Nonapeptide-1 kev tu tawv nqaijyog cov khoom peptide, nrog rau nws qhov zoo tshaj plaws yog nws qhov kev ua siab mos, kev nyab xeeb, thiab kev ua haujlwm zoo. Los ntawm inhibiting qhov khi ntawm - MSH rau receptors, melanin synthesis yog tiv thaiv los ntawm qhov chaw, uas muaj ntau yam xws li whitening, lightening me ntsis, thiab txhim kho daim tawv nqaij. Los ntawm cov txheej txheem ntawm kev tsim melanin, nws tuaj yeem pom tias tyrosinase yog qhov tseem ceeb hauv kev tsim melanin. Yog tias qhov kev ua ntawm tyrosinase txo qis, kev tsim ntawm melanin tuaj yeem txo. Tus tswj hwm tseem ceeb uas txhawb nqa kev ua kom tyrosinase hauv melanocytes yog melanocortin receptor-1 (MC1-R). Tom qab MC1-R khi rau ib qho tshwj xeeb molecule - MSH, nws yog qhib los ntawm adenylate cyclase (AC) los tsim cyclic adenosine monophosphate (cAMP). Qhov nce hauv cAMP txhawb kev ua kom tyrosinase, uas yog tom qab ntawd oxidized rau dopaquinone, yog li txhawb kev tsim cov melanin.
Nonapeptide-1 COA
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| Certificate of Analysis | ||
| Compound npe | Nonapeptide-1 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 158563-45-2 | |
| Ntau | 70g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090067 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.58% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.49% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.68% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 140 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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| Chemical Formula: | C61H87N15O9S |
| Exact Mass: | 1206 |
| Molecular Luj: | 1207 |
| m/z: | 1206 (100.0%), 1207 (66.0%), 1208 (21.4%), 1207 (5.2%), 1209 (4.6%), 1208 (4.5%), 1208 (3.7%), 1209 (3.0%), 1208 (1.8%), 1209 (1.2%), 1209 (1.2%), 1207 (1.0%) |
| Elemental Analysis: | C, 60.73; H, 7.27; N, 17.41; O, 11.93; S, 2.66 |
NonapeptideSiv
Nonapeptide-1 kev tu tawv nqaij(neptide-1 Melanostatine-5), Molecular formula C ₆₁ H ₈₇ N ₁₅ O ₉ S, molecular hnyav 1206.50, CAS naj npawb 158563-45-2, amino acid sequence Met-Pro-D-Ph-Arg-D-Trp-Phe-Lys-Pro-Var-NH ₂. Lub hauv paus ntawm nws lub peev xwm kho derma nyob rau hauv qhov tseeb hais tias nws yog ib tug me me molecule active peptide uas muaj peev xwm simulate lub superficial tus kheej signaling mechanism, activating endogenous kho cov kev pab cuam los ntawm "dag" cell receptors.
Kev tsim ntawm ob hom D-hom amino acids (D-Phe thiab D-Trp) nrog C-terminal amidation ua rau nws nyuaj heev rau degrade nyob rau hauv derma protease ib puag ncig, thiab nws bioavailability deb tshaj li ntawm ntuj peptides. Tag nrho cov qauv yog amphiphilic, muaj zog alkaline, compact, thiab muaj zoo heev cell membrane nkag tau, uas muaj peev xwm ncaj qha mus txog lub basal txheej ntawm lub epidermis rau exert nws muaj nuj nqi.
Qhov no txhais tau hais tias nws tsis yog "txheej" nyob rau saum npoo ntawm lub derma, tab sis nws yog tiag tiag nkag mus thiab tsav kho los ntawm theem teeb liab.
Anti-inflammatory, soothing, thiab kho - txiav tawm lub voj voog vicious ntawm o thiab raug mob
1. Tswj kev mob ntsig txog kev taw qhia txoj hauv kev
Nws tuaj yeem tswj kev mob ntsig txog cov cim qhia thiab txo cov ntaub so ntswg puas tsuaj tshwm sim los ntawm o. Derma o yog tus yeeb ncuab loj tshaj ntawm kev kho - inflammatory yam tseem ceeb txuas ntxiv ua rau cov ntaub so ntswg tsim tshiab, ua rau qhov txhab rov ua dua thiab ua rau muaj kev cuam tshuam ntau zaus. Los ntawm kev txo qis kev tso tawm ntawm cov kab mob inflammatory, lub voj voog vicious ntawm "kev mob → cov ntaub so ntswg puas → ntau o" raug txiav tawm ntawm qhov chaw.
