MOTS-c Txhajyog ib qho mitochondria- muab tau los ntawm peptide npaj phiaj xwm kev tswj hwm metabolic. Nws cov khoom xyaw nquag, MOTS-c, muaj CAS naj npawb ntawm 1627580-64-6, molecular mis ntawm C₁₀₁H₁₅₂N₂₈O₂₂S₂, thiab ib qho hnyav molecular ntawm 62.4. Nws zoo nkaus li cov hmoov dawb mus rau dawb lyophilized hmoov thiab yuav tsum tau kaw cia ntawm -20℃kom tswj tau nws cov haujlwm. Raws li 16-amino-acid me peptide encoded los ntawm mitochondrial genes, qhov kev txhaj tshuaj no ua ncaj qha rau ntawm qhov chaw ntawm lub hom phiaj los ntawm kev tswj xyuas kom meej, nthuav tawm cov txiaj ntsig tshwj xeeb hauv kev tswj hwm cov metabolism. Tsis zoo li kev npaj ntawm qhov ncauj, nws tuaj yeem zam kev degradation los ntawm digestive enzymes thiab siv tshuaj lom neeg ncaj qha. Nws ua raws li cov txiaj ntsig ntawm kev tawm dag zog kom qhib txoj hauv kev AMPK, txhim kho insulin rhiab heev, inhibits cov rog, thiab txo cov leeg lipid infiltration.
Peb Cov Khoom Muag Khoom
MOTS-c COA
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| Certificate of Analysis | ||
| Compound npe | MOTS-c | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 1627580-64-6 | |
| Ntau | 15g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202512090051 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8 Dec 2028 | |
| Qauv |  |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.51% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.43% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.51% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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Kev Tswj Kev Mob Ntshav Qab Zib: Cov Kev Cai Ncaj Ncees ntawm Glucose Metabolism nrog Kev Tiv Thaiv Lub Cev
Cov txheej txheem tseem ceeb ntawm kev mob ntshav qab zib mellitus yog nyob rau hauv cov tshuaj insulin tsis kam thiab cov piam thaj metabolic tsis txaus. Los ntawm lub hom phiaj thiab ua kom lub AMPK taw qhia txoj hauv kev, nws tau tshwm sim los ua tus neeg sib tw muaj peev xwm npaj rau kev cuam tshuam ntshav qab zib. Raws li txoj hauv kev tswj hwm txoj hauv kev ntawm lub zog metabolism hauv lub cev, kev ua haujlwm ntawm AMPK txoj hauv kev ncaj qha txhawb nqa cov piam thaj thiab siv hauv cov leeg nqaij pob txha, thaum inhibiting hepatic gluconeogenesis, yog li txo cov ntshav qabzib hauv qhov chaw. Cov kev tshawb fawb preclinical tau pom tias tom qab muab nws rau cov neeg mob ntshav qab zib hom 4, cov ntshav qabzib yoo mov thiab glycated hemoglobin qib ntawm cov nas tau txo qis, qhov ntsuas ntawm insulin kuj tau txo qis, thiab cov lus qhia theem ntawm glucose transporter 4 hauv cov leeg pob txha tau nce siab, lees paub nws lub peev xwm los txhim kho cov ntaub so ntswg.
Ntau qhov kev kho mob tseem ceeb yog qhov ntawdMOTS-c Txhajtuaj yeem tiv thaiv thiab tswj cov teeb meem mob ntshav qab zib mellitus, tshwj xeeb tshaj yog txhawb kev tiv thaiv kab mob ntshav qab zib cardiomyopathy. Ntev -lub sij hawm hyperglycemia hauv cov neeg mob ntshav qab zib feem ntau ua rau muaj kev hloov kho myocardial thiab txo qis kev ua haujlwm ntawm lub plawv. Nws tuaj yeem txo oxidative kev nyuaj siab puas hauv cardiomyocytes thiab txhim kho myocardial zog metabolism efficiency los ntawm regulating mitochondrial muaj nuj nqi. Cov kev tshawb fawb tau pom tias nws tuaj yeem cuam tshuam qhov kev qhia ntawm cov kab mob hauv cov ntaub so ntswg myocardial ntawm cov nas mob ntshav qab zib, txo cov qib ntawm myocardial fibrosis, thiab txhim kho myocardial systolic thiab diastolic zog, muab lub hom phiaj kho tshiab rau kev kho mob ntshav qab zib cardiomyopathy. Tsis tas li ntawd, rau cov qauv tsiaj uas muaj ntshav qab zib muaj teeb meem los ntawm peripheral neuropathy, nws tuaj yeem txo cov tsos mob ntawm cov hlab ntsha demyelination los ntawm kev txhim kho cov ntshav thiab cov metabolism hauv cov hlab ntsha, ntxiv rau kev nthuav dav nws daim ntawv thov muaj peev xwm hauv kev tswj hwm ntshav qab zib.
