Botulinum Toxin Peptide(cov tshuaj lom neeg CAS No.: 93384-43-1) yog ib qho neurotoxic polypeptide uas tsim los ntawm Clostridium botulinum, thiab ib qho ntawm cov tshuaj lom neeg uas paub zoo tshaj plaws hauv cov xwm txheej. Nws cov txheej txheem tseem ceeb ntawm kev ua haujlwm yog thaiv kev tso tawm ntawm acetylcholine ntawm qhov sib txuas neuromuscular kom inhibit cov leeg nqaij, yog li tsim cov leeg nqaij. Nws yog dav siv los kho cov kab mob neuromuscular xws li blepharospasm thiab hemifacial spasm hauv kev kho mob; Hauv kev kho mob zoo nkauj, nws feem ntau siv rau kev txhim kho wrinkle thiab lub ntsej muag slimming. Tsis tas li ntawd, nws qhia tau hais tias muaj peev xwm siv tau hauv kev tswj qhov mob thiab kev kho mob hyperhidrosis. Kev tswj kev noj tshuaj nruj me ntsis yuav tsum tau siv hauv kev kho mob kom muaj kev nyab xeeb.
Peb Cov Khoom Muag Khoom
Botulinum Toxin COA
Molecular Structure
Botulinum Toxin Peptideyog macromolecular neurotoxic polypeptide, tsim cov qauv heterodimer tsim los ntawm cov saw hnyav (kwv yees li 100 kDa) thiab cov saw teeb (kwv yees li 50 kDa) txuas los ntawm cov nyiaj disulfide. Cov saw hnyav yog lub luag haujlwm rau kev lees paub thiab khi rau receptors ntawm cov paj hlwb ntawm cov paj hlwb, thaum lub teeb sawb muaj cov haujlwm protease, uas yog lub luag haujlwm tseem ceeb hauv cheeb tsam rau exerting nws cov tshuaj lom.
Toxicity yam ntxwv
Raws li ib qho ntawm cov tshuaj lom neeg tshaj plaws paub hauv qhov xwm txheej, nws cov tshuaj toxicity yog qhov tshwj xeeb, ua haujlwm tsuas yog ntawm cholinergic paj terminals ntawm lub neuromuscular hlws ris. Ib koob tshuaj me me heev (nanogram theem) tuaj yeem ua rau mob hlab ntsha tawg loj heev, thiab qhov koob tshuaj tuag nruab nrab (LD₅₀) rau cov tsiaj muaj tsawg heev.
Kev ruaj ntseg
Cov polypeptide no yog qhov kub thiab txias -rhiab heev thiab tuaj yeem ua tsis tau los ntawm cua sov ntawm 55-60℃rau ob peb feeb. Nws yog feem ntau ua rau inactivation thaum khaws cia rau hauv chav tsev kub thiab yuav tsum tau muab kaw thiab khaws cia ntawm qhov kub thiab txias (feem ntau qis dua -20 degree). Lub caij no, nws muaj qee qhov kev xav tau rau pH tus nqi, ua kom ruaj khov nyob rau hauv qhov nruab nrab rau qhov tsis muaj zog acidic ib puag ncig, thiab muaj zog acid lossis alkali tej yam kev mob yuav rhuav tshem nws cov qauv spatial thiab ua rau poob ntawm kev ua haujlwm.
Solubility
Nws muaj qee qhov dej solubility thiab tuaj yeem yaj hauv cov kev daws teeb meem tsis zoo xws li cov ntsev ib txwm, tab sis nws cov solubility cuam tshuam los ntawm pH tus nqi thiab ionic zog ntawm cov tshuaj. Nws tuaj yeem ua rau hauv siab -cov ntsiab lus ntsev ntsev. Yog li ntawd, cov txheej txheem tshwj xeeb tsis yog feem ntau siv hauv chaw kho mob thiab kev sim ua kom nws cov solubility thiab kev ua haujlwm.
Qhov tshwj xeeb ntawm Kev Ua Txhaum Cai
Nws cov qauv tshuaj txiav txim siab qhov tshwj xeeb ntawm nws cov haujlwm lom neeg. Nws tsuas tuaj yeem tshwj xeeb hydrolyze cov proteins uas cuam tshuam nrog acetylcholine tso tawm hauv cov hlab ntsha (xws li SNAP-25, VAMP, thiab lwm yam), yog li thaiv kev tso tawm neurotransmitter. Qhov no mechanism ntawm kev txiav txim muaj nruj substrate tshwj xeeb thiab tsis cuam tshuam rau lwm yam cellular physiological txheej txheem.
