KPV 10 mgyog ib qho tshuaj tiv thaiv -cov tshuaj tiv thaiv kab mob tsim los ntawm tripeptide KPV (lysine proline valine), uas nws cov txheej txheem tseem ceeb yog txhawm rau tsom thiab tswj cov kab mob inflammatory, qhia tau tias muaj peev xwm rau kev kho mob ntau yam. Raws li ib feem ntawm alpha melanocyte stimulating hormone (alpha MSH), nws muaj zog tiv thaiv - inflammatory los ntawm inhibiting NF - κ B txoj kev thiab tso tawm ntawm pro- inflammatory cytokines xws li TNF - thiab IL-6, thaum tsis txhob muaj kev tiv thaiv kab mob sib kis. Cov kev tshawb fawb tam sim no tsom rau kev txhim kho kev xa khoom zoo (xws li nanoparticles, microneedle thaj thaj ua rau thaj) txhawm rau txhim kho lub hom phiaj thiab tshawb nrhiav lawv cov kev sib koom ua ke los tiv thaiv cov qog nqaij hlav nrog lub cev tiv thaiv kab mob. Nrog rau kev sib sib zog nqus ntawm kev tshawb fawb mechanism, nws xav tias yuav dhau los ua thawj txoj kab kev kho mob rau cov kab mob inflammatory.
Peb cov khoom los ntawm
KPV COA
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| Certificate of Analysis | ||
| Compound npe | KPV | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 67727-97-3 | |
| Ntau | 3 37,3kg | |
| Ntim txheem | 25kg / nruas | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090030 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.36% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.28% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib qho impurity | <0.8% | 0.49% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 99 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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Anti-inflammatory nyhuv: tsom rau lub hauv paus inflammatory txoj kev
Lub luag haujlwm tseem ceeb ntawmKPV 10 mgyog inhibit qhov mob ntev, thiab nws cov txheej txheem cuam tshuam nrog kev tswj hwm ntawm ntau theem thiab lub hom phiaj. Los ntawm kev cuam tshuam hauv cov kev sib txuas tseem ceeb xws li cov teeb liab hloov pauv, cytokine tso tawm, thiab lipid metabolism, nws muab lub tswv yim tshiab rau kev kho mob ntsig txog kab mob.
Los ntawm inhibiting ob classic inflammatory signaling pathways ntawm NF - κ B thiab MAPK, qhov kev qhia ntawm tseem ceeb pro-inflammatory yam xws li TNF - , IL-6, thiab IL{10}}1 yog ho txo. Nyob rau hauv tus qauv rheumatoid mob caj dab, nws tuaj yeem txo qhov infiltration ntawm macrophages thiab neutrophils hauv kev sib koom synovium, thaum txo cov ntshav C-reactive protein (CRP) ntau dua 60%. Nws lub zog ntawm kev ua yog piv rau dexamethasone, tab sis tsis muaj kev phiv xws li cov pob txha metabolism hauv inhibition, ntshav qabzib nce siab, thiab kev tiv thaiv kab mob los ntawm glucocorticoids. Tsis tas li ntawd, inhibiting JAK-STAT txoj hauv kev thiab thaiv kev ua haujlwm ntawm IL-23 / IL-17 axis tuaj yeem txo cov epidermal thickening thiab keratosis hauv psoriasis qauv. Nws cov nyhuv zoo ib yam li cov tshuaj lom neeg xws li IL-17 inhibitors, tab sis nws qis dua thiab muaj kev nyab xeeb dua.
Inhibit inflammasome activation
Nws tuaj yeem thaiv NLRP3 inflammasome sib dhos, txo IL-18 thiab IL-1 kev loj hlob thiab tso tawm los ntawm inhibiting ASC oligomerization thiab caspase-1 ua kom. Cov txheej txheem no yog qhov tseem ceeb hauv kev kho mob gouty mob caj dab: tom qab kev txhaj tshuaj hauv zos, qhov concentration ntawm IL-1 hauv cov kab noj hniav sib koom ua ke txo qis los ntawm 85% hauv 2 teev, thiab cov tsos mob ntawm qhov liab, o, kub, thiab qhov mob tau sai sai, nrog rau kev kho mob ntev dua 48 teev. Txoj kev tshawb no kuj pom tias muaj peev xwm kho tau tus nqi rau tus kheej inflammatory kab mob tshwm sim los ntawm kev hloov pauv hauv NLRP3 noob, xws li mob khaub thuas pyridine ntsig txog lub caij nyoog syndrome (CAPS), uas tuaj yeem txo qhov zaus ntawm kub taub hau thiab qhov ntsuas kub hauv cov neeg mob.