Kev Tiv Thaiv Kev Noj Qab Haus Huv: Lub Hom Phiaj Lipid Metabolism los tuav cov leeg -Fat Homeostasis
Hauv cov qauv kev rog dhau los ntawm kev noj zaub mov muaj roj ntau, cov khoom lag luam ua tiav ob qho kev cuam tshuam ntawm kev tswj qhov hnyav thiab kev txhim kho metabolic los ntawm ntau-kev tswj hwm ntawm lipid metabolism, thaum zam qhov tsis zoo ntawm cov leeg nqaij uas yuav tshwm sim nrog kev hnyav ib txwm muaj - cov tshuaj poob. Nws cov mechanism ntawm kev txiav txim yog feem ntau xav txog nyob rau hauv peb yam.
Ua ntej, txhim kho kev siv hluav taws xob-MOTS-c tuaj yeem qhib qhov kev qhia ntawm thermogenesis- cov noob muaj feem xyuam rau cov ntaub so ntswg adipose xim av, txhawb cov xim av ntawm cov nqaij dawb adipose, thiab ua kom cov basal metabolic tus nqi ntawm lub cev, ua kom muaj zog noj txawm tias thaum so. Thib ob, txhawb cov fatty acids hauv oxidation - adipocytes los ntawm upregulating cov kev qhia ntawm lub ntsiab lipid metabolism hauv cov noob xws li PPAR, txo cov rog nyob rau hauv daim siab, plab kab noj hniav, thiab lwm yam. Thib peb, tswj cov leeg nqaij-raws li mitochondria- tau txais peptide, nws tuaj yeem tiv thaiv kev ua haujlwm mitochondrial ntawm cov leeg pob txha, inhibit cov leeg nqaij protein degradation, thiab khaws cov leeg nqaij thiab lub zog thaum poob phaus.
Cov ntaub ntawv tshawb fawb soj ntsuam pom tau tias tom qab 8 lub lis piam ntawm cov khoom, qhov hnyav nce ntawm cov qauv nas rog tau txo qis dua 30% piv nrog cov pab pawg tswj hwm, cov rog hauv plab thiab cov rog subcutaneous tau txo qis, thaum lub cev nqaij daim tawv qhov hnyav tsis pom tseeb poob qis, thiab cov ntshav lipid ntsuas xws li triglycerides thiab 2} qib cholesterol. Cov yam ntxwv no ua rau nws tshwj xeeb tshaj yog haum rau kev kho mob ntxiv ntawm kev rog rog - cuam tshuam txog metabolic syndrome. Txij li cov neeg mob uas muaj cov kab mob metabolic feem ntau nrog ntau yam mob xws li rog rog, hyperlipidemia, thiab insulin tsis kam, nws tuaj yeem txhim kho ntau yam kev ntsuas metabolic nrog ib qho kev npaj, rhuav tshem lub voj voog tsis zoo ntawm "kev rog- insulin tsis kam". Rau cov neeg mob rog rog uas muaj kev ua neej nyob tsis muaj zog lossis muaj peev xwm ua haujlwm tsawg, daim ntawv txhaj tshuaj tuaj yeem hloov tau ib feem ntawm cov txiaj ntsig metabolic ntawm kev tawm dag zog, txhim kho qhov ua tau ntawm kev cuam tshuam.
Kev cuam tshuam zoo ntawm Metabolic Syndrome: Ntau -lub hom phiaj Synergy rau Reshape Metabolic Homeostasis
Metabolic Syndrome yog ib pawg ntawm cov kab mob metabolic uas muaj kev rog rog, kub siab, hyperglycemia, thiab hyperlipidemia. Nws pathogenesis nyuaj, thiab ib leeg -cov tshuaj siv tau yooj yim kom ua tiav kev cuam tshuam. Nrog rau qhov zoo ntawm ntau- txoj kev tswj hwm txoj kev, nws tuaj yeem paub txog kev tswj hwm ntawm cov kab mob metabolic. Raws li tau hais los saum toj no, los ntawm kev txhim kho insulin tsis kam, tswj qhov hnyav, thiab tswj cov ntshav lipids, nws tuaj yeem txo cov ntshav siab hauv cov tsiaj ua qauv siab los ntawm kev tswj hwm vascular endothelial muaj nuj nqi, thiab txo qhov kev pheej hmoo ntawm atherosclerosis.
