5-Amino-1MQ hmoov(CAS naj npawb 42464-96-0) yog dawb crystalline hmoov, tshuaj npe 5-amino-1-methylquinoline-1-ium iodide, molecular mis C10H11N2.I, molecular hnyav 286.11. Nws cov qauv tshuaj muaj peb ntu: quinoline nplhaib, amino hloov pauv, thiab methylammonium ion. Qhov tsim tshwj xeeb molecular no ua rau nws tshwj xeeb khi thiab inhibit qhov chaw nquag ntawm nicotinamide N-methyltransferase (NNMT). Raws li lub zog inhibitor ntawm NNMT, 5-Amino-1MQ sib tw khi rau S-adenosylmethionine (SAM) khi qhov chaw ntawm NNMT, thaiv nws cov txheej txheem catalytic rau nicotinamide methylation. Cov txheej txheem no muaj qhov tseem ceeb hauv kev tshawb fawb metabolic, muab cov cuab yeej tshiab molecular rau kev tswj hwm NAD ⁺ metabolic txoj hauv kev.
Peb tsis tsuas yog muab cov hmoov ntshiab thiab cov tshuaj ntsiav, tab sis kuj muaj lwm yam tshuaj. Yog tias tsim nyog, thov hu rau peb pab neeg muag khoom.
Peb cov khoom los ntawm
5-Amino-1MQ COA
Cov kab mob neurodegenerative xws li Alzheimer's disease, Parkinson's disease, thiab kev paub tsis meej los ntawm ntau lub hlwb raug mob tau dhau los ua teeb meem loj rau kev noj qab haus huv thoob ntiaj teb. Cov kab mob thiab kev raug mob no feem ntau nrog los ntawm kev poob ntawm cov neurons tsis tu ncua, ua rau maj mam poob qis hauv kev paub thiab lub cev muaj zog, ua rau muaj kev ntxhov siab thiab nyiaj txiag loj heev rau cov neeg mob thiab lawv tsev neeg. Tam sim no, txawm hais tias muaj kev txhim kho txuas ntxiv ntawm kev kho mob thev naus laus zis, tseem tsis muaj txoj hauv kev kho mob kom rov qab los yog ncua kev loj hlob ntawm cov kab mob thiab kev raug mob. Yog li ntawd, nws yog ib qho tseem ceeb kom nrhiav tau cov kev ntsuas neuroprotective zoo thiab cov hau kev los txhim kho kev txawj ntse.5-Amino-1MQ hmoov, raws li qhov sib xyaw nrog cov qauv tshuaj lom neeg thiab kev ua haujlwm lom neeg, tau txais kev saib xyuas thoob plaws hauv thaj chaw ntawm neuroscience hauv xyoo tas los no. Kev tshawb fawb tau pom tias nws nthuav tawm cov txiaj ntsig zoo hauv kev tiv thaiv neuroprotection thiab kev paub txog kev ua haujlwm zoo, muab cov tswv yim tshiab thiab cov lus qhia rau kev daws cov teeb meem uas tau hais tseg. Kev tshawb fawb tob hauv - kev tshawb fawb txog kev siv tshuab thiab cov txiaj ntsig ntawm 5-Amino-1MQ ntawm kev tiv thaiv neuroprotection thiab kev paub txog kev ua haujlwm zoo yog qhov tseem ceeb rau kev txhim kho cov tshuaj kho tshiab thiab cov tswv yim.
