Hauv thaj tsam ntawm kev tu tawv nqaij, xiav tooj liab peptide (GHK-Cu) tau ntev tau qhuas tias yog lub hnub qub muaj nyob rau hauv kev tiv thaiv- cov qauv kev laus rau nws qhov kev ua tau zoo tshwj xeeb hauv kev txhawb nqa collagen, muab cov txiaj ntsig antioxidant, thiab ua kom lub qhov txhab zoo. Txawm li cas los xij, kev tshawb fawb tsis ntev los no qhia tau hais tias GHK-Cu lub peev xwm txuas ntxiv mus deb dhau qhov no - nws tab tom hla lub npe ntawm kev tu tawv nqaij kom venture mus rau hauv tag nrho cov frontiers tshiab xws li neuroprotection, metabolic regulation, thiab txawm hla - hom ntawv thov. Qhov kev hloov pauv tshiab no tsis yog tsuas yog qhia cov lus qhia tshiab rau kev tshawb fawb kho mob tab sis tuaj yeem hloov kho tib neeg txoj kev nkag siab ntawm "tiv thaiv- laus."
Kub muag
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Daim ntawv pov thawj ntawm Analysis |
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Compound npe |
GHK-Cu |
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CAS Nr. |
49557-75-7 |
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Ntau |
50kg ua |
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Chaw tsim tshuaj paus |
Shaanxi BLOOM TECH Co., Ltd |
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Ntau No. |
20250528015 |
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MFG |
Peb 28, 2025 |
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EXP |
Peb 28, 2028 |
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Qauv |
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Test txuj |
GB/T 24768 -2009 Kev lag luam. Txuj |
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Yam khoom |
Enterprise txheem |
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Qhov tshwm sim |
Lub teeb xiav rau xiav khoom |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 5.0% |
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Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
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Tsawg dua lossis sib npaug li 0.5ppm |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
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Purity (HPLC) |
Ntau dua lossis sib npaug li 99.2% |
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Ib qho impurity |
<0.5% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 500cfu / g |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
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Salmonella |
N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 3000ppm |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm 2-8 degrees |
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Kho daim tawv nqaij
"Molecular Hloov" rau Collagen Synthesis
Cov txheej txheem tswj hwm ntawm GHK-Cu ntawm collagen synthesis hauv paus muaj kev ua haujlwm ntawm cov tooj liab ions thiab cov qauv tripeptide. tooj liab ions, raws li cofactors rau lysyl oxidase, ncaj qha koom rau hauv tus ntoo khaub lig-txuas thiab solidification ntawm collagen fibers. Lub caij no, GHK tripeptide activates TGF- /Smad signaling pathway to upregulate the expression of type I procollagen genes. Cov ntaub ntawv kho mob qhia tau tias 0.5% GHK-Cu cov tshuaj ua kom cov dermal collagen ceev 23% hauv 28 hnub. Cov nyhuv no tshwm sim los ntawm nws qhov kev txhawb nqa ntawm fibroblast proliferation-kev sim ua kom pom GHK-Cu txhim kho fibroblast migration tus nqi los ntawm 40% thaum tib lub sijhawm inhibiting MMP-1 (matrix metalloproteinase) kev ua haujlwm, tsim kom muaj ib qho kev hloov pauv hloov pauv hloov pauv.
Molecular Reconstruction ntawm Barrier Function
Hauv kev kho cov tawv nqaij rhiab heev, GHK-Cu rov tsim kho daim tawv nqaij lub cev tiv thaiv los ntawm kev tswj cov filaggrin synthesis. Cov txheej txheem no suav nrog GHK tripeptide khi rau integrin 1 ntawm keratinocyte daim nyias nyias, ua kom txoj hauv kev PI3K/Akt, thiab txhawb kev nthuav qhia cov proteins nruj sib txuas (Claudin-1, Occludin). Hauv kev tshaj tawm- kho laser, GHK-Cu/hyaluronic acid nanocomplex txo cov dej tsis zoo (TEWL) los ntawm 18%, nrog cov teebmeem pom nyob rau hauv 24 teev tom qab- txheej txheem-kho qhov tseem ceeb tshaj cov khoom lag luam loj hlob.
