Tesamorelin Peptide Txhajyog FDA- pom zoo txhaj tshuaj ntawm cov tshuaj synthetic growth hormone- tso tawm cov tshuaj hormone (GHRH) analog, nrog nws cov ntsiab lus tseem ceeb yog 44-amino-acid polypeptide.Qhov tseem ceeb ntawm qhov kev txhaj tshuaj no yog nyob rau hauv nws cov hom phiaj rog- txo cov nyhuv, ua rau nws tshwj xeeb tshaj yog rau cov neeg mob uas muaj kab mob HIV visceral improving. antiretroviral therapy-associated lipodystrophy. Nws ua tiav qhov txo qis ntawm cov rog los ntawm kev ua kom IGF-1 lipolysis txoj hauv kev, thaum tib lub sijhawm ua kom cov lipid metabolism thiab kev noj qab haus huv ntawm lub plawv.Clinically, nws raug pom zoo kom ua raws li kev txhaj tshuaj subcutaneous hauv plab ib hnub ib zaug. Kev txhaj tshuaj yuav tsum tau diluted nrog rau cov dej tsis muaj mob tshwj xeeb thiab muab tshuaj tam sim ntawd. Tig qhov chaw txhaj tshuaj tuaj yeem txo qhov tshwm sim hauv zos. Cov yam ntxwv ntawm kev xa tshuaj meej ntawm daim ntawv txhaj tshuaj ua rau nws yog ib qho kev kho tshwj xeeb rau cov metabolically cuam tshuam txog cov roj ntsha txawv txav, ntsuas kev ua tau zoo thiab kev nyab xeeb tshuaj.
Peb Cov Khoom Muag Khoom
Tesamorelin COA
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| Certificate of Analysis | ||
| Compound npe | Tesamorelin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 218949-48-5 | |
| Ntau | 3 37,3kg | |
| Ntim txheem | 25kg / nruas | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202512090051 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8 Dec 2028 | |
| Qauv | N/A | |
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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Nrog rau kev siv dav dav ntawm kev kho tshuaj tiv thaiv kab mob (ART), lub sijhawm muaj sia nyob ntawm cov neeg nyob nrog HIV (PLHIV) tau ntev heev, thiab kev tsom mus rau kev tswj hwm kab mob tau maj mam hloov mus rau kev tiv thaiv thiab kev tswj hwm ntawm ART- cuam tshuam nrog cov teeb meem. HIV-sociated lipodystrophy yog ib qho ntawm cov teeb meem metabolic feem ntau ntawm ART, tshwj xeeb tshaj yog los ntawm kev faib cov rog tsis zoo. Nws tsis tsuas yog cuam tshuam rau cov neeg mob lub neej zoo, tab sis kuj tseem ua rau muaj kev pheej hmoo ntawm cov txiaj ntsig tsis zoo xws li kab mob plawv thiab ntshav qab zib mellitus.Tesamorelin Peptide Txhaj raws li thawj FDA- pom zoo txhaj tshuaj loj hlob hormone- tso tawm cov tshuaj hormones (GHRH) analogue rau tus mob no, tau tshwm sim los ua ib qho tseem ceeb ua ntej - kab kws kho mob rau tus kab mob HIV- koom nrog lipodystrophy vim nws lub hom phiaj ua tau zoo thiab kev nyab xeeb zoo.
Clinical Harms and Treatment Needs of HIV-sociated Lipodystrophy
HIV-sociated lipodystrophy yog ib qho mob ntawm cov roj metabolism tsis zoo uas tshwm sim los ntawm kev sib xyaw ua ke ntawm tus kab mob HIV nws tus kheej thiab cov tshuaj ART. Nws cov kev kho mob phenotypes yog heterogeneous, feem ntau categorized rau hauv rog tsub zuj zuj (lipohypertrophy) thiab rog poob (lipoatrophy), nrog rau qee cov neeg mob nthuav tawm cov phenotype sib xyaw. Ntawm cov kev tshwm sim no, ntau dhau visceral adipose ntaub so ntswg (VAT) tsub zuj zuj nyob rau hauv lub plab yog tus sawv cev tshaj plaws. Cov neeg mob feem ntau nthuav tawm lub duav ncig, qhov chaw kho mob ntawm "nyuaj plab", thiab qee qhov kuj yuav muaj teeb meem xws li dorsocervical fat pad thickening (buffalo hump) thiab lub mis hypertrophy.
