Atosiban 6.75 Mg, nws qhov hnyav molecular yog 994.19, molecular mis yog C35H49N11O9S2, CAS 90779-69-4. Nws yog tsim los ntawm 9 amino acids thiab yog disulfide txuas cyclic polypeptide nrog cov qauv zoo sib xws rau nobitocins, tab sis nrog kev hloov kho rau txoj haujlwm 1, 2, 4, thiab 8 ntawm cov qauv molecular ntawm nobitocins. Ib qho cysteine residue tau txais N-terminal deamination los tsim 3-mercaptopropionic acid, ob L-tyrosine residues raug hloov kho rau D-tyrosine, ethoxy hloov phenol, plaub threonine residues hloov glutamine, thiab yim ornithine residues hloov leucine.
Peb Cov Khoom Muag Khoom
Atosiban COA
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| Certificate of Analysis | ||
| Compound npe | Atosiban | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 188627-80-7 | |
| Ntau | 70g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090078 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia |
Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree |
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| Tshuaj Formula | C43H67N11O12S2 |
| Exact Mass | 993 |
| Molecular Luj | 994 |
| m/z | 993 (100.0%), 994 (46.5%), 995 (10.6%), 995 (9.0%), 996 (4.2%), 994 (4.1%), 995 (2.5%), 995 (1.9%), 994 (1.6%), 996 (1.1%) |
| Elemental Analysis | C, 51.95; H, 6.79; N, 15.50; O, 19.31; S, 6.45 |
Atosiban 6.75 mgyog ib qho khoom siv peptide khoom uas belongs rau nobitocins receptor antagonists thiab plays lub luag hauj lwm tseem ceeb nyob rau hauv lub teb ntawm obstetrics thiab gynecology, tshwj xeeb tshaj yog nyob rau hauv kev kho mob ntawm yug ntxov ntxov thiab pab reproductive technology.
Lub hauv paus ntsiab lus ntawm kev ua: Kev sib tw khi rau nobitocins receptors
Nws lub luag haujlwm tseem ceeb ntawm kev ua haujlwm yog nyob rau hauv nws lub peev xwm los sib tw khi rau nobitocins receptors ntawm daim nyias nyias ntawm lub tsev menyuam cov leeg nqaij. Nobitocins yog ib yam tshuaj uas tsim los ntawm hypothalamus thiab tso tawm los ntawm lub caj pas neuropituitary. Nws ua lub luag haujlwm tseem ceeb thaum yug me nyuam los ntawm kev khi rau nobitocins receptors ntawm lub tsev menyuam cov leeg nqaij, ua kom muaj ntau txoj hauv kev qhia, thiab thaum kawg ua rau lub tsev menyuam contractions. Nws muaj cov qauv zoo sib xws rau nobitocins thiab tuaj yeem khi rau nobitocins receptors ua ntej, tuav qhov chaw sib txuas ntawm cov receptor, yog li tiv thaiv kev sib khi ntawm nobitocins rau cov receptor. Qhov kev sib tw sib tw no tiv thaiv nobitocins los ntawm kev ua haujlwm ntawm kev ua kom lub plab contractions.
Li no inhibiting uterine contractions thiab ua tiav cov nyhuv ntawm kev tiv thaiv fetus.
Cov kev tshawb fawb cuam tshuam tau pom tias hauv kev kho mob ntawm kev yug ntxov ntxov, thaum cov poj niam cev xeeb tub muaj kev sib kis tsis tu ncua thiab lwm cov tsos mob yug ntxov ntxov, theem ntawm nobitocins hauv lub cev nce. Los ntawm kev sib tw losis tswvyim dabtsi rau nobitocins receptors, nws zoo txo qhov zaus thiab nro ntawm uterine contractions. Piv txwv li, hauv kev sim tshuaj, rau cov poj niam cev xeeb tub uas muaj kev mob plab tsis tu ncua ntawm 24-33 lub lis piam ntawm cev xeeb tub, qhov zaus ntawm cov qog nqaij hlav hauv tsev menyuam tau txo qis tom qab siv, uas muab lub sijhawm tseem ceeb rau kev txhim kho ntxiv ntawm tus menyuam hauv niam lub cev.