Kev Tshawb Nrhiav Thaum Ntxov thiab Nomenclature (Late 19th Century)
Xyoo 1895, Belgian bacteriologist Emile van Ermengem tau ua thawj qhov kev tshawb fawb txog botulinum toxin. Thaum lub sij hawm ntawd, muaj ntau yam mob lom tom qab noj pickled nqaij npua hauv Belgium.Nws cais ib qho anaerobic clostridium (tom qab lub npe hu ua Clostridium botulinum) los ntawm cov neeg mob lub cev thiab cov nqaij ntshiv, tau lees paub tias cov tshuaj lom uas tsim los ntawm nws yog tus neeg ua txhaum ntawm kev lom, thiab hu ua cov tshuaj lom no "botulinum botulinum" los ntawm Latin "botulinum toxus" feem ntau muaj feem xyuam rau cov khoom noj nqaij lwj).
Initial Purification thiab Preliminary Characterization of the Toxin (1920s-1930s)
Nyob rau xyoo 1920, tus kws tshawb fawb Asmeskas George Atkinson ua thawj zaug sim ua kom huv botulinum toxin, tso lub hauv paus rau kev tshawb fawb tom ntej. Nyob ib ncig ntawm 1930, cov kws tshawb fawb ntxiv tau lees paub tias cov tshuaj lom yog neurotoxic thiab tuaj yeem ua rau cov kab mob neuromuscular hlws ris cuam tshuam rau cov leeg nqaij, tab sis lub peptide tsis tau tshwm sim ntawm lub sijhawm no.
Kev lees paub ntawm Peptide Structure thiab Serotyping (1950s-1970s)
Hauv xyoo 1950, kev txhim kho ntawm cov thev naus laus zis biochemical tau txhawb nqa hauv - kev tshawb fawb tob txog cov qauv ntawm cov tshuaj lom. Siv cov tswv yim xws li gel filtration thiab electrophoresis, cov kws tshawb fawb tau lees paub tias cov ntsiab lus tseem ceeb ntawm botulinum toxin yog polypeptide, thiab qhia meej tias nws muaj cov qauv heterodimeric polypeptide.Tom qab ntawd txog rau xyoo 1970, cov kws tshawb fawb tau tshawb pom tias cov tshuaj lom muaj ntau yam serotypes (A, B, thiab lwm yam). Cov serotypes sib txawv muaj qhov sib txawv hauv cov qauv polypeptide, nrog rau cov tshuaj lom neeg thiab kev ua haujlwm.
Kev Tshawb Fawb Txog Kev Siv Tshuaj Kho Mob thiab Kev Tshaj Tawm Txog Kev Ua Haujlwm (Tom qab xyoo 1980s)
Hauv xyoo 1980, tus kws kho mob Asmeskas kws kho mob Alan Scott thawj zaug siv cov tshuaj botulinum toxin hom A polypeptide rau kev kho mob ntawm blepharospasm, qhib lub prelude rau nws daim ntawv thov kev kho mob. Cov kev tshawb fawb tom qab maj mam qhia cov txheej txheem los ntawm qhov no polypeptide exerts nws cov txiaj ntsig los ntawm kev thaiv kev tso tawm ntawm acetmuscular daim ntawv thov nyob rau hauv cov ntaub so ntswg. tshuaj, kev kho mob zoo nkauj thiab lwm yam kev lag luam, thiab tseem txhawb kev txheeb xyuas thiab txhim kho nws cov keeb kwm kev tshawb pom.
Kev kho cov kab mob Neuromuscular
Raws li qhov tseem ceeb ntawm daim ntawv thov kev kho mob,botulinum tshuaj lom peptidefeem ntau yog siv los kho ntau yam kab mob ntawm cov leeg nqaij hypercontraction ntsig txog lub hauv nruab nrab lossis peripheral paj hlwb. Piv txwv li, nws yog siv los txhim kho cov leeg nqaij tsis muaj zog hauv cov neeg mob uas muaj blepharospasm thiab hemifacial spasm, txo qis caj dab nqaij torsion los ntawm spasmodic torticollis, thiab kho limb spasticity tshwm sim los ntawm cerebral palsy hauv cov menyuam yaus, pab txhim kho cov neeg mob lub cev muaj zog thiab lub neej zoo.
Nws cov txheej txheem ntawm kev ua haujlwm yog kom ua tiav cov leeg nqaij so los ntawm kev thaiv qhov tso tawm ntawm acetylcholine ntawm cov hlab ntsha neuromuscular.
Lub Cev Shaping thiab Anti-Kev laus hauv kev kho mob zoo nkauj
Nws yog dav siv hauv kev kho mob zoo nkauj, feem ntau yog rau lub ntsej muag tiv thaiv -aging thiab contour shaping. Rau dynamic wrinkles (xws li cov kab glabellar, crow's ko taw, hauv pliaj kab, thiab lwm yam), txhaj tshuaj tuaj yeem cuam tshuam cov leeg nqaij hauv zos, txo qis kev tsim, thiab ua tiav daim tawv nqaij; Nyob rau tib lub sijhawm, nws tuaj yeem siv rau lub cev ua haujlwm xws li lub ntsej muag thinning, lub xub pwg nyom, thiab calf thinning.