Dual -Action Antioxidant Tiv Thaiv
GHK-Cu's antioxidant mechanism nthuav tawm spatiotemporal synergy: tooj liab ions ncaj qha quench superoxide anions ntawm redox cov tshuaj tiv thaiv (Cu²⁺↔Cu⁺), thaum GHK tripeptide activates Nrf2/ARE txoj hauv kev rau upregulate antioxidant enzymes zoo li SOD thiab CAT. Nyob rau hauv ib tug qauv raug UV, GHK-Cu txo malondialdehyde (MDA) qib-ib lipid peroxidation khoom-los ntawm 60% thaum tswj intracellular glutathione (GSH) qib siab tshaj 85% ntawm ib txwm muaj. Qhov "scavening tam sim ntawd + kev tiv thaiv ruaj khov" txoj hauv kev ua tiav cov txiaj ntsig antioxidant tsib zaug ntau dua li cov vitamin C.
Neuroprotection
Novel Intervention Targets rau Alzheimer's Disease:Hauv A -cov qauv ua rau muaj kev puas tsuaj rau neurotoxicity, GHK-Cu ua haujlwm tiv thaiv los ntawm ob lub tshuab. Ua ntej, tooj liab ions khi rau histidine residues hauv A 42 peptide, inhibiting oligomer tsim thiab txo cov fibrillation los ntawm 60%. Qhov thib ob, GHK tripeptide ua rau Wnt / -catenin txoj hauv kev, txhawb nqa hippocampal neural qia cell proliferation thiab nce BDNF qhia los ntawm 35%. Cov kev sim ua kom pom tau tias GHK-Cu txhawb nqa synaptic plasticity markers SYN thiab PSD-95 qhia los ntawm 35% hauv AD qauv nas, thaum txhim kho spatial nco muaj peev xwm los ntawm 40%. Hais txog kev xa tshuaj, cov liposomal formulation ntawm GHK-Cu (particle loj 120 nm, nto{17}}hloov nrog transferrin) nkag mus rau hauv cov hlab ntsha-hlwb barrier, ua tiav cov ntaub so ntswg hauv hlwb 3.2 npaug ntau dua li cov ntshav plasma. Lub hom phiaj kev xa khoom no tau qhia txog kev kho mob tseem ceeb hauv AD qauv nas: tom qab 8 lub lis piam ntawm kev tswj hwm tas mus li, hippocampal A plaque qib txo qis los ntawm 42%, thiab cov kab mob neuronal ciaj sia tau nce 67%.
Restoration of Motor Function in Parkinson's Disease:Hauv MPTP-induced PD macaque qauv, GHK-Cu txhim kho lub cev muaj zog los ntawm kev hloov kho txoj hauv kev nigrostriatal. Nws cov txheej txheem suav nrog peb yam: Ua ntej, nws inhibits kev sib sau ua ke ntawm -synuclein ( -syn), txo Lewy lub cev suav los ntawm 58%; Qhov thib ob, nws qhib txoj hauv kev PI3K / Akt / mTOR los txhawb kev muaj sia nyob dopaminergic neuron. Qhov thib peb, nws upregulated GDNF qhia los txhim kho neuroprotection. Kev ntsuam xyuas tus cwj pwm tau qhia tias tom qab 12 lub lis piam ntawm kev tswj hwm tas li, macaques nthuav tawm 58% kev txhim kho hauv kev ruaj ntseg thiab 41% mus rau 79% nce hauv kev tuav tau zoo.
Tiv thaiv Cerebral Ischemia-Reperfusion Injury:Hauv cov qauv nas nas MCAO, GHK-Cu pretreatment (0.2 mg / kg, tail vein txhaj, 24 teev ua ntej- phais) txo qhov ntim ntawm infarct los ntawm 53% thiab txo cov qhab nia ntawm cov paj hlwb los ntawm 62%. Nws cov txheej txheem tiv thaiv cuam tshuam nrog inhibiting mitochondrial permeability hloov pore (mPTP) qhib, nce mitochondrial membrane muaj peev xwm tuav tau los ntawm 41% mus rau 78% thaum txo cytochrome c tso tawm los ntawm 64%. Cov kev tshawb fawb ntxiv tau qhia tias GHK-Cu txhim kho cov cellular kam rau oxidative kev nyuaj siab los ntawm kev ua rau txoj kev Nrf2/ARE, txhawb nqa HO-1 thiab NQO1 qhia.
Molecular Mechanisms ntawm Neural Regeneration thiab Kho:
GHK-Cu lub luag hauj lwm hauv neural regeneration yog ze ze rau nws txoj cai ntawm qia cell tus cwj pwm. Kev sim hauv vitro tau pom tias 0.1μM GHK-Cu nce neural qia cell proliferation tus nqi los ntawm 2.3-fold thaum txhawb kev sib txawv rau hauv neurons thiab oligodendrocytes. Cov nyhuv no tshwm sim los ntawm GHK-Cu qhov inhibition ntawm Notch signaling txoj kev thiab ua kom lub BMP signaling txoj kev, yog li cuam tshuam qia cell quiescence thiab pib qhov kev pab cuam tsim dua tshiab.