2. Txo UV induced ntawm daim tawv nqaij liab
UV irradiation tsis tsuas yog ua rau pigmentation, tab sis kuj ua rau mob inflammatory tshwm sim xws li liab, o, kub, thiab mob.
Cov tshuaj tiv thaiv -cov khoom ua rau nws muaj kev kho dual tus nqi hauv kev saib xyuas tom qab hnub ci: nws tsis tsuas yog inhibits kev puas tsuaj, tab sis kuj soothes liab. Kev tshawb fawb tau pom tias nws tuaj yeem txo qis qhov liab liab ntawm cov leeg nqaij rhiab los ntawm 19.3%, uas ncaj qha ua pov thawj nws qhov kev kho mob zoo hauv kev tiv thaiv - kho mob.
3. Ib 'txoj kev nyab xeeb' rau kev kho mob tom qab
Cov khoom xyaw qub qub (xws li cov ntsiab lus siab ntawm VC thiab txiv hmab txiv ntoo acid) tuaj yeem ua rau khaus khaus thaum mob. Nws muab txoj hauv kev nyab xeeb ntawm "tshuaj tiv thaiv - mob ua ntej, tom qab ntawd kho": nws tsis txhawb cov kab mob uas twb muaj lawm tsis yooj yim, tab sis es tsis txhob tsim lub microenvironment ruaj khov rau kev kho tom ntej los ntawm inhibiting inflammatory pathways xws li NF - κ B. Qhov no ua rau nws tshwj xeeb tshaj yog siv thaum lub sij hawm "qhov rai lub sij hawm ntawm kev kho mob, kho cov kab mob." xws li tom qab kho cov kua qaub.
Txhawb kev loj hlob ntawm tes thiab rov ua dua tshiab - ua kom lub qhov txhab zoo
1. Ua kom cov tawv nqaij loj hlob tuaj thiab sib txawv
Nonapeptide-1 kev tu tawv nqaijtuaj yeem txhawb kev loj hlob thiab kev sib txawv ntawm cov hlwb sab nraud. Qhov tseem ceeb ntawm kev kho qhov muag sab nraud yog kev tshem tawm cov hlwb qub thiab hloov cov hlwb tshiab. Los ntawm kev ua kom cov teeb liab proliferation ntawm basal txheej qia hlwb, lub voj voog rov ua dua tshiab ntawm keratinocytes yog nrawm dua, tso cai rau lub cev puas tsuaj los ntawm cov hlwb noj qab haus huv sai dua.
2. Txhawb nqa rov qab epithelialization
Nyob rau hauv tus qauv kev raug mob superficial, los ntawm kev txhim kho lub zog ntawm kev loj hlob thiab extracellular matrix (ECM), granulation cov ntaub so ntswg kev loj hlob thiab neovascularization yog txhawb, accelerating tus txheej txheem ntawm re epithelialization.
Cov txheej txheem no zoo ib yam li kev kho qhov laj thawj ntawm qhov kev loj hlob ntawm placental 2 (PIGF-2) - ntxiv dag zog rau kev sib raug zoo ntawm kev loj hlob thiab ECM, ua kom kho cov teeb meem txuas ntxiv thiab ua haujlwm tau zoo.
3. Hloov kho lub voj voog optimization
Lub voj voog rov ua dua qub qub yog li 28 hnub. Los ntawm kev txhawb nqa kev rov ua dua tshiab ntawm tes, lub voj voog no tuaj yeem ua kom zoo rau lub xeev muaj txiaj ntsig zoo dua. Kev soj ntsuam kev soj ntsuam tau pom tias siv cov khoom siv sab nrauv uas muaj cov tshuaj no tuaj yeem txhim kho cov suab nrov tsis sib xws hauv 14 hnub, thiab tom qab 28 hnub (kev ua tiav cov txheej txheem metabolic), muaj kev txhim kho tseem ceeb hauv qhov zoo tshaj plaws. Qhov no tsis yog qhov chaw npog, tab sis qib cellular 'kev rov ua kom nrawm dua'.
Collagen thiab Elastic Fiber Repair - Anti Aging Repair
1. Txhawb collagen synthesis
Nws tuaj yeem txhawb cov synthesis ntawm collagen, txhim kho superficial elasticity, thiab txo cov kab zoo thiab wrinkles. Qhov no ua rau nws tsis yog tsuas yog kho cov khoom xyaw xwb, tab sis kuj tseem muaj ob txoj haujlwm peptide ntawm "kho + tiv thaiv- laus". Ntxiv cov khoom xyaw no rau cov kua dej thiab lub ntsej muag qab zib tuaj yeem ua tiav lub hom phiaj ntawm "kho collagen puas + tiv thaiv collagen poob".
