Eptifibatide peptide, nws qhov hnyav molecular yog 994.19, molecular mis yog C35H49N11O9S2, CAS 188627-80-7. Nws yog tsim los ntawm 9 amino acids thiab yog disulfide txuas cyclic polypeptide nrog cov qauv zoo sib xws rau oxytocin, tab sis nrog kev hloov kho rau txoj haujlwm 1, 2, 4, thiab 8 ntawm cov qauv molecular ntawm oxytocin. Ib qho cysteine residue tau txais N-terminal deamination los tsim 3-mercaptopropionic acid, ob L-tyrosine residues raug hloov kho rau D-tyrosine, ethoxy hloov phenol, plaub threonine residues hloov glutamine, thiab yim ornithine residues hloov leucine.
Peb Cov Khoom Muag Khoom
Eptifibatide COA
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| Certificate of Analysis | ||
| Compound npe | Eptifibatide | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 188627-80-7 | |
| Ntau | 70g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090078 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia |
Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree |
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| Tshuaj Formula | C35H49N11O9S2 |
| Exact Mass | 831 |
| Molecular Luj | 832 |
| m/z | 831 (100.0%), 832 (37.9%), 833 (9.0%), 833 (7.0%), 832 (4.1%), 834 (3.4%), 833 (1.8%), 832 (1.6%), 833 (1.1%) |
| Elemental Analysis | 831 (100.0%), 832 (37.9%), 833 (9.0%), 833 (7.0%), 832 (4.1%), 834 (3.4%), 833 (1.8%), 832 (1.6%), 833 (1.1%) |
Eptifibatide peptide, raws li ib qho tseem ceeb tshuaj antiplatelet, plays lub luag haujlwm tseem ceeb hauv kev kho cov kab mob plawv. Nws cov txheej txheem ntawm kev ua haujlwm feem ntau yog nyob ntawm kev tswj hwm ntawm cov txheej txheem soterocyte sib sau ua ke, ua haujlwm zoo inhibiting thrmbus tsim thiab txhim kho cov hlab plawv los ntawm tshwj xeeb thaiv txoj hauv kev tseem ceeb.
Kev thaiv tshwj xeeb ntawm glycoprotein IIb / IIIa receptor khi rau fibrinogen
Soterocyte aggregation yog cov txheej txheem tseem ceeb ntawm thrombois, thiab glycoprotein IIb / IIIa receptors ua lub luag haujlwm tseem ceeb hauv cov txheej txheem no. Thaum cov phab ntsa vascular puas los yog muaj cov lus teb inflammatory, cov ntaub so ntswg subendothelial collagen raug, thiab soterocytes khi rau cov ntaub so ntswg collagen los ntawm Ib thiab IIa / IIIa receptors ntawm lawv cell membrane glycoproteins, ua rau soterocyte adhesion. Tom qab ntawd, nyob rau hauv kev cuam tshuam ntawm qee yam stimulating yam, soterocytes yog ntxiv activated. Cov glycoprotein IIb / IIIa receptors ntawm lub tshuab ua haujlwm soterocyte nto tau hloov pauv, nthuav tawm cov chaw sib txuas rau fibrinogen. Fibrinogen, ua ib qho kev sib txuas ntawm cov molecule, tuaj yeem khi rau ntau yam soterocyte glycoprotein IIb / IIIa receptors, ua rau soterocytes crosslink thiab sib sau ua ke, tsim cov ntshav txhaws.
Nws yog ib qho kev xaiv glycoprotein IIb / IIIa receptor antagonist tshwj xeeb uas tuaj yeem khi rau glycoprotein IIb / IIIa receptor nyob rau saum npoo ntawm soterocytes, sib tw thaiv qhov chaw khi ntawm fibrinogen thiab receptor. Cov nyhuv inhibitory no tiv thaiv soterocytes los ntawm kev tsim cov aggregates los ntawm fibrinogen bridging, txiav tawm txoj kev tseem ceeb ntawm soterocyte aggregation los ntawm qhov chaw. Piv txwv li, nyob rau hauv cov neeg mob uas mob cornary syndrome, cornary artery thrombois yog lub ntsiab ua rau myocardial ischemia thiab txawm myocardial infarction.