Hauv qhov sib piv, kev poob rog feem ntau cuam tshuam rau lub ntsej muag, qhov kawg, thiab pob tw, ua rau lub ntsej muag nkim thiab ceg tawv nyias, uas ua rau muaj kev qias neeg loj heev thiab kev puas siab puas ntsws, thiab tej zaum yuav cuam tshuam txog kev ua raws li ART.
Piv nrog rau kev rog dhau lawm, qhov teeb meem ntawm HIV-kev sib txuas lipodystrophy yog qhov tshwj xeeb dua. Cov kev tshawb fawb pathophysiological tau pom tias cov ntaub so ntswg visceral adipose tsis yog ib lub zog cia khoom; Nws cov khoom sib xyaw ntau dhau ua rau cov lus teb mob ntev, ua rau cov kab mob metabolic xws li insulin tsis kam thiab dyslipidemia (hypertriglyceridemia thiab qis siab -} ntom lipoprotein cholesterol). Cov kev txawv txav no ua rau muaj kev pheej hmoo ntawm cov kab mob plawv hauv PLHIV rau ntau dua ob npaug ntawm cov pej xeem. Txawm hais tias nyob rau hauv cov neeg mob uas muaj tus kab mob zoo - txwv tsis pub kis kab mob, cov roj visceral ntau dhau los ua rau muaj kev cuam tshuam zoo nrog rau 10-xyoo atherosclerotic kab mob plawv, ua rau nws yog ib qho tseem ceeb txwv tsis pub noj qab haus huv hauv cov pej xeem no.
Hais txog kev xav tau kev kho mob, kev cuam tshuam hauv kev ua neej ib txwm muaj (kev tswj hwm kev noj zaub mov thiab kev tawm dag zog) muaj qhov txwv tsis pub muaj txiaj ntsig hauv kev txhim kho HIV-txoj kev sib txuas lipodystrophy, thaum kho cov txheej txheem ART tsuas tuaj yeem ua rau mob qeeb zuj zus tab sis tsis tuaj yeem thim rov qab tsim cov roj ntsha txawv txav. Yog li ntawd, muaj qhov xav tau kev kho mob sai sai rau cov tshuaj muaj kev nyab xeeb thiab muaj txiaj ntsig zoo uas tuaj yeem ua rau lub hom phiaj ntawm lipid metabolic, txo qis cov roj visceral, ameliorate metabolic ntshawv siab, thiab tsis txhob muaj kev puas tsuaj rau theem nrab xws li exacerbating lipoatrophy.
Clinical Efficacy of it: Txhawb nqa los ntawm Pov Thawj -raws li Tshuaj
Ntau theem III kev sim tshuaj kho mob thiab ntev -cov kev tshawb fawb txuas ntxiv tau lees paub tias muaj txiaj ntsig zoo ntawmTesamorelin Peptide Txhajhauv kev kho mob HIV-sociated lipodystrophy. Nws cov ntsiab lus tseem ceeb ntawm kev ua tau zoo suav nrog txo qis hauv cov roj visceral, kev txhim kho hauv cov metabolism, thiab txhim kho lub neej zoo.
Nyob rau theem III ob - dig muag, placebo- tswj kev tshawb fawb nrog 410 PLHIV nrog HIV- txuam nrog cov rog hauv plab, cov neeg mob tau txais kev txhaj tshuaj subcutaneous txhua hnub ntawm 2mg nws rau 26 lub lis piam. Cov txiaj ntsig tau pom tias cov roj visceral ntim tau txo qis los ntawm 18% los ntawm cov hauv paus ntsiab lus, piv nrog tsuas yog 2% txo qis hauv cov placebo pab pawg, nrog rau cov ntaub ntawv tseem ceeb ntawm - pab pawg sib txawv (P<0.001). Further subgroup analyses indicated that it exerted consistent visceral fat-lowering effects regardless of whether patients had concurrent dorsocervical fat pad thickening. It also significantly reduced waist circumference and improved the sign of "hard abdomen", suggesting that its efficacy is not affected by specific patient phenotypes.