Cov ntaub ntawv ntawm qhov kev ua haujlwm no yog los ntawm ntau qhov chaw, suav nrog ntau cov ntaub ntawv tshawb fawb txog kev kho mob thiab cov vev xaib kev kho mob, xws li cov ntawv tshaj tawm hauv WeChat pej xeem platform (Tencent) thaum lub Cuaj Hlis 21, 2024, Lub Yim Hli 28, 2025, Lub Peb Hlis 21, 2026, thiab lwm yam, uas tau muab cov lus piav qhia ntxaws txog qhov no.
Intracellular signal transduction cuam tshuam: thaiv calcium ion tso tawm thiab qhib channel
Tom qab khi rau cov receptors, nobitocins pib ua cov txheej txheem teeb meem nyuaj hauv lub xov tooj ntawm tes, nrog rau cov kauj ruam tseem ceeb yog qhov kev txhawb nqa ntawm kev tsim cov inositol triphosphate (IP3). Raws li tus xa xov thib ob, IP3 tuaj yeem khi rau IP3 receptor ntawm endoplasmic reticulum, txhawb kev tso tawm calcium ions khaws cia hauv endoplasmic reticulum rau hauv cytoplasm. Meanwhile, extracellular calcium ions tuaj yeem nkag mus rau hauv lub cell los ntawm qhov hluav taws xob -gated calcium channels, ua rau muaj kev nce ntxiv hauv cov cellular calcium ion concentration.
Calcium ions yog cov cim qhia tseem ceeb uas ua rau lub plab cov leeg contraction, thiab kev nce hauv lawv cov concentration ua rau myosin lub teeb saw kinase (MLCK), phosphorylating myosin lub teeb saw thiab ua rau cov leeg nqaij sib zog.
Atoxiban sib tw khi rau nobitocins receptors, tiv thaiv cov txheej txheem teeb liab uas tau hais los ntawm nobitocins. Tshwj xeeb, nws inhibits tiam IP3, yog li txo qis cov calcium ions los ntawm endoplasmic reticulum thiab tiv thaiv qhov qhib ntawm qhov hluav taws xob -gated calcium channels, txo cov influx ntawm extracellular calcium ions.
Nyob rau hauv txoj kev no, cov calcium ion concentration ntawm intracellular tsis tuaj yeem nce mus rau theem txaus los ua kom lub plab contractions, thiab lub tsev menyuam cov leeg nqaij tseem nyob hauv lub xeev so. Cov kev sim tsiaj tau muab pov thawj muaj zog rau qhov kev ua haujlwm no. Tom qab txhaj tshuaj ntawm atosiban rau nas thiab guinea npua, khi rau nobitocins receptors tuaj yeem txo qhov mob plab thiab nro, inhibit plab contractions, thiab tsis muaj kev cuam tshuam rau cov hlab plawv. Qhov no qhia tau hais tias nws muaj peev xwm cuam tshuam nrog calcium signaling nyob rau hauv uterine smooth nqaij hlwb yam tsis muaj kev cuam tshuam rau lub cev ua hauj lwm ntawm lwm lub cev.
Cov txiaj ntsig kev tshawb fawb ntsig txog tuaj yeem pom hauv cov ntawv luam tawm hauv ChemicalBook thaum Lub Plaub Hlis 12, 2024, thiab Lub Peb Hlis 21, 2026.
