Histrelin Acetate, Suav lub npe yog acetanilide, uas yog ib qho khoom siv hluavtaws peptide tshuaj uas yog nyob rau hauv chav kawm ntawm gonadotropin - tso cov tshuaj hormones (GnRH) analogs. Nws muaj ntau yam kev siv hauv kev kho mob, tshwj xeeb tshaj yog ua lub luag haujlwm tseem ceeb hauv kev kho mob ntawm qee yam tshuaj hormones dependent kab mob. Nws yog cuaj peptide analogue ntawm GnRH. GnRH yog peptide hormone secreted los ntawm hypothalamus uas ua lub luag haujlwm tseem ceeb hauv kev tswj cov kev ua me nyuam. Nws cov txheej txheem ntawm kev ua haujlwm feem ntau yog raws li nws cov txiaj ntsig excitatory ntawm GnRH receptors. GnRH receptors yog dav faib rau gonadotropin hlwb nyob rau hauv lub anterior pituitary caj pas. Thaum nws nkag mus rau hauv cov hlab ntsha, nws khi rau GnRH receptors ntawm cov hlwb no, ua kom cov kab mob hauv lub cev thiab ua rau muaj zog tso tawm ntawm luteinizing hormone (LH) thiab follicle stimulating hormone (FSH).
Peb tsis tsuas yog muab cov hmoov ntshiab thiab cov tshuaj ntsiav, tab sis kuj muaj lwm yam tshuaj. Yog tias tsim nyog, thov hu rau peb pab neeg muag khoom.
Peb cov khoom los ntawm
Histrelin COA
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| Certificate of Analysis | ||
| Compound npe | Histrelin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 76712-82-8 | |
| Ntau | 15g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090031 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.36% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.27% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.48% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 98 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Chemical Formula: | C66H86N18O12 |
| Exact Mass: | 1322.67 |
| Molecular Luj: | 1323.53 |
| m/z: | 1322.67 (100.0%), 1323.67 (71.4%), 1324.67 (25.1%), 1323.66 (6.6%), 1325.68 (5.8%), 1324.67 (4.7%), 1324.67 (2.5%), 1325.67 (1.8%), 1325.67 (1.7%) |
| Elemental Analysis: | C, 59.89; H, 6.55; N, 19.05; O, 14.51 |
Histrelin Acetate, Lub npe tshuaj acetaminophen yog cuaj peptide analogue ntawm gonadotropin - tso cov tshuaj hormone (GnRH), uas yog los ntawm GnRH receptor agonist. Nws simulates qhov kev txiav txim ntawm tej yam ntuj tso GnRH, khi rau GnRH receptors nyob rau hauv lub anterior pituitary caj pas, tswj kev tso tawm ntawm gonadotropins, thiab yog li cuam tshuam rau kev sib deev hormone theem.
Kev kho mob qog noj ntshav prostate
Prostate cancer yog ib qho ntawm cov qog nqaij hlav ntau tshaj plaws hauv cov txiv neej. Nws qhov xwm txheej thiab cov neeg tuag yog qhov siab tshaj plaws hauv ntiaj teb. Nrog rau kev laus ntawm cov pejxeem thiab kev nce qib ntawm kev tshuaj ntsuam thev naus laus zis, qhov tshwm sim ntawm tus mob qog noj ntshav prostate tau nce zuj zus txhua xyoo. Prostate cancer tsis tsuas yog cuam tshuam loj rau lub neej zoo ntawm cov neeg mob, tab sis kuj coj lub nra hnyav rau tsev neeg thiab zej zog. Cov kev kho mob ib txwm muaj xws li kev phais, kev kho hluav taws xob, tshuaj khomob, thiab lwm yam, tab sis cov txheej txheem no muaj qee qhov kev txwv hauv kev kho mob qog noj ntshav prostate. Histrelin, raws li cov tshuaj kho tshiab, tau coj kev cia siab tshiab rau kev kho mob qog noj ntshav prostate.
Cov ntaub ntawv yooj yim
Chemical Structure thiab Properties
Histrelin yog cuaj peptide analogue ntawm gonadotropin - tso tawm cov tshuaj hormones (GnRH) nrog ib qho hnyav molecular ntawm 1383.58, molecular mis ntawm C66H86N18O12 · XC2H4O2, thiab CAS naj npawb ntawm 220810-26-4. Nws yog ib qho dawb rau cov khoom dawb, soluble hauv dej, nrog kev solubility ntawm ntau dua lossis sib npaug li 10mg / mL.
