neuroendocrine thiab ua rau muaj kev cuam tshuam antioxidant. Cov cuab yeej no ua rau nws ua tiav qhov tseem ceeb ntawm lub neej txuas ntxiv thiab ncua kev laus phenotypes hauv cov qauv kab mob. Txawm hais tias kev tshawb fawb tib neeg ua ntej tau pom nws cov telomere-lengthening teebmeem thiab muaj peev xwm los txhawb kev laus noj qab haus huv, cov lus xaus tseem xav tau kev lees paub los ntawm kev tshawb fawb loj -.
Yog li, cov tub ntxhais ntawm Epitalon hmoov tsis kam tiv thaiv kev laus yog "telomere telomerase" tswj axis.
Epitalon restores lub peev xwm proliferative ntawm telomeres
Raws li cov hluavtaws tetrapeptide, Epitalon tshwj xeeb khi rau thaj tsam txhawb nqa ntawm tib neeg telomerase thim rov qab transcriptase (hTERT) noob. Los ntawm kev txhim kho cov kev ua haujlwm ntawm cov neeg txhawb nqa no, nws txhawb kev qhia ntawm hTERT noob, yog li ua kom yooj yim rau kev sib txuas thiab sib sau ua ke ntawm telomerase. Cov txheej txheem no ua rau kom muaj txiaj ntsig zoo ntawm telomerase, uas txwv tsis pub ua haujlwm qis lossis tseem tsis ua haujlwm.
(2) Cov txheej txheem tshwj xeeb ntawm Telomere Elongation
Activated telomerase tshwj xeeb paub txog telomere sequences ntawm chromosome kawg. Siv nws tus kheej RNA ua tus qauv, nws ntxiv TTAGGG rov ua ntu zus rau telomere xaus los ntawm kev rov qab hloov dua siab tshiab, ncaj qha elongating telomere ntev thiab them nyiaj rau lub ntuj shortening uas tshwm sim thaum lub cell faib.
(3) Qhov tseem ceeb ntawm kev rhuav tshem Hayflick txwv
Thaum nyob rau hauv vitro kab lis kev cai ntawm ib txwm somatic hlwb, telomeres maj mam luv nrog txhua qhov kev faib. Thaum telomeres luv luv mus rau qhov ntev, cov hlwb nkag mus rau hauv lub xeev ntawm senescence lossis apoptosis-ib qho tshwm sim hu ua Hayflick txwv. Los ntawm elongating telomeres, Epitalon ua tau zoo los ntawm qhov kev txwv no, ncua kev cellular senescence thiab txo cov naj npawb ntawm apoptotic hlwb.
Qhov ntev telomere ruaj khov pab tswj lub peev xwm loj hlob ntawm cov qia hlwb (xws li, hematopoietic qia hlwb, mesenchymal qia hlwb) thiab cov hlwb somatic. Qhov no ua kom cov cellular txuas ntxiv txuas ntxiv thiab kev ua haujlwm ntawm lub cev, tiv thaiv qhov poob ntawm cov ntaub so ntswg thiab lub cev ua haujlwm vim txo qis kev loj hlob. Cov kev tshawb fawb soj ntsuam pom tau hais tias telomeres hauv cov hlwb ib txwm luv luv los ntawm kwv yees li 50-100 bp ib xyoos ib zaug, thaum Epitalon tuaj yeem txuas ntxiv telomeres li ntawm 100-300 bp hauv 2-3 lub hlis. Qhov tseem ceeb elongation nyhuv no tuaj yeem kho qhov ntev telomere rau qib piv rau cov neeg hluas.
Downregulation ntawm Aging Markers
Inhibition ntawm Cell Cycle Inhibitory Proteins
p16INK4a thiab p21WAF1 yog classic senescence-sociated cell cycle inhibitors. Lawv cov theem qhia tau nce zuj zus nrog kev laus ntawm cov cellular, yog li thaiv cov hlwb los ntawm kev nkag mus rau theem S thiab inhibiting cell proliferation. Epitalon tuaj yeem cuam tshuam ncaj qha rau kev hloov pauv thiab kev qhia ntawm p16INK4a thiab p21WAF1 cov noob los ntawm kev hloov kho cov kev taw qhia tseem ceeb, txo lawv cov qib protein ntau hauv cov hlwb thiab txo qhov txhaws ntawm lub voj voog ntawm tes.
Kev txo qis ntawm Heterochromatin Condensation
Raws li lub hnub nyoog hlwb, heterochromatin condensation tshwm sim hauv genome. Cov kua dej ntau dhau ntawm heterochromatin tuaj yeem ua rau transcriptional silencing, impairing ib txwm cellular physiological functions. Epitalon tuaj yeem txo qis heterochromatin condensation los ntawm kev tswj hwm cov haujlwm ntawm chromatin- hloov cov enzymes, tswj chromatin nyob rau hauv lub xeev so ntau dua thiab ua kom muaj kev hloov pauv ntawm cov noob.