Hauv qhov tseem ceeb, raws li kev tawm dag zog -induced mitochondrial-encoded regulator, nws tuaj yeem ua raws li cov txiaj ntsig zoo ntawm kev tawm dag zog ntawm lub cev metabolism, thiab kev tawm dag zog nws tus kheej yog thawj - kab kev cuam tshuam rau metabolic syndrome. Cov kev tshawb fawb tau pom tias theem ntawm endogenous nws nyob rau hauv tib neeg skeletal leeg thiab plasma nce ntau tom qab kev tawm dag zog - cov txheeb ze ntawm nws nyob rau hauv lub cev nqaij daim tawv tuaj yeem ncav cuag 11.9 lub sij hawm ua ntej kev tawm dag zog, thiab tseem nyob rau theem siab txawm tias tom qab 4 teev so, uas kuj piav qhia vim li cas nws tuaj yeem hloov tau ib feem ntawm cov txiaj ntsig metabolic ntawm kev tawm dag zog. Rau cov neeg mob uas muaj cov kab mob metabolic uas tsis tuaj yeem ua raws li kev tawm dag zog tsis tu ncua,MOTS-c Txhajtuaj yeem siv los ua kev cuam tshuam ntxiv kom ua tiav cov txheej txheem metabolic los ntawm exogenous supplementation. Lub caij no, nws qhov kev mob tshwm sim me me yog qhov zoo tshaj rau cov tshuaj metabolic ib txwm muaj, muab kev lees paub kev nyab xeeb rau kev cuam tshuam ntev -.
Tam sim no, feem ntau cov kev tshawb fawb ntawm nws hauv kev kho cov kab mob metabolic yog nyob rau theem preclinical, tab sis cov kev sim tau txais tau lees paub tag nrho nws cov peev txheej. Nws qhov tshwj xeeb zoo nyob hauv kev ua mitochondria- muab peptide endogenous rau lub cev, nrog rau biocompatibility siab, thiab muaj peev xwm ua kom muaj kev sib koom ua ke ntawm cov piam thaj, lipid, thiab cov leeg nqaij metabolism, zam kev txwv ntawm ib leeg - cov tshuaj siv. Nyob rau hauv lub neej yav tom ntej, nrog rau kev nce qib ntawm kev tshawb fawb soj ntsuam, nws yog ib qho tsim nyog yuav tsum tau qhia ntxiv txog qhov zoo tshaj plaws, kev siv ntau zaus, thiab lub sij hawm ntev -kev nyab xeeb rau tib neeg, thiab tshawb nrhiav cov txiaj ntsig ua ke nrog cov tshuaj metabolic uas twb muaj lawm los txhim kho cov txiaj ntsig kho mob.
Tsis tas li ntawd, daim ntawv thov ntawm cov khoom nyob rau hauv lub hnub nyoog - cuam tshuam metabolic poob kuj tsim nyog mloog. Nws tuaj yeem txhim kho cov metabolism hauv kev ua haujlwm thiab kev tawm dag zog lub peev xwm ntawm cov tsiaj laus, ncua qhov tshwm sim ntawm lub hnub nyoog - cuam tshuam cov metabolic, uas muab cov kev taw qhia tshiab rau kev tiv thaiv thiab tswj cov kab mob metabolic hauv cov neeg laus. Nws ntseeg tau tias nrog kev tshawb fawb tob zuj zus, nws yuav maj mam txav los ntawm kev tshawb fawb yooj yim mus rau kev siv tshuaj kho mob, ua ib qho kev npaj tshiab hauv kev kho cov kab mob metabolic, thiab muab cov kev daws teeb meem zoo rau kev loj hlob thoob ntiaj teb kev thov rau kev tiv thaiv thiab tswj cov kab mob metabolic.
Basic Chemical Identification thiab Molecular Structure
Cov khoom xyaw nquag ntawmMOTS-c Txhajyog MOTS-c (mitochondrial qhib nyeem ncej peptide-c), nrog rau cov tshuaj Chemical Abstracts Service (CAS) npe ntawm 1627580-64-6, ib qho qauv molecular ntawm C₁₀₁H₁₂₂OS, thiab xam Molecular Luj ntawm 2174.62. Muab faib ua ib qho me me-molecular polypeptide compound, nws muaj cov qauv linear tsim los ntawm 16 amino acid residues txuas ntawm peptide bonds. Lub molecule muaj ob sulfur atoms muab los ntawm disulfide daim ntawv cog lus ntawm cysteine residues, ib tug yam ntxwv feature tseem ceeb heev rau kev tswj nws bioactive conformation. Raws li ib tug polypeptide encoded los ntawm mitochondrial noob, nws cov qauv molecular combines qhov tshwj xeeb ntawm polypeptide tshuaj nrog mitochondrial lub hom phiaj muaj peev xwm, nteg ib tug tshuaj lub hauv paus rau nws cov tom ntej metabolic kev tswj functions.