Mechanism ntawm Action
Histrelin yog GnRH receptor agonist. Nyob rau hauv ib txwm muaj xwm txheej, lub hypothalamus secretes GnRH, uas ua rau lub anterior pituitary caj pas los txhawb kev tso tawm ntawm luteinizing hormone (LH) thiab follicle stimulating hormone (FSH), yog li tswj lub secretion ntawm gonadal hormones. Tom qab nkag mus rau tib neeg lub cev, Histrelin tsis tu ncua txhawb kev tso tawm ntawm LH thiab FSH los ntawm lub caj pas pituitary, uas pib ua rau luv luv ntawm LH thiab FSH qib, yog li nce qib testosterone. Txawm li cas los xij, tom qab siv tas mus li, GnRH receptors nyob rau hauv lub caj pas anterior pituitary yog overstimulated, ua rau desensitization thiab inhibition ntawm LH thiab FSH secretion, ua rau txo qis hauv testosterone qib. Vim tias qhov tseeb tias testosterone tuaj yeem txhawb kev loj hlob ntawm cov qog nqaij hlav qog nqaij hlav prostate, txo cov qib testosterone tuaj yeem pab txo qis kev loj hlob ntawm cov qog nqaij hlav qog nqaij hlav prostate thiab inhibit qog nqaij hlav.
Kev siv tshuaj kho mob hauv kev kho mob qog noj ntshav prostate
Cov lus qhia
Histrelin feem ntau yog siv rau kev kho mob palliative ntawm kev mob qog noj ntshav prostate. Late stage "hais txog kev mob qog noj ntshav uas tau kis mus rau lwm qhov hauv lub cev. Raws li kev kho mob palliative, nws pab txo cov tsos mob xws li tso zis nyuaj thiab mob pob txha, txhim kho lub neej zoo rau cov neeg mob qog noj ntshav siab.
Kev siv thiab siv
Histrelin yog siv rau hauv daim ntawv cog lus, tso ncaj qha rau hauv daim tawv nqaij (subcutaneous), thiab cov neeg ua haujlwm kho mob feem ntau muab tso rau hauv nruab nrab ntawm cov biceps thiab triceps cov leeg nyob rau sab hauv ntawm caj npab. AHistrelin Acetateimplant feem ntau kav ntev li 12 lub hlis, tom qab ntawd nws yuav tsum tau muab tshem tawm ua ntej muab lwm yam cog. Qhov no ntev - txoj kev tswj hwm lub sij hawm txo cov sij hawm cov neeg mob noj tshuaj thiab txhim kho lawv cov kev ua raws li cov tshuaj.
Ua ke daim ntawv thov nrog lwm txoj kev kho mob
Kev sib xyaw nrog kev siv hluav taws xob
Kev kho mob hluav taws xob yog ib txoj hauv kev kho mob uas feem ntau siv rau kev mob qog noj ntshav prostate, uas tua cov qog nqaij hlav cancer los ntawm siab - hluav taws xob hluav taws xob. Kev sib xyaw ntawm Histrelin thiab radiotherapy tuaj yeem txhim kho cov txiaj ntsig kho mob. Kev kho hluav taws xob tuaj yeem ua ncaj qha rau cov qog nqaij hlav hauv zos, tua cov qog nqaij hlav cancer, thaum Histrelin tswj tus mob los ntawm kev pom zoo los ntawm kev txo qis testosterone qib, inhibiting kev loj hlob thiab kev sib kis ntawm cov qog hlwb. Kev sib xyaw ua ke ntawm ob tuaj yeem muaj kev sib koom ua ke, txhim kho kev tswj hwm hauv cheeb tsam ntawm cov qog thiab cov ciaj sia taus ntawm cov neeg mob.
Kev sib xyaw ua ke nrog kev kho mob
Chemotherapy yog ib txoj kev kho mob uas siv tshuaj tua kab mob qog noj ntshav. Txawm hais tias kev siv tshuaj khomob tsis tshua muaj txiaj ntsig hauv kev kho mob qog noj ntshav prostate, nws cov kev sib xyaw nrog Histrelin tuaj yeem muaj qee yam kev sib koom ua ke. Histrelin txo qis qib testosterone, tso cov qog hlwb hauv lub xeev uas muaj kev cuam tshuam, ua rau nws yooj yim dua rau kev siv tshuaj khomob kom ua haujlwm thiab txhim kho kev siv tshuaj khomob. Lub caij no, Histrelin tseem tuaj yeem txo qee qhov kev mob tshwm sim ntawm kev siv tshuaj khomob, xws li kev txhim kho cov neeg mob lub cev thiab txhim kho lawv txoj kev kam rau cov kws khomob.
Kev sib xyaw nrog Immunotherapy
Immunotherapy tau yog lub ntsiab lus kub hauv kev kho mob qog noj ntshav hauv xyoo tas los no, uas lees paub thiab tua cov qog nqaij hlav cancer los ntawm kev ua kom lub cev tiv thaiv kab mob. Lub immunosuppressive qog microenvironment ntawm prostate cancer txwv qhov kev ua tau zoo ntawm immunotherapy. Histrelin tuaj yeem txo cov qib testosterone, tswj cov qog microenvironment, txo lub cev tiv thaiv kab mob, thiab txhim kho kev ua haujlwm ntawm kev tiv thaiv kab mob. Piv txwv li, thaum siv ua ke nrog cov tshuaj tiv thaiv kab mob qog noj ntshav, Histrelin tuaj yeem txhim kho cov qog microenvironment, ua kom yooj yim rau cov tshuaj tiv thaiv kom lub cev tiv thaiv kab mob thiab txhim kho nws lub peev xwm tua cov qog hlwb.