Cov nyhuv ncaj qha rau ntawm lub tsev menyuam cov leeg nqaij: txo qhov nro thiab contraction zaus
Ntxiv nrog rau inhibiting plab contractions los ntawm kev cuam tshuam nrog intracellular signaling,6.75 mg tabkuj muaj kev cuam tshuam ncaj qha rau hauv plab cov leeg nqaij nws tus kheej. Nws tuaj yeem txo qhov nro ntawm lub tsev menyuam cov leeg nqaij thiab ua kom lub tsev menyuam nyob rau hauv lub xeev uas tau so. Thaum yug ntxov ntxov, lub tsev menyuam cov leeg nqaij yog nyob rau hauv lub xeev zoo siab heev, nrog nce nro, uas tuaj yeem yooj yim ua rau nquag thiab mob hnyav. Tom qab ua yeeb yam ntawm lub tsev menyuam du cov leeg.
Nws txo qhov excitability ntawm cov leeg nqaij los ntawm kev tswj cov ion tshuav nyiaj li cas thiab cov qauv cytoskeleton hauv cov leeg nqaij, yog li txo qis qhov contraction zaus ntawm cov leeg nqaij. Cov kev soj ntsuam soj ntsuam tau pom tias rau cov poj niam cev xeeb tub uas muaj kev hem thawj ua rau lub cev tsis muaj zog uas muaj lub plab tsis tu ncua thiab mob plab paroxysmal, qhov kev siv ntawm lub plab contractions yog txo qis thiab lub caij nyoog ntawm kev cog lus ntev dua tom qab siv.
Piv txwv li, qee zaum, cov poj niam cev xeeb tub yuav muaj ntau tshaj 4 qhov kev cog lus txhua 30 feeb ua ntej siv atosiban, nrog rau txhua qhov kev cog lus ntev li ntawm 30 vib nas this, lub ncauj tsev menyuam dilation ntawm 1-3cm (0-3cm rau cov poj niam primiparous), thiab lub ncauj tsev menyuam ploj ntau dua 50%; Tom qab siv, qhov zaus ntawm lub tsev me nyuam contractions poob mus rau 1-2 zaug ib 30 feeb, los yog tsawg dua, thiab qhov ceev ntawm lub ncauj tsev menyuam dilation thiab ploj lawm kuj ua rau qeeb qeeb, muab ib qho chaw ruaj khov rau tus me nyuam hauv plab.
Cov txheej txheem ntawm kev ua haujlwm no tau raug lees paub nyob rau hauv ntau qhov kev coj ua thiab kev tshawb fawb, thiab cov ntaub ntawv tseem ceeb tuaj yeem pom hauv cov ntawv luam tawm ntawm WeChat pej xeem platforms (Tencent) thaum Lub Ob Hlis 24, 2023 thiab Cuaj Hlis 21, 2024.
Kev sib cuam tshuam nrog lwm cov tshuaj hormones: khi rau vasopressin V1A receptor
Nws tsis tsuas yog khi rau nobitocins receptors, tab sis kuj rau vasopressin V1A receptors. Vasopressin yog ib yam tshuaj uas tsim los ntawm hypothalamus thiab tso tawm los ntawm cov qog nqaij hlav neuropituitary, uas muaj kev cuam tshuam ntawm cov hlab ntsha, ua kom ntshav siab, thiab txhawb nqa lub tsev menyuam. Thaum yug me nyuam, kev nce qib ntawm vasopressin tuaj yeem ua rau muaj kev cuam tshuam ntawm plab hnyuv. Tom qab khi rau vasopressin V1A receptor, nws tuaj yeem cuam tshuam qhov kev ua ntawm vasopressin, ntxiv txo cov stimulating yam ntawm lub tsev menyuam contractions.
Kev tshawb fawb pom tau hais tias vasopressin activates intracellular signaling pathways los ntawm kev khi rau V1A receptors ntawm lub tsev menyuam du nqaij, txhawb calcium influx thiab pab txhawb lub plab du nqaij contractility. Tom qab khi rau V1A receptor, nws thaiv txoj hauv kev ntawm kev txiav txim ntawm vasopressin, ua rau nws tsis tuaj yeem ua rau lub plab ua haujlwm. Qhov no ob lub tswv yim ntawm kev ua, uas ib txhij antagonizes cov teebmeem ntawm nobitocins thiab vasopressin, ua rau nws zoo dua nyob rau hauv inhibiting plab contractions.