2. Txhawb cov synthesis ntawm elastic fibers
Ntxiv nrog rau collagen, nws tseem tuaj yeem tiv thaiv cov fibers tseem ceeb (elastic fibers) lub luag haujlwm rau superficial elasticity, noo noo, thiab lub zog, ua kom lub ntsej muag du thiab tiv thaiv kev tsim cov kab zoo thiab roughness. Collagen muab 'kev txhawb nqa', thaum elastic fibers muab 'resilience'. Tsuas yog thaum ob leeg ua haujlwm ua ke tuaj yeem ua rau lub ntsej muag tiag tiag rov ua nws lub xeev hluas.
3. Tiv thaiv collagen degradation los ntawm ultraviolet hluav taws xob
Ultraviolet hluav taws xob yog tus naj npawb ib tus neeg tua neeg ntawm collagen - nws qhib MMP (matrix metalloproteinases), txiav collagen rau hauv cov khoom tawg. Los ntawm inhibiting o signals induced los ntawm ultraviolet hluav taws xob, lub activation ntawm MMP yog indirectly txo, tiv thaiv ntxiv kev puas tsuaj rau collagen uas twb muaj lawm. Qhov no yog 'kev tiv thaiv kev kho' - tsis yog kho qhov tshiab xwb, tab sis kuj tiv thaiv cov qub.
4. Txhawb cov synthesis ntawm hom I, III, thiab IV collagen proteins
Kev tshawb fawb tau pom tias nws muaj peev xwm txhawb nqa cov synthesis ntawm hom I (cov qauv kev txhawb nqa), hom III (mos elasticity), thiab hom IV (hauv qab daus membrane anchoring) collagen proteins. Hom I collagen tso nyiaj ntau dua 80% ntawm qhov hnyav qhuav ntawm derma thiab yog tus yuam sij rau kev tiv thaiv derma sagging; Hom III collagen txiav txim qhov "softness" ntawm derma; Hom IV collagen yog "adhesive" ntawm epidermis thiab dermis. Kev txhawb nqa ib txhij ntawm peb hom yog qhov tseeb tag nrho cov txheej txheem kho.
Tshaj tawm hnub kho - "tshuaj tua hluav taws" rau kev puas tsuaj UV
1. Rov qab UVA induced cell puas
Nonapeptide-1 kev tu tawv nqaij(20 μ M, 3 hnub) tuaj yeem thim rov qab UVA kev puas tsuaj hauv tib neeg epidermal melanocytes (HEM hlwb). UVA muaj zog nkag mus thiab tuaj yeem ncaj qha mus txog txheej dermis, ua rau collagen thiab elastic fibers, uas yog lub ntsiab ua rau photoaging. Los ntawm inhibiting qhov nce ntawm cAMP signaling thiab oxidative kev nyuaj siab tshwm sim los ntawm UVA, peb tuaj yeem tua hluav taws ntawm qib cellular.
2. Cov khoom xyaw tseem ceeb ntawm cov khoom kho tom qab hnub ci
Ntxiv rau tom qab lub hnub kho cov khoom tuaj yeem txo qis tom qab hnub redness thiab ua kom cov tawv nqaij rov qab zoo.
Nws ob lub tswv yim ntawm "tiv thaiv- mob + kho" ua rau kev saib xyuas lub hnub tsis txwv rau kev so, tab sis tib lub sijhawm hais txog ob qhov teeb meem loj ntawm "sunburn (inflammation)" thiab "sunburn (cov ntaub so ntswg puas)".
3. Kev sib koom tes kho nrog cov tshuaj pleev thaiv hnub
tuaj yeem sib xyaw nrog cov tshuaj pleev thaiv hnub los thaiv UV rays thaum kho cov residual UV ua rau muaj kev puas tsuaj ntawm cov cellular theem. Qhov no yog qhov ua tiav ntawm "kev tiv thaiv sab nraud + kev kho sab hauv" - tshuaj pleev thaiv hnub yog thawj kab ntawm kev tiv thaiv, thiab neptide-1 yog kab thib ob ntawm kev tiv thaiv.
