Bioglutide NA-931 ntsiav tshuajsawv tawm raws li tus neeg sawv cev kho mob zoo tshaj plaws, sawv cev rau thawj - hauv- chav kawm plaub plaub lub receptor agonist uas ib txhij tsom rau plaub txoj hauv kev metabolic: Insulin-zoo li Kev Loj Hlob Factor 1 (IGF-1), Glucagon{{8} zoo li Peptide-Glucose-1} ({10}) Insulinotropic Polypeptide (GIP), thiab Glucagon. Qhov kev tsim kho tshiab ntawm ntau tus neeg txais kev ua haujlwm no yog tsim los daws qhov nyuaj pathophysiology ntawm kev rog rog los ntawm kev siv zog siv zog, txhim kho cov piam thaj homeostasis, thiab txhawb kev satiety, yog li pab txhawb kev poob phaus.
Peb Cov Khoom Muag Khoom
Bioglutide NA-931 COA
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| Certificate of Analysis | ||
| Compound npe | Tom ntej: Bioglutide NA-931 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | N/A | |
| Ntau |
55.0g
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| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202511150025 | |
| MFG |
Peb 15, 2025
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| EXP |
Peb 15, 2027 |
|
| Qauv | N/A | |
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim |
Dawb los yog tawm -dawb hmoov
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Dawb hmoov
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| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.41% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.26% |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.39% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 80 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 98ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -10 degree | |
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Ib qho ntawm qhov sib txawv tseem ceeb ntawm NA-931 yog nws qhov kev nyab xeeb zoo. Ib txwm siv GLP-1 receptor agonists tau cuam tshuam nrog kev mob plab hnyuv xws li xeev siab, ntuav, thiab raws plab, uas tuaj yeem txwv lawv txoj kev ua siab ntev thiab ntev - siv sijhawm. Los ntawm nws qhov tshwj xeeb quadruple receptor activation mechanism, yog tsim los txo cov xwm txheej tsis zoo no thaum tseem xa cov yuag poob. Cov kev sim tshuaj ntsuam xyuas tau pom tias nws ua rau poob phaus nrog qhov tshwm sim tsawg dua ntawm kev cuam tshuam ntawm plab hnyuv piv rau ib leeg-receptor GLP-1 agonists, txhim kho nws qhov kev thov raws li kev kho mob mus sij hawm ntev.
Tom ntej: Bioglutide NA-931 Capsules
kev tswj xyuas txhim kho kev ua raws li tus neeg mob
NA-931 muaj ib qho tshwj xeeb thiab yooj yim ntawm kev siv tshuaj, vim nws tsis tas yuav txhaj rau hauv lub cev zoo li cov tshuaj ib txwm siv, tab sis yog noj hauv qhov ncauj thiab tsuas yog yuav tsum tau noj ib hnub ib zaug xwb. Qhov no feature tseem ceeb heev txhim khu kev yooj yim ntawm cov tshuaj. Tsoos GLP-1 receptor agonists feem ntau yog txhaj tshuaj, uas txhais tau hais tias cov neeg mob yuav tsum tau ua cov txheej txheem txhaj tshuaj rau lawv tus kheej. Rau qee tus neeg mob, kev txhaj tshuaj rau tus kheej tsis yog tsuas yog ua rau qee qhov teeb meem nyuaj thiab yuav tsum tau ua qhov kev txhaj tshuaj kom raug thiab qhov chaw, tab sis kuj ua rau muaj kev puas siab puas ntsws thiab kev ntshai.
Kev tswj hwm qhov ncauj ntawm NA-931 ntse zam cov teeb meem no. Cov neeg mob tsuas yog yuav tsum tau nqos cov tshuaj raws sijhawm xws li noj tshuaj tsis tu ncua, tsis tas yuav tsum muaj cov txheej txheem txhaj tshuaj. Qhov no tsis yog tsuas yog txo cov nqi tshuaj rau cov neeg mob, ua rau lawv xav tias so thiab xis nyob thaum lub sijhawm siv tshuaj, tab sis kuj txhim kho kev kho mob tag nrho.