Cov khoom siv tshuaj thiab cov txheej txheem ntawm kev ua ntawm 5-Amino-1MQ
Cov yam ntxwv tshuaj
Cov tshuaj formula ntawm 5-Amino-1MQ (5-amino-1-methylquinoline chloride) yog C10H11N2. Kuv, nrog qhov hnyav molecular ntawm 194.6. Nws feem ntau tshwm raws li xim av xim av hmoov thiab feem ntau ntim rau hauv 1kg / pob lossis 25kg / nruas. Nws cov purity tuaj yeem ua tiav ntawm qib siab los ntawm kev ua kom zoo dua qub, thiab siab purity txhais tau tias zoo dua bioavailability, uas muab cov kev mob zoo rau nws txoj haujlwm hauv cov kab mob nyob. Nyob rau tib lub sijhawm, nws muaj kev ruaj ntseg zoo thiab tuaj yeem tswj hwm nws cov haujlwm thiab kev ua tau zoo nyob rau hauv ib puag ncig sib txawv thiab kev cia khoom, uas muab kev yooj yim rau kev tsim tshuaj, khaws cia, thiab siv.
Mechanism ntawm Action
5-Amino-1MQ yog ib qho muaj zog inhibitor ntawm nicotinamide N-methyltransferase (NNMT). NNMT ua lub luag haujlwm tseem ceeb hauv lub cev los ntawm kev tswj hwm qib ntawm nicotinamide precursors xav tau rau NAD + biosynthesis, ua lub luag haujlwm tseem ceeb hauv kev tswj hwm NAD + txoj kev khaws cia. NAD + yog ib qho tseem ceeb coenzyme nyob rau hauv ntau yam txheej txheem metabolic hauv cov hlwb, koom nrog cov txheej txheem tseem ceeb ntawm lub cev xws li lub zog metabolism, kho DNA, thiab kev taw qhia ntawm tes. Thaum NNMT kev ua haujlwm tsis zoo, nws tuaj yeem cuam tshuam rau txoj hauv kev metabolic ntawm nicotinamide, yog li cuam tshuam rau kev sib txuas thiab kev ua haujlwm ntawm NAD +, ua rau cov cellular metabolic mob thiab ua haujlwm tsis zoo.
Lub luag haujlwm hauv neuroprotection
Antioxidant nyhuv
Oxidative kev nyuaj siab yog ib qho ntawm cov txheej txheem tseem ceeb uas ua rau muaj kev puas tsuaj rau neuronal thiab kev tuag hauv lub paj hlwb. Thaum cov neurons raug txhawb los ntawm ntau yam sab hauv thiab sab nraud, lawv tsim ntau cov dawb radicals, xws li superoxide anion radicals, hydroxyl radicals, peroxynitrite, thiab lwm yam. Cov dawb radicals no muaj siab reactivity thiab tuaj yeem tawm tsam biomolecules hauv hlwb, xws li lipids, proteins, thiab DNA, ua rau cov lipid peroxidation, protein oxidative kev hloov pauv ntawm cov cell thiab DNA. ua rau kev tuag ntawm neuronal. 5-Amino-1MQ muaj cov khoom antioxidant thiab tuaj yeem tshem tawm cov dawb radicals los ntawm ntau txoj hauv kev, txo cov oxidative kev nyuaj siab rau cov neurons. Ntawm ib sab, nws tuaj yeem cuam tshuam ncaj qha nrog cov dawb radicals, neutralize lawv cov haujlwm, thiab yog li txo qis kev puas tsuaj ntawm cov dawb radicals rau cov hlwb. Ntawm qhov tod tes, nws tuaj yeem txhim kho lub peev xwm antioxidant ntawm cov hlwb los ntawm kev tswj cov kab mob hauv cov cellular antioxidant enzyme, xws li superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), thiab lwm yam. Cov enzymes antioxidant no tuaj yeem ua rau kev hloov pauv thiab decomposition ntawm dawb radicals rau hauv cov khoom tsis zoo, yog li tiv thaiv cov hlwb los ntawm oxidative puas.
