PT-141 Txhaj(Bremer Wanda Txhaj) yog peptide hluavtaws-raws li tshuaj nyob rau hauv daim ntawv ntawm hmoov dawb. Nws cov mis molecular yog C50H68N14O10 thiab nws muaj cov ntawv thov tseem ceeb hauv kev kho mob. Raws li melanocortin receptor agonist, nws tsis tuaj yeem ua tsis tau - xaiv qhib receptor subtypes xws li MC1R thiab MC4R, thiab los ntawm kev tswj cov kev tso tawm ntawm cov neurotransmitters hauv nruab nrab paj hlwb (xws li dopamine, norepinephrine, thiab oxytocin), nws muaj peev xwm ua kom muaj kev sib deev thiab muaj peev xwm ntawm kev sib deev. Xyoo 2019, US FDA tau pom zoo rau kev kho mob ntawm kev sib deev tsis zoo hauv cov poj niam premenopausal (HSDD), thiab nws kuj tau pom tias muaj txiaj ntsig zoo rau cov txiv neej erectile kawg (tshwj xeeb tshaj yog rau cov neeg uas tsis teb rau cov tshuaj tsoos). Cov tshuaj no yog siv los ntawm kev txhaj tshuaj subcutaneous thiab feem ntau yog siv 45 feeb ua ntej kev sib deev. Nws cov txheej txheem ntawm kev ua yog cuam tshuam nrog kev txhawb nqa cov ntshav ntws mus rau qhov chaw mos thiab txhim kho kev sib deev arousal, muab kev kho tshiab rau cov neeg mob uas muaj kev sib deev tsis zoo.
Peb Cov Khoom Muag Khoom
PT-141 COA
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| Certificate of Analysis | ||
| Compound npe | Bremelanotide / PT-141 | |
| CAS Nr. | 189691-06-3 | |
| Ntau | 189kg ua | |
| Ntim txheem | 25kg / nruas | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 20251005035 | |
| MFG | 05 Peb 2025 | |
| EXP | 05 Peb 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb kom tawm -dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.25% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.32% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.10% |
| Ib leeg impurity | <0.8% | 0.23% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 89 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400pm ib |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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PT-141 TxhajRaws li cov tshuaj tshiab, ua kom pom tus nqi tshwj xeeb hauv kev kho cov txiv neej erectile kawg (ED). Nws daim ntawv thov tuaj yeem txheeb xyuas los ntawm cov kev pom hauv qab no:
Mechanism of Action: Central Regulation, Ua kom muaj kev sib deev muaj siab
PT-141 activates melanocortin-4 receptor (MC4R) nyob rau hauv lub hypothalamus ntawm lub hlwb, ua rau ib tug neurochemical cov tshuaj tiv thaiv saw, uas ncaj qha txhawb kev sib deev muaj siab thiab arousal. Cov txheej txheem no yog qhov txawv ntawm cov tshuaj ED ib txwm:
Tsoos tshuaj:Nws txhim kho cov ntshav hauv zos los ntawm dilating cov hlab ntsha, hais txog cov teeb meem "hardware" (xws li erectile hardness lossis lubrication), thiab yuav tsum muaj kev sib deev stimulation.
Qauv TSIS MUAJ: PT-141Nws hla txoj hauv kev hormonal thiab ua ncaj qha rau ntawm txoj hauv kev neural ntsig txog kev txhawb siab thiab nqi zog, hais txog "software" cov teeb meem (xws li poob ntawm kev xav deev lossis kev xav tsis zoo).
Cov kev tshawb fawb tau pom tias PT-141 tuaj yeem ua rau lub sijhawm ntev ntawm erections, thiab cov nyhuv yog nyob ntawm koob tshuaj. Hauv cov tib neeg noj qab haus huv, txawm tias tsis pom kev sib deev stimulation, cov lus teb erectile nce nrog koob tshuaj; rau cov neeg mob ED uas tsis teb zoo rau sildenafil, qhov kev vam meej ntawm erections tom qab kev tswj hwm subcutaneous ntawm PT-141 ua tau zoo dua.
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Clinical zoo: Sau qhov sib txawv ntawm kev kho mob ib txwm muaj
Ua txhaum ntawm kev txwv ntawm vascular dependence
PT-141 tsis ua rau cov hlab ntsha, zam cov kev mob tshwm sim xws li mob taub hau, ua rau lub ntsej muag, thiab qhov muag tsis pom kev tshwm sim los ntawm cov tshuaj ib txwm siv, thiab tshwj xeeb tshaj yog rau cov neeg mob uas muaj kab mob plawv lossis cov neeg noj tshuaj nitrate.