Kev kho ntawm Genomic Stability
Heterochromatin condensation thiab telomere shortening ua rau muaj kev pheej hmoo ntawm DNA puas thiab chromosomal aberrations, thaum hais lus siab ntawm p16INK4a thiab p21WAF1 tuaj yeem ua rau genomic tsis ruaj khov. Los ntawm kev txo qis cov cim kev laus thiab ruaj khov telomere ntev, Epitalon zoo txo qhov txawv txav xws li DNA ob npaug -strand so thiab chromosomal misalignment, khaws cia genomic kev ncaj ncees thiab kev ruaj ntseg los tiv thaiv kev laus - cuam tshuam txog cellular dysfunction.
Kev khaws cia ntawm Gene Transcriptional Activity
Thaum tuav tswj kev ruaj ntseg genomic, lub xeev chromatin so kom ntseeg tau tias cov ntaub ntawv hloov pauv tuaj yeem khi tau zoo rau thaj chaw txhawb nqa cov noob. Qhov no txhawb nqa qhov kev hloov pauv ib txwm thiab kev qhia ntawm cov noob muaj feem xyuam rau kev ua haujlwm ntawm cov cellular physiological, tiv thaiv kev ua haujlwm tsis zoo vim yog gene silencing thiab txuas ntxiv ncua kev laus ntawm tes.
Epitalon hloov kho cov neuroendocrine rhythms
Restoration ntawm Pineal Gland Function
Lub caj pas pineal yog lub hauv paus hauv nruab nrab hauv tib neeg lub cev neuroendocrine lub luag haujlwm rau kev tswj cov circadian rhythms. Lub melatonin nws secretes plays lub luag haujlwm tseem ceeb hauv kev hloov pauv kev pw tsaug zog, ua kom muaj zog antioxidant, thiab ncua kev laus. Raws li cov tib neeg muaj hnub nyoog, kev ua haujlwm ntawm pineal caj pas maj mam poob qis, ua rau txo melatonin synthesis thiab cuam tshuam circadian rhythms. Epitalon tuaj yeem rov ua haujlwm li qub ntawm lub caj pas pineal los ntawm kev ua kom muaj teeb meem cuam tshuam hauv cov hlwb pineal, yog li ua kom melatonin ntau lawm.
Epitalon tsis tsuas yog txhim kho melatonin secretion tab sis kuj pab kho nws cov qauv zais cia txhua hnub. Nws txhawb nqa melatonin secretion peaks thaum hmo ntuj (lub sijhawm pw tsaug zog) thaum tswj qis qis thaum nruab hnub, ua raws li tib neeg lub cev circadian atherosclerosis. Txoj cai no pab txhawb kev pw tsaug zog zoo dua qub thiab txo kev laus -txog teeb meem xws li insomnia thiab pw tsaug zog fragmentation.
Stabilization ntawm Hormone secretion, suav nrog Cortisol
Cortisol yog ib qho tseem ceeb ntawm kev ntxhov siab hormone hauv tib neeg lub cev, thiab nws cov secretion kuj ua raws li lub voj voog circadian. Kev laus tuaj yeem cuam tshuam cov qauv cortisol secretion, ua rau muaj teeb meem xws li cov qib siab siab ntxov ntxov thiab txo cov kev hloov pauv hauv diurnal, uas ua rau cov metabolism tsis txaus, tsis muaj zog tiv thaiv kab mob, thiab kev puas siab puas ntsws. Epitalon pab txhim kho cov kev tso tawm txhua hnub ntawm cortisol thiab lwm yam tshuaj hormones los ntawm kev hloov pauv kev ua haujlwm ntawm hypothalamus-pituitary-adrenal (HPA) axis, txo qhov kev pheej hmoo ntawm kev laus- cuam tshuam txog hormonal dysregulation.
Kev txhim kho hauv Pw tsaug zog thiab Metabolism
Kev tswj kom zoo ntawm melatonin thiab cortisol rhythms synergistically txhawb tib neeg pw tsaug zog -Wake cycle, txhim khu kev pw tsaug zog zoo. Tsis tas li ntawd, stabilized hormone rhythms txhawb nqa cov piam thaj, lipid, thiab lub zog metabolism, txo kev laus - cuam tshuam cov kab mob metabolic xws li rog rog thiab insulin tsis kam, yog li indirectly exerting los tiv thaiv - laus.