Hauv kev kho cov hlab ntsha peripheral, cov kab mob neurotrophic tsim los ntawm GHK-Cu thiab chitosan qhia tau zoo heev. Nyob rau hauv tus nas sciatic paj hlwb tsis xws luag qauv, qhov no conduit enabled regenerated axon suav mus txog 91% ntawm cov autologous transplantation pab pawg neeg, nrog rau lub cev muaj zog muaj nuj nqi rov qab cov qhab nia txhim kho mus rau 87%. Cov txheej txheem cuam tshuam nrog GHK-Cu txhawb nqa Schwann cell migration thiab inducing myelin tsim, nce myelin thickness los ntawm 40%.
Los ntawm Basic Research mus rau Biomaterials Innovation
Tswj tau -Tshuaj Systems hauv Neural Conduits
GHK tshiab tsim tawm -Cu/PLGA neural conduit ntiav 3D tshuab luam ntawv los tsim cov qauv scaffold nrog gradient porosity. Nyob rau hauv vitro tso tawm kev kuaj pom pom qhov tawg tawm ntawm 28% hauv thawj 72 teev, ua raws li kev tso tawm ntawm 62% hauv 14 hnub tom ntej. Tom qab implantation nyob rau hauv tus nas sciatic paj hlwb tsis xws luag qauv, regenerated axon suav mus txog 91% ntawm autologous hloov pab pawg neeg ntawm 8 lub lis piam, nrog rau lub cev muaj nuj nqi rov qab cov qhab nia txhim kho mus rau 87%.
Synergistic Delivery hauv Hydrogels
GHK-Cu/BDNF composite hydrogel raws li hyaluronic acid-chitosan forms nanocomposites ntawm electrostatic kev sib cuam tshuam. Cov kab ke no ib txhij tso tawm GHK-Cu (82% hauv 14 hnub) thiab BDNF (76% hauv 14 hnub) hauv vitro, txhim kho Schwann cell migration rate los ntawm 3.2-fold thiab myelin tsim tus nqi los ntawm 2.8-fold. Hauv kab mob ntshav qab zib nas peripheral paj hlwb raug mob qauv, hydrogel tau kho cov paj hlwb rov qab mus rau 84% ntawm cov qib ib txwm muaj.
Biofunctionalization ntawm Antioxidant Coatings
GHK-Cu qhia txog qhov zoo ntawm kev ua haujlwm ntawm biomaterials. Piv txwv li, covalently bonding GHK-Cu rau titanium alloy implant nto nce osteoblast adhesion los ntawm 2.1-fold thiab ceev osseointegration los ntawm 40%. Cov txheej txheem no suav nrog GHK-Cu qhov kev tswj hwm ntawm integrin 1 qhia thiab ua kom lub MAPK teeb liab txoj hauv kev, yog li txhawb nqa cov khoom siv ntxiv ntawm cov cellular matrix deposition.
Kev Tshawb Fawb Kev Txhim Kho ntawm Hla - Daim Ntawv Thov Ciam Teb ntawm GHK-Cu
Kev tshawb fawb txog kev sib txuas ntawm daim tawv nqaij thiab lub hlwb noj qab haus huv
Nyob rau hauv xyoo tas los no, nrog rau kev tshawb fawb tob rau ntawm "lub hlwb- tawv nqaij axis," cov kws tshawb fawb tau maj mam nrhiav pom muaj kev sib raug zoo ntawm daim tawv nqaij thiab lub hlwb noj qab haus huv. Psychological yam xws li kev ntxhov siab thiab kev xav hloov pauv tuaj yeem cuam tshuam rau ntawm daim tawv nqaij kev noj qab haus huv los ntawm cov txheej txheem physiological nyuaj, thiab rov ua dua. GHK-Cu, ua ib yam khoom muaj peev xwm ua haujlwm ib txhij ntawm daim tawv nqaij thiab lub hlwb, tau tshwm sim los ua ib qho cuab yeej tseem ceeb rau kev kawm "lub hlwb- ntawm daim tawv nqaij." Kev tshawb fawb qhia tias GHK-Cu tsis yog tsuas yog txhim kho cov tawv nqaij noj qab haus huv xwb tab sis kuj txhawb lub hlwb kev noj qab haus huv los ntawm kev tswj cov neurotransmitter synthesis thiab tso tawm, txhim kho kev txawj ntse, thiab lwm yam.