Los ntawm kev txhim kho cov lus qhia ntawm 15 lipoxygenase (15-LOX), cov synthesis ntawm anti-inflammatory lipid mediator lipoxygenase A4 (LXA4) yog txhawb nqa, thaum inhibiting qhov kev ua ntawm 5-LOX thiab txo qhov tsim ntawm pro-inflammatory mediator leukotriene B4. Qhov kev cai thib ob ntawm "txhawb kev tiv thaiv- mob - inhibiting thiab txhawb kev o" tuaj yeem tsim muaj kev tiv thaiv microenvironment hauv zos. Hauv cov qauv kev mob ntsws asthma, qhov nqus nqus nqus tau tuaj yeem txo qhov ua pa ntawm txoj hlab ntsws los ntawm 40%, uas yog qhov zoo dua li kev siv budesonide ib leeg, thiab tsis muaj kev pheej hmoo ntawm qhov ncauj kab mob candidiasis. Tsis tas li ntawd, nws tseem tuaj yeem cuam tshuam COX-2 qhia hauv arachidonic acid metabolism txoj hauv kev, txo cov prostaglandin E2 (PGE2) ntau lawm, thiab txo qhov mob hauv osteoarthritis.
Daim ntawv thov kev kho mob: ib qho kev xaiv tshiab rau kev kho mob ntau yam kab mob
Mob caj dab
Osteoarthritis: Kev tswj hwm qhov ncauj (200-400 mg / hnub) tuaj yeem txhim kho WOMAC tus qhab nia mob ntawm cov neeg mob, thiab nws cov txiaj ntsig zoo piv rau celecoxib, tab sis qhov tshwm sim ntawm kev mob plab hnyuv yog txo los ntawm 57%. Cov kev tshawb fawb tshuab tau pom tias nws tuaj yeem cuam tshuam qhov kev qhia ntawm MMP-13 hauv chondrocytes, txo collagen degradation, txhawb cov pob txha mos matrix synthesis, thiab ncua kev sib koom ua ke kev puas tsuaj.
Rheumatoid mob caj dab: Kev kho mob nrog methotrexate tuaj yeem txo DAS28 cov qhab nia los ntawm 2.8 cov ntsiab lus thiab nce qhov kev ua raws li 71%. Nws txoj haujlwm yog cuam tshuam nrog inhibiting osteoclast sib txawv thiab RANKL qhia, uas tuaj yeem txo qis kev sib tsoo thiab deformity. Tsis tas li ntawd, nws tseem tuaj yeem txo cov qib ntawm cov kab mob rheumatoid (RF) thiab cov tshuaj tiv thaiv cyclic citrullinated peptide antibodies (CCP), qhia tias lawv tuaj yeem tswj cov lus teb autoimmune.
Txoj kev lis ntshav ntawm KPV (50 mg / zaug, ob zaug ib hnub) ua ke nrog mesalazine tuaj yeem ua rau cov kab mob kho mob ntawm cov neeg mob ulcerative colitis mus rau 72% (tsuas yog 41% hauv pawg kho mob monotherapy), thiab ncua sijhawm rov qab mus rau 14 lub hlis. Hauv cov neeg mob nrog Crohn tus kab mob fistula, hauv zos txhaj tshuajKPV 10 mgtuaj yeem ua tiav qhov fistula kaw ntawm 65%, zoo dua li kev kho tshuaj tua kab mob. Nws cov txheej txheem muaj feem xyuam rau kev txhawb nqa cov ntaub so ntswg granulation nyob ib ncig ntawm lub fistula thiab inhibiting kab mob biofilm tsim.
