IGF-1 LR3 Txhaj, raws li kev txhaj tshuaj peptide hluavtaws nrog cov yam ntxwv lom neeg, maj mam tau txais kev saib xyuas thoob plaws. IGF-1 LR3 yog ib qho kev hloov pauv hloov pauv ntawm cov tshuaj insulin-zoo li kev loj hlob zoo-1 (IGF-1), uas nws cov haujlwm lom neeg thiab cov tshuaj pharmacokinetic tau ua kom zoo dua los ntawm kev hloov kho cov qauv tshwj xeeb. Insulin zoo li kev loj hlob zoo-1 (IGF-1) yog ib qho saw hlau alkaline polypeptide tsim los ntawm 70 amino acids, nrog cov qauv molecular zoo li insulin. IGF-1 feem ntau yog synthesized thiab secreted los ntawm lub siab, thiab nws synthesis thiab tso tawm nce nyob rau hauv lub stimulation ntawm kev loj hlob hormone (GH). IGF-1 muaj ntau yam kev ua haujlwm lom neeg hauv lub cev, suav nrog kev txhawb nqa cell proliferation, kev sib txawv, thiab kev tsiv teb tsaws, tswj cov tshuaj metabolism, thiab txhawb cov pob txha thiab cov leeg. Piv nrog rau ntuj IGF-1, qhov sib txawv ntawm cov qauv ntawm IGF-1 LR3 feem ntau yog tshwm sim hauv N-terminal extension thiab amino acid hloov. Cov txheej txheem sib txawv no ua rau muaj qhov sib txawv tseem ceeb hauv kev ua haujlwm lom neeg thiab cov tshuaj pharmacokinetic ntawm IGF-1 LR3 thiab ntuj IGF-1. Piv txwv li, lub peev xwm khi ntawm IGF-1 LR3 rau insulin-zoo li kev loj hlob zoo li kev khi cov proteins (IGFBPs) tau txo qis, yog li txo qhov kev pheej hmoo ntawm IGF-1 LR3 raug khi thiab tshem tawm los ntawm IGFBPs hauv cov ntshav thiab ncua nws ib nrab-lub neej hauv lub cev.
Peb tsis tsuas yog muab cov hmoov ntshiab thiab cov tshuaj ntsiav, tab sis kuj muaj lwm yam tshuaj. Yog tias tsim nyog, thov hu rau peb pab neeg muag khoom.
Peb cov khoom los ntawm
IGF-1 LR3 COA
 |
||
| Certificate of Analysis | ||
| Compound npe | IGF-1 LR3 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 946870-92-4 | |
| Ntau | 15g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090029 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv | N/A | |
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.35% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.27% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.48% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 98 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
|
|
||
IGF-1 LR3 Txhaj(Long R3 Insulin-zoo li Growth Factor-I) Nws yog ib qho kev hloov kho ntev ntev - ua insulin-zoo li kev loj hlob uas hloov cov qauv tseem ceeb ntawm IGF ntuj -1 los ntawm genetic engineering technology, prolonging nws ib nrab - lub neej thiab txhim kho nws cov khoom lom. Nws cov ntawv thov tseem ceeb suav nrog kev kho mob, kho kev ua kis las, thiab kev tiv thaiv kev laus, tab sis nws yuav tsum nruj me ntsis ua raws li kev tshawb fawb thiab cov qauv kev kho mob.
Mechanism of action: Dual breakthrough of structural modification and biological activation
Kev hloov kho ntawm IGF-1 LR3 yog raws li cov qauv molecular ntawm ntuj IGF-1 thiab ua tiav kev ua haujlwm zoo los ntawm ob qhov kev hloov pauv tseem ceeb:
N-terminal extension:
Ntxiv 13 amino acid peptide ntu mus rau N- qhov kawg ntawm IGF-1 los ua tus qauv "Long R3". Qhov txuas ntxiv peptide no txo qhov kev sib txuas ntawm IGF-1 rau IGF khi cov proteins (IGFBPs) los ntawm steric hindrance, uas ua rau muaj kev nce ntxiv hauv cov concentration ntawm dawb IGF-1 LR3.