Kho microcirculation - txhim kho daim tawv nqaij qaug zog
1. Txhawb cov ntshav khiav
Muaj peev xwm txhawb nqa derma microcirculation thiab ua kom cov ntshav khiav. Ib qho ntawm cov laj thawj tseem ceeb rau dull thiab nkeesderma yog cov microcirculation tsis zoo - cov as-ham tsis tuaj yeem xa thiab pov tseg tsis tuaj yeem tso tawm. Los ntawm kev txhawb nqa microvascular dilation, "cov khoom noj khoom haus kab" ntawm derma yog txhim kho.
2. Txhim kho cov hnab qhov muag thiab o
Nws cov yam ntxwv ntawm kev txhawb nqa cov ntshav ntws kuj muaj qee yam kev txhim kho ntawm cov hnab qhov muag thiab lub ntsej muag o.
Txawm hais tias qhov no tsis yog nws cov lus qhia tseem ceeb, nws feem ntau tshwm sim raws li cov khoom siv pabcuam hauv cov khoom kho qhov muag.
3. Txhim kho lub zuag qhia tag nrho "kuj tseem ceeb" ntawm daim tawv nqaij
Cov neeg siv tswv yim qhia tau hais tias tom qab siv tas li ntawm cov khoom, cov derma tshwm "rosy thiab ci" es tsis txhob daj ntseg "dawb dawb". Qhov no yog ib qho kev nthuav dav ntawm kev txhim kho microcirculation, ua kom lub cell rov ua dua tshiab, thiab ua tiav kev kho qhov teeb meem.
Lub peev xwm ntawm kev kho qib kho mob scenarios
1. Kev kho tom qab phais
Yog tsis muaj cytotoxicity thiab los tiv thaiv - cov khoom inflammatory, nws muaj peev xwm siv tau nyob rau hauv "barrier rupture lub sij hawm" tom qab laser phais, microneedling phais, thiab txiv hmab txiv ntoo acid derma hloov phais. Nws tsis txhawb cov txheej dermis, tab sis es tsis txhob ua kom lub qhov txhab zoo los ntawm kev txhawb nqa cell proliferation thiab collagen synthesis.
2. Kho qhov txhab mob
Txawm hais tias tam sim no tsuas yog siv hauv kev lag luam tshuaj pleev ib ce.
Nws ntau lub tswv yim ntawm kev txhawb nqa kev loj hlob ntawm tes, txhim kho ECM synthesis, thiab tswj kev mob yog ua raws li cov cai tseem ceeb ntawm kev kho qhov txhab mob. Hauv ECM hydrogels, hnav khaub ncaws collagen thiab lwm yam kev hnav khaub ncaws tshiab, kev tshawb fawb ntawm cov khoom siv ntxiv tau txhawb nqa.
3. Kho qhov kev xav hauv kev tshawb fawb los tiv thaiv kab mob qog noj ntshav
Nonapeptide-1 kev tu tawv nqaij, raws li MC1R antagonist, yog siv los ua cov cuab yeej tshuaj hauv kev tshawb fawb derma cancer. Los ntawm kev kho qhov muag, nws cov kev cai meej ntawm txoj kev taw qhia melanocyte muab qhov kev xav tshiab rau kev nkag siab txog kev kho tsis ua haujlwm ntawm "kev loj hlob txawv txav → carcinogenesis".
Cov ntaub ntawv
[1] Sohu Neptide-1; H-Met-Pro-D-Ph-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂; Muaj D-Phe thiab D-Trp, tus qauv qauv rau kev kho daim tawv nqaij 2026-03-02.
[2] MedChemExpress. Neptide -1. 2026-05-29.
[3] Zhihu Column Whitening Peptide/Nanopeptide-1- ntau yam khoom muaj nqis peptide uas tuaj yeem ua kom cov pigmentation, ci thiab ua kom tawv nqaij 2023-12-22.
[4] Zoo siab txais tos rau lub vev xaib ntawm Phau Tsom Faj Txog Kev Tshawb Fawb Kev Tshawb Fawb Txog Kev Tshawb Fawb ntawm extracellular matrix hauv daim tawv nqaij kho qhov txhab 2023-12-23.
[9] Peptide Biology 【Tshaj Tawm Tshiab Hauv Lub Hom Phiaj Dawb】 Peptide Nine Peptide-1 2025-05-05.
[15] SciPeptide. Cuaj Peptide-1|CAS Nr .: 158563-45-2|Neptide -1. 2025-09-10
Cim npe nrov: Tuam Tshoj nonapeptide-1 skincare manufacturers, lwm tus neeg