Cov kab mob o
Nyob rau hauv tus qauv sepsis, kev txhaj tshuaj txhaj tshuaj (5 mg / kg) tuaj yeem txo qhov tshwm sim ntawm ntau yam kabmob dysfunction syndrome (MODS) los ntawm 38%, thiab nws cov txheej txheem muaj feem xyuam rau inhibiting kev tso tawm ntawm cov protein ntau B1 (HMGB1) thiab thaiv txoj hauv kev TLR4 / MyD88. Cov kev tshawb fawb hauv tsev kho mob kuj tau pom tias nws tuaj yeem txhim kho cov pa oxygenation Performance index, txo cov cua tshuab lub sij hawm, thiab txo qhov tshwm sim ntawm mob raum raug mob hauv cov neeg mob uas mob ua pa nyuaj siab (ARDS).
Kev tswj lub cev tsis muaj zog: kev sib npaug ntawm kev tiv thaiv kab mob
Los ntawm bidirectionally tswj lub cev tiv thaiv kab mob kom siv cov kev kho mob, nws tsis tsuas yog suppresses lub cev tiv thaiv kab mob ntau dhau, tab sis kuj tseem txhim kho lub cev tiv thaiv kab mob, muab cov tswv yim tshiab rau kev kho mob ntawm cov kab mob autoimmune thiab qog.
Hauv cov kab mob autoimmune, nws tuaj yeem thaiv T cell activation (txo CD25 qhia) thiab B cell antibody ntau lawm (txo IgG secretion). Hauv kev sim autoimmune encephalomyelitis (EAE) qauv, qhov feem pua ntawm Th17 hlwb tau txo qis los ntawm 58% thiab cov qhab nia kho mob tau txo qis los ntawm 72%, uas tau ua haujlwm zoo dua li cyclophosphamide thiab tsis muaj pob txha pob txha los yog kev pheej hmoo kis mob. Tsis tas li ntawd, nws tuaj yeem cuam tshuam kev ua kom muaj zog ntxiv, txo qis C5a ntau lawm, yog li txo qis glomerular puas hauv lupus nephritis thiab txo qis proteinuria.
Txhim khu kev tiv thaiv kab mob
Los ntawm kev txhim kho NK cell kev ua haujlwm (nce granzyme B secretion) thiab txhawb kev dendritic cell maturation (nce CD80/CD86 qhia), tiv thaiv- qog tiv thaiv kab mob. Hauv cov qauv mob qog noj ntshav, kev sib xyaw ua ke ntawm PD-1 antibody txo cov qog ntim los ntawm 83% thiab ntev kev ciaj sia los ntawm 2.1 npaug. Cov txheej txheem muaj feem xyuam rau kev nce cov CD8+T hlwb infiltrating lub qog thiab txhawb T cell tua muaj nuj nqi. Tsis tas li ntawd, nws tseem tuaj yeem cuam tshuam M2 polarization ntawm cov qog txuam nrog macrophages (TAMs) thiab txo qhov tsim ntawm kev tiv thaiv kab mob microenvironment.
Nws tuaj yeem ua rau Treg cell sib txawv (nce FoxP3 qhia) thiab inhibit Th17 cell polarization, uas cuam tshuam rau kev ua kom AMPK / mTOR txoj hauv kev thiab kev txhim kho ntawm TGF - 1 kev qhia. Hauv cov neeg mob rheumatoid mob caj dab, kev kho mob tau nce qhov sib piv Treg / Th17 los ntawm 0.3 mus rau 1.2, thiab cov nyhuv no txuas ntxiv mus txog 6 lub hlis tom qab txiav tawm, qhia tias nws yuav ua tiav ntev - lub sij hawm tiv thaiv kab mob los ntawm kev hloov kho epigenetic xws li DNA methylation.
Daim ntawv thov scenario expansion
Hloov cev
Qhov xwm txheej ntawm kev tsis lees paub yuav raug txo los ntawm kev txo qis IL-17 ntau lawm. Hauv cov qauv hloov pauv hauv lub raum, kev sib xyaw ua ke ntawm tacrolimus nce 1-xyoo txoj sia nyob mus txog 92% yam tsis muaj glucocorticoid cuam tshuam txog cov kab mob metabolic xws li hyperglycemia thiab hyperlipidemia. Nws cov txheej txheem muaj feem xyuam rau inhibiting dendritic cell (DC) maturation thiab txo cov kev qhia ntawm T cell co stimulatory molecules (CD80/CD86), yog li txo qhov kev pheej hmoo ntawm kab mob graft-tiv thaiv tus tswv tsev (GVHD).
