MT2 hmoov

MT2 hmoovib tug nplua, soluble khoom formulation, yog ib daim ntawv tshwj xeeb ntawmMelanotan II, uas belongs rau lub broader qeb ntawmMelanotanSynthetic peptide analogues. Tsuas yog lwm tus tswv cuab ntawm tsev neeg peptide no yogMelanotan I, kuj paub los ntawm nws lub npe genericAfamelanotide, uas qhia txog cov qauv thiab kev ua haujlwm zoo sib xws tseem sib txawv hauv nws cov amino acid ib ntus thiab cov tshuaj pharmacological. MT2 hmoov exerts nws cov teebmeem lom neeg feem ntau los ntawm lub hom phiaj mechanism: nws xaiv khi rau thiab qhib lubmelanocortin 1 receptor (MC1 receptor). Qhov no G-protein-coupled receptor tsis yog tsuas yog dav dav thoob plaws hauv cellular membrane ntawm melanocytes-cov xim - tsim cov hlwb nyob rau hauv lub basal txheej ntawm epidermis- tab sis kuj qhia tau hais tias muaj kev qhia tshwj xeeb hauv cov hlwb. Thaum ua kom tiav los ntawm MT2 hmoov, MC1 receptor ua rau ib qho kev cuam tshuam ntawm intracellular signaling txoj hauv kev uas ncaj qha txhim khu kev ua haujlwm tyrosinase; tyrosinase, raws li tus nqi - txwv enzyme hauv melanin biosynthesis, tom qab ntawd catalyzes hloov pauv ntawm tyrosine rau dopaquinone, yog li ua kom cov khoom tsim tawm thiab sib sau ntawm melanin hauv melanocytes thiab thaum kawg ua rau pom kev tsaus ntuj ntawm daim tawv nqaij. Tsis tas li ntawd, dhau ntawm nws qhov zoo - lub luag haujlwm tseem ceeb hauv cov tawv nqaij pigmentation, MC1 receptor plays lub luag haujlwm tseem ceeb thiab ntau yam hauv kev tswj hwm lub cev tiv thaiv kab mob thiab hloov kho cov lus teb, pab tswj qhov sib npaug ntawm kev tiv thaiv kab mob thiab cov ntaub so ntswg homeostasis nyob rau hauv ntau yam physiological thiab pathological mob.

Peb tsis tsuas yog muab cov hmoov ntshiab xwb, tab sis kuj muaj lwm cov ntaub ntawv ntau npaum. Yog tias tsim nyog, thov hu rau peb pab neeg muag khoom.

MT2 COA

Certificate of Analysis
Compound npe	Melanotan II
Qib	Pharmaceutical qib
CAS Nr.	121062-08-6
Ntau	3 37,3kg
Ntim txheem	25kg / nruas
Chaw tsim tshuaj paus	Shaanxi BLOOM TECH Co., Ltd
Ntau No.	202501090027
MFG	Peb 9, 2025
EXP	Peb 8, 2028
Qauv
Yam khoom	Enterprise txheem	Kev txheeb xyuas qhov tshwm sim
Qhov tshwm sim	Dawb los yog yuav luag dawb hmoov	Ua raws
Cov ntsiab lus dej	Tsawg dua lossis sib npaug li 5.0%	0.35%
Poob rau ziab	Tsawg dua lossis sib npaug li 1.0%	0.27%
Hnyav Hlau	Pb Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Hg Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Cd Tsawg dua lossis sib npaug li 0.5ppm	N.D.
Purity (HPLC)	Ntau dua lossis sib npaug li 99.0%	99.90%
Ib leeg impurity	<0.8%	0.48%
Tag nrho microbial suav	Tsawg dua lossis sib npaug li 750cfu / g	98
E. Coli	Tsawg dua lossis sib npaug li 2MPN / g	N.D.
Salmonella	N.D.	N.D.
Ethanol (los ntawm GC)	Tsawg dua lossis sib npaug li 5000ppm	400ppm ua
Cia	Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree

Chemical Profile ntawm MT2 Powder:

MT2 hmoov yogib yam khoom siv peptide feem ntau tsim los ua rau lub cev lub cev cov tshuaj hormones -melanocyte-stimulating hormone ( -MSH). Nws ua haujlwm los ntawm kev ua kom cov melanocortin receptor (MC1R) los tswj cov khoom melanin. Thaum pib, nws tau kawm txog kev kho mob ntawm daim tawv nqaij pigmentation teeb meem (xws li vitiligo) thiab photosensitive dermatitis. Tom qab ntawd, vim nws lub peev xwm los txhawb cov tawv nqaij tanning, nws kuj tau tshawb nrhiav rau kev siv hauv kev kho mob zoo nkauj.
CAS Number of Melanotan II: 121062-08-6
Molecular Formula: C₅₀H₆₉N₁₅O₉

Discovery and Development History of Melanotan II (MT-II)