Site mutation:
Hloov glutamic acid (Glu) ntawm txoj hauj lwm 3 ntawm IGF-1 nrog arginine (Arg), ntxiv txo nws cov affinity rau IGFBPs. Kev sim cov ntaub ntawv qhia tau hais tias kev khi muaj peev xwm ntawm IGF-1 LR3 rau IGFBPs yog txo los ntawm ntau dua 90% piv rau ntuj IGF-1, thiab nws cov kev ua lom lom yog nce 2-3 zaug.
Ib nrab lub neej txuas ntxiv: Ib nrab ntawm -lub neej ntawm IGF ntuj -1 tsuas yog 20 feeb xwb, thaum IGF-1 LR3 txuas lub neej ib nrab mus rau 20-30 teev los ntawm kev txo qis "kev sib khi" cuam tshuam ntawm kev khi cov protein. Cov yam ntxwv no ua rau nws txuas ntxiv mus qhib IGF-1 receptor (IGF-1R) ntawm lub xovtooj ntawm tes, ua tiav cov teebmeem lom neeg ntev dua.
Ua kom muaj kev taw qhia txoj hauv kev: IGF-1 LR3 khi rau IGF-1R thiab tswj kev ua haujlwm ntawm tes los ntawm ob txoj hauv kev:
PI3K/Akt/mTOR txoj kev
Txhawb nqa protein synthesis thiab glycogen synthesis, inhibiting protein degradation thiab cell apoptosis, yog lub ntsiab mechanisms rau cov nqaij ntshiv kev loj hlob thiab cell ciaj sia taus.
Ras/MAPK/ERK pathway
Tswj lub voj voog ntawm tes, kev hloov pauv ntawm cov noob, thiab kev sib txawv ntawm tes, thiab sib koom ua ke txhawb kev loj hlob ntawm tes nrog txoj hauv kev PI3K.
Targeting nqaij atrophy kab mob
Ib qho laj thawj tseem ceeb rau cov leeg nqaij atrophy yog qhov tsis sib xws ntawm cov protein synthesis thiab degradation, ua rau poob ntawm cov leeg nqaij protein. IGF-1 LR3 activates Akt/mTOR txoj hauv kev, txhawb kev tsim cov ribosome thiab cov protein txhais lus, yog li ua kom cov nqaij protein synthesis. Kev tshawb fawb tau pom tias IGF-1 LR3 tuaj yeem ua rau muaj txiaj ntsig zoo ntawm cov protein synthesis hauv cov leeg nqaij thiab ua kom cov leeg nqaij.
Ntxiv nrog rau kev txhawb nqa cov protein synthesis, IGF-1 LR3 tuaj yeem cuam tshuam cov leeg nqaij protein. Nws txo qis kev degradation ntawm cov leeg nqaij protein los ntawm ubiquitin proteasome system los ntawm inhibiting kev ua ntawm FOXO3 txoj kev. FOXO3 yog ib qho kev hloov pauv uas tuaj yeem qhib qhov kev qhia ntawm cov leeg nqaij tshwj xeeb E3 ubiquitin ligases xws li MAFbx / atrogin-1 thiab MuRF-1, yog li txhawb kev degradation ntawm cov leeg nqaij. IGF-1 LR3 phosphorylates FOXO3, hloov nws los ntawm lub nucleus mus rau cytoplasm, yog li inhibiting nws transcriptional kev ua si thiab txo cov degradation ntawm cov nqaijrog proteins.
Ua kom cov cell satellite thiab tiv thaiv - cov teebmeem inflammatory
Satellite cells yog cov leeg pob txha nyob hauv qab lub hauv paus hauv qab ntawm cov nqaij fibers. Thaum lub sij hawm raug mob los yog atrophy, satellite cell tuaj yeem qhib tau thiab nthuav tawm kom sib txawv rau hauv cov leeg nqaij tshiab, koom nrog cov leeg nqaij thiab kho. IGF-1 LR3 tuaj yeem txhawb nqa kev ua kom muaj zog thiab nthuav dav ntawm satellite cell, nce tus naj npawb thiab kev ua haujlwm ntawm satellite cell, thiab muab cov khoom siv cell txaus rau cov leeg nqaij. Kev tshawb fawb pom tau hais tias cov xov tooj ntawm satellite cell nyob rau hauv cov nqaij ntshiv cov nqaij ntshiv nce thiab cov nqaij ntshiv muaj peev xwm rov qab tau zoo dua tom qab kho nrog.IGF-1 LR3 txhaj.