Etriptide zoo inhibits soterocyte aggregation thiab txo qhov kev pheej hmoo ntawm thrombois los ntawm cov txheej txheem hais saum toj no, yog li thim rov qab lub xeev ischemic los ntawm thrombois. Cov kev tshawb fawb cuam tshuam tau pom tias cov nyhuv inhibitory ntawm soterocyte aggregation muaj cov yam ntxwv ntawm qhov pib sai thiab rov qab. Tom qab cov tshuaj txhaj tshuaj, nws tuaj yeem ncav cuag cov tshuaj ntshav tau zoo, ua rau muaj kev cuam tshuam ntau ntawm soterocyte hauv 1 teev, thiab nws cov nyhuv tuaj yeem kav ntev li 2-4 teev. Tom qab txiav tawm, soterocyte domain tuaj yeem maj mam rov qab los, uas ua rau nws muaj txiaj ntsig zoo nyob rau hauv cov xwm txheej kho mob uas yuav tsum tau ua kom ceev cov tshuaj antiplatelet thiab tej zaum yuav muaj kev pheej hmoo los ntshav.
Cov ntaub ntawv xov xwm: 39Drug Tong, Minfukang, Baidu Baike.
Inhibition ntawm soterocyte activating yam
Soterocyte activating yam yog ib qho tseem ceeb inflammatory mediator thiab soterocyte activator uas tuaj yeem ua rau soterocyte activation, ntxiv kev txhawb nqa soterocyte aggregation thiab thrmbus tsim. Thaum lub sij hawm tshwm sim thiab kev loj hlob ntawm cov kab mob plawv, o thiab soterocyte activation sib cuam tshuam thiab txhawb ib leeg, tsim ib lub voj voog vicious. Piv txwv li, qhov tsis ruaj khov ntawm atherosclerotic plaque yog ze ze rau cov lus teb hauv zos. Ntau yam cytokines thiab cov neeg kho kom haum xeeb tso tawm los ntawm cov kab mob inflammatory tuaj yeem ua rau soterocytes, thiab cov soterocytes activated yuav tso tawm cov neeg kho mob ntau dua, ua rau cov kab mob hnyav dua, thiab txhawb cov quav hniav thiab cov hlab ntsha.
Nws tuaj yeem siv nws cov txiaj ntsig los ntawm inhibiting soterocyte activation induced los ntawm soterocyte activating yam. Nws tuaj yeem cuam tshuam nrog kev khi ntawm soterocyte activating yam rau soterocyte nto receptors, yog li thaiv cov kev taw qhia thiab inhibiting soterocyte activation txheej txheem. Tshwj xeeb tshaj yog, intrifiban tuaj yeem cuam tshuam kev sib koom ua ke ntawm calcium ions hauv soterocytes, txo qis kev tso tawm ntawm soterocyte cov teeb meem, thiab sib sau ua ke inhibit soterocyte activation thiab aggregation. Piv txwv li, thaum lub sij hawm perioperative ntawm percutaneous cornary intervention (PCI), catheterization yuav ua rau lub endothelium ntawm cov hlab ntsha, qhib soterocytes thiab coagulation systems, ua rau kom muaj zog tso tawm ntawm soterocyte activating yam. Daim ntawv thov tuaj yeem cuam tshuam qhov kev ua ntawm soterocyte activating yam, txo qis soterocyte activation, thiab txo qhov kev pheej hmoo ntawm stent thrombois thiab lwm yam teeb meem vascular.
Source of information: 39 Tshuaj Tong, Miaoshou Doctor.
