IGF-1 LR3 Creamyog ib qho kev npaj sab nraud nrog tib neeg cov tshuaj insulin{0}}zoo li kev loj hlob zoo-1 LR3 (IGF-1 LR3) ua cov ntsiab lus tseem ceeb, thov txhawb kev loj hlob ntawm tes, ua kom cov ntaub so ntswg kho, txhim kho daim tawv nqaij, thiab pab cov leeg loj hlob. Cov tshuaj no yog siv rau hauv zos kom tso cai rau IGF-1 LR3 nkag mus rau ntawm daim tawv nqaij los yog mucosa, khi rau IGF1R nyob rau saum npoo ntawm lub hom phiaj hlwb, thiab qhib intracellular signaling. Nws cov teebmeem tseem ceeb suav nrog kev ua kom rov ua dua tshiab ntawm daim tawv nqaij, cov leeg hlwb, thiab fibroblasts, thiab txhim kho cov ntaub so ntswg. Txhim kho cov leeg nqaij protein synthesis, inhibit protein tawg, thiab txhawb cov leeg nqaij. Nws puas tuaj yeem txo cov cell tuag, tswj cov ntaub so ntswg homeostasis, txhawb nqa cov piam thaj thiab rog rog, thiab muab lub zog rau cov hlwb. Thov kom txo wrinkles, txhim kho daim tawv nqaij elasticity, thiab ua kom lub qhov txhab zoo, nws yog feem ntau siv nyob rau hauv kev zoo nkauj thiab kev tu tawv nqaij.
Peb cov khoom los ntawm
IGF-1 LR3 COA
Keratinum txheej: IGF-1 LR3 molecular kis nyob rau hauv "cib phab ntsa mortar" qauv
Raws li lub cev loj tshaj plaws nyob rau hauv tib neeg lub cev, lub epidermis lub teeb meem muaj nuj nqi yog tswj los ntawm ib tug "cib phab ntsa mortar" qauv tsim los ntawm ntau txheej ntawm keratinocytes thiab intercellular lipids. Cov qauv no xav tau kom muaj kev tiv thaiv zoo tiv thaiv cov kab mob sab nraud thiab kev sib npaug ntawm cov dej hauv sab hauv. Txawm li cas los xij, kev siv hauv zos ntawm cov tshuaj insulin recombinant-zoo li kev loj hlob zoo-1 ntev-ua yeeb yam analogs (IGF-1 LR3 Cream) yog ua rau muaj kev hem thawj rau qhov sib npaug ntawm qhov sib npaug los ntawm kev ua kom lub cev tiv thaiv kab mob, cuam tshuam nrog lipid metabolism, thiab ua rau muaj kev txawv txav ntawm tes.
Molecular hauv paus thiab thaiv kev tswj ntawm "cib ntsa mortar" qauv
Cov qauv thiab kev ua haujlwm ntawm stratum corneum
Lub stratum corneum yog nyob rau ntawm txheej txheej sab nraud ntawm lub epidermis, muaj 5-20 txheej ntawm cov keratinocytes tuag ("cib") thiab intercellular lipids ("mortar"). Nws cov haujlwm tseem ceeb suav nrog:
Lub cev tiv thaiv: Los ntawm nruj txheej txheej keratinocytes thiab lipid bilayers, nws tiv thaiv kab mob ntxeem tau thiab dej poob.
Chemical barrier: inhibits microbial kev loj hlob los ntawm acidic pH (5.0-5.6) thiab tswj cov moisturizing muaj nuj nqi ntawm natural moisturizing factor (NMF).
Kev tiv thaiv kab mob: paub txog cov kab mob thiab pib tiv thaiv kab mob los ntawm Langerhans hlwb thiab Tus Xov Tooj Zoo li receptors (TLRs).
Dynamic equilibrium ntawm lipid bilayer
Intercellular lipids yog tsim los ntawm ceramides (50%), dawb fatty acids (25%), thiab cholesterol (10%) nyob rau hauv ib tug 1: 1: 1 molar ratio, tsim ib tug ntom lipid bilayer. Nws cov metabolism yog tswj los ntawm cov enzymes hauv qab no:
Synthases, xws li serine palmitoyltransferase (SPT), catalyze cov synthesis ntawm ceramides.
Degradation enzymes, xws li sphingomyelinase (SMase), zom sphingomyelin los tsim ceramides, thaum - glucosinolate lipase (GBA) koom nrog hauv glycosphingolipid metabolism.
Hydrolases, xws li phospholipase A2 (PLA2), tso cov fatty acids dawb thiab tswj cov lipid fluidity.