tiv thaiv -apoptotic nyhuv
Apoptosis yog ib txoj hauv kev tseem ceeb ntawm kev tuag neuronal, ua lub luag haujlwm tseem ceeb hauv kev tsim cov kab mob neurodegenerative thiab mob hlwb. Kev tswj hwm ntawm cell apoptosis suav nrog ntau txoj hauv kev taw qhia thiab cov molecules, ntawm cov tsev neeg caspase thiab Bcl-2 / Bax proteins yog cov txheej txheem tswj hwm tseem ceeb. Cov tsev neeg caspase yog ib pab pawg ntawm cysteine proteases uas ua raws li cov txheej txheem ntawm cell apoptosis. Lawv tuaj yeem qhib tau thiab tshem tawm cov substrates tshwj xeeb, ua rau muaj kev puas tsuaj rau lub cev thiab ua haujlwm tsis zoo ntawm cov hlwb. Bcl-2 tsev neeg cov proteins suav nrog cov proteins apoptotic (xws li Bax) thiab cov tshuaj tiv thaiv apoptotic (xws li Bcl-2), uas tswj qhov tshwm sim ntawm cell apoptosis los ntawm kev tswj cov permeability ntawm mitochondrial membranes thiab tswj kev tso tawm ntawm apoptotic yam xws li cytochrome C.
5-Amino-1MQ hmoovtuaj yeem inhibit neuronal apoptosis los ntawm kev tswj cov apoptosis ntsig txog cov molecules thiab cov kev taw qhia. Kev tshawb fawb pom tau hais tias nyob rau hauv ib tug neural raug mob qauv, kev kho mob nrog 5-Amino-1MQ inhibits cov kev ua ntawm caspase tsev neeg cov proteins, upregulates Bcl-2 protein qhia, downregulates Bax protein qhia, txo mitochondrial membrane permeability, txo cytochrome C tso, thiab txo cov neuronal apoptosis. Qhov no qhia tau hais tias 5-Amino-1MQ tuaj yeem tiv thaiv cov neurons los ntawm kev puas tsuaj thiab txhawb kev muaj sia nyob los ntawm kev tiv thaiv apoptotic.
Regulating lub neurotransmitter system
Lub kaw lus neurotransmitter plays lub luag haujlwm tseem ceeb hauv kev xa cov teeb liab thiab kev tswj hwm kev ua haujlwm ntawm cov neurons. Ntau yam neurotransmitters, xws li serotonin (5-HT), norepinephrine (NE), acetylcholine (ACh), glutamate (Glu), thiab lwm yam, muaj kev koom tes hauv ntau yam physiological xws li kev kawm thiab kev nco, kev xav, thiab kev tswj lub cev muaj zog. Thaum cov kab mob neurotransmitter tsis sib npaug, nws tuaj yeem ua rau lub paj hlwb tsis ua haujlwm thiab ua rau muaj ntau yam kab mob hauv lub paj hlwb . 5-Amino-1MQ tuaj yeem muaj kev tswj hwm ntawm cov kab mob neurotransmitter. Piv txwv li, nws tuaj yeem cuam tshuam rau kev qhia thiab kev ua haujlwm ntawm 5-HT receptors. 5-HT yog ib qho tseem ceeb neurotransmitter koom nrog ntau yam txheej txheem physiological xws li kev xav, kev pw tsaug zog, thiab kev paub. Kev tshawb fawb tau pom tias cov tshuaj tsom rau 5-HT4 receptors muaj peev xwm txhim kho kev paub txog kev ua haujlwm . 5-Amino-1MQ tuaj yeem txhim kho kev txawj ntse los ntawm kev hloov pauv cov haujlwm ntawm 5-HT4 receptors, cuam tshuam rau neuronal excitability thiab teeb liab transduction. Tsis tas li ntawd, 5-Amino-1MQ kuj tseem muaj kev tswj xyuas cov teebmeem ntawm lwm cov kab mob neurotransmitter xws li NE, ACH, Glu, thiab lwm yam, tab sis cov txheej txheem tshwj xeeb thiab cov teebmeem tseem xav tau kev tshawb fawb ntxiv.
