Octreotide Txhaj 100 mcg, raws li kev sib xyaw ua ke ntawm somatostatin analogues, ua lub luag haujlwm tseem ceeb hauv kev kho mob xwm txheej ceev vim nws cov txiaj ntsig ntev -, kev xaiv muaj zog, thiab cov kev mob tshwm sim me me. Tshwj xeeb tshaj yog nyob rau hauv kev kho mob thaum muaj xwm ceev ntawm esophageal thiab gastric variceal los ntshav los ntawm portal hypertension nyob rau hauv cirrhosis, nws plays lub luag hauj lwm tseem ceeb irreplaceable. Esophageal thiab gastric variceal rupture thiab los ntshav yog cov teeb meem txaus ntshai tshaj plaws ntawm portal hypertension nyob rau hauv nruab nrab thiab lig theem ntawm daim siab cirrhosis. Qhov pib tshwm sim tam sim ntawd thiab cov ntshav los ntshav loj heev, uas tuaj yeem ua rau muaj qhov tshwm sim loj xws li hemorrhagic shock thiab hepatic encephalopathy. Qhov kev kuaj mob tuag yog siab li 30% -50%, ua rau muaj teeb meem loj rau kev kho mob xwm txheej ceev. Los ntawm qhov tseeb lub hom phiaj ntawm pathogenesis, nws tuaj yeem ua tiav cov txiaj ntsig ntawm kev txo qhov siab ntawm lub portal thiab thaum muaj xwm txheej ceev hemostasis, thaum tsim kom muaj kev nyab xeeb rau kev kho mob endoscopic radical tom ntej, ua rau nws yog ib qho ntawm cov tshuaj kho mob xwm txheej ceev rau kev daws qhov xwm txheej ceev no. Kab lus no yuav tsom mus rau cov kev kho mob tshwj xeeb ntawm tus kab mob no, thiab muab cov lus piav qhia ntxaws raws li nws cov txheej txheem pathophysiological thiab cov yam ntxwv ntawm kev siv tshuaj kho mob.
Peb cov khoom tsim
Octreotide hmoov
Kev txhaj tshuaj Octreotide
Cov tshuaj Octreotide
Octreotide Capsule
Cov tshuaj Octreotide
Octreotide COA
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| Certificate of Analysis | ||
| Compound npe | Octreotide | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 79517-01-4 | |
| Ntau | 35g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090096 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib qho impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Tshuaj Formula | C49H66N10O10S2 |
| Exact Mass | 1018.44 |
| Molecular Luj | 1019.25 |
| m/z | 1018.44 (100.0%), 1019.44 (53.0%), 1020.45 (13.8%), 1020.44 (9.0%), 1021.44 (4.8%), 1019.44 (3.7%), 1020.44 (2.1%), 1020.44 (2.0%), 1019.44 (1.6%), 1021.45 (1.5%), 1022.44 (1.2%), 1021.45 (1.1%) |
| Elemental Analysis | C, 57.74; H, 6.53; N, 13.74; O, 15.70; S, 6.29 |
Esophageal thiab gastric variceal los ntshav yog ib qho ntawm cov teeb meem loj tshaj plaws thiab txaus ntshai ntawm portal hypertension hauv nruab nrab thiab lig theem ntawm daim siab cirrhosis. Nws qhov pib tshwm sim tam sim ntawd thiab nce mus sai, feem ntau tshwm sim raws li ntuav loj ntawm cov ntshav thiab cov quav dub nyob rau lub sijhawm luv luv. Qee tus neeg mob tuaj yeem ua rau hemorrhagic shock sai heev. Yog tias tsis muaj kev cuam tshuam rau lub sijhawm, qhov chaw kho mob tuag yog siab, txog li 30% -50%.Kev txhaj tshuaj Octreotide, raws li kev sib xyaw ua ke ntawm somatostatin analogues, muaj qhov zoo ntawm lub sijhawm ua haujlwm ntev dua, kev xaiv muaj zog dua, thiab cov teebmeem me me piv rau ntuj somatostatin. Yog li ntawd, nws tau dhau los ua ib qho ntawm cov tshuaj tseem ceeb rau kev kho mob xwm txheej ceev no. Raws li kev soj ntsuam kev kho mob logic, nws lub luag haujlwm tseem ceeb ib txwm nyob ib puag ncig peb qhov ntev: "ua kom nrawm nrawm nrawm, tswj cov ntshav sai sai, thiab tsim kom muaj kev nyab xeeb rau kev kho mob endoscopic radical tom ntej". Cov ntsiab lus tshwj xeeb tau piav qhia meej hauv cov ntawv hauv qab no.