Ntev - cov ntaub ntawv siv tau ntev yog qhov sib npaug.Lub 26- lub lim tiam txuas ntxiv ntawm txoj kev tshawb fawb no tau qhia tias cov neeg mob uas txuas ntxiv kho nws rau 52 lub lis piam khaws cov roj visceral txo qis dua 18%. Tsis tas li ntawd, lawv cov qib triglyceride txo qis los ntawm 51mg / dl los ntawm cov hauv paus ntsiab lus, tag nrho cov roj cholesterol zoo tuaj, thiab cov kab mob metabolic tau raug kho tas li. Hauv qhov sib piv, cov neeg mob uas tsis tau txais kev kho mob tau ntsib cov roj visceral sai sai, lees paub qhov ntev - lub sij hawm kho tus nqi ntawm cov tshuaj. Tsis tas li ntawd, kev soj ntsuam sib koom ua ke pom tau tias nws kho tau txo qis cov neeg mob 10-xyoo atherosclerotic kab mob plawv, uas muaj kev tiv thaiv ntev rau cov hlab plawv.
Hais txog tus neeg mob- tau tshaj tawm cov txiaj ntsig, cov kev tshawb fawb soj ntsuam pom tias tom qab 6 lub hlis ntawm kev kho mob, cov neeg mob lub cev cov duab txaus siab tau nce ntau, qhov tshwm sim ntawm cov tsos mob ntawm kev puas siab puas ntsws xws li kev ntxhov siab thiab kev nyuaj siab poob qis, thiab kev ua raws li ART tau zoo dua. Qhov no qhia txog tus nqi kho mob ntawm kev ua tiav cov txiaj ntsig ntawm lub cev thiab lub hlwb.
Thawj - Kab Kev Kho Mob Cov Qauv rau nws
Raws li ib qho tshuaj txhaj tshuaj, kev siv tshuaj kho mob ntawmTesamorelin Peptide Txhajyuav tsum nruj me ntsis ua raws li cov qauv tshuaj kom ua tau zoo thiab txo qhov kev pheej hmoo ntawm kev nyab xeeb. Nws cov ntsiab lus tseem ceeb ntawm cov tshuaj muaj xws li kev tshuaj ntsuam xyuas, kev tswj hwm kev tswj hwm, thiab kev tswj xyuas.
Nyob rau hauv cov nqe lus ntawm kev tshuaj ntsuam xyuas, cov lus qhia meej yog: cov neeg laus PLHIV uas tau lees paub tias muaj cov rog ntau dhau los ntawm kev kuaj pom (xws li CT lossis MRI), nrog rau lipodystrophy-cov tsos mob (xws li, nce lub duav ncig, metabolic abnormalities), thiab tsis suav nrog cov kab mob hauv plab, nrog rau cov kab mob hauv plab, nrog rau cov kab mob hauv plab. Nws yuav tsum raug sau tseg tias lub luag haujlwm tseem ceeb ntawm cov tshuaj no yog txo cov roj visceral ntau dua li ua rau lub cev poob qis, thiab yog li nws tsis tau qhia rau PLHIV nrog cov rog yooj yim.
Kev tswj hwm kev tswj hwm yog tus qauv zoo heev thiab yooj yim. Cov koob tshuaj pom zoo yog 2mg ib hnub, muab los ntawm kev txhaj tshuaj subcutaneous. Qhov chaw txhaj tshuaj uas nyiam tshaj plaws yog thaj chaw periumbilical plab (tsis txhob umbilicus, nti, thiab qhov chaw mob), thiab qhov chaw txhaj tshuaj yuav tsum tau hloov txhua hnub kom txo tau qhov kev pheej hmoo ntawm cov tshuaj tiv thaiv hauv zos. Cov tshuaj yog muab raws li lyophilized hmoov formulation, uas yuav tsum tau reconstituted nrog sterile dej siab rau kev txhaj tshuaj ua ntej siv. Thaum lub sij hawm reconstitution, lub ampoule yuav tsum tau maj mam dov kom yaj cov hmoov, tsis txhob muaj zog co. Cov tshuaj reconstituted yuav tsum meej, tsis muaj xim, thiab tsis muaj hais ua ntej tam sim ntawd tswj.
Hauv kev kho mob, nws raug nquahu kom cov neeg mob txhaj tshuaj ntawm lub sijhawm teem sijhawm txhua hnub (piv txwv li, ua ntej yuav mus pw) kom zoo dua simulate physiological secretion atherosclerosis ntawm kev loj hlob hormone (GH).