Npog cov neeg tshwj xeeb ED
Psychogenic ED:Rau ED tshwm sim los ntawm kev puas siab puas ntsws xws li kev ntxhov siab thiab kev nyuaj siab, PT-141 ncaj qha txhim kho kev sib deev muaj siab los ntawm kev tswj hwm hauv nruab nrab, rhuav tshem lub voj voog tsis zoo ntawm "kev puas siab puas ntsws - kev mob hnyav dua".
Refractory ED:Rau cov neeg mob uas tsis muaj txiaj ntsig lossis tsis haum rau PDE5 inhibitors, PT-141 muab lwm txoj kev daws teeb meem. Hauv kev sim tshuaj, qee cov neeg mob tau ua tiav "muaj zog thiab nquag" erections tom qab siv PT-141, nrog lub sijhawm ntawm 2-6 teev.
Haum rau cov txiv neej thiab poj niam
PT-141 yog thawj tus neeg sawv cev hauv nruab nrab tau pom zoo rau kev kho tus poj niam hypoactive kev sib deev muaj siab tsis meej (HSDD), thiab nws yog ib qho ntawm ob peb cov tshuaj kho mob ED uas tseem cuam tshuam rau txiv neej thiab poj niam xav tau.
Kev nyab xeeb thiab ceev faj: Kev ntsuas nruj, kev siv tus qauv
Cov teebmeem tshwm sim
Kev xeev siab (txog 40% ntawm cov neeg mob), feem ntau me me mus rau nruab nrab, tuaj yeem txo qis nrog qhov nce ntawm cov koob tshuaj.
Kev tawm ntawm lub ntsej muag, mob taub hau, thiab qhov chaw txhaj tshuaj, nrog rau qhov xwm txheej tsawg thiab tswj tau qhov xwm txheej.
Contraindications thiab txaus ntshai
Cov kab mob plawv:PT-141 tuaj yeem ua rau cov ntshav siab nce siab ib ntus thiab txo lub plawv dhia. Nws yog txwv tsis pub siv rau cov neeg mob uas tsis tswj ntshav siab lossis kab mob plawv. Cov xwm txheej ntawm lub plawv yuav tsum tau soj ntsuam ua ntej siv, vim tias ED yuav yog ib qho kev tshwm sim hauv zos ntawm cov kab mob atherosclerosis.
Ntev -kev nyab xeeb lub sij hawm:Cov ntaub ntawv tam sim no feem ntau yog ua raws li luv luv - kev sim tshuaj ntsuam xyuas. Kev siv sijhawm ntev - yuav tsum tau saib xyuas cov kev mob tshwm sim thiab kev ua tau zoo.
Cov lus qhia siv
Dosage thiab zaus:Rau cov poj niam, thawj koob tshuaj yog 750 ug - 1mg, tsis pub ntau tshaj ib zaug hauv 24 teev, thiab tsis pub ntau tshaj 8 zaug hauv ib hlis. Rau cov txiv neej, cov koob tshuaj yuav tsum tau hloov kho raws li cov lus teb ntawm tus kheej, tsis txhob noj ntau dhau.
Lub sijhawm txhaj tshuaj:Nws raug nquahu kom txhaj 45 feeb ua ntej kev sib deev. Lub sijhawm tuaj yeem ua kom zoo raws li lub sijhawm ntawm cov kev mob tshwm sim (xws li kev cuam tshuam ntawm xeev siab ntawm kev siv tshuaj).
Kev ntsuam xyuas tsis tu ncua: Kev siv sijhawm ntev- yuav tsum tau soj ntsuam tas li ntawm kev txhim kho kev sib deev thiab kev pheej hmoo ntawm cov kev mob tshwm sim, tshwj xeeb tshaj yog saib xyuas cov ntsuas kev noj qab haus huv ntawm cov hlab plawv.
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Kev ua lag luam Positioning thiab yav tom ntej Outlook
Raws li thawj qhov tseem ceeb ntawm - ua yeeb yam ED kev kho mob, PT-141 tau qhib txoj hauv kev tshiab hauv kev sib deev tshuaj. Nws qhov zoo nyob hauv:
Ua lag luam qhov khoob
Muab cov kev xaiv tshiab rau cov neeg mob uas tsis teb lossis tsis tuaj yeem zam cov tshuaj ib txwm muaj, tshwj xeeb tshaj yog rau cov neeg uas muaj kev puas siab puas ntsws erectile kawg lossis cov uas muaj co- cov kab mob plawv.