Octreotide ua rau txoj hlab pas thiab plab variceal rupture los ntshav
Mechanism of Action: Octreotide haib thiab xaiv constricts cov hlab ntsha splanchnic (tshwj xeeb tshaj yog cov hlab ntsha ntawm lub plab hnyuv thiab spleen), txo cov ntshav ntws mus rau thaj tsam splanchnic.
Qhov zoo: Nws ua haujlwm sai thiab mob me, siv sijhawm li 10-15 feeb tom qab txhaj tshuaj. Nws tuaj yeem txo qhov siab ntawm lub portal sai thaum muaj kev cuam tshuam me me ntawm cov ntshav siab (piv rau lwm cov vasoconstrictors, nws muaj kev nyab xeeb dua thiab tsim nyog rau cov neeg mob cirrhosis ntev).
Lub hauv paus ntsiab lus tshwj xeeb: Nyob rau hauv cirrhosis, hepatic fibrosis ua rau obstructed portal venous ntshav rov qab, ua rau cov ntshav mus rau hauv lub portal venous system. Qhov no ua rau muaj qhov txawv txav ntawm lub portal venous siab (portal hypertension), uas nyob rau hauv lem ua rau compensatory dilation thiab varicose leeg nyob rau hauv lub esophageal thiab gastric fundus. Los ntawm constricting cov hlab ntsha splanchnic, nws txo cov ntshav ntws mus rau hauv cov hlab ntsha portal, txo cov siab nyob rau hauv cov hlab ntsha portal thiab nws cov ceg ntawm qhov chaw, yog li alleviating lub xeev congested ntawm varicose leeg.
Hemostatic Mechanism
Raws li kev txo qis hauv cov ntshav siab, cov ntshav ntws hauv cov hlab ntsha varicose txo qis, thiab cov ntshav siab poob qis. Qhov no ua rau qeeb cov ntshav ntws ntawm qhov chaw tawg, ua kom cov platelet sib sau ua ke thiab ua haujlwm ntawm coagulation yam, yog li tsim cov thrombus txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau thiab ua tiav qhov xwm txheej ceev hemostasis.
Cov ntsiab lus tseem ceeb siv
Yuav tsum tau txhaj tshuaj rau hauv cov hlab ntsha (subcutaneous txhaj tshuaj muaj qhov pib qeeb thiab tsis tsim nyog rau kev kub ntxhov). Nws feem ntau suav nrog "kev thauj khoom noj + tshuaj noj" txoj hauv kev kom ua tiav cov ntshav siab sai thiab txhawb nqa los ntshav.
Kev thov kho mob
Feem ntau yog siv rau mob -theem kev kho mob thaum muaj xwm txheej ceev ntawm txoj hlab pas thiab plab hnyuv variceal los ntshav. Nws tuaj yeem tswj tau cov ntshav los sai sai, txo qhov zaus thiab ntim ntawm hematemesis thiab melena, thiab tiv thaiv cov teeb meem loj xws li poob siab lossis mob hepatic encephalopathy tshwm sim los ntawm qhov mob hnyav heev.
Lub luag haujlwm ntawm Kev Kho Mob Endoscopic: Endoscopic hemostasis (xws li ligation, sclerotherapy) yog qhov kev kho mob "tseem ceeb" rau txoj hlab pas thiab plab hnyuv variceal los ntshav, ncaj qha hais txog cov hlab ntsha varicose thiab tiv thaiv ntshav los ntshav. Txawm li cas los xij, nws yuav tsum muaj cov cim tseem ceeb ruaj khov thiab tswj kev los ntshav ua ntej.
Nco tseg: Qhov no tsuas yog "kev pabcuam xwm txheej ceev + kev npaj ua ntej" thiab tsis tuaj yeem hloov kho endoscopic. Tom qab hemostasis, kev kho mob endoscopic raws sijhawm yog qhov tsim nyog los tiv thaiv kev los ntshav.
Pab tus nqi ntawmKev txhaj tshuaj Octreotide: (I) Tswj cov ntshav los ntshav, txo cov ntshav poob thaum lub sij hawm endoscopic txheej txheem thiab zam kev ua haujlwm nyuaj lossis tsis pom qhov chaw tawg vim qhov muag tsis pom. (II) Stabilizes tus neeg mob cov cim tseem ceeb (xws li, ntshav siab, lub plawv dhia), txo kev pheej hmoo thaum lub sij hawm endoscopic txheej txheem (xws li, poob siab, arrhythmias). (III) Yuav sijhawm rau kev kho mob endoscopic. Feem ntau, tom qab siv nws los tswj los ntshav, kev kho mob endoscopic tau teem sijhawm hauv 24-48 teev, txhim kho qhov ua tiav ntawm endoscopic hemostasis.
