Palmitoyl tetrapeptide-7 txhaj tshuajyog ib qho kev txhaj tshuaj me me uas ua kom zoo nkauj tsim nrog palmitoyl tetrapeptide-7 raws li cov khoom xyaw tseem ceeb thiab kev kho mob isotonic buffer tov. Nws yog lipophilic teeb liab peptide tiv thaiv- tus neeg saib xyuas kev laus nrog CAS tus lej 221227-05-0. Cov khoom xyaw nquag pib los ntawm cov amino acid fragment ntawm txoj haujlwm 341-344 ntawm cov saw hnyav ntawm tib neeg immunoglobulin G. Nws qhov chaw tseem ceeb nyob hauv kev txhim kho cov tawv nqaij laus thiab glycation - ntxias dullness. Hloov chaw ncaj qha txhawb nqa collagen neosynthesis, nws tso siab rau kev tiv thaiv kab mob thiab tiv thaiv glycation raws li txoj hauv kev tseem ceeb los rhuav tshem lub voj voog ntawm kev laus ntawm cov tawv nqaij, thaum kho cov qauv ntawm cov dermal extracellular matrix. Nws hais txog ntau yam kev txhawj xeeb ntawm daim tawv nqaij nrog rau kev yees duab, dullness los ntawm kev pw tsaug zog deprivation, post-inflammatory hyperpigmentation thiab aging rhiab cutis.
Peb Cov Khoom Muag Khoom
Palmitoyl tetrapeptide-7COA
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| Certificate of Analysis | ||
| Compound npe | palmitoyl tetrapeptide-7 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 221227-05-0 | |
| Ntau | 65g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090056 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.24% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.13% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.44% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 400 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 5 60ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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| Tshuaj Formula | C34H62N8O7 |
| Exact Mass | 694.47 |
| Molecular Luj | 694.92 |
| m/z | 694.47 (100.0%), 695.48 (36.8%), 696.48 (6.6%), 695.47 (3.0%), 696.48 (1.4%), 696.47 (1.1%) |
| Elemental Analysis | C, 58.77; H, 8.99; N, 16.13; O, 16.12 |
Molecular Mechanism ntawm Inflammatory Aging Inhibition
Core Pathogenesis ntawm Inflammatory Skin Aging
Cutis aging poob rau hauv peb pawg: chronological intrinsic ageing, photoageing thiab ntev inflammatory ageing. Ntawm lawv, tsis tshua muaj - qib o (inflammageing) ua raws li cov tub ntxhais zais zais ua kom nrawm cutis deterioration. Cov kab mob sab nraud xws li hluav taws xob ultraviolet, ib puag ncig muaj kuab paug, pw tsaug zog tsis txaus thiab qhov cuam tshuam ntawm cutis barrier qhib lub intracellular NF-κB nuclear transcription factor taw qhia txoj hauv kev hauv cutis hlwb, ua rau keratinocytes thiab dermal fibroblasts secrete ntau ntau ntawm pro-, inflammatory {9} tseem ceeb cytokines. (IL-6), interleukin-1 (IL-1) thiab qog necrosis factor- (TNF- ).
Tshaj pro-cov kab mob cytokines pib ua rau muaj kev cuam tshuam tsis zoo.
Ntawm ib sab, lawv upregulate cov lus qhia ntawm matrix metalloproteinases (MMP-1, MMP-3), uas ncaj qha degrade hom I thiab hom III collagen nrog rau elastic fibers nyob rau hauv lub dermis, ua rau cutis laxity thiab nplua kab. Ntawm qhov tod tes, lawv tsis tu ncua cuam tshuam cov epidermal barrier, tsis muaj zog ntawm daim tawv nqaij, thiab tsis muaj zog ntawm daim tawv nqaij. Loop: o → collagen poob → barrier puas → aggravated inflammatory.Pas anti- cov khoom laus tsuas yog rov ua dua collagen uas ploj lawm yam tsis thaiv cov dej ntws tawm, ua rau lub neej luv luv thiab rov qab los tiv thaiv kev laus. Piv txwv li,palmitoyl tetrapeptide-7 txhaj tshuajinhibits inflammatory activation nyob rau hauv lub upstream signaling txoj kev, fundamentally cuam tshuam lub inflammage voj voog.
Lub Hom Phiaj Txoj Cai ntawm NF-κB Txoj Kev los Thaiv Kab Mob Kab Mob Sib Kis
Hloov kho nrog cov pab pawg lipophilic palmitoyl, nws nkag mus rau hauv cell membranes sai heev kom nkag mus rau cytoplasm, qhov twg nws tshwj xeeb khi rau IκB kinase. Qhov kev khi no inhibits phosphorylation thiab degradation ntawm IκB cov proteins, ntxiv tiv thaiv kev hloov pauv ntawm cov NF-κB transcription factor thiab txiav tawm qhov transcriptional qhia ntawm inflammatory genes ntawm qhov chaw.