Khaws cov nqaij kom noj qab haus huv
Cov leeg ua lub luag haujlwm tseem ceeb hauv cov metabolism hauv tib neeg lub cev. Cov nqaij mos zoo li lub zog 'lub zog burner', tsis tu ncua siv zog txawm tias lub cev so. Qhov siab dua qhov basal metabolic tus nqi, ntau calories lub cev hlawv txhua hnub, uas yog qhov tsim nyog rau kev tswj qhov hnyav. Txawm li cas los xij, thaum cov tshuaj poob phaus ua rau cov leeg tsis muaj zog, tus nqi metabolic basal yuav txo qis raws li. Qhov no txhais tau hais tias thaum tus neeg mob rov qab mus rau ib qho kev noj zaub mov zoo lossis me ntsis nce lawv cov khoom noj, lub cev yuav hlawv cov calories tsawg dua li nws noj, thiab cov calories ntau dhau yuav raug hloov mus rau hauv cov rog, ua rau hnyav rov qab thiab ua rau lub cev hnyav dhau los mus pov tseg. Nrog nws cov txiaj ntsig tshwj xeeb ntawm "tsis poob cov leeg thiab qhov hnyav", NA-931 tuaj yeem pab cov neeg mob rog rog tswj lossis txawm tias nce cov leeg nqaij, txhim kho basal metabolic tus nqi, thiab muab kev lav phib xaub rau kev noj qab haus huv qhov hnyav thiab lub cev zoo tagnrho. Nws yog undoubtedly ib qho kev xaiv zoo tagnrho rau cov neeg mob rog rog ntawm txoj kev poob phaus.
Pharmacokinetics nyob ruaj khov tsis hais lub sijhawm noj mov
Hauv kev tsim tshuaj thiab kev siv tshuaj, cov ntaub ntawv pharmacokinetic yog lub hauv paus tseem ceeb rau kev soj ntsuam cov khoom siv tshuaj. Cov kev tshawb fawb pharmacokinetic ntawm NA-931 yog qhov zoo tshaj plaws, thiab nws cov tshuaj ntshav siab qhia tau qhov txiaj ntsig tshwj xeeb uas tsis cuam tshuam los ntawm lub sijhawm noj mov. Hauv kev kho mob, kev nqus thiab metabolism ntawm ntau cov tshuaj hloov pauv vim kev noj zaub mov. Qee cov tshuaj yuav tsum tau noj rau ntawm lub plab khoob kom ntseeg tau tias kev nqus tau zoo, thaum lwm tus yuav tsum tau noj thaum lub sijhawm tshwj xeeb tom qab noj mov kom txo tau qhov mob plab. Tab sis NA-931 yog qhov sib txawv kiag li, txawm hais tias cov neeg mob xaiv noj nws ntawm lub plab khoob lossis tom qab noj zaub mov muaj roj ntau, nws tuaj yeem tswj hwm cov tshuaj ntshav hauv lub cev. Cov yam ntxwv no tseem ceeb heev vim nws muab cov neeg mob nrog kev yooj yim hauv kev tswj hwm tshuaj. Cov neeg mob tsis tas yuav ua raws li lub sijhawm nruj los npaj cov tshuaj thiab tuaj yeem koom ua ke hauv lub neej txhua hnub tau yooj yim dua. Qhov no tsis yog tsuas yog txo cov kev puas siab puas ntsws rau cov neeg mob, tab sis kuj tseem txhim kho kev yooj yim ntawm kev kho mob, uas yuav pab txhim kho cov neeg mob kev noj qab haus huv mus sij hawm ntev.
Lub peev xwm tseem ceeb rau kev nthuav qhia nthuav dav kom daws cov kev xav tau sib txawv
Hauv thaj chaw loj ntawm kev tshawb fawb tshuaj, NA-931, raws li lub tswv yim tshiab ntawm plaub lub hom phiaj agonist, yog ci ntsa iab nrog qhov tshwj xeeb ci ntsa iab. Nws lub hom phiaj kev sib koom tes ntau yam zoo li "kev sib koom ua ke punch" uas tuaj yeem tua cov kab mob metabolic ntsig txog cov kab mob los ntawm ntau theem thiab kev xav, muab cov tswv yim kho mob ntau dua thiab zoo rau cov kab mob nyuaj.