Dual lub luag haujlwm ntawm protease system
Kev rov ua dua tshiab ntawm stratum corneum tso siab rau kev tswj hwm ntawm cov kab mob protease:
Cov nyhuv degradation: Serine proteases (KLK5, KLK7) thiab matrix metalloproteinases (MMP-1, MMP-9) rhuav tshem Desmoglein-1 thiab Occludin, txhawb keratinocyte shedding.
Kho cov nyhuv: Protease inhibitors (TIMP-1, TIMP-2) tiv thaiv kev cuam tshuam tsis zoo los ntawm kev degradation ntau dhau los ntawm inhibiting MMP kev ua.
Cov kev cai sib txawv: Tom qab KLK5 ua kom, filaggrin yog degraded rau hauv cov amino acids dawb, tsim NMF los tswj cov tawv nqaij moisturizing muaj nuj nqi.
Kev tswj tsis tau kev cuam tshuam kev cuam tshuam: cov pov thawj kho mob thiab cov xwm txheej txaus ntshai
Contradictory teebmeem nyob rau hauv mob qhov txhab kho
Cov nyhuv zoo: txhawb kev kho mob, piv txwv li,IGF-1 LR3 creamtuaj yeem txhawb kev loj hlob ntawm fibroblasts thiab keratinocytes hauv cov ntshav qab zib ko taw rwj, txo lub sijhawm kho los ntawm 14 hnub, thiab nce tus nqi kho kom zoo rau 72%. Venous ulcers tuaj yeem txhawb kev tsim cov ntaub so ntswg granulation, nce tus nqi ntawm cov ntaub so ntswg granulation hauv lub txaj qhov txhab los ntawm 2.1 npaug thiab nce collagen ntom ntawm 31%.
Cov teebmeem tsis zoo: Cov kev pheej hmoo ntev xws li kev tsim caws pliav, kev siv lub sijhawm ntev - tuaj yeem ua rau cov ntaub so ntswg granulation ntau dhau, ua rau qhov tshwm sim ntawm caws pliav mus txog 18%. Kev ua kom ruaj khov ntawm MMPs ua rau muaj kev pheej hmoo rov tshwm sim dua li MMP-9 cov haujlwm tseem tshuav 57% siab dua li ib txwm muaj txawm tias tom qab txiav tawm.
Collagen imbalance hauv photoaging kho
Cov nyhuv zoo: txhim kho wrinkles, xws li lub ntsej muag wrinkles. Tom qab 12 lub lis piam ntawm kev siv tas mus li, daim tawv nqaij roughness parameter (Ra) txo los ntawm 34% thiab collagen ceev tau nce 29%. Melasma kuj yog tshwm sim los ntawm kev sib xyaw ntawm cov vitamin C, uas txo cov pigment intensity index (MSI) los ntawm 41% thiab ua kom cov tawv nqaij brightness los ntawm 27%.
Cov teebmeem tsis zoo: cov nyhuv rov qab los, xws li kev poob collagen sai, qhov twg cov ntsiab lus collagen poob mus rau 68% ntawm pre- qib kev kho mob thiab qhov tob tob rebounds los ntawm 19% hauv 3 lub hlis tom qab tsis siv tshuaj. Post inflammatory hyperpigmentation (PIH) tuaj yeem nce qhov xwm txheej ntawm PIH mus rau 12% tom qab siv sijhawm ntev -, tshwj xeeb tshaj yog hauv Fitzpatrick IV-VI daim tawv nqaij.
Dual kev cai nyob rau hauv cov kab mob ntawm daim tawv nqaij
Cov nyhuv zoo: txo qhov mob. Piv txwv li, atopic dermatitis txo cov qhab nia SCORAD los ntawm 52% thiab KLK5 qhia los ntawm inhibiting Th2 hom tiv thaiv kab mob. Psoriasis muaj PASI tus qhab nia txhim kho tus nqi ntawm 63% thiab epidermal thickness tau rov qab mus rau qhov qub ntawm 81%.
Cov teebmeem tsis zoo: Cov kab mob sib txawv, xws li kev puas tsuaj rau cov qauv desmosome, tuaj yeem ua rau txo qis desmosome ntom rau 54% ntawm cov qib ib txwm yog siv rau lub sijhawm ntev, ua rau tawv nqaij qhuav thiab tev tawm. Nws kuj tseem tuaj yeem ua rau muaj kev rov ua kom rov zoo dua, nrog qee tus neeg mob tau rov zoo li qub hauv 4 lub lis piam tom qab txiav cov tshuaj, thiab PASI cov qhab nia nce mus rau 71% ntawm qib ua ntej- kho.
