Tsis ntev los no, peb ua tiav peb thawj zaug kev koom tes nrog cov neeg siv khoom German txog cov khoom peptide. Cov txheej txheem tag nrho yog du, thiab kev sib txuas lus ntawm ob tog tau zoo. Kev sib koom tes tau zoo heev. Cov khoom lag luam yuav los ntawm tus neeg siv khoom npog ntau yam peptide, suav nrogRetatrutide, TSI-31, MOTS-C, DSIP, Epitalon, etc., tag nrho 11 lub thawv. Tag nrho cov khoom tau ntim thiab sau npe raws li tus neeg siv khoom xav tau, thiab kev xa khoom tau ua tiav raws li lub sijhawm pom zoo. Tus neeg siv khoom tau qhia txog lawv qhov kev lees paub ntawm cov khoom lag luam zoo thiab tseem tau muab cov lus pom zoo rau kev npaj thauj khoom thiab tom qab- kev muag khoom. Raws li kev txiav txim mus sib hais, qhov kev koom tes no tau tsim lub hauv paus zoo rau kev sib txuas ntxiv hauv - kev koom tes tob. Peb yuav txuas ntxiv tswj xyuas cov khoom zoo thiab cov qauv kev xa khoom, thiab tswj hwm tus cwj pwm kev tshaj lij thiab ua haujlwm zoo los pab txhua tus neeg siv khoom zoo. Peb ua tsaug rau kev ntseeg siab ntawm cov neeg siv khoom German thiab tos ntsoov yuav txuas ntxiv thiab ruaj khov kev koom tes hauv kev tshawb fawb thiab kev noj qab haus huv ntau ntxiv -txog thaj chaw yav tom ntej.
kev lag luam
Nyob rau hauv lub hnub qub loj heev ntawm neuroscience, muaj ib lub hnub qub uas, tab sis tsis dazzling, illuminates ib tug frontier ntawm kev tshawb fawb pw tsaug zog nrog nws lub teeb tshwj xeeb. Nws yog DSIP-Delta Pw tsaug zog-Inducing Peptide, CAS naj npawb 62568-57-4, ib tug natural neuropeptide woven los ntawm cuaj amino acids, nrog ib tug molecular mis ntawm C₃₅H₄₄N₁₀O₁ 4 acid molecular. Cov kab ke yog WAGGDASGE, uas sawv cev rau tryptophan-alanine-glycine-glycine-aspartic acid-alanine-serine-glycine-glutamic acid. Lub npe anchors plaub lo lus "pw tsaug zog induction," tab sis ib nrab xyoo ntawm kev tshawb fawb tau ua pov thawj tias nws zaj dab neeg muaj ntau dua li plaub lo lus qhia.
Tracing qhov chaw: Pw messengers ntes los ntawm cov ntshav venous nyob rau hauv luav hlwb
Xyoo 1977, Swiss cov kws tshawb fawb Schoenberger thiab Monnier tau ua qhov kev sim ua pov thawj: lawv ua rau pw tsaug zog hauv cov luav los ntawm hluav taws xob stimulating lub nucleus ntawm thalamic medulla oblongata, thiab tom qab ntawd cais cov tshuaj nquag muaj peev xwm ua kom qeeb qeeb -yoj pw tsaug zog los ntawm hemorrhagic cerebralys. Thaum cov tshuaj no tau txhaj rau hauv cov tsiaj uas tsaug zog, cov yam ntxwv delta nthwv dej sai sai tshwm sim ntawm electroencephalogram- qhov no yog qhov tseeb ntawm electrophysiological cim ntawm kev pw tsaug zog. Qhov kev tshawb pom no tau luam tawm nyob rau hauv phau ntawv journal "Science" nyob rau hauv lub npe "Kev cais ntawm kev pw tsaug zog-inducing peptide los ntawm lub hlwb ntawm luav", officially ncaws tawm kev tshawb fawb ntawm DSIP.