Epitalon Exhibits Oxidative Stress Defense
Kev txo qis ntawm Reactive Oxygen Hom (ROS) ntau lawm
Oxidative stress yog ib qho tseem ceeb ntawm kev laus. Raws li cov neeg muaj hnub nyoog, mitochondrial kev ua haujlwm poob qis, ua rau muaj ROS ntau lawm hauv cov hlwb. Ntau ROS tawm tsam cov biomacromolecules tseem ceeb xws li DNA, cov proteins, thiab lipids, ua rau cov cellular puas thiab ua haujlwm tsis zoo. Epitalon pab tiv thaiv mitochondrial muaj nuj nqi, inhibits ROS tiam nyob rau hauv lub mitochondrial respiratory saw, txo intracellular ROS tsub zuj zuj, thiab mitigates oxidative kev nyuaj siab puas nyob rau hauv nws qhov chaw.
Txhim kho ntawm Endogenous Antioxidant System Kev Ua Haujlwm
Tib neeg lub cev muaj cov kab mob antioxidant endogenous, suav nrog superoxide dismutase (SOD), glutathione (GSH), thiab catalase (CAT), uas ua haujlwm kom tshem tawm ROS ntau dhau. Epitalon tuaj yeem txhim kho qhov kev qhia ntawm cov noob ntsig txog SOD thiab glutathione synthesis, nce qib ntawm cov tshuaj antioxidants. Qhov no txhim kho lub peev xwm tshem tawm ntawm endogenous antioxidant system, zoo tshem tawm ROS ntau dhau ntawm cov hlwb.
Kev tiv thaiv DNA thiab Protein kev ncaj ncees
ROS ntau dhau tuaj yeem ua rau DNA strand tawg, kev hloov pauv hauv paus, protein oxidation, denaturation, thiab degradation, impairing cellular physiological functions. Los ntawm kev txo qis ROS tiam thiab txhawb nqa lub peev xwm antioxidant, Epitalon zoo tiv thaiv DNA thiab cov proteins los ntawm kev puas tsuaj oxidative, khaws cia DNA kev ncaj ncees thiab tswj cov qauv protein kom zoo. Qhov no pab tiv thaiv cellular aging thiab apoptosis los ntawm biomolecular puas.
Txo ntawm Chromosomal Aberration Rate
Yog tias ROS-induced DNA kev puas tsuaj tsis kho tam sim ntawd, nws tuaj yeem ua rau chromosomal aberrations, xws li so, deletions, thiab translocations, uas cuam tshuam genomic stability thiab ua kom cov cellular aging. Los ntawm nws cov oxidative kev nyuaj siab tiv thaiv mechanisms, Epitalon txo DNA kev puas tsuaj thiab txo tus nqi ntawm chromosomal aberrations, khaws cia ib txwm cellular genetic yam ntxwv thiab ncua kev laus.
Xaus
Hauv cov ntsiab lus, kev tiv thaiv kev tiv thaiv - kev laus ntawm Epitalon yog nyob rau ntawm "telomere-telomerase" txoj cai axis, txhawb nqa los ntawm plaub lub tswv yim sib koom ua ke uas ua ke tsim kom muaj kev tiv thaiv kev laus - kev tiv thaiv kev laus. Nws qhib cov noob hTERT thiab elongates telomeres, hauv paus kov yeej cellular aging txwv thiab txhawb nqa kev loj hlob muaj peev xwm. Los ntawm downregulating aging markers thiab stabilizing genomic qauv, nws txo cellular dysfunction txuam nrog kev laus. Los ntawm kev hloov kho neuroendocrine rhythms, nws txhim kho kev pw tsaug zog thiab metabolic homeostasis, alleviating hormonal imbalances tshwm sim los ntawm kev laus. Tsis tas li ntawd, los ntawm kev txhim kho oxidative kev nyuaj siab tiv thaiv, nws tiv thaiv kev ncaj ncees ntawm intracellular biomacromolecules thiab mitigates aging - ntsig txog kev puas tsuaj.
Cov txheej txheem plaub no ua haujlwm tau zoo, muaj kev sib koom ua ke, tsom mus rau ob qho tib si hauv cellular Cheebtsam xws li telomeres thiab genome, nrog rau kev ua haujlwm dav dav xws li kev tswj hwm neuroendocrine thiab kev tiv thaiv antioxidant. Thaum kawg, Epitalon ua tiav nws cov thawj coj los tiv thaiv - cov hom phiaj kev laus ntawm kev ncua sijhawm ntawm cov cellular senescence, ameliorating organismal aging phenotypes, and controling systemic health. Qhov no muab kev txhawb nqa theoretical tseem ceeb thiab kev coj ua zoo rau ob qho tib si kev tshawb fawb kev laus thiab kev txhim kho ntawm cov kev cuam tshuam.
Cim npe nrov: Tuam Tshoj epithalon hmoov manufacturers, lwm tus neeg