Kev tiv thaiv kev pheej hmoo thiab tswj cov tswv yim thiab cov lus qhia yav tom ntej
Biomarkers yog siv los kuaj ntshav IGF-1 qib: ntshav IGF-1 concentration yog kuaj los ntawm ELISA los tshuaj xyuas cov neeg tsim nyog (ib txwm ntau: 50-300ng / mL).
MMP/IMP piv: Siv qPCR los kuaj MMP-1/IMP-1 mRNA piv rau ntawm daim tawv nqaij los ntsuas qhov kev pheej hmoo ntawm protease imbalance (ib txwm ntau yam: 0.5-1.5).
Gene polymorphism tsom xam: Pom MMP-1-1607G/A thiab TIMP-1 txhawb kev hloov pauv los ntawm SNP typing los kwv yees tus kheej rhiab heev rau IGF-1 LR3.
Kev noj tshuaj kom zoo pib los ntawm cov koob tshuaj tsawg: pib los ntawm 0.1-0.5 ng / mL, maj mam hloov mus rau qhov ua tau zoo ntawm 0.2-20 ng / mL raws li kev ua siab ntev.
Pulse kev tswj hwm: Kev tswj hwm tsis tu ncua yog siv 2-3 zaug hauv ib lub lis piam los txo cov lus tawm tswv yim los ntawm kev ua kom muaj zog.
Kev sib xyaw ua ke: Siv ua ke nrog cov tshuaj tiv thaiv kab mob antioxidant (xws li vitamin C), protease inhibitors (xws li TIMP-1 mimetic peptides), los yog cov tshuaj tiv thaiv kab mob (xws li IL-4 inhibitors) kom sib npaug ntawm cov kev cai txwv.
Kev xa khoom tshiab thiab kev tswj hwm hauv zos
Lub microneedle array yog ib qho polymer microneedle soluble: soluble microneedle yog npaj siv polylactic acid glycolic acid copolymer (PLGA) kom ua tiav qhov tso tawm ntawm cov txheej dermis thiab txo qhov kev pheej hmoo ntawm kev raug mob. Hauv cov qauv tsiaj, microneedle tus me nyuam tau nce hauv zos IGF-1 LR3 concentration los ntawm 5.7 npaug thiab txo qis kev raug mob hauv pawg txhaj tshuaj los ntawm 12%.
Nanocrystalline cab kuj: Kev kub siab homogenization tshuab yog siv los npaj IGF-1 LR3 nanocrystals (particle loj<200 nm) to improve skin penetration efficiency. In the ex vivo skin model, the transdermal absorption rate of the nano crystalline carrier is 3.2 times that of traditional cream.
Qhov kub thiab txias teb hydrogel yog poly (N-isopropylacrylamide) (PNIPAAm): nws tsim ib lub pas dej rau ntawm daim tawv nqaij los ntawm qhov kub thiab txias theem hloov cov yam ntxwv. Thaum qhov kub nce mus txog 32 degree, cov hydrogel shrinks thiab tso tawm IGF-1 LR3 rau 72 teev, yog li txo qhov zaus ntawm kev tswj hwm.
Chitosan/ - glycerophosphate sodium (CS/ - GP): kub rhiab hydrogel yog tsim los ntawm ionic crosslinking, thiab cov tshuaj maj mam tso tawm ntawm lub cev kub. Nyob rau hauv tus qauv kho qhov txhab, CS/ - GP hydrogel tuav lub zos concentration ntawm IGF-1 LR3 nyob rau hauv qhov zoo ntawm 10-20ng / mL, txhawb collagen synthesis thiab inhibits kev qhia ntawm MMPs.
Kev hloov kho cov qauv thiab kev tsim qauv tsim
Polyethylene glycol (PEG) kev hloov kho: PEG molecules (molecular hnyav 2000-5000) chemically ob peb nrog lysine residues ntawm IGF-1 LR3, ncua ib nrab-lub neej mus rau 72 teev thiab txo cov kev pheej hmoo kis mob. Hauv cov qauv tsiaj, qhov kev faib tawm ntawm PEG-IGF-1 LR3 tau txo qis rau 18% ntawm nws daim ntawv tsis hloov kho, thaum cov teebmeem kev kho mob hauv zos tau sib piv.