Qhov zoo ntawm Histrelin hauv kev kho mob qog noj ntshav prostate
Kev ua tau zoo
Cov kev tshawb fawb soj ntsuam tau pom tias Histrelin tuaj yeem txo qis testosterone theem, ua tiav cov tshuaj castration. Txo tus neeg mob cov qib testosterone mus rau qib qis heev hauv lub sijhawm luv luv, zoo inhibiting kev loj hlob thiab kev sib kis ntawm cov qog nqaij hlav prostate. Piv nrog rau cov tsoos castration phais, Histrelin tsis xav tau kev phais, zam kev raug mob thiab cov teeb meem tshwm sim los ntawm kev phais, thaum tseem ua tiav cov txiaj ntsig zoo sib xws.
Kev ua haujlwm ntev
Histrelin implant muaj lub sijhawm ua haujlwm txog li 12 lub hlis, thiab cov neeg mob tsuas yog yuav tsum tau hloov cov tshuaj cog ib xyoos ib zaug kom tswj tau qhov kev kho mob. Txoj kev tswj xyuas lub sij hawm ntev no txo cov sij hawm cov neeg mob noj tshuaj thiab txhim kho kev ua raws li cov tshuaj, tshwj xeeb tshaj yog tsim nyog rau cov neeg mob uas tsis nco qab lossis txwv tus kheej - muaj peev xwm saib xyuas. Nyob rau tib lub sijhawm, kev ua haujlwm ntev - ua haujlwm tau zoo kuj txo cov teeb meem ntawm kev kho mob ntau zaus rau cov neeg mob thiab txo cov nqi kho mob.
Kev ruaj ntseg
Piv nrog rau cov kev kho mob ib txwm muaj, Histrelin muaj kev nyab xeeb dua. Nws zam qhov kev pheej hmoo ntawm kev phais thiab cov kev mob tshwm sim loj ntawm kev siv tshuaj khomob thiab kev kho hluav taws xob. Txawm hais tias tej zaum yuav muaj qee qhov kev tshwm sim hauv zos thaum siv, xws li liab, o, thiab mob ntawm qhov chaw cog qoob loo, cov tshuaj tiv thaiv no feem ntau yog me me thiab tuaj yeem txo tau los ntawm kev kho kom tsim nyog. Tsis tas li ntawd, Histrelin muaj kev cuam tshuam me me rau cov kabmob tseem ceeb xws li cov hlab plawv, daim siab, thiab ob lub raum, ua rau nws tsim nyog rau cov neeg mob feem ntau siv.
Txhim Kho Lub Neej Zoo
Cov neeg mob uas muaj mob qog noj ntshav prostate feem ntau muaj cov tsos mob xws li tso zis nyuaj thiab mob pob txha, uas cuam tshuam rau lawv lub neej zoo.Cov tshuaj Histrelin acetatetuaj yeem txo cov tsos mob no zoo thiab txo qhov mob ntawm cov neeg mob. Tib lub sijhawm, nws tseem tuaj yeem txhim kho lub cev, lub hlwb, thiab kev sib deev ua haujlwm ntawm cov neeg mob, txhim kho lawv lub neej zoo, thiab pab kom lawv muaj kev zoo siab rau lub neej.
Cov lus nug nquag
Dab tsi yog histrelin acetate siv rau?
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Ib qho tshuaj siv raws li lub npe Vantas ua palliative therapy rau kev mob qog noj ntshav prostate. Histrelin acetate pib ua rau lub caj pas pituitary ua ntau dua luteinizing hormone (LH) thiab follicle-stimulating hormone (FSH), ib ntus nce qib testosterone hauv cov txiv neej.
Puas yog histrelin yog puberty blocker?
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Histrelin subdermal implant yog FDA- pom zoo rau kev kho mob ntawm precocious puberty rau 1 xyoo. Cov implants no tau siv tawm ntawm - daim ntawv lo rau hauv cov tub ntxhais hluas hloov pauv, thiab tsis tau kawm txog lub sijhawm kho tau zoo.
Dab tsi yog qhov generic rau histrelin cog?
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Supprelin LA Supprelin LA (histrelin) pab tiv thaiv kev laus thaum ntxov ntawm cov menyuam yaus hnub nyoog 2 xyoos thiab laus dua. Cov tshuaj ua haujlwm zoo los ncua kev puberty, tab sis nws yog ib qho kev cog qoob loo uas muab tso rau hauv koj daim tawv nqaij thaum lub sijhawm phais me.
Cim npe nrov: Tuam Tshoj histrelin acetate manufacturers, lwm tus neeg