Nws muaj peev xwm inhibit degranulation ntawm mast hlwb (txo histamine tso), nrog tag nrho cov txiaj ntsig ntawm 89% hauv kev kho mob rhinitis, thiab tsis muaj kev phiv xws li qaug zog. Hauv cov qauv atopic dermatitis, nws cov qab zib tuaj yeem txo cov qhab nia SCORAD los ntawm 52%, nrog rau cov nyhuv piv rau pimecrolimus, tab sis tsis muaj tawv nqaij kub hnyiab. Tsis tas li ntawd, nws tseem tuaj yeem tiv thaiv IgE kho cov kev tsis haum tshuaj, txo cov kev hloov pauv ntawm txoj hlab ntsws thiab lub ntsws ua haujlwm poob qis.
Neuroinflamation
KPV 10 mgtuaj yeem nkag mus rau hauv cov ntshav- lub hlwb teeb meem, inhibit microglial activation (txo iNOS qhia), txo A plaque cheeb tsam los ntawm 40% hauv Alzheimer's kab mob qauv, thiab txhim kho kev txawj ntse. Tsis tas li ntawd, nws tseem tuaj yeem cuam tshuam cov kab mob demyelinating nyob rau hauv lub hauv nruab nrab lub paj hlwb ntawm ntau yam sclerosis, txo cov axonal puas, thiab nws cov txheej txheem muaj feem xyuam rau kev tswj hwm Th1 / Th2 tshuav nyiaj li cas thiab txhawb oligodendrocyte regeneration.
Cov lus nug nquag
KPV 10mg yog dab tsi?
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KPV 10mg yog ib qho tripeptide (muaj li ntawm lysine, proline, thiab valine) uas yog C-terminal fragment ntawm alpha melanocyte stimulating hormone ( - MSH). Nws muaj cov tshuaj tiv thaiv tseem ceeb -inflammatory zog thiab tau kawm txog kev kho mob plab hnyuv, kab mob autoimmune, daim tawv nqaij o, thiab lwm yam.
Cov txiaj ntsig tseem ceeb ntawm KPV 10mg yog dab tsi?
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Cov tshuaj tiv thaiv kab mob: inhibits qhov ua kom muaj zog ntawm nuclear kappa B (NF - κ B) thiab txo cov kev tsim tawm ntawm pro-inflammatory cytokines xws li TNF - , IL-6, thiab IL-1 .
Txhawb kev kho qhov txhab: nrawm kho cov ntaub so ntswg puas thiab txhim kho daim tawv nqaij noj qab haus huv.
Antibacterial nyhuv: Nws muaj inhibitory cuam tshuam rau cov kab mob xws li Staphylococcus aureus thiab Candida albicans.
Kev tswj kev tiv thaiv kab mob: pab tswj lub cev tiv thaiv kab mob thiab txo cov kev mob tshwm sim ntau dhau.
Txoj kev siv KPV 10mg yog dab tsi?
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Dosage: Feem ntau 1-2 zaug hauv ib hnub, 10mg txhua zaus, cov koob tshuaj tshwj xeeb yuav tsum tau hloov kho raws li kev tshawb fawb raws tu qauv lossis tus kws kho mob cov lus qhia.
Txoj kev tswj hwm: kev txhaj tshuaj subcutaneous, diluted nrog cov kab mob hauv cov dej tseem ua ntej siv.
Kev kho mob: Feem ntau, nws yuav siv li 4-8 lub lis piam raws li lub voj voog, thiab lub sijhawm tshwj xeeb yuav tsum tau txiav txim siab raws li kev tshawb fawb.
Dab tsi yog qhov chaw cia rau KPV 10mg?
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Undiluted lub xeev: Nws yuav tsum muab cia rau hauv qhov chaw txias, qhuav, thiab tsaus ntuj, thiab tuaj yeem tso rau hauv tub yees.
Tom qab dilution: Yog tias nws tau diluted nrog cov kab mob tseem dej, nws yuav tsum tau muab tso rau hauv tub yees thiab siv li ntawm lub sijhawm teev tseg.
Lub sijhawm cia ntev: Yog tias yuav tsum tau khaws cia ntev ntev, nws tuaj yeem khov ntawm -20℃C.
Cim npe nrov: kpv 10mg, Tuam Tshoj kpv 10mg manufacturers, lwm tus neeg