Los ntawm atrophying cov leeg masseter, cov leeg trapezius thiab lwm cov leeg hauv lub hom phiaj, nws ua tiav txoj kab optimization. Daim ntawv thov no yog ib qho ntawm cov haujlwm tseem ceeb hauv kev kho mob zoo nkauj vim nws cov txiaj ntsig tseem ceeb thiab lub sijhawm rov qab los luv.
Kev kho cov kab mob ua haujlwm
Nws qhia tau hais tias muaj txiaj ntsig zoo hauv kev kho mob ntawm ntau yam kev ua haujlwm tsis zoo. Rau thawj hyperhidrosis (xws li tawm hws ntau dhau ntawm xib teg, caj npab, thiab ob txhais taw), nws tuaj yeem txo hws secretion los ntawm kev thaiv cov hlab ntsha ntawm cov qog hws.
Nws tuaj yeem siv los kho tus mob migraine, tshwj xeeb tshaj yog rau cov neeg mob uas muaj mob migraine, uas tuaj yeem txo qhov zaus thiab qhov hnyav ntawm migraine tawm tsam los ntawm inhibiting neurogenic o thiab tswj kev mob ntawm txoj kev; Tsis tas li ntawd, nws tseem tuaj yeem siv los txo cov zis nquag, tso zis sai thiab lwm yam tsos mob tshwm sim los ntawm lub zais zis ntau dhau, txhim kho cov neeg mob tso zis ua haujlwm.
Kev Tshawb Fawb Txog Lwm Cov Kev Siv Hluav Taws Xob
Nrog rau hauv - kev tshawb fawb tob, nws daim ntawv thov teb tau nthuav dav tas li. Nyob rau hauv dermatology, nws muaj peev xwm pab tau nyob rau hauv kev kho mob ntawm flushing thiab telangiectasia tshwm sim los ntawm rosacea, raws li zoo raws li kev tiv thaiv thiab kev kho mob ntawm keloids; nyob rau hauv stomatology, nws yog siv los txo cov leeg mob thiab nyuaj rau kev qhib lub qhov ncauj los ntawm temporomandibular joint disorder syndrome.
Tib lub sijhawm,botulinum tshuaj lom peptidetseem yog nyob rau hauv kev tshawb fawb thiab daim ntawv thov kev tshawb fawb theem nyob rau hauv lub adjuvant kev kho mob ntawm neuropathic mob (xws li trigeminal neuralgia), muab ib tug tshiab kev taw qhia rau kev kho mob ntawm lwm yam kab mob.
Txoj kev tswj hwm
Kev txhaj tshuaj yog txoj hauv kev tseem ceeb ntawm kev tswj hwm. Hauv kev kho mob thiab kev kho mob zoo nkauj, kev txhaj tshuaj subcutaneous lossis txhaj tshuaj intramuscular tau txais, thiab kev txhaj tshuaj tob yog xaiv raws li lub hom phiaj kev kho mob -superficial subcutaneous txhaj tshuaj feem ntau yog siv los txhim kho cov tawv nqaij tawv nqaij, thaum sib sib zog nqus intramuscular txhaj tshuaj yuav tsum tau siv los txo cov leeg nqaij thiab lub cev shaping; nyob rau hauv cov xwm txheej tshwj xeeb (xws li kev kho mob hyperhidrosis), kev txhaj tshuaj microneedle tuaj yeem ua rau hauv hws qog- thaj chaw ntom ntom kom ntseeg tau tias cov tshuaj ua haujlwm ntawm lub hom phiaj.
Dosage Principple
Lub hauv paus ntsiab lus ntawm "kev siv tus kheej muaj tseeb" yuav tsum ua raws. Cov koob tshuaj yuav tsum tau hloov kho raws li qhov chaw kho mob, qhov hnyav ntawm tus kab mob, tus neeg mob lub hnub nyoog thiab kev zam rau tus kheej. Piv txwv li, qhov ntau npaum li cas rau ib lub ntsej muag tiv thaiv - qhov chaw laus feem ntau yog 2-5 units, thiab ntau npaum li cas rau kev kho cov kab mob xws li spasmodic torticollis tuaj yeem ncav cuag kaum rau ntau pua units; Kev noj ntau dhau yog txwv nruj kom tsis txhob muaj qhov tshwm sim tsis zoo.