Inflammatory teb plays lub luag haujlwm tseem ceeb hauv qhov tshwm sim thiab kev loj hlob ntawm cov leeg nqaij atrophy. Kev mob ntev tuaj yeem ua rau ubiquitin proteasome system thiab autophagy lysosome system, txhawb kev degradation ntawm cov leeg nqaij. IGF-1 LR3 muaj cov tshuaj tiv thaiv kab mob, uas tuaj yeem cuam tshuam qhov kev qhia thiab tso tawm ntawm cov kab mob inflammatory, txo cov inflammatory teb ntawm cov leeg nqaij, thiab tiv thaiv cov leeg nqaij los ntawm kev puas tsuaj.
Kev siv rau cov kab mob ntawm cov leeg nqaij atrophy
Duchenne muscular dystrophy (DMD)
Duchenne muscular dystrophy yog cov kab mob loj zuj zus nrog X-chromosome recessive qub txeeg qub teg, tshwm sim los ntawm kev hloov pauv hauv cov noob dystrophin. Tus neeg mob pib nrog maj mam necrosis ntawm skeletal nqaij fibers thiab rog hloov, thaum kawg ua rau ua pa tsis ua hauj lwm thiab lub plawv tsis ua hauj lwm. Hauv cov neeg mob DMD, kev puas tsuaj thiab kho qhov tsis sib xws ntawm cov leeg nqaij ua rau cov leeg nqaij atrophy thiab fibrosis. IGF-1 LR3 txhawb nqa kev ua kom muaj zog thiab nthuav dav ntawm cov xov tooj cua satellite, ua rau muaj cov leeg nqaij tshiab, thiab txhim kho cov leeg nqaij. Lub caij no, IGF-1 LR3 kuj tseem tuaj yeem cuam tshuam qhov degradation ntawm cov leeg nqaij thiab txo cov leeg nqaij. Tsis tas li ntawd, cov tshuaj tiv thaiv -cov nyhuv inflammatory ntawm IGF-1 LR3 tuaj yeem txo qhov kev mob tshwm sim ntawm cov leeg nqaij thiab ncua kev kis kab mob. Cov kev sim tsiaj tau pom tias hauv mdx nas (DMD qauv), IGF-1 LR3 kev kho mob tuaj yeem ua rau cov leeg muaj zog thiab ntu ntu ntu, thiab txo cov fibrosis. Hauv kev sim ob qhov muag tsis pom kev tsom rau cov neeg mob DMD, pawg kho mob IGF-1 LR3 tau nce cov leeg nqaij los ntawm 2.1kg hauv 12 lub lis piam, thaum pawg tswj hwm tsuas yog nce los ntawm 0.3kg, thiab tsis muaj kev cuam tshuam loj heev. Cov txiaj ntsig no qhia tias IGF-1 LR3 muaj peev xwm kho tus nqi rau cov neeg mob DMD.
mob cancer cachexia
Cancer cachexia yog ib hom kab mob metabolic nyob rau hauv cov neeg mob qog noj ntshav siab, uas tshwm sim los ntawm kev poob sai sai, cov leeg nqaij atrophy, thiab rog dhau. Cachexia cuam tshuam rau lub neej zoo thiab kev ciaj sia ntawm cov neeg mob, thiab yog ib qho tseem ceeb ntawm kev tuag ntawm cov neeg mob qog noj ntshav. Qhov tshwm sim ntawm mob qog noj ntshav cachexia muaj feem cuam tshuam nrog rau yam xws li inflammatory teb, hormonal imbalance, thiab metabolic ntshawv siab. IGF-1 LR3 thim rov qab los yog qeeb cov leeg nqaij los ntawm kev txhawb nqa protein synthesis, inhibiting protein degradation, thiab activating satellite hlwb. Lub caij no, IGF-1 LR3 tuaj yeem txhim kho cov neeg mob lub zog sib npaug, txhim kho cov rog rog thiab siv cov piam thaj, thiab txo cov tsos mob ntawm cachexia. Cov kev sim tsiaj tau pom tias nyob rau hauv tus qauv nas ntawm lub ntsws cancer cachexia, IGF-1 LR3 kev kho mob tuaj yeem tswj cov leeg nqaij thiab ua kom muaj sia nyob ntev. Hauv kev sim qhib lub hom phiaj rau cov neeg mob qog noj ntshav siab tshaj plaws, IGF-1 LR3 ua ke nrog kev noj zaub mov zoo tau txhim kho cov leeg nqaij thiab kev ua haujlwm zoo. Cov txiaj ntsig no qhia tiasIGF-1 LR3 txhajmuaj peev xwm kho tus nqi rau cov neeg mob cancer cachexia.