Kev hloov kho lub hom phiaj: Los ntawm kev hloov kho cov tshuaj tiv thaiv kab mob lossis ligand, kev xa tawm meej ntawm IGF-1 LR3 rau cov xov tooj tshwj xeeb xws li fibroblasts thiab keratinocytes tau ua tiav. Piv txwv li, kev sib txuas cov tshuaj tiv thaiv integrin 5 1 cov tshuaj tiv thaiv kab mob tau nce cov tshuaj ntxiv rau ntawm qhov chaw ntawm fibroblasts los ntawm 4.3 npaug.
Hydrazone daim ntawv cog lus: IGF-1 LR3 yog txuas rau ib pawg npog (xws li p-hydroxybenzoic acid) los ntawm hydrazone daim ntawv cog lus los tsim cov tshuaj. Hauv cov qog microenvironment (pH<6.5) or inflammatory region (pH<7.0), hydrolysis of hydrazone bonds releases active drugs. In animal models, the tumor tissue concentration of acid sensitive prodrug was 7.2 times that of normal tissue, while systemic exposure decreased to 23% of free drug.
Esterase rhiab heev prodrug: IGF-1 LR3 yog txuas rau fatty acid chains los ntawm ester bonds los tsim prodrugs. Hauv stratum corneum ntawm daim tawv nqaij, esterase hydrolysis tso tawm cov tshuaj nquag, ua tiav qhov kev tso tawm hauv zos. Nyob rau hauv ex vivo tus qauv ntawm daim tawv nqaij, tus transdermal nqus tus nqi ntawm esterase rhiab heev prodrug yog 2.8 npaug ntawm cov tshuaj dawb, thaum lub systemic faib yog txo mus rau 15%.
Cov lus nug nquag
Nws puas zoo rau cov tawv nqaij tsis zoo thiab noj qab nyob zoo?
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Nws yog qhov yuav ua rau tsis muaj txiaj ntsig. Cov kev tshawb fawb soj ntsuam tau pom tias exogenous IGF-1 (xws li nws cov analogues) yog qhov nyuaj rau nkag mus rau qhov tsis zoo stratum corneum barrier rau ntawm daim tawv nqaij tsis zoo, thiab feem ntau tsuas yog ua haujlwm hauv qhov chaw mob qhov chaw ntawm daim tawv nqaij barrier puas.
Daim ntawv thov hauv zos yuav ua li cas kom tsis txhob muaj kev mob tshwm sim?
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Txoj kev xav cia siab rau kev xa khoom hauv zos. Kev tswj hwm kev tso tawm hauv zos thiab kev tswj hwm los ntawm cov ntawv tshwj xeeb (xws li gel thiab hydrogel hnav khaub ncaws) yog npaj kom txwv tsis pub cov tshuaj lom neeg hauv thaj chaw tsom, zam cov tshuaj nkag mus rau hauv lub cev, thiab yog li txo qhov cuam tshuam ntawm cov kab mob endocrine thiab lwm yam kabmob.
Dab tsi yog qhov txawv ntawm kev txhawb nqa kev kho mob thiab kev loj hlob ib txwm muaj xws li EGF?
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Lub hom phiaj ntawm kev ua yog dav dua. IGF-1 LR3 tsis tsuas yog txhawb kev loj hlob ntawm epidermal cell proliferation, tab sis kuj tseem tsom rau kev txhawb nqa kev ua haujlwm ntawm cov hlwb sib sib zog nqus (xws li fibroblasts), thiab tej zaum yuav muaj zog txhawb zog rau collagen synthesis thiab granulation cov ntaub so ntswg loj hlob, ua rau nws haum rau cov qhov txhab ntxaum.
Vim li cas nws txwv tsis pub ua cov khoom siv tshuaj pleev ib ce thoob ntiaj teb?
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Feem ntau yog vim muaj kev txhawj xeeb txog kev nyab xeeb ntev ntev. Kev loj hlob yam muaj peev xwm txhawb nqa kev faib tawm ntawm tes, thiab siv sij hawm ntev - siv rau hauv daim tawv nqaij noj qab haus huv theoretically ua rau muaj kev pheej hmoo ntawm inducing txawv txav thickening ntawm stratum corneum, tawv tawv, thiab txawm muaj peev xwm txhawb kev loj hlob ntawm cov qog hlwb uas twb muaj lawm. Yog li ntawd, cov teb chaws xws li Tuam Tshoj tau txwv tsis pub nws ntxiv los ua cov khoom xyaw kom zoo nkauj.
Cim npe nrov: Tuam Tshoj igf-1 lr3 cream manufacturers, lwm tus neeg