Muaj peev xwm rau kev sib xyaw ua ke
Cov kev sim thaum ntxov tau pom tias kev sib xyaw ntawm PT-141 nrog sildenafil tuaj yeem ua rau lub sijhawm ntev ntawm erections yam tsis muaj kev pheej hmoo rau kev noj qab haus huv. Kev tshawb nrhiav ntxiv ntawm ntau txoj kev kho mob ua ke tuaj yeem ua tau yav tom ntej.
Txawm li cas los xij, nws txoj kev txhawb nqa ntsib cov teeb meem:
Side Effect Management:Qhov tshwm sim ntawm xeev siab yog qhov siab, uas tuaj yeem cuam tshuam rau kev ua raws li kev noj tshuaj thiab yuav tsum tau hais los ntawm kev hloov tshuaj los yog kev kho ua ke.
Kev kawm ua lag luam:Nws yog ib qho tsim nyog kom paub qhov txawv ntawm "cov tshuaj kho mob" thiab "cov tshuaj lom zem" los tiv thaiv kev tsim txom. Tam sim no, tsis muaj - cov khoom lag luam tshuaj tau sau npe tias "cov tshuaj tshawb fawb" nthuav tawm hauv khw, uas muaj kev tswj tsis tau zoo thiab ua rau muaj kev pheej hmoo ntawm kev nyab xeeb.
Kev kho mob scenario
PT-141 Txhajqhia tshwj xeeb daim ntawv thov tus nqi hauv kev kho mob scenarios. Nws cov txheej txheem tshawb fawb thiab kev tsim kho, daim ntawv tshuaj, siv txoj hauv kev, thiab kev ua lag luam txhua qhov cuam tshuam txog kev tsim kho tshiab thiab qhov tseeb ntawm kev tshawb fawb tshuaj niaj hnub.
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Kev tshawb fawb keeb kwm: Ib qho kev npaj txhij txog los ntawm "kev zoo nkauj" mus rau "kev kho mob"
Qhov kev tshawb pom ntawm PT-141 tshwm sim los ntawm qhov "tsis xav txog" cov kev mob tshwm sim. Cov kws tshawb fawb pib tsim cov peptide hu ua Melanotan I, txhawm rau txhawb melanocyte- txhawb nqa cov tshuaj tiv thaiv tawv nqaij thiab tiv thaiv kab mob qog noj ntshav. Txawm li cas los xij, thaum kev sim tshuaj, ob tus kws tshawb fawb thiab cov neeg koom tau tshaj tawm cov txiaj ntsig tseem ceeb - spontaneous kev sib deev arousal thiab erection. Qhov kev tshawb pom tsis zoo no tau coj txoj kev tshawb fawb mus rau qhov kev coj ua tshiab. Raws li cov qauv ntawm Melanotan I, cov kws tshawb fawb tau tsim ib qho analogue ntau dua, Melanotan II, tab sis nws cov kev mob tshwm sim (xws li xeev siab thiab lub ntsej muag yaug) tseem pom tseeb. Tom qab kev ua kom zoo dua ntxiv, kev ua haujlwm ntawm kev sib deev pro-kev sib deev tau khaws cia thaum txo lwm yam kev mob tshwm sim. Thaum kawg, PT-141 tau txais thiab tsim tshwj xeeb rau kev kho mob ntawm poj niam kev ntshawv siab.
Kev Tsim Tshuaj thiab Cov Lus Qhia Tshwj Xeeb: Ua tau raws li qhov xav tau ntau yam ntawm kev tshawb fawb thiab kev siv tshuaj kho mob
PT-141 yog ib qho hluavtaws cyclic heptapeptide. Nws daim ntawv acetate (PT-141 Acetate) yog soluble hauv dej, ua rau nws yooj yim los npaj thiab txhaj tshuaj. Hauv cov chaw kho mob, PT-141 tau muab rau hauv ntau qhov tshwj xeeb, suav nrog 1mg, 5mg, 10mg, 25mg, thiab lwm yam, kom tau raws li kev tshawb fawb sib txawv thiab kev kho mob. Nws cov purity feem ntau yog siab dua 95%, ua kom muaj kev ruaj ntseg thiab kev ua tau zoo ntawm cov tshuaj. Tsis tas li ntawd, cov xwm txheej khaws cia rau PT-141 yog nruj heev, yuav tsum tau khaws cia ntawm -20℃txhawm rau tiv thaiv cov tshuaj degradation thiab tsis ua haujlwm.