Nyob rau hauv vitro cellular assay cov ntaub ntawv qhia tau hais tias nyob rau hauv tib neeg cutis cell qauv stressed los ntawm UVA irradiation, nws nyob rau hauv concentrations ntawm 1-10 ppm txo cellular IL-6 secretion los ntawm 40%–60% thiab IL-8 secretion los ntawm 30% – 50%, nrog rau xoom cytotoxicity kev ua tau zoo. Tsis zoo li glucocorticoid cov tshuaj tiv thaiv kab mob, cov khoom siv no ua rau lub cev hloov kho lub cev tsis muaj zog tiv thaiv daim tawv nqaij lub cev tiv thaiv kab mob. Nws tsuas yog tshem tawm cov kab mob pathologically overactivated mob ntev, ntsuas qhov muaj zog tiv thaiv kab mob nrog rau kev tiv thaiv kab mob hauv lub cev.
Downregulation ntawm Matrix Metalloproteinases kom txo Collagen degradation
Pro-cov kab mob cytokines ua haujlwm raws li cov kab hluav taws xob ua kom muaj zog rau matrix metalloproteinases. Los ntawm kev txwv qhov kev tso tawm ntawm cov kab mob cytokines, nws tsis ncaj qha txo qis cov kev ua haujlwm enzymatic ntawm MMP tsev neeg thiab txo qis qis ntawm collagen fibers.
Reconstructed human epidermal cutis qauv kev ntsuam xyuas paub meej tias tom qab kev cuam tshuam nrog cov khoom no, MMP-1 qhia hauv UV-kev puas tsuaj cutis poob los ntawm 35% txheeb ze rau pawg tswj dawb paug, nrog kev khaws cia tseem ceeb ntawm dermal hom I collagen cov ntsiab lus. Meanwhile, peptide upregulates cov synthesis ntawm laminin V, hom IV collagen thiab hom VII collagen los txhawb cov dermoepidermal hlws ris qauv, kho kev puas tsuaj rau dermal reticular txheej los ntawm o. Nws muab peb npaug los tiv thaiv kev laus - cov txiaj ntsig kev laus: kev tswj kev mob, kev khaws collagen thiab kho qhov teeb meem, ameliorating inflammatory-induced redness, fragility, laxity thiab lwm yam aging manifestations.
Anti-Glycation & Brightening Efficacy thiab Mechanism
Kev sib raug zoo ntawm daim tawv nqaij glycation thiab glycation-Induced dull Aging
Daim tawv nqaij glycation yog qhov thib ob txoj kev laus loj uas tsis muaj qhov mob. Ntau cov piam thaj dawb hauv tib neeg cov ntshav thiab cov nqaij tawv nqaij ua rau tsis muaj -enzymatic glycation nrog collagen thiab elastin yam tsis muaj catalytic enzymes. Cov tshuaj tiv thaiv thawj zaug tsim cov khoom lag luam reversible thaum ntxov glycation, uas thaum kawg hloov mus rau irreversible advanced glycation kawg khoom (AGEs).
AGEs harden, embrittle thiab daj collagen fibers, depleting lawv elasticity thiab ya raws -locking peev xwm. Deposited nyob rau hauv lub epidermis, lawv ua rau lub cutis uniformly salllow, dull thiab tsis muaj luster - ib tug mob uas feem ntau hu ua "daj complexion". Tsis tas li ntawd, AGEs txuas ntxiv ua rau NF-κB txoj hauv kev inflammatory, tsim kom muaj ib qho kev sib tw superimposed -aging effect ntawm glycation ntxiv rau qhov mob uas ua rau cov tawv nqaij laus zuj zus.
Feem ntau cov tshuaj tiv thaiv -aging txhaj tshuaj nyob rau hauv lub khw tam sim no tsuas yog lub hom phiaj tiv thaiv -mob los yog collagen stimulation yam tsis muaj kev mob siab rau kev tiv thaiv -glycation pathways.Palmitoyl tetrapeptide-7 txhaj tshuajintervenes nyob rau hauv ob qho tib si inflammatory thiab glycation txoj kev ib txhij kom xa ua ke los tiv thaiv -aging thiab brightening tshwm sim.