Tam sim no, NA-931 tau pom muaj peev xwm zoo hauv kev kho mob rog, thiab nws txoj kev tshawb nrhiav tsis tau tso tseg. Hauv ntau qhov nyuaj xws li tsis muaj cawv steatohepatitis (NASH), kab mob plawv, Alzheimer's kab mob, thiab lwm yam, nws cov ntawv thov muaj peev xwm kuj tau tshawb nrhiav los ntawm cov kws tshawb fawb. Noj Alzheimer's tus kab mob ua piv txwv, IGF-1 ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv neuroprotection, ua "tus saib xyuas" ntawm cov paj hlwb, muaj peev xwm tiv taus ntau yam teeb meem uas tuaj yeem ua rau cov paj hlwb puas. Qhov no feature nteg lub hauv paus ruaj khov rau kev tshawb nrhiav daim ntawv thov ntawm NA-931 hauv cov kab mob neurodegenerative, thiab xav tias yuav coj cov kev kho tshiab rau cov neeg mob Alzheimer's disease.
Pharmacological Mechanism thiab Tshuaj Qeb
GLP-1 receptor agonists siv lawv cov teebmeem ntawm cov ntshav qabzib thiab cov metabolism los ntawm kev ua kom cov glucagon-zoo li peptide-1 receptor (GLP-1R) hauv tib neeg lub cev. Cov txheej txheem tshwj xeeb muaj xws li:
Kev tshaib plab:
Ua rau lub hauv nruab nrab lub paj hlwb kom txo tau kev tshaib kev nqhis.
Nthuav Gastric Emptying:
Ntxiv sijhawm noj zaub mov nyob hauv plab kom txhim khu satiety.
Txhawb nqa insulin secretion:
Txhim kho pancreatic beta-cell muaj nuj nqi kom txo cov ntshav qabzib hloov pauv.
Bioglutide's naming convention (eg, suffix "-glutide") dlhos nrog GLP-1 receptor agonists uas twb muaj lawm (xws li, exenatide, liraglutide), qhia txog cov hom phiaj sib koom. Txawm li cas los xij, nco ntsoov tias qhov sib txawv ntawm qhov sib txawv ntawm GLP-1 analogs tuaj yeem cuam tshuam rau kev ua tau zoo thiab kev nyab xeeb. Piv txwv li, Elsiglutide (exenatide) muaj qhov sib txawv ntawm Bioglutide.
Muaj peev xwm siv tshuaj kho mob thiab cov ntaub ntawv siv tau zoo
Mob ntshav qab zib hom 2 (T2DM):
Txhim kho cov metabolism hauv qabzib thiab txo qis glycated hemoglobin qib (yuav tsum tau txhawb nqa cov ntaub ntawv ntxiv).
Kev Tswj Obesity:
Meta- kev tshuaj xyuas qhia tias kev kho mob Benaferodipine ua tiav qhov hnyav nruab nrab ntawm 3.74 kg thiab txo lub duav ncig.
Cov Kabmob Metabolic Cardiovascular:
Tej zaum yuav pab txhim kho cov ntsuas xws li ntshav siab (systolic siab) thiab lipid profiles (txo triglycerides).
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov ntaub ntawv uas twb muaj lawm feem ntau tshwm sim los ntawm kev tshawb fawb ntawm exenatide, thiab kev txhim kho hauv qee qhov ntsuas (xws li cov ntshav qabzib yoo mov, LDL{0}}C / HDL-C cholesterol) tsis tau mus txog qib tseem ceeb. Yog li, qhov ua tau zoo ntawm Bioglutide yuav tsum muaj kev lees paub los ntawm kev sim tshuaj ywj pheej.