Kev tuav cov ntshav- lub hlwb barrier muaj nuj nqi
Cov ntshav- lub paj hlwb barrier yog ib qho teeb meem ntawm lub hlwb capillary endothelial hlwb, hauv qab daus daim nyias nyias, thiab astrocyte terminals. Nws tuaj yeem xaiv tso cai rau qee yam khoom hla dhau, tiv thaiv cov khoom tsis zoo los ntawm kev nkag mus rau lub hlwb, thiab tswj kev ruaj ntseg ntawm lub hlwb ib puag ncig. Nyob rau hauv cov ntaub ntawv ntawm cov kab mob neurodegenerative thiab raug mob lub hlwb, kev ua haujlwm ntawm cov ntshav- lub paj hlwb teeb meem feem ntau cuam tshuam, ua rau muaj zog vascular permeability, cov khoom tsis zoo nkag mus rau hauv lub hlwb, ua rau cov tshuaj tiv thaiv neuroinflammatory thiab neuronal puas tsuaj . 5-Amino-1MQ tej zaum yuav muaj kev saib xyuas ntawm cov ntshav-hlwb barrier muaj nuj nqi.
Nws tuaj yeem txhim kho kev ncaj ncees ntawm cov ntshav- lub hlwb thaiv thiab txo cov vascular permeability los ntawm kev tswj cov kev qhia thiab kev faib tawm ntawm cov protein sib txuas nruj ntawm cov hlwb endothelial. Kev tshawb fawb tau pom tias hauv cov qauv kev raug mob ntawm lub hlwb, kev kho mob nrog 5-Amino-1MQ txo cov permeability ntawm cov hlab ntsha-hlwb barrier, txo cov infiltration ntawm inflammatory hlwb nyob rau hauv cov ntaub so ntswg hlwb, thiab txo cov℃ntawm neuronal puas. Qhov no qhia tau hais tias 5-Amino-1MQ tuaj yeem ua rau muaj kev tiv thaiv neuroprotective los ntawm kev tswj cov ntshav-hlwb lub hlwb kev ua haujlwm, txo qhov kev puas tsuaj ntawm cov tshuaj phem rau lub hlwb.
Lub luag haujlwm hauv kev txhim kho kev txawj ntse
Kev kawm thiab kev nco yog ib qho tseem ceeb ntawm kev paub txog kev ua haujlwm, nrog rau ntau yam txheej txheem xws li kev tau txais cov ntaub ntawv, khaws cia, thiab rov qab. Nyob rau hauv cov ntaub ntawv ntawm cov kab mob neurodegenerative thiab kev raug mob ntawm lub hlwb, kev kawm thiab kev nco muaj peev xwm feem ntau cuam tshuam loj heev, ua rau cov tsos mob xws li tsis nco qab thiab kev paub tsis meej hauv cov neeg mob. Ob qho kev sim tsiaj thiab kev tshawb fawb soj ntsuam tau pom tias 5-Amino-1MQ muaj kev txhim kho kev kawm thiab kev nco muaj peev xwm. Hauv kev sim tsiaj, kev kho mob nrog 5-Amino-1MQ tau txhim kho qhov kev ua tau zoo ntawm cov tsiaj hauv kev kawm thiab kev sim nco xws li kev sim maze thiab kev sim ntshai. Piv txwv li, nyob rau hauv maze thwmsim, tsiaj muaj peev xwm nrhiav tau lub hom phiaj qhov chaw sai dua thiab txo tus naj npawb ntawm qhov yuam kev; Hauv qhov kev sim ua kom ntshai, tsiaj muaj lub cim xeeb muaj zog ntawm kev ntshai stimuli thiab ntev lub sij hawm immobility. Cov txiaj ntsig no qhia tau tias 5-Amino-1MQ tuaj yeem txhim kho kev kawm thiab kev nco txog tsiaj txhu.