DSIP tau pib pom nyob rau hauv cov ntshav ntawm luav thiab nas. Cov kev tshawb fawb tom qab tau lees paub tias nws muaj ntau nyob hauv cov ntaub so ntswg ntawm lub hlwb, cov kua cerebrospinal (CSF), thiab txawm tias ntshav ntshav. Txawm hais tias nws qhov concentration tsawg heev, xws li pg mus rau ng qib, nws ua lub luag haujlwm ntawm lub cev uas tsis tuaj yeem tsis quav ntsej. Qhov xav tsis thoob tshaj yog qhov kev tshawb pom ntawm DSIP-zoo li cov tshuaj hauv tib neeg cov kua mis, nrog rau qhov siab ntawm kwv yees li 10-30 ng / mL, qhia tias nws yuav koom nrog hauv kev tsim kho thaum ntxov ntawm cov menyuam mos pw tsaug zog. Los ntawm lub hlwb luav mus rau tib neeg cov mis nyuj, DSIP tiv thaiv kev pw tsaug zog zoo sib xws nyob rau hauv ib qho kev ntsiag to tsis tau ruaj khov.
Core function: deb tshaj "pab koj pw"
Txawm hais tias nws lub npe "pw tsaug zog induction", tom qab ze li tsib xyoos ntawm kev tshawb fawb tsub zuj zuj, qhov ua haujlwm ntawm DSIP tau ntev dhau los ntawm ib pawg ntawm kev txhawb nqa kev pw tsaug zog, dhau los ua ntau yam neeg uas ua rau kev pw tsaug zog, kev tiv thaiv neuroprotection, tiv thaiv - kev ntxhov siab, thiab kev tswj hwm endocrine.
Induce physiological pw tsaug zog
Lub peev xwm tseem ceeb ntawm DSIP yog los txhawb lub ntuj qeeb -wave pw (delta yoj pw). Tsis zoo li cov tshuaj sedative ib txwm siv -cov tshuaj hypnotic, DSIP tsis cuam tshuam rau hauv nruab nrab lub paj hlwb, tsis tsim cov nyhuv hangover, thiab tsis yog - nyob ntawm. Nws ua rau cov tsiaj sai sai ua rau qeeb -yoj pw tsaug zog los ntawm kev txhim kho GABA kev ua si thiab inhibiting NMDA receptors, thaum lub sij hawm luv luv kom tsaug zog thiab ua kom lub sij hawm pw tsaug zog ntev. Hauv kev sim tsiaj, tom qab txhaj tshuaj DSIP, qhov nce hauv qhov kev ua haujlwm ntawm cov ntxaiv nthwv dej thiab qhov qis qis hauv lub plawv dhia thiab lub ntsws ua pa tuaj yeem pom tau - qhov no yog qhov tseeb "kev pw tsaug zog" es tsis yog kev yuam kaw los ntawm cov tshuaj.
Kev tshawb fawb qhia tias DSIP muaj txiaj ntsig tshwj xeeb hauv kev kho kev ntxhov siab-txog insomnia, txo tus naj npawb ntawm kev pw tsaug zog thaum hmo ntuj, thiab pab cov neeg mob insomnia txhim kho lawv txoj kev pw tsaug zog. Qee qhov kev tshawb fawb kuj tau tshawb nrhiav nws lub luag haujlwm pabcuam hauv cov txheej txheem tshem tawm ntawm cov neeg quav yeeb quav tshuaj, pab txhim kho kev pw tsaug zog thiab zoo tag nrho- ua.
Tswj lub moos lom neeg thiab circadian atherosclerosis
DSIP tuaj yeem synchronize lub moos hypothalamic biological thiab tswj kev pw tsaug zog -Wake cycle disorders los ntawm jet lag, nyob lig, thiab ua haujlwm. Nws yog tswj hwm los ntawm glucocorticoids thiab nws cov concentration hloov nyob rau hauv cov kev ntxhov siab, koom nrog kev saib xyuas ntawm neuro-endocrine-immune homeostasis. Qhov sib sib zog nqus khi nrog circadian rhythms ua rau DSIP yog ib qho tseem ceeb ntawm cov cim molecular hauv kev tshawb fawb txog roj ntsha.
Anti-kev ntxhov siab thiab kev tiv thaiv neuroprotection
Hauv cov qauv nas kev ntxhov siab, cov koob tshuaj me me ntawm DSIP tuaj yeem txhim kho lub peev xwm antioxidant ntawm cov hlwb thiab txo kev puas tsuaj los ntawm oxidative kev nyuaj siab.
Nws tuaj yeem cuam tshuam qhov nce ntau ntawm cortisol nyob rau hauv cov xwm txheej kev ntxhov siab thiab txo qis kev ua siab ntev, yog li txo kev ntxhov siab thiab ntxhov siab.