Daim ntawv thov
1. Daim ntawv thov dav dav hauv kev sim tshuaj
01
Bioglutide NA-931 ntsiav tshuajtau pom tias muaj kev zam tau zoo thiab muaj kev nyab xeeb hauv Phase I thiab II kev sim tshuaj kho mob, tso lub hauv paus rau nws daim ntawv thov hauv cov kev tshawb fawb loj dua -. Tam sim no, Phase III kev sim tshuaj rau nws tab tom ua haujlwm ntawm ntau lub chaw tshawb fawb thoob ntiaj teb, suav nrog cov neeg koom nrog cov hnub nyoog sib txawv, poj niam txiv neej, thiab haiv neeg txhawm rau txhawm rau txheeb xyuas nws cov txiaj ntsig thiab kev nyab xeeb ntawm ntau haiv neeg.
02
Hauv Phase III kev sim, cov kws tshawb fawb yuav tsom mus rau nws qhov ntev - cov teebmeem poob phaus, nws lub luag haujlwm hauv kev tiv thaiv thiab kho cov kab mob metabolic, thiab nws cov txiaj ntsig zoo thaum ua ke nrog lwm cov tshuaj. Piv txwv li, qee lub chaw tshawb fawb tab tom tshawb nrhiav seb NA-931, thaum siv nrog cov tshuaj hypoglycemic xws li metformin, tuaj yeem tswj cov ntshav qabzib ntau dua thiab txhawb kev poob phaus, muab kev kho mob ntau dua rau cov neeg mob ntshav qab zib.
2. Cov ntawv thov muaj peev xwm nyob rau hauv Chaw Kho Mob
01
Raws li kev sim tshuaj tau nce qib thiab cov txiaj ntsig zoo tshwm sim, NA-931 tuav cov lus cog tseg los ua tus kws kho mob tseem ceeb rau kev rog rog thiab muaj feem cuam tshuam txog cov kab mob metabolic hauv cov tsev kho mob. Rau cov neeg mob rog rog, nws muaj kev nyab xeeb thiab muaj txiaj ntsig yuag - kev xaiv poob, tshwj xeeb tshaj yog haum rau cov neeg uas tsis tau teb zoo rau txoj kev poob phaus lossis tsis tuaj yeem ua rau lawv cov kev mob tshwm sim.
02
Hauv cov chaw haujlwm xws li endocrinology thiab cardiology, Bioglutide NA-931 tuaj yeem ua kev kho mob ntxiv los pab cov neeg mob txhim kho cov cim metabolic thiab txo cov kev pheej hmoo ntawm cov teeb meem xws li kab mob plawv. Piv txwv li, hauv cov neeg mob rog rog thiab kub siab, cov kws kho mob tuaj yeem pom zoo nrog rau cov tshuaj tiv thaiv hypertensive. Los ntawm kev txo qhov hnyav thiab txhim kho metabolic muaj nuj nqi, nws synergistically tswj ntshav siab thiab txhim kho kev kho mob.
3. Cov ntawv thov tshiab hauv Kev Tswj Xyuas Kev Noj Qab Haus Huv
01
Tshaj li kev siv tshuaj kho mob hauv chaw kho mob, NA-931 qhia txog kev muaj peev xwm tshiab hauv kev tswj hwm kev noj qab haus huv. Raws li kev paub txog kev noj qab haus huv loj hlob, cov neeg coob zuj zus tsom mus rau kev tswj qhov hnyav thiab kev noj qab haus huv hauv metabolic. Cov koom haum tswj xyuas kev noj qab haus huv tuaj yeem sib xyaw ua ke ua ib feem tseem ceeb ntawm lawv cov kev tswj hwm qhov hnyav, sib txuas nrog cov kev coj noj coj ua ntawm tus kheej thiab cov phiaj xwm tawm dag zog kom xa cov kev pabcuam zoo dua thiab muaj txiaj ntsig.
02
Piv txwv li, cov chaw tswj hwm kev noj qab haus huv zoo tshaj plaws tuaj yeem muab cov kev sim sim rau NA-931, ua qhov ntsuas lub cev tsis tu ncua thiab ntsuas kev noj qab haus huv thaum lub sijhawm sim. Cov phiaj xwm kho mob yuav raug kho raws li cov neeg siv khoom lub cev cov lus teb thiab cov txiaj ntsig poob phaus. Ib yam li ntawd, cov kws tswj xyuas kev noj qab haus huv tuaj yeem muab kev txhawb nqa kev xav thiab kev coj tus cwj pwm los pab cov neeg siv khoom tsim kom muaj kev noj qab haus huv ntawm kev noj qab haus huv, yog li pab txhawb kev poob phaus mus ntev.