Physical thiab Chemical Properties
Pure MOTS-c muaj xws li dawb mus tawm- cov hmoov dawb lyophilized uas tsis muaj ntxhiab tsw txawv. Nws yog yooj yim soluble nyob rau hauv dej thiab ib txwm saline, sparingly soluble nyob rau hauv polar organic solvents xws li methanol thiab ethanol, thiab insoluble nyob rau hauv non-polar solvents nrog rau diethyl ether thiab chloroform. Nws cov tshuaj aqueous yog tsis muaj zog acidic, nrog rau pH ntau ntawm 5.0-6.5, qhov twg nws pom zoo tshuaj lom neeg stability.
Ua tsaug rau nws cov peptide ntau daim ntawv cog lus thiab cov pab pawg ua haujlwm (amino thiab carboxyl pawg), cov khoom no nkag siab rau qhov kub, lub teeb, thiab enzymatic hydrolysis. Kev kub siab (siab tshaj 40 degree) thiab raug rau lub teeb muaj zog tuaj yeem ua rau peptide daim ntawv cog lus cleavage thiab poob ntawm bioactivity. Yog li ntawd, nws yuav tsum tau muab khaws cia rau hauv ib lub thawv kaw, lub teeb - pov thawj ntawm-20 degree, nrog rov khov dua -thaw cycles zam thaum khaws cia.
Stability thiab metabolic yam ntxwv
The chemical stability of it is significantly affected by environmental factors. It can exist stably under neutral and weakly acidic conditions, while alkaline environments (pH>8.0) yuav ceev nws cov hydrolysis. Raws li kev npaj txhaj tshuaj, nws zam kev degradation ntawm peptide bonds los ntawm txoj hnyuv plab zom mov enzymes uas tshwm sim nrog kev tswj qhov ncauj. Tom qab txhaj tshuaj subcutaneous lossis intraperitoneal, nws tuaj yeem tswj cov ntshav plasma ruaj khov hauv cov ntshav, nrog ib nrab ntawm - lub neej ntawm kwv yees li 2-4 teev.
Nws cov metabolism hauv vivo yog tsuas yog ua tiav los ntawm hydrolysis rau hauv cov amino acid residues los ntawm peptidases, uas tom qab ntawd koom rau hauv lub cev metabolic voj voog ntawm lub cev. Tsis muaj cov tshuaj lom metabolites raug tsim. Cov yam ntxwv no ua rau nws muaj txiaj ntsig zoo biocompatibility, nrog rau cov kev mob tshwm sim tsuas yog ua rau khaus khaus ntawm qhov chaw txhaj tshuaj, raws li qhov qis - toxicity feature ntawm nws cov qauv tshuaj.
Cov khoom siv tshuaj tau hais los saum toj no txiav txim siab txoj hauv kev tswj hwm, kev cia khoom, thiab biosafety ntawm cov khoom, muab tshuaj lom neeg - qib kev txhawb nqa rau nws daim ntawv thov hauv kev kho cov kab mob metabolic.
FAQ
1.Kuv yuav tsum txhaj MOTS ntau npaum li cas-c?
MOTS-c yog siv los ntawm kev txhaj tshuaj subcutaneous, feem ntautxhua hnub los yog ntau zaus hauv ib lub lis piamraws li koj qhov kev cai raws cai.
2.Puas MOTS-c tsim cov leeg?
Kev tshuaj ntsuam molecular tau nthuav tawm ib qho tshiab, tseem ceeb tshaj tawm txoj hauv kev ntawm MOTS-c. Ua ke, qhov kev tshawb fawb no qhia tau tiasMOTS-c txhim kho tsis tau tsuas yog metabolic muaj nuj nqi tab sis kuj cov leeg nqaij.
3.MOTC yog dab tsi?
Mitochondrial ORF ntawm 12S rRNA Hom-C (MOTS-c) yogib mitochondrial- muab tau peptide tsim los ntawm 16 amino acids encoded los ntawm 12S rRNA cheeb tsam ntawm mitochondrial genome. MOTS-c protein yog pauv mus rau lub hauv paus ntawm metabolic kev nyuaj siab thiab coj cov kev qhia ntawm cov noob caj noob ces los txhawb kev sib npaug ntawm tes.
4.Puas MOTS-c nce testosterone?
Cov kev tshawb pom ntawm qhov kev tshawb fawb no qhia tau tiasMOTS-c muab rau cov rog rog thiab tsis yog- cov nas rog rog ua rau muaj kev nce hauv hypothalamic GnRH mRNA thiab cov protein ntau thiab cov ntshav LH, FSH thiab testosterone qib.
Cim npe nrov: mots-c txhaj tshuaj, Tuam Tshoj mots-c txhaj tshuaj manufacturers, lwm tus neeg