Yog vim li cas vim li cas Octreotide txo qhov siab ntawm cov hlab ntsha portal thiab nws cov ceg
Raws li cov yam ntxwv pathological ntawm cirrhosis-induced portal hypertension thiab pharmacological zog ntawm no, cov txheej txheem tseem ceeb no yuav muab faib ua peb interconnected ua rau-thiab- cov kauj ruam cuam tshuam, piav qhia hauv qab no:
Kauj Ruam 1: Qhia meej txog kev sib raug zoo ntawm cov tub ntxhais kawm -Cov hlab ntsha Splanchnic yog "Qhov chaw muab ntshav" ntawm Portal Vein.
Feem ntau ntawm cov ntshav khiav hauv lub portal venous system pib los ntawm cov hlab ntsha splanchnic nyob rau hauv cov cheeb tsam xws li cov plab hnyuv siab raum thiab spleen (xws li cov hlab ntsha hauv plab, cov hlab ntsha hauv plab, cov hlab ntsha splenic). Tom qab dhau los ntawm cov kabmob no, cov ntshav los ntawm cov hlab ntsha no nkag mus rau hauv cov hlab ntsha portal thiab nkag mus rau lub siab rau cov metabolism.
Kauj Ruam 2: Cov nyhuv ncaj qha ntawm Octreotide-Kev nruj ntawm cov hlab ntsha Splanchnic txo qis ntshav.
Qhov no muaj lub zog thiab xaiv cov nyhuv ntawm cov hlab ntsha splanchnic (nrog rau qhov cuam tshuam tsawg kawg ntawm cov hlab ntsha hauv lwm qhov ntawm lub cev). Thaum cov hlab ntsha no nruj, lawv cov lumens nqaim, txo qhov ntim ntawm cov ntshav ntws los ntawm lawv ib chav tsev ntawm lub sijhawm. Qhov no, nyob rau hauv lem, ua rau ib tug synchronous txo nyob rau hauv lub "tag nrho cov ntshav ntws mus rau hauv lub portal leeg" (sib npaug rau txo lub portal leeg ntshav input ntawm lub "muab qhov chaw").
Kauj Ruam 3: Cov txiaj ntsig zaum kawg-Txo cov ntshav ntws → Tsis tshua muaj siab → txo qis qis.
Nyob rau hauv cirrhosis, hepatic fibrosis obstructs portal venous ntshav rov qab thiab ua rau cov ntshav tsub zuj zuj, uas yog lub ntsiab mechanism ntawm portal hypertension. Los ntawm kev txo cov ntshav portal venous,Kev txhaj tshuaj octreotidencaj qha txo cov "ntshav congestion nra" nyob rau hauv lub portal venous system, txo cov intravascular siab nyob rau hauv lub portal hlab ntsha thiab nws cov ceg los ntawm qhov chaw. Raws li vascular siab txo qis, qhov passive dilation thiab congestion nyob rau hauv esophageal thiab gastric fundal varices -thaum pib los ntawm kev kub siab- maj mam txhim kho, thiab vascular nro txo raws li, nteg lub hauv paus rau hemostasis tom ntej.
Octreotide coagulates platelets rau thaum muaj xwm ceev hemostasis
Cov txheej txheem hemostatic ntawm nws cuam tshuam nrog kev sib cuam tshuam ntawm kev hloov pauv pathophysiological tom qab txo qhov siab ntawm lub portal, tsis yog ib kauj ruam cais. Raws li kev kho mob thiab pathological yam ntxwv, cov txheej txheem no tuaj yeem piav qhia hauv plaub lub ntsiab lus hauv qab no:
Yam yuavtsum tau kawm uantej: Kev txo qis hauv Portal Siab (Txuas ntxiv los ntawm cov txheej txheem Core yav dhau los).
Octreotide txo cov hlab ntshasiab nyob rau hauv lub portal leeg thiab esophageal -pastric varices los ntawm constricting splanchnic hlab ntsha thiab txo portal venous ntshav txaus. Qhov no yog lub hauv paus rau hemostasis. Tsis muaj kev txo qis ntawm cov ntshav siab, cov hlab ntsha variceal tseem nyob hauv qhov kub siab thiab congestion, ua rau nws nyuaj rau tsim cov hlab ntsha ruaj khov thiab ua rau los ntshav tsis tu ncua, txawm tias muaj cov teebmeem coagulative.