Xaiv qhov chaw siv tau
Qhov chaw txhaj tshuaj yuav tsum raug nyob raws li qhov xav tau kev kho mob. Hauv kev kho mob zoo nkauj, nws yog tsom rau lub ntsej muag (glabella, periorbital cheeb tsam, hauv pliaj, thiab lwm yam), caj dab, lub xub pwg nyom, calves thiab lwm qhov chaw; Kev kho mob tsom mus rau cov nqaij ntshiv (xws li cov leeg nyob ib ncig ntawm daim tawv muag, cov leeg trapezius ntawm caj dab, cov nqaij ntshiv ntawm cov ceg ntawm cov menyuam yaus uas muaj mob hlwb), cov chaw hyperhidrotic (xws li xib teg, armpits, soles) thiab qhov chaw ua haujlwm xws li lub zais zis phab ntsa.
Course of Treatment and Interval Cycle
Cov nyhuv ntawm ib qho kev txhaj tshuaj yuav kav ntev li 3-6 lub hlis, thiab rov txhaj tshuaj yuav tsum tau nyob rau ib ntus kom tswj tau cov nyhuv. Lub sijhawm ua haujlwm rau kev kho mob zoo nkauj los tiv thaiv kev laus thiab lub cev zoo nkauj yog 4-6 lub hlis, thiab lub sijhawm rau kev kho mob ntawm cov kab mob neuromuscular yuav tsum tau hloov kho raws li qhov rov tshwm sim ntawm cov tsos mob, feem ntau yog 3-6 lub hlis; Kev txhaj tshuaj tas mus li hauv tib qhov chaw yuav tsum zam lub sijhawm luv luv kom txo tau qhov kev pheej hmoo ntawm cov leeg nqaij atrophy ntau dhau.
Cov Kev Cai Ua Haujlwm Kev Ua Haujlwm
Kev ua haujlwm yuav tsum tau ua los ntawm cov kws kho mob cov neeg ua haujlwm hauv ib puag ncig tsis muaj menyuam. Ua ntej txhaj tshuaj, tus neeg mob qhov kev noj qab haus huv, keeb kwm tsis haum tshuaj thiab keeb kwm tshuaj yuav tsum tau ua tib zoo soj ntsuam kom tsis txhob muaj contraindications; Thaum txhaj tshuaj, cov hlab ntsha thiab cov hlab ntsha - yuav tsum zam qhov chaw ntom ntom. Tom qab ua haujlwm, maj mam nias qhov chaw txhaj tshuaj tiv thaiv kom tsis txhob kis mus rau qhov tsis yog - cov phiaj xwm thiab ua rau muaj kev phiv
FAQ
Puas yog botulinum toxin yog peptide?
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Cov kab mob toxicity tsim los ntawm hom CLOSTRIDIUM BOTULINUM. Cov co toxins yog synthesized raws li ib tug tib peptide saw uas yog ua tiav rau hauv ib tug paub tab proteins uas muaj ib tug hnyav saw thiab lub teeb saw txuas los ntawm ib tug disulfide daim ntawv cog lus.
Dab tsi yog peptide Botox?
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Neuromodulators (Botox®, Dysport®, Jeuveau®): ceev, kwv yees, thiab siv tau. Lawv smooth wrinkles los ntawm relaxing cov leeg uas ua rau lawv. Cov txiaj ntsig tau siv sijhawm li 3-4 lub hlis. Kev txhaj tshuaj peptides: qeeb, subtler, thiab sim.
Puas peptides cuam tshuam rau Botox?
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Txhim kho daim tawv nqaij elasticity: Peptides pab txhawb cov tawv nqaij elasticity thiab firmness, ntxiv rau qhov wrinkle -smoothing los ntawm Botox. Youthful Radiance: Los ntawm rejuvenating ntawm daim tawv nqaij ntawm ib tug cellular theem, Botox thiab Peptide Therapy synergize kom ib tug hluas glow thiab tseem ceeb heev rau daim tawv nqaij.
Puas yog botulinum toxin zoo ib yam li Botox?
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Botox® yog ib lub npe nrov tshaj plaws ntawm kev txhaj tshuaj botulinum toxin. Botulinum toxins yog cov neurotoxins uas cuam tshuam rau cov hlab ntsha thiab ua rau cov leeg tsis muaj zog. Tej zaum koj yuav tau txhaj tshuaj botulinum toxin rau tshuaj pleev ib ce lossis kho mob.
Dab tsi yog peptide toxin?
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Peptide toxins muaj zog thiab feem ntau exquisitely xaiv probes ntawm cov qauv thiab kev ua ntawm ion channels thiab receptors thiab xws li yog ib qho tseem ceeb txaus siab rau cov kws kho mob thiab biotech industries raws li ob qho tib si kho mob coj thiab cov cuab yeej tshuaj.
Cim npe nrov: Tuam Tshoj botulinum toxin peptide manufacturers, lwm tus neeg