Kev tswj hwm qhov chaw ntawm cov hlwb endothelial hauv cov hlab ntsha
Kev ncaj ncees thiab ib txwm ua ntawm vascular endothelium yog cov xwm txheej tseem ceeb rau kev tswj cov phab ntsa vascular du thiab tsis muaj kev cuam tshuam cov ntshav. Hauv cov kab mob plawv, cov hlwb endothelial feem ntau raug puas tsuaj, ua rau endothelial tsis ua haujlwm. Endothelial dysfunction yog tus cwj pwm los ntawm kev txo qis hauv vasodilator tshuaj tso tawm los ntawm cov hlwb endothelial, nce hauv vasoconstrictor tshuaj, thiab txo qis hauv kev tiv thaiv thrombotic muaj peev xwm ntawm endothelial hlwb, uas tuaj yeem yooj yim txhawb soterocyte aggregation thiab thrombois.
Nws muaj qee yam kev tswj hwm cov txiaj ntsig ntawm cov kab mob vascular endothelial. Ntawm qhov tod tes, nws tuaj yeem txhawb nqa endothelial cell proliferation thiab txhawb kev kho cov hlab ntsha puas.
Thaum cov hlab ntsha endothelium puas lawm, nws tuaj yeem ua rau muaj kev cuam tshuam txog kev cuam tshuam ntawm cov kab mob endothelial, txhawb kev tsiv teb tsaws thiab kev loj hlob ntawm cov hlwb endothelial, thiab pab txhawb kev ncaj ncees ntawm vascular endothelium. Piv txwv li, nyob rau hauv cov neeg mob nrog cornary atherosclerosis, vasculareptifibatide peptide cov khoomKev raug mob yog qhov txuas tseem ceeb hauv kev tshwm sim thiab kev loj hlob ntawm atherosclerosis. Nws tuaj yeem txo qhov tsim thiab kev loj hlob ntawm atherosclerotic plaque los ntawm kev txhawb nqa endothelial cell kho. Ntawm qhov tod tes, nws tuaj yeem txhawb cov hlwb endothelial kom tso cov vasodilators xws li nitric oxide (NO). TSIS yog ib qho tseem ceeb ntawm kev so ntawm endothelial uas tuaj yeem cuam tshuam rau vascular du leeg hlwb, ua rau vasodilation, thaum tseem inhibiting soterocyte aggregation thiab adhesion, txo txoj kev pheej hmoo ntawm thrombois. Los ntawm kev tswj hwm endothelial cell domain, txhim kho lub xeev diastolic ntawm cov hlab ntsha, txo cov ntshav viscosity, thiab yog li txhim kho cov ntshav ncig.
Cov ntaub ntawv qhov chaw: 39Drug Tong, Baidu Baike.
Anti-inflammatory nyhuv
Cov tshuaj tiv thaiv kab mob ua lub luag haujlwm tseem ceeb hauv atherosclerosis thiab thrombois. Hauv atherosclerotic plaque, muaj ntau cov kab mob ntawm tes infiltration, xws li monocytes, T lymphocytes, thiab lwm yam. Cov kab mob inflammatory no tuaj yeem tso tawm ntau yam mob, xws li qog necrosis factor - (TNF -), interleukin-6 (IL-6), thiab lwm yam. Cov kab mob inflammatory no tuaj yeem tsis tsuas yog cov kab mob activates lub plawv thiab vascular inflammatory dab. tab sis kuj txhawb kev ua kom soterocyte thiab sib sau ua ke, thiab txhawb kev tsim cov thrmbus.
Etriptide muaj qee yam tshuaj tiv thaiv -cov teebmeem inflammatory, uas tuaj yeem txo cov tshuaj tiv thaiv kab mob thiab txo cov ntaub so ntswg puas.