Nrog rau kev kho mob HIV nkag mus rau lub sijhawm ntawm "kev kho mob ua haujlwm", qhov ntev - lub neej zoo thiab kev tswj xyuas cov teeb meem ntev ntawm cov neeg mob tau dhau los ua qhov tseem ceeb ntawm kev kho mob. Cov khoom lag luam, nrog nws qhov tshwj xeeb zoo ntawm daim ntawv txhaj tshuaj (cov tshuaj meej meej, hloov mus rau lub cev lub cev), lub hom phiaj rog -txo cov txheej txheem, thiab kev ruaj ntseg profile zoo, muab cov kev xaiv kho mob zoo rau HIV- koom nrog lipodystrophy, ua rau muaj qhov sib txawv hauv kev kho mob. Nws tsis tsuas yog txo cov roj visceral, ameliorates metabolic ntshawv siab, thiab txo cov kev pheej hmoo ntawm cov kab mob plawv, tab sis kuj txhim kho cov neeg mob lub siab lub ntsws thiab kev kho mob los ntawm kev txhim kho lawv lub cev, ua tiav cov txiaj ntsig ntawm lub cev thiab lub hlwb.
Nyob rau hauv lub neej yav tom ntej, nrog rau qhov tob ntawm kev tshawb fawb soj ntsuam, daim ntawv thov scenarios ntawm nws tej zaum yuav nthuav ntxiv, xws li rau kev tswj cov roj metabolism hauv cov neeg laus PLHIV thiab kev cuam tshuam rau cov neeg mob nrog sarcopenia concurrent. Txawm li cas los xij, nws tus nqi tseem ceeb tam sim no tseem tsom mus rau thawj - kab kev kho mob HIV- koom nrog lipodystrophy. Hauv daim ntawv thov kev kho mob, nws yog ib qho tseem ceeb uas yuav tsum ua raws li cov qauv tshuaj nruj me ntsis, tsim cov kev kho mob raws li tus neeg mob tus neeg mob, thiab ntxiv dag zog rau lub sijhawm ntev - saib xyuas kom ua kom tau txais txiaj ntsig zoo tshaj plaws.
FAQ
1.Tesamorelin peptide ua li cas?
Kev piav qhia. Kev txhaj tshuaj Tesamorelin yog ib yam tshuaj uas zoo ib yam li ib txwm tso tawm los ntawm lub qog hypothalamus hauv lub hlwb. Nws yog siv lostxo cov rog ntau dhau (lipodystrophy) hauv plab hauv cov neeg mob uas muaj tus kab mob tiv thaiv kab mob HIV (HIV).
2.Puas rog rov qab tom qab nres tesamorelin?
Tesamorelin yog ib qho kev kho mob tas mus li thiabrog rov qab yog tias tsis kho. Kev saib xyuas qis dua ntawm tesamorelin tsis tau tsim. Tsis yog tesamorelin lossis rHGH raug pom zoo hauv Tebchaws Europe raws li kev kho mob rau lipodystrophy. Txawm li cas los xij, rHGH tuaj yeem raug txiav tawm ntawm - daim ntawv lo rau ntawm tus neeg mob.
3.Puas tesamorelin ua rau kuv hnyav?
Tsis tas li ntawd, qee cov neeg mob yuav muaj kev noj qab haus huv ntxiv thaum nyob ntawm Tesamorelin acetate. Txawm hais tias qhov no yuav tsis zoo li qhov tsis zoo,nws tuaj yeem ua rau tsis xav tau qhov hnyav nce yog tias tsis tswj kom raug. Kev tswj hwm kev noj zaub mov kom zoo thiab kev tawm dag zog tsis tu ncua tuaj yeem pab txo qhov kev pheej hmoo no.
4.Dab tsi zoo dua, tesamorelin lossis Ipamorelin?
Tesamorelin → ntws, metabolic & lub cev muaj pes tsawg leeg tsom. Ipamorelin → xaiv, rov qab & pw tsaug zog tsom. Tias yog vim li cas lawv feem ntau siv ua ke, tsis yog siv ib leeg.
Cim npe nrov: Tuam Tshoj tesamorelin peptide txhaj tshuaj manufacturers, lwm tus neeg