Kev Kawm Preclinical
Kev tshawb fawb ua ntej ua pov thawj ntxiv GHK-Cu's cross- daim ntawv thov muaj peev xwm. Cov kev tshawb fawb tsiaj pom tau hais tias GHK-Cu ua kom cov tawv nqaij kho qhov txhab thiab cov paj hlwb rov qab thaum txhim kho kev txawj ntse. Piv txwv li, nyob rau hauv cov neeg mob ntshav qab zib cov qauv ntawm cov qhov txhab ischemic, GHK-Cu txhawb kev kho qhov txhab, txo TNF- qib alpha, thiab txhawb nqa collagen synthesis. Hais txog kev paub txog kev txawj ntse, kev tshawb fawb tsiaj pom tau tias GHK-Cu txhawb kev loj hlob thiab kev sib txawv ntawm hippocampal neurons, txhim kho synaptic plasticity, thiab yog li txhim kho kev nco thiab kev kawm muaj peev xwm.
Kev sim tshuaj
Txawm hais tias kev sim tshuaj ntawm GHK-Cu daim ntawv thov hauv lub hlwb tseem muaj qhov txwv, kev tshawb fawb ua ntej tau qhia nws lub peev xwm. Piv txwv li, ib qho me me - ntsuas kev soj ntsuam hauv cov neeg laus pom tias GHK-Cu supplementation tau txhim kho kev paub txog kev ua haujlwm zoo xws li kev nco thiab kev saib xyuas. Tsis tas li ntawd, cov ntaub ntawv tshawb fawb tau tshaj tawm cov txiaj ntsig zoo ntawm GHK-Cu hauv kev txo cov tsos mob ntawm cov kab mob neurodegenerative. Txawm li cas los xij, vim muaj qee yam xws li cov qauv qis thiab qhov txawv ntawm cov qauv tsim, cov kev tshawb pom no yuav tsum muaj kev siv tau ntxiv.
Cov lus nug nquag
GHK-Cu peptide ua dab tsi?
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GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) yog ib qho peptide tshwm sim uas txhawb nqa cov tawv nqaij rejuvenation, kho cov ntaub so ntswg, thiab cov plaub hau loj hlob los ntawm stimulating collagen / elastin ntau lawm, txhim kho qhov txhab kho, txo cov kab mob o, thiab ua kom rov ua kom cov kab mob zoo li qub elasticity, thiab thinning plaub hau, thiab yog siv nyob rau hauv cov tshuaj pleev ib ce thiab kev kho mob rau daim tawv nqaij noj qab haus huv thiab kev txhawb nqa plaub hau.
Nws siv sijhawm ntev npaum li cas rau GHK-Cu ua haujlwm?
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GHK-Cu (Copper Peptide) cov txiaj ntsig sib txawv, tab sis cia siab tias yuav txhim kho me ntsis (hydration, kev ntxhib los mos) hauv 2-4 lub lis piam, nrog rau kev hloov pauv tseem ceeb dua xws li txo cov kab zoo, firmness, thiab elasticity tshwm sim hauv 1-3 lub hlis, thiab cov txiaj ntsig zoo tshwm sim tom qab 3-6 lub hlis ntawm kev siv zoo ib yam, tshwj xeeb tshaj yog rau cov tawv nqaij rejuvenation thiab plaub hau loj hlob. Kev ua siab ntev thiab kev ua siab ntev yog qhov tseem ceeb, vim nws ua haujlwm nrog cov txheej txheem ntuj tsim dua li hmo ntuj.
GHK puas tuaj yeem-Cu regrow plaub hau?
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Yog lawm, GHK-Cu (tooj liab peptide) qhia tau hais tias muaj peev xwm txhawb cov plaub hau regrowth thiab txhim kho tawv taub hau kev noj qab haus huv los ntawm stimulating follicles, ua kom cov ntshav txaus, txhawb collagen, thiab txo qhov mob, ua rau cov plaub hau tuab, tab sis nws yog qhov zoo tshaj plaws raws li kev txhawb nqa kev kho mob nrog rau lwm txoj kev, yuav tsum tau siv ntau lub hlis kom pom cov txiaj ntsig zoo li cov plaub hau poob. Thaum cov kev tshawb fawb hauv chaw kuaj mob tau txais txiaj ntsig, tib neeg cov pov thawj kho mob tseem tab tom txhim kho, yog li nws tsis yog ib leeg kho tab sis muaj txiaj ntsig zoo ntxiv rau cov kev tu plaub hau, feem ntau siv nrog minoxidil lossis microneedling rau kev txhim kho cov teebmeem.
Cim npe nrov: zoo tshaj plaws ghk cu peptide txhaj tshuaj, Tuam Tshoj zoo tshaj ghk cu peptide txhaj tshuaj manufacturers, lwm tus neeg