Kev hloov pauv ncaj qha: Ib txhij txo qis hauv cov ntshav ntws thiab siab hauv cov leeg variceal.
Tom qab lub portal siab txo qis, cov ntshav ntws los ntawm esophageal thiab gastric varices txo qis, txo cov intravascule.ar siab mus rau ntau yam kev nyab xeeb thiab zam kev tsis tu ncua siab -siab cuam tshuam rau ntawm qhov chaw tawg. Tsis tas li ntawd, txo cov ntshav khiav qeeb qeeb ntawm cov ntshav hauv cov hlab ntsha, ua rau lub voj voog tsis zoo ntawm "siab- cov ntshav khiav nrawm nrawm rau qhov chaw tawg thiab cuam tshuam cov coagulation," uas yog qhov hloov pauv tseem ceeb rau hemostasis.
Pib ntawm Coagulation: Platelet Aggregation thiab ua kom cov coagulation Factors.
Raws li cov ntshav khiav qeeb ntawm qhov chaw tawg, platelets hauv cov ntshav yooj yim dua ua rau cov hlab ntsha puas tsuaj.helium, maj mam sib sau ua "platelet thrombus." Qhov no muab qhov pib hemostasis ib ntus los ntawm kev sib khi ib nrab ntawm qhov tawg. Tib lub sijhawm, cov ntshav qis qis tso cai rau lub sijhawm txaus rau coagulation yam (xws li thrombin thiab fibrinogen) ua. Thaum ua haujlwm, cov khoom no txhawb kev tsim cov fibrin, uas khi cov platelets thiab cov qe ntshav ua ke, ua kom ruaj khov "fibrin thrombus."
Qhov kawg tshwm sim: ruaj khov thrombus tsim, kaw qhov chaw tawg thiab ua tiav hemostasis.
Lub fibrin thrombus adheres nruj nreem rau qhov chaw rupture nyob rau hauv variceal leeg, tag nrho thaiv cov ntshav tawm. Raws li cov thrombus maj mam txhim kho thiab vascular endothelium maj mam kho, los ntshav tsis tu ncua, ua tiav lub hom phiaj kho mob ntawm hemostasis thaum muaj xwm ceev. Cov txheej txheem no feem ntau tshwm sim nyob rau hauv 30 feeb mus rau 1 teev tom qab octreotide yuav siv tau (piv txwv li, tom qab lub portal siab txo), nrog rau lub sij hawm pes tsawg nyob ntawm tej yam xws li qhov hnyav ntawm los ntshav thiab tus neeg mob lub coagulation muaj nuj nqi.
FAQ
- Dab tsi yog octreotide siv rau hauv GI ntshav?
Qhov no yog siv rau hauv plab hnyuv (GI) los ntshav, feem ntau rau variceal los ntshav (los ntawm cov hlab ntsha loj, feem ntau hauv txoj hlab pas) los ntawm kev txo cov ntshav ntws thiab siab, thiab tseem qhia tau hais tias kev cog lus hauv kev tswj qee yam tsis yog - variceal los ntshav zoo li angiodysplasia, los ntawm kev txwv cov hlab ntsha, feem ntau ua rau cov kua qaub, tab sis nws cov kua qaub. rau kev kho mob endoscopic
- Vim li cas octreotide siv hauv pancreatitis?
Lub luag haujlwm tseem ceeb ntawm somatostatin (SST) lossis nws cov analogues xws li nws hauv kev kho mob pancreatitis tau raug tshaj tawm txij li lawv tau pom tias inhibit pancreatic secretion hauv koob tshuaj - thiab sijhawm - nyob ntawm seb. Ntau qhov kev sim tau pom qhov ua tau zoo ntawm qhov no hauv kev kho AP hauv cov tsiaj.
- Leej twg yuav tsum tsis txhob noj octreotide?
Kab mob pancreatic. Cov kab mob thyroid. Ib qho txawv txav los yog ua xua rau nws, lwm yam tshuaj, khoom noj, tshuaj zawv plaub hau, los yog tshuaj tua kab mob. cev xeeb tub los yog sim xeeb tub.
Cim npe nrov: octreotide txhaj 100 mcg, Tuam Tshoj octreotide txhaj 100 mcg manufacturers, lwm tus neeg