Kev siv: Precise txhaj, yooj yim thiab siv tau
Txoj kev siv ntawmPT-141 Txhajyooj yim heev. Nws feem ntau yog siv los ntawm kev txhaj tshuaj subcutaneous. Qhov chaw txhaj tshuaj tuaj yeem xaiv tau raws li lub plab lossis tus ncej puab. Rau cov poj niam cov neeg mob, nws raug nquahu kom txhaj tshuaj tsawg kawg 45 feeb ua ntej kev sib deev los xyuas kom meej tias cov tshuaj tau nqus tag nrho thiab siv tau. Thaum lub sij hawm txhaj tshuaj, cov neeg mob tuaj yeem siv tus cwj mem txhaj tshuaj tsis siv neeg, uas yooj yim rau kev khiav lag luam thiab ua rau mob tsawg heev. Txoj kev txhaj tshuaj meej no tsis yog tsuas yog txhim kho qhov kev siv ntawm cov tshuaj tab sis kuj txo cov kev mob tshwm sim tsis tsim nyog thiab kev pheej hmoo.
Kev ua lag luam qhov chaw: Sau qhov sib txawv hauv kev kho poj niam kev ntshaw kev sib deev
Qhov chaw ua lag luam ntawm PT-141 Kev txhaj tshuaj hauv kev kho mob yog qhov tseeb heev. Raws li thawj zaug thiab tam sim no tsuas yog cov tshuaj uas feem ntau ua rau hauv nruab nrab lub paj hlwb los kho cov poj niam kev ntshaw kev sib deev txo qis, nws tau ua rau muaj qhov sib txawv ntawm kev ua lag luam. Raws li cov ntaub ntawv los ntawm ib qho loj - nplai, randomized, ob npaug - dig muag, placebo- tswj Phase III kev soj ntsuam, PT-141 tau pom zoo rau kev lag luam los ntawm US Food and Drug Administration (FDA) thiab yog siv los kho cov poj niam pre-menopausal uas tau txais, kev sib deev muaj siab. Tsis tas li ntawd, PT-141 kuj tau pom zoo hauv Canada thiab lwm thaj chaw, muab kev kho mob tshiab rau cov neeg mob thoob ntiaj teb.
Kev Tshawb Fawb Tus Nqi: Txhawb Kev Txhim Kho Kev Kho Mob
Sib nrug los ntawm nws cov ntaub ntawv kho mob, PT-141 kuj tseem muaj txiaj ntsig tseem ceeb hauv kev tshawb fawb. Raws li melanocortin receptor agonist, nws muab cov cuab yeej tshiab rau kev kawm txog kev ua haujlwm ntawm lub cev xws li kev sib deev arousal, qab los noj mov, thiab daim tawv nqaij pigmentation. Cov kws tshawb fawb tuaj yeem tshawb nrhiav cov txheej txheem ntawm kev ua ntawm PT-141 kom nkag siab ntxiv txog lub luag haujlwm ntawm lub hauv paus paj hlwb hauv kev tswj hwm kev sib deev, yog li muab lub hauv paus theoretical rau kev tsim cov tshuaj tshiab rau kev sib deev.
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FAQ
1. PT-141 siv rau dab tsi?
PT-141 (Bremelanotide) yog ib qho hluavtaws peptide siv feem ntau los kho kev sib deev dysfunction, boosting libido thiab arousal los ntawm kev ua ntawm melanocortin receptors nyob rau hauv lub hlwb, pab ob leeg premenopausal poj niam nrog HSDD (Hypoactive Sexual Desire Disorder) thiab cov txiv neej feem ntau-lab rau cov txiv neej, nrog rau cov txiaj ntsig suav nrog kev muaj siab, kev xav, thiab kev xav zoo, tab sis yuav tsum tau kev sab laj kev kho mob vim muaj kev phiv xws li xeev siab, ntshav siab hloov pauv, thiab qaug zog.
2. Puas yog PT-141 yuav raug cai?
PT-141 tau pom zoo los ntawm FDA rau hypoactive kev sib deev muaj siab tsis meej nyob rau hauv cov poj niam premenopausal thiab tsis raug rau categorization txwv nyob rau hauv Tshooj 503A. Nws tsis pom zoo rau kev kho kev sib deev tsis ua haujlwm hauv cov poj niam postmenopausal lossis txiv neej.
3. Kev txhaj tshuaj PT-141 ntev npaum li cas?
Kev Ruaj Ntseg Rov Qab: Tshaj li qhov kev xav ntawm lub cev, PT-141 txhawb nqa qhov kev xav rov qab los. Koj yuav pom koj tus kheej tsis yog xav tau koj tus khub xwb tab sis kuj xav tias muaj kev sib raug zoo ntau dua ntawm kev xav. Cov teebmeem ntev ntev: Cov teebmeem ntawm PT-141 tuaj yeem kav ntev li ntawm rau rau 72 teev.
Cim npe nrov: pt-141 txhaj tshuaj, Tuam Tshoj pt-141 txhaj tshuaj manufacturers, lwm tus neeg