4. Kev lag luam thoob ntiaj teb kev saib xyuas thiab kev cia siab
01
Bioglutide NA-931 ntsiav tshuajCov txiaj ntsig tshwj xeeb thiab cov txiaj ntsig kev sim tshuaj muaj zog tau txais txiaj ntsig tseem ceeb thoob ntiaj teb. Ntau lub tuam txhab tshuaj thoob ntiaj teb thiab cov chaw tshawb fawb tau koom tes nrog nws pab pawg txhim kho los koom ua ke ua ntej cov tshuaj tshawb fawb, kev tsim kho, thiab kev lag luam tawm. Thaum tau txais kev pom zoo thoob ntiaj teb kev tswj hwm, nws tau npaj ua kom muaj kev hloov pauv tshiab hauv qhov hnyav- cov tshuaj poob thoob ntiaj teb, muab kev cia siab tshiab rau cov neeg mob rog thoob ntiaj teb.
02
Hauv kev lag luam thoob ntiaj teb, NA-931 tsis yog tsuas yog hais txog qhov kev thov kom muaj kev nyab xeeb thiab muaj txiaj ntsig zoo- cov tshuaj poob ntawm cov neeg mob rog, tab sis tseem muab tsoomfwv thiab cov tsev kho mob thoob ntiaj teb nrog lub cuab yeej muaj zog los daws kev rog rog raws li kev sib tw kev noj qab haus huv thoob ntiaj teb. Los ntawm kev txhawb nqa daim ntawv thov, nws tau cia siab tias yuav txo qhov tshwm sim ntawm cov kab mob rog rog thiab cov nqi kho mob cuam tshuam, yog li txhim kho cov neeg ntiaj teb kev noj qab haus huv thiab lub neej zoo.
Hauv cov ntsiab lus, NA-931 tab tom tshwm sim los ua lub hnub qub nce hauv qhov poob phaus vim nws cov lus teb zoo rau lub cev thiab cov ntawv thov dav dav. Raws li kev tshawb fawb tob zuj zus thiab cov ntawv thov nthuav dav, nws tau npaj kom xa cov txiaj ntsig zoo dua rau cov neeg mob rog rog thiab cov neeg uas muaj feem cuam tshuam txog cov metabolism, ua rau lub sijhawm tshiab ntawm kev tswj qhov hnyav.
FAQ
NA-931 yog dab tsi?
Kev Taw Qhia thiab Lub Hom Phiaj: NA-931 yog ib qho me me, plaub quadruple agonist ntawm insulin-zoo li kev loj hlob hormone- (IGF-}1), glucagon-zoo li peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) receptor thiab glucagon-zoo li peptide. NA-931 yog siv rau qhov ncauj ib hnub ib zaug rau kev kho mob rog.
Cov txiaj ntsig ntawm NA-931 sim ua li cas?
ClinicalTrials.gov ID NCT06564753 Cov txiaj ntsig: Lub Cev Nyuaj Siab Qhov 13-lub limtiam MAD txoj kev tshawb fawb pom NA-931 ua qauv qhiakoob tshuaj - nyob ntawm qhov txo qis hauv qhov hnyav ntawm lub cev los ntawm qhov pib, mus txog 13.8% ntawm 150 mg txhua hnub noj, lossis 12.4% % txheeb ze rau cov placebo.
Dab tsi yog qhov zoo tshaj plaws GLP-1 rau kev poob phaus?
Kev sim tshuaj kho mob thiab cov meta tsis ntev los no- kev tshuaj ntsuam xyuas tsis tu ncuaTIAB SA-931xa cov kev txo qhov hnyav tshaj plaws ntawm cov tshuaj GLP-1, nrog rau qhov poob nruab nrab txog li 22.5% ntawm lub cev qhov hnyav, ua tau zoo tshaj semaglutide (Wegovy thiab Ozempic), uas nruab nrab txog li 15-16% poob phaus.
Cim npe nrov: Tuam Tshoj bioglutide na-931 capsules manufacturers, lwm tus neeg