Thaiv ntawm Glycation los Ncua AGE Tsim thiab Deposition
Xibtes -GQPR muaj cov glycation hauv nruab nrab- thaiv kev ua haujlwm. Nws sib tw khi dawb qabzib molecules nyob rau hauv cov ntaub so ntswg ntawm daim tawv nqaij, txo kev sib cuag ntawm qabzib thiab loj dermal structural proteins thiab inhibiting kev hloov ntawm glycation intermediates thaum ntxov mus rau mature AGEs.
Tsis tas li ntawd, peptide txhawb nqa kev ua haujlwm hauv lub cev ntawm cov tshuaj tiv thaiv kab mob antioxidant suav nrog superoxide dismutase thiab glutathione peroxidase, tshem tawm cov pa oxygen loj heev uas tau tsim thaum lub sij hawm glycation thiab cuam tshuam cov synergistic oxidative -glycation puas cascade. Tib neeg kev soj ntsuam kev sim qhia tias tom qab plaub lub lis piam sib law liag nrog kev kho mob. corneum ntawm cov ntsiab lus txo qis los ntawm qhov nruab nrab ntawm 22.7%, yielding cim kev txhim kho hauv sallow cutis tone.
Kev Tiv Thaiv Cov Kab Mob Ntshav Qab Zib rau Uniform, Luminous Complexion
Cov tawv nqaij dullness tshwm sim tsis tau tsuas yog los ntawm glycation- ntsig txog yellowing tab sis kuj post-inflammatory hyperpigmentation. Cov kab mob ntawm daim tawv nqaij ntev nkoos melanocytes kom overproduce melanin, ua rau lub ntsej muag pigmented me ntsis, suab tsis sib xws thiab dull post- pob txuv.
Los ntawm lub sij hawm ntev - kev tsub zuj zus ntawm cov kab mob hauv cov kab mob cutis, xibtes-GQPR curbs o-kev ua kom melanocyte nruab nrab thiab thaiv kev thauj melanin txawv txav.
Qhov txawv ntawm melanin ncaj qha - inhibiting cov khoom xyaw xws li niacinamide thiab arbutin, cov khoom no tsis tsom tyrosinase ncaj qha. Hloov chaw, nws tshem tawm melanin-inducing triggers ntawm inflammatory qhov chaw ntawm ib tug maj endogenous brightening mechanism uas tsis txhob irritant puas rau rhiab cutis. Tsis tas li ntawd, nws txhim kho cov microcirculation ntawm daim tawv nqaij thiab ua kom cov pa tawm ntawm cov kab mob epidermal metabolic pov tseg kom ntxiv dag zog rau daim tawv nqaij translucency, ua tiav ntau yam - qhov ci ci los ntawm qhov loj me nrog rau cov xim daj txo qis, lub ntsej muag zoo nkauj thiab ci ntsa iab.
Clinical Advantages of Dual-Pathway Synergistic Anti-Kev laus
Los ntawm kev koom ua ke dual anti-inflammatory thiab anti-glycation mechanisms,palmitoyl tetrapeptide-7 txhaj tshuajtsim kom muaj tag nrho -round endogenous los tiv thaiv- kev laus tiv thaiv kab mob tiv thaiv kab mob, glycation inhibition, collagen tiv thaiv thiab hyperpigmentation suppression, them nyiaj rau cov kev txwv ntawm ib zaug - muaj nuj nqi txhaj tshuaj.
Rau cov neeg mob nrog photoageing: nws alleviates inflammatory thiab oxidative puas tsuaj tshwm sim los ntawm ultraviolet hluav taws xob;
Rau salllow cutis tshwm sim los ntawm kev pw tsaug zog tsis txaus thiab siab - noj qab haus huv: nws zoo tshem cov glycation adducts kom rov qab dullness;
Rau cov txheej txheem cutis tsis yooj yim tom qab kev zoo nkauj: nws sai sai tshem tawm cov tshuaj tiv thaiv kab mob me me, txo qis tom qab- kho lub sijhawm rov qab thiab txo qhov kev pheej hmoo ntawm post- txheej txheem hyperpigmentation.
Piv nrog rau cov tshuaj pleev peptide formulations, cov tshuaj txhaj tshuaj ua ncaj qha rau ntawm daim tawv nqaij thaum hla lub stratum corneum barrier, accelerating pib ceev los ntawm 3-5 lub sij hawm thiab sustaining efficiency rau 14-21 hnub. Nws ua raws li cov kev xav tau ntawm cov neeg siv khoom niaj hnub no kom muaj txiaj ntsig zoo, ua kom zoo nkauj zoo nkauj los tiv thaiv - kev laus tsis muaj kev phom sij.