Cov txiaj ntsig kev tshawb fawb ntsig txog tuaj yeem pom hauv cov ntawv luam tawm ntawm WeChat pej xeem platforms (Tencent) thaum lub Cuaj Hlis 21, 2024 thiab Lub Peb Hlis 21, 2026.
Lub mechanism ntawm kev txiav txim nyob rau hauv lub teb ntawm pab reproduction: txhim kho endometrial receptivity
Hauv kev pabcuam kev ua menyuam yaus, tshwj xeeb tshaj yog nyob rau hauv cov txheej txheem ntawm kev hloov embryo, nws kuj ua lub luag haujlwm tseem ceeb, thiab nws cov txheej txheem ntawm kev ua haujlwm feem ntau cuam tshuam txog kev txhim kho endometrial receptivity. Endometrial receptivity yog hais txog lub peev xwm ntawm lub endometrium kom txais embryos, thiab zoo endometrial receptivity yog ib qho tseem ceeb rau kev vam meej embryo implantation.
Kev tswj hwm ntawm zes qe menyuam hyperstimulation yog ib txoj hauv kev siv ntau hauv kev pabcuam kev ua me nyuam, tab sis txoj kev no tuaj yeem ua rau muaj kev nce qib hauv cov tshuaj estrogen hauv lub cev, uas ua rau muaj kev tsim cov tshuaj nobitocins ntau hauv lub tsev menyuam.
Ua rau muaj kev hloov pauv hauv tsev menyuam ua haujlwm uas yog li 6 npaug siab dua ua ntej lub voj voog ovulation.
Qhov siab no -mob lub tsev menyuam ntau zaus tsis tsuas yog cuam tshuam rau cov ntshav ntws ntawm endometrium, txo nws lub peev xwm los txais embryos, tab sis kuj tseem tuaj yeem tshem tawm cov embryos hloov mus rau hauv lub tsev menyuam. Kev tshawb fawb tau pom tias tsawg dua 50% ntawm embryos tuaj yeem nyob ruaj khov hauv plab kab noj hniav ib teev tom qab hloov embryo.
Raws li ib tug nobitocins receptor antagonist, nws muaj peev xwm inhibit lub plab contractions, txo peristaltic tsis nyob rau hauv lub endometrium, txhim kho cov ntshav txaus perfusion nyob rau hauv lub endometrium, thiab txhim khu lub endometrium lub peev xwm los txais embryos. Ntxiv rau,6.75 mg tabkuj tseem tuaj yeem txhawb txoj kev txiav txim siab ntawm endometrium los ntawm kev tswj cov noob qhia thiab cytokine secretion ntawm endometrial hlwb, tsim kom muaj ib qho chaw zoo rau microenvironment rau embryo implantation. Qee qhov kev tshawb fawb rov qab qhia tau tias rau cov viv ncaus uas tau hloov siab - embryos zoo rau ntau zaus tab sis tseem cev xeeb tub, qhov txawv txav hauv plab yog ib qho tseem ceeb rau kev txiav txim siab tom qab tsis suav nrog embryonic yam, endometrial organic kab mob thiab lwm yam. Tom qab siv, tus nqi cev xeeb tub ntawm qee cov neeg mob tau raug txhim kho.
Cov txiaj ntsig kev tshawb fawb ntsig txog tuaj yeem pom nyob rau hauv nthuav dav hauv tsab xov xwm luam tawm los ntawm Baijia thaum Lub Peb Hlis 2, 2026.
Cim npe nrov: Tuam Tshoj atosiban 6.75 mg manufacturers, lwm tus neeg