Hnub nyoog -txog sarcopenia
Sarcopenia yog ib qho kev mob tshwm sim ntawm cov leeg nqaij qis thiab lub zog hauv cov neeg laus, cuam tshuam nrog kev ntog, pob txha, thiab kev tuag ntau ntxiv. Raws li lub hnub nyoog nce, kev kho lub peev xwm ntawm cov leeg nqaij txo qis, cov xov tooj ntawm cov xov tooj ntawm satellite txo, ua rau cov leeg nqaij atrophy thiab tsis muaj zog. IGF-1 LR3 txhim kho cov leeg nqaij thiab lub zog hauv cov neeg laus los ntawm kev txhawb nqa kev rov qab los ntawm satellite cell muaj nuj nqi, txhim kho protein synthesis, thiab inhibiting protein degradation. Lub caij no, cov tshuaj tiv thaiv kab mob ntawm IGF-1 LR3 tuaj yeem txo qhov mob ntawm cov leeg nqaij thiab ncua kev loj hlob ntawm sarcopenia.
Cov lus nug nquag
Qhov twg txhaj IGF-1 LR3?
+
-
Qhov twg txhaj IGF-1 LR3. Kev txhaj tshuaj yog feem ntau subcutaneous, siv cov koob txhaj tshuaj insulin rau hauv thaj chaw uas muaj kev txhim khu kev qha, xws li lub plab lossis ncej puab.
Puas yog IGF-1 LR3 zoo dua HGH?
+
-
HGH txhawb lub siab los tsim cov endogenous IGF-1, tab sis cov lus teb no qeeb thiab txwv. IGF-1 peptides (xws li LR3 lossis DES) hla GH-rau-lub siab kauj ruam thiab khi ncaj qha rau cov leeg receptors kom nrawm dua, meej dua cov teebmeem anabolic.
IGF-1 LR3 ua dab tsi?
+
-
Cov kev tshawb fawb yav dhau los los ntawm pab pawg no tau qhia tias kev siv cov yaj hauv plab ib txwm muaj nrog cov koob tshuaj siab (6.6 µg·kg⁻¹·h⁻¹) ntawm IGF-1 LR3, ib qho analog rau IGF-1, nce lub cev hnyav thaum tib lub sijhawm txo cov qib insulin thiab GSIS.
IGF-1 LR3 muaj zog npaum li cas?
+
-
IGF-1 LR3, los yog Ntev-R3-IGF-1, yog ib qho kev sim ua los ntawm cov tshuaj insulin zoo li kev loj hlob-1. Los ntawm tweaking nws cov qauv, ntxiv 13 amino acids ntxiv thiab hloov ib qho, cov molecule yuav muaj zog thiab kav ntev hauv lub cev. Haiv neeg IGF-1 feem ntau tawg hauv li 12 teev, thaum IGF-1 LR3 tuaj yeem nyob twj ywm rau 20-30 teev.
Dab tsi yog qhov txawv ntawm IGF-1 thiab IGF-1 LR3?
+
-
IGF1 LR3 yog ib qho piv txwv ntawm IGF-1 uas glutamic acid ntawm carbon 3 (Glu3) hloov los ntawm arginine thiab muaj 13 ntxiv amino acids rau N-terminus. Nws muaj kev sib raug zoo tsawg heev rau IGFBPs piv rau IGF-1.
Cim npe nrov: igf-1 lr3 txhaj tshuaj, Tuam Tshoj igf-1 lr3 txhaj tshuaj manufacturers, lwm tus neeg