Synthetic txheej txheem
Khoom -theem peptide synthesis (SPPS) sawv cev rau kev lag luam thiab kev kho mob tseem ceeb - qib kev tsim khoom rau xibtes-GQPR, nrog rau cov txheej txheem txheej txheem rau kev tsim cov qib siab -purity injectable peptide raw khoom. Kev ua haujlwm tag nrho muaj plaub theem: amino acid sequence sib dhos, hloov pauv palmitoylation, cleavage thiab purification, thiab kev npaj lyophilized.
Amino acid ib ntus sib dhos: Rink-Amide resin ua lub luag haujlwm txhawb nqa. Fmoc-cov amino acids tiv thaiv tau txais cov tshuaj tiv thaiv kab mob ua ntu zus tom qab Gly-Gln-Pro-Arg tetrapeptide ib ntus. Coupling reagents pab txhawb kev tsim peptide daim ntawv cog lus kom maj mam tsim cov pob txha tetrapeptide. Deprotection yog nqa tawm tom qab txhua kauj ruam condensation los lav qhov tseeb peptide saw elongation.
Palmitoylation lipid hloov kho: Thaum ua tiav ntawm peptide saw sib dhos, ib qho palmitic acid fatty acid saw txuas rau N-terminus ntawm peptide txhawm rau txhim kho transdermal permeability thiab cellular affinity ntawm peptide.
Cleavage thiab purification: Trifluoroacetic acid cleavage solution cais cov crude peptide los ntawm cov resin thiab tshem tawm sab -chain tiv thaiv pawg. High-kev ua haujlwm ua kua chromatography (HPLC) yog siv rau kev ua kom huv si kom tshem tawm luv luv -peptide impurities thiab unreacted monomers, yielding injectable- qib xibtes-GQPR hmoov nrog purity ntau dua los yog sib npaug rau 98%.
Kev npaj txhaj tshuaj: High-purity peptide hmoov yog yaj nyob rau hauv kev kho mob phosphate buffered saline, raug sterile filtration thiab aseptic filling los tsim cov khoom txhaj tshuaj zaum kawg.
Cov txheej txheem hluavtaws no muaj cov tshuaj tiv thaiv uas tswj tau, cov khoom lag luam siab purity thiab tsawg tsawg los ntawm - cov khoom, ua tau raws li qhov zoo ntawm cov tshuaj zoo nkauj npaj rau kev tsis muaj menyuam, siab bioactivity thiab cov ntsiab lus tsis zoo. Nws tseem yog tus paub tab thiab dav saws kev lag luam hluavtaws rau hnub no.
Cov ntaub ntawv
- KnowYourPeptide Research Team. Palmitoyl Tetrapeptide-7: Dermal Cell Research thiab Skin Biology[R]. 2026, Tus kws kho mob tshuaj xyuas cov ntaub ntawv.
- Flossman E, et al. Sederma Technical Report: Los tiv thaiv - inflammatory mechanism ntawm palmitoyl tetrapeptide regulating NF -κB txoj kev [R] . 2004.
- Lintner K, et al. Cov tshuaj tiv thaiv -kev ua haujlwm inflammatory ntawm ib tug palmitoyl tetrapeptide hauv tib neeg keratinocytes[J]. Phau ntawv Journal of Cosmetic Science, 2010, 61(3): 245–252.
- Zhang Y, et al. Stimulation ntawm extracellular matrix synthesis los ntawm palmitoyl peptides nyob rau hauv dermal fibroblasts [J]. Experimental Dermatology, 2015, 24(8): 612–617.
- Li JH, et al. Anti-glycation thiab daim tawv nqaij brightening los ntawm palmitoyl tetrapeptide-7[J]. International Journal of Cosmetic Science, 2018, 40(5): 478–485.
FAQ
Nws ua li cas rau daim tawv nqaij?
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Nws muajcollagen{0}} txhawb nqa cov khoom uas tsom wrinkles thiab kab zoo. Nws kuj tseem pab kho cov tawv nqaij firmness thiab elasticity los ntawm kev txhawb nqa ntawm daim tawv nqaij cov qauv, ua rau lub ntsej muag firmer thiab hluas dua. Tsis tas li ntawd, cov peptide no paub txog nws cov tshuaj tiv thaiv - inflammatory thiab hydrating cov txiaj ntsig.
Lwm lub npe rau nws yog dab tsi?
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Ib qho ntawm ob lub peptides uas ua rau nto moo Matrixyl 3000 duo, nws yog ib qho zoo tshaj plaws -study cosmetic peptides. Kuj hu uaGQPRrau nws cov amino acid ib ntus, nws tuaj yeem pab txhawb kev tsim cov collagen, ua rau cov tawv nqaij firmer, smoother.
Cim npe nrov: Tuam Tshoj Palmitoyl tetrapeptide-7 txhaj tshuaj manufacturers, lwm tus neeg