Cov keeb kwm kev loj hlob ntawm Melanotan II (MT-II) tau nyob ib ncig ntawm cov lus qhia ntawm kev tiv thaiv kab mob qog noj ntshav ntawm daim tawv nqaij, tanning, thiab kev ua haujlwm ntawm kev sib deev, mus txog theem xws li kev sib txuas, kev tshawb fawb soj ntsuam, hloov pauv thiab kev loj hlob, nrog rau kev tswj hwm thiab kev lag luam evolution. Cov txheej txheem ntxaws yog raws li nram no:

1. Kev Tshawb Fawb Thaum Ntxov thiab Kev Sib Txuas (1960s-1980s)

Thaum xyoo 1960, cov kev tshawb fawb pom tau tias txhaj tshuaj -melanocyte- stimulating hormone ( -MSH) rau hauv nas tuaj yeem ua rau muaj kev sib deev, ua lub hauv paus rau kev tshawb fawb tom ntej ntawm cov tshuaj peptides.

Nyob rau xyoo 1980, pab pawg tshawb fawb coj los ntawm Dr. Victor Hruby ntawm University of Arizona hauv Tebchaws Meskas tau pib ua ke thiab tshuaj ntsuam -MSH analogs txhawm rau nrhiav kev hloov pauv rau kev tiv thaiv kab mob qog noj ntshav. Thaum kawg, pab pawg tau ua tiav cov txheej txheem Melanotan II, uas txhawb cov xim ntujntau lawm mechanism los tsim ib tug tanning nyhuv yam tsis muaj ntau dhau ultraviolet hluav taws xob, yog li txo qhov kev pheej hmoo ntawm mob qog noj ntshav ntawm daim tawv nqaij.

2. Kev Tshawb Fawb Phaj (1990s)

Xyoo 1996, Lub Tsev Haujlwm Saib Xyuas Tshuaj Kho Mob ntawm University of Arizona College of Medicine tau ua ib qho me me -Tsev Kawm Ntawv Qib I. Peb tus txiv neej tau txais kev txhaj tshuaj subcutaneous ntawm qis- koob MT-II txhua hnub rau tag nrho tsib zaug. Cov txiaj ntsig tau pom tias MT-II muaj tanning kev ua si, nrog rau cov kev mob tshwm sim xws li xeev siab me, yawning, kev xav ntawm lub cev so, thiab nrog rau kev ua haujlwm ntawm qhov chaw mos.

Xyoo 1998, kev ua raws- nce mus sim los ntawm tib pab pawg ntawm 10 tus txiv neej uas muaj kev puas siab puas ntsws erectile kawg tau pom tias MT-II yog ib qho muaj zog inducer ntawm penile erection, nthuav nws cov peev xwm siv rau kev kho mob ntawm kev sib deev dysfunction.

3. Kev Hloov Kho Tshuab thiab Kev Txhim Kho Tom Qab (Late 1990s-2000s)

Los ntawm nws cov thev naus laus zis hloov pauv kev koom tes nrog Kev Sib Tw Technologies, University of Arizona tau tso cai patents ntsig txog MT-II rau Palatin Technologies rau kev txhim kho cov tshuaj tsom rau kev ua txhaum kev sib deev. Hauv qhov sib piv, Melanotan I (tom qab hloov npe hu ua Afamelanotide) tau tso cai rau Australia -raws li Epitan Limited (renamed Clinuvel hauv 2006) rau kev txhim kho cov tshuaj tanning.

Hauv xyoo 2008, Kev Sib Tw Txuj Ci thiab Palatin Technologies tau mus txog qhov kev daws teeb meem ntawm kev tsis sib haum xeeb txog kev ua tswv cuab ntawm Bremelanotide. Raws li daim ntawv cog lus, Palatin Technologies khaws cov cai rau Bremelanotide, xa rov qab cov cai rau MT-II, thiab them nyiaj rau 800,000 US las.

Powder Handling Protocol for Melanotan II (MT-II)

Ua ntej-Kev Npaj Ua Ntej

Reconstitution: MT-II hmoov yog muab los ua lyophilized hmoov, uas yuav tsum tau yaj nyob rau hauv sterile ib txwm saline, bacteriostatic dej los yog dej rau txhaj. Tsis yog - cov kuab tshuaj tsis huv xws li cov dej kais dej thiab cov dej huv huv yog nruj me ntsis txwv tsis pub kom tsis txhob muaj kab mob los yog kev ua haujlwm tsis zoo. Maj mam swirl cov tshuaj thaum lub sij hawm reconstitution; kev tshee tshee yog txwv tsis pub.

Kev Npaj Kom Qhuav: Qhov feem ntau siv cov concentration hauv kev tshawb fawb tshawb fawb yog li ntawm 0.5 txog 2 mg / mL. Qhov tshwj xeeb concentration yuav tsum tau kho raws li hom, lub cev hnyav ntawm cov tsiaj sim thiab cov hom phiaj tshawb fawb.