Hauv cov qauv ntawm cerebral ischemia, hypoxia, thiab lub hlwb qaug zog, DSIP nthuav tawm cov khoom tiv thaiv neuroprotective los ntawm kev txo cov neuronal apoptosis thiab inhibiting excitotoxicity.
Tswj lub endocrine system
DSIP tuaj yeem tswj hwm qhov tso tawm ntawm cov tshuaj hormones loj hlob (GH), gonadotropins, thiab thyroid-stimulating hormone, thiab muaj peev xwm los txhim kho cov kab mob endocrine uas tshwm sim los ntawm kev ntxhov siab ntev thiab pw tsis txaus.
Qhov kev ua haujlwm no muab nws nrog qhov chaw tshawb nrhiav loj hauv kev tswj hwm kev noj qab haus huv tag nrho.
Kev txawj ntse muaj nuj nqi thiab tiv thaiv - cov nyhuv inflammatory
Cov kev tshawb fawb tsis ntev los no tau pom tias DSIP tuaj yeem txhim kho kev kawm thiab kev nco muaj peev xwm, txhim kho kev paub tsis meej, thiab nws cov txheej txheem yuav cuam tshuam nrog kev txhim kho ntawm synaptic plasticity.
Lub caij no, DSIP tuaj yeem tiv thaiv kev tso tawm ntawm cov kab mob inflammatory thiab alleviate neuroinflammatory cov tshuaj tiv thaiv, muab cov kev tshawb fawb muaj peev xwm rau cov kab mob neuroimmune- ntsig txog.
Tsis tas li ntawd, DSIP kuj muaj cov cuab yeej ntawm kev nce qhov mob, txo qhov mob ntev thiab mob neuropathic, ua rau nws tsim nyog rau kev saib xyuas hauv kev kho mob.
Mechanism ntawm kev txiav txim: ib tug meej network nthuav tawm
Cov txheej txheem ntawm kev ua ntawm DSIP tsis tau qhia meej meej, tab sis kev tshawb fawb tam sim no tau piav qhia ntau txoj hauv kev tseem ceeb:
Neurotransmitter kev tswj hwm txoj hauv kev: DSIP tswj kev pw tsaug zog- lub voj voog tsaug zog los ntawm kev cuam tshuam cov neurotransmitter systems xws li gamma-aminobutyric acid (GABA) thiab serotonin. Nws tsis tsuas yog "kaw" lub hlwb, tab sis theej ua raws li kev tswj hwm dav dav, ua rau muaj kev cuam tshuam me me tab sis kav ntev thoob plaws tib neeg thiab cov xwm txheej.
Hormonal regulatory pathway: DSIP cuam tshuam rau kev tso tawm ntawm cov tshuaj hormones xws li adrenocorticotropic hormone (ACTH) thiab melatonin, tsis ncaj qha tswj kev pw tsaug zog.
Receptor binding pathway: DSIP tuaj yeem ua rau muaj kev tiv thaiv kab mob neuroprotective thiab kev paub txog kev tswj xyuas los ntawm kev khi rau cov G protein tshwj xeeb-coupled receptors thiab ua kom cov kev taw qhia hauv qab.
Nws yog qhov tseeb no ntau- lub hom phiaj, ntau- txoj hauv kev ntawm kev nqis tes ua uas ua rau DSIP nrog cov nplua nuj ua haujlwm zoo li no. Nws tsis zoo li tus yuam sij qhib lub xauv, tab sis yog tus neeg xyuas pib tswj kev sib haum xeeb ntawm ntau lub tshuab xws li pw tsaug zog, mus ob peb vas, tiv thaiv kab mob, thiab endocrine.
Daim duab sib koom tes ntawm DSIP thiab lwm yam peptides
DSIP tsis ua haujlwm ib leeg. Nyob rau hauv lub molecular network ntawm kev tswj kev pw tsaug zog, nws tsim ib tug functionally complementary kev sib koom ua ke nrog melatonin (Melatonin), Selank, Semax, thiab lwm yam. GABA, raws li ib tug central inhibitory neurotransmitter, koom tes nrog DSIP ntawm pw tsaug zog - txhawb txoj kev; thaum txoj cai ntawm 5-hydroxytryptamine system los ntawm DSIP ua rau nws txoj kev sib tshuam nrog kev tiv thaiv- thaj chaw ntxhov siab. Daim duab no ntawm kev sib koom ua ke peptide muab lub hauv paus molecular-theem rau kev tsim cov kev daws teeb meem ntau dua rau kev pw tsaug zog thiab mob hlwb.