Kev cuam tshuam rau kev saib xyuas thiab kev ua haujlwm
Kev saib xyuas thiab kev ua haujlwm yog lwm yam tseem ceeb ntawm kev paub txog kev ua haujlwm. Kev saib xyuas yog hais txog ib tus neeg lub peev xwm los xaiv lub siab xav thiab txhawb nqa kev mloog ntawm cov stimuli tshwj xeeb, thaum lub luag haujlwm tseem ceeb suav nrog cov txheej txheem kev txawj ntse xws li kev npaj, kev npaj, kev txiav txim siab- ua, thiab kev tswj hwm inhibitory. Hauv cov xwm txheej ntawm cov kab mob neurodegenerative thiab raug mob ntawm lub hlwb, kev saib xyuas thiab kev ua haujlwm feem ntau cuam tshuam, ua rau cov tsos mob xws li tsis muaj kev xav, kev txiav txim siab- ua rau muaj teeb meem, thiab kev coj cwj pwm tsis zoo hauv cov neeg mob. Kev tshawb fawb tau pom tias 5-Amino-1MQ tuaj yeem muaj kev txhim kho ntawm kev mloog thiab kev ua haujlwm. Hauv kev sim tsiaj, kev kho mob nrog 5-Amino-1MQ txhim kho kev ua tau zoo ntawm cov tsiaj hauv kev soj ntsuam cov haujlwm, ua rau lawv xaiv lub hom phiaj stimuli ntau dua thiab txo qhov cuam tshuam ntawm kev cuam tshuam stimuli. Hauv kev ua cov haujlwm kuaj kev ua haujlwm, tsiaj txhu kev npaj thiab kev txiav txim siab muaj peev xwm raug txhim kho, ua rau lawv ua tiav cov haujlwm nyuaj. Cov txiaj ntsig no qhia tias 5-Amino-1MQ tuaj yeem txhim kho kev mloog zoo thiab kev ua haujlwm los ntawm kev tswj cov kab mob neurotransmitter, txhim kho kev ua haujlwm neuronal, thiab lwm txoj hauv kev.
Kev nkag siab yooj yim yog hais txog ib tus neeg lub peev xwm los kho cov tswv yim kev txawj ntse thiab kev coj tus cwj pwm hauv kev teb rau cov kev hloov ntawm ib puag ncig, thiab nws yog ib qho tseem ceeb ntawm kev txawj ntse rau kev hloov mus rau ib puag ncig nyuaj. Hauv cov xwm txheej ntawm cov kab mob neurodegenerative thiab kev raug mob ntawm lub hlwb, kev paub yooj yim yog feem ntau cuam tshuam, ua rau nws nyuaj rau cov neeg mob hloov mus rau qhov chaw tshiab thiab kev ua haujlwm. Cov kev sim tsiaj tau pom tias 5-Amino-1MQ tuaj yeem muaj kev txhim kho ntawm kev nkag siab yooj yim. Hauv kev ua haujlwm ntawm kev paub txog kev paub yooj yim, cov tsiaj kho nrog 5-Amino-1MQ tuaj yeem kawm cov cai tshiab thiab cov tswv yim sai dua, hloov mus rau cov kev hloov pauv hauv txoj haujlwm, thiab ua kom pom kev nkag siab zoo dua. Qhov no tej zaum yuav muaj feem xyuam rau cov kev cai ntawm neural plasticity thiab txhawb kev sib txuas thiab kev sib txuas lus ntawm cov neurons los ntawm 5-Amino-1MQ. Neuroplasticity yog lub hauv paus rau lub paj hlwb hloov mus rau ib puag ncig kev hloov pauv, thiab5-Amino-1MQ hmoovtuaj yeem txhim kho neuroplasticity thiab txhim kho kev nkag siab yooj.
Cim npe nrov: 5-amino-1mq hmoov, Tuam Tshoj 5-amino-1mq hmoov manufacturers, lwm tus neeg