Kev sim tswj txoj kev

Kev txhaj tshuaj subcutaneous: Qhov no yog txoj hauv kev siv ntau tshaj plaws hauv kev tshawb fawb tshawb fawb. Qhov chaw txhaj tshuaj feem ntau yog xoob subcutaneous cov ntaub so ntswg ntawm lub plab lossis nraub qaum ntawm cov khoom. Cov txheej txheem aseptic yuav tsum tau ua raws li nruj me ntsis thaum lub sijhawm ua haujlwm los tiv thaiv kev kis kab mob.

Kev Txhaj Tshuaj Intraperitoneal: Txoj kev no tau txais los ntawm qee qhov kev sim tshwj xeeb. Txawm li cas los xij, cov koob tshuaj yuav tsum tau tswj nruj me ntsis kom tsis txhob muaj qhov khaus khaus hauv cov neeg mob.

Kev Txhaj Tshuaj Txhaum: Txoj kev no tsuas yog txwv rau cov xwm txheej sim tshwj xeeb nkaus xwb. Nws xav tau cov qauv kev ua haujlwm siab heev; cov tshuaj yuav tsum tau txhaj maj mam kom tsis txhob muaj kev hloov pauv loj hauv cov neeg mob ntshav siab.

Kev ceev faj rau kev tshawb fawb siv

Txog kev khaws cia, tsis tsim kho MT-II hmoov yuav tsum khaws cia hauv qab -20℃tiv thaiv los ntawm lub teeb. Cov tshuaj reconstituted yuav tsum tau siv sai li sai tau. Yog tias tsim nyog khaws cia rau lub sijhawm luv luv, cov tshuaj tuaj yeem muab tso rau hauv lub tub yees 4℃nrog lub sijhawm cia siab tshaj plaws ntawm 24 teev.

Kev tsim cov txheej txheem ntawm MT2 Powder

1. Txheej Txheem: Khoom-Phase Synthesis
MT2 hmoov yog tsim los sivsolid-phase peptide synthesis (SPPS)thev naus laus zis, ib txoj hauv kev tseem ceeb rau kev tsim peptide muaj nuj nqis rau nws qhov kev ua tau zoo thiab qhov tseeb. Cov txheej txheem pib nrog cov khoom tsis sib xws-theem resin cab kuj, qhov chaw tiv thaiv cov amino acids txuas ntxiv raws li MT2 qhov tshwj xeeb amino acid ib ntus -ntau zoo li cov hlaws hlaws hauv qhov kev txiav txim ruaj khov. Cov txheej txheem kev sib txuas ua ke no ua tau zoo kom tsis txhob muaj kev cuam tshuam sab, thaum kawg tsim kom tiav cov kab peptide saw.

2. Cov kauj ruam tseem ceeb: Purification thiab ziab
Cov khoom tsim los ntawm cov khoom siv raw khoom muaj cov khoom tsis huv, suav nrog cov amino acids tsis ua haujlwm, tsis tiav peptide fragments, thiab los ntawm - cov khoom los ntawm cov tshuaj tiv thaiv sab. Rov ua kom huv ntawmSiab -Kev Ua Haujlwm Liquid Chromatography (HPLC)yog cov kauj ruam tseem ceeb hauv kev tau txais cov khoom siab tshaj -purity, vim nws tuaj yeem cais cov hom phiaj peptides los ntawm impurities raws li lawv cov kev coj cwj pwm sib txawv hauv kab chromatographic. Cov tshuaj purified undergoeskhov- ziabnyob rau hauv qis-kub thiab lub tshuab nqus tsev kom maj mam tshem tawm tag nrho cov dej noo yam tsis ua rau cov qauv peptide ua rau qhov kawg fluffy MT2 hmoov nrog kev ua haujlwm lom lom.

3. Qhov kawg Theem: Kev Tswj Xyuas Zoo
Cov khoom tsim nyog yuav tsum tau ua raws li cov txheej txheem kev sim nruj kom ua tau raws li cov qauv zoo, suav nrog kev siv siab - daws teeb meem loj spectrometry thiab nuclear magnetic resonance (NMR) spectroscopy kom paub meej cov qauv molecular thiab xyuas qhov purity ntawm peptide. Ua raws li theem kev sim no, cov MT2 cov hmoov siv tau ua tib zoo ntim thiab muab ntim rau hauv qhov chaw tswj tsis muaj menyuam, nrog rau cov ntim ntim nrog cov roj inert xws li nitrogen los tiv thaiv oxidation thiab noo noo nqus, yog li ua kom ntev -lub sij hawm ruaj khov ntawm cov khoom kawg.

Cim npe nrov: mt2 hmoov, Tuam Tshoj mt2 hmoov manufacturers, lwm tus neeg