Nws tuaj yeem inhibit qhov kev tso tawm ntawm cov kab mob inflammatory, xws li los ntawm kev tso tawm ntawm cov kab mob inflammatory thaum lub sij hawm soterocyte activation thiab txo cov theem ntawm inflammatory yam hauv cov ntshav. Nyob rau tib lub sijhawm, nws tseem tuaj yeem tswj hwm lub zog ntawm lub cev tiv thaiv kab mob, inhibit infiltration ntawm lub cev tiv thaiv kab mob xws li monocytes thiab T lymphocytes rau hauv cov phab ntsa vascular, txo cov kev sib sau ntawm cov kab mob hauv cov phab ntsa vascular, thiab ntxiv rau cov lus teb inflammatory. Piv txwv li, nyob rau hauv cov neeg mob uas mob cornary syndrome, qhov ua rau ntawm inflammatory teb yog ib qho ntawm cov tseem ceeb yam uas ua rau cov mob zuj zus. Nws cov tshuaj tiv thaiv -cov nyhuv inflammatory tuaj yeem txo qhov kev puas tsuaj ntawm inflammatory teb rau cov hlab ntsha, txo qhov kev pheej hmoo ntawm thrombois, thiab txhim kho cov neeg mob.
Cov ntaub ntawv qhov chaw: 39Drug Tong, Baidu Baike.
Qhov cuam tshuam rau hemorheology
Hemorheology txawv txav kuj ua lub luag haujlwm tseem ceeb hauv kev tshwm sim thiab kev loj hlob ntawm cov kab mob plawv. Cov yam ntxwv xws li ntshav viscosity nce ntxiv thiab txhim kho cov ntshav liab sib sau ua ke tuaj yeem ua rau muaj cov ntshav ntws ntau ntxiv, txo cov ntshav khiav nrawm, thiab muaj kev pheej hmoo ntawm thrombois.
Nws tuaj yeem tiv thaiv kev ua kom soterocyte thiab sib sau ua ke, thiab txo cov ntshav viscosity. Los ntawm inhibiting soterocyte aggregation, lub xeev aggregation ntawm soterocytes hauv cov ntshav yog txo, uas ua rau muaj kev nce hauv cov ntshav fluidity. Lub caij no, kev tswj xyuas cov nyhuv ntawm intrifiban ntawm endothelial cell domain tseem pab txhim kho hemorheology. Piv txwv li, nws txhawb kev tso tawm vasodilators xws li NO los ntawm cov hlwb endothelial, ua rau vasodilation thiab txo cov ntshav tsis kam, ntxiv dag zog rau cov ntshav. Qhov kev txhim kho hauv cov ntshav rheology no pab tiv thaiv thrombois thiab txo qhov tshwm sim ntawm cov hlab plawv.
Los ntawm tshwj xeeb thaiv kev khi ntawm glycoprotein IIb / IIIa receptors rau fibrinogen, inhibiting qhov kev ua ntawm soterocyte activating yam, tswj endothelial cell domain, exerting anti- cov teebmeem inflammatory, thiab muaj kev cuam tshuam zoo ntawm hemorheology, ntau yam kev ua haujlwm tau zoo ua haujlwm rau inhibit card soterocytes thiab txhim kho cov kab mob ntawm cov kab mob, sau npe. Cov txheej txheem ntawm kev ua haujlwm no ua haujlwm ua ke thiab muab lub hauv paus zoo theoretical rau lawv daim ntawv thov hauv kev kho mob plawv. Nyob rau hauv kev kho mob, tag nrho nkag siab lub mechanism ntawm kev txiav txim ntawmeptifibatide peptide cov khoomtuaj yeem pab cov kws kho mob siv cov tshuaj kom tsim nyog, txhim kho kev kho mob kom zoo, thiab txo qhov kev pheej hmoo ntawm kev phiv tshuaj.
Cov ntaub ntawv xov xwm: 39 Tshuaj Tong, Minfukang.
Cim npe nrov: Tuam Tshoj eptifibatide peptide manufacturers, lwm tus neeg
