Myristoyl pentapeptide 17 rau kev loj hlob ntawm cov plaub hauyog ib qho khoom siv hluavtaws lipopeptide ua haujlwm raw khoom tau los ntawm covalent hloov kho ntawm myristic acid. Nws belongs rau qeb ntawm cov teeb liab hom kev ua haujlwm peptides hauv cov khoom siv tu tus kheej, nrog rau tus lej CAS rau npe ntawm 959610-30-1. Nws cov molecule sib txuas ua ke kaum plaub carbon saturated fatty acid saw nrog pentapeptide hydrophilic sib lawv liag los ntawm ruaj khov amide bonds, nrog rau ib kawg uas muaj ib tug hydrophobic penetrating nutmeg residue thiab lwm yam kawg uas muaj ib tug polar peptide ntu nqa lom lom. Qhov no amphiphilic molecular configuration endows nws nrog tshwj xeeb physicochemical zog thiab ua hauj lwm zoo uas txawv nws los ntawm zoo tib yam unmodified dej-soluble peptides.
Cov khoom siv raw no, nrog rau nws cov qauv tsim qauv molecular, muaj peev xwm sib sib zog nqus ntawm daim tawv nqaij, lub hom phiaj ntawm cov tawv taub hau pilus follicle conditioning effect, thiab kev sib raug zoo nrog ntau daim ntawv ntau npaum, tuaj yeem ua tau raws li qhov yuav tsum tau ua ntawm cov khoom siv kho mob pilus yam tsis tas yuav muaj kev hloov pauv ntxiv. Nws yog ib qho tseem ceeb active ingredient nrog zoo heev daim ntawv thov nqi nyob rau hauv tam sim no tawv taub hau los tiv thaiv shedding, pilus ntxiv dag zog rau thiab tu cov khoom. Raws li qhov tseem ceeb ntawm daim ntawv thov tus nqi ntawm cov khoom siv raw no, tsab xov xwm no pib los ntawm peb theem tseem ceeb: pilus follicle tsom rau kev nkag mus thiab cov yam ntxwv nkag, tawv taub hau pilus follicle lub voj voog txij nkawm kev ua tau zoo, thiab ntau qhov kev hloov pauv ntawm cov qauv kev ua haujlwm. Kev sib xyaw cov qauv molecular logic thiab formula application scenarios, cov ncauj lus kom ntxaws thiab ntau qhov kev xav hauv - qhov kev soj ntsuam tob yog ua tiav.
Peb cov khoom
Myristoyl Pentapeptide 17 COA
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| Certificate of Analysis | ||
| Compound npe | Myristoyl pentapeptide 17 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 959610-30-1 | |
| Ntau | Customized | |
| Ntim txheem | Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090055 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |  |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.36% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.24% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.80% |
| Ib leeg impurity | <0.8% | 0.37% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 80 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav, 2-8 degree | |
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| Tshuaj Formula | C41H81N9O6 |
| Exact Mass | 795.63 |
| Molecular Luj | 796.16 |
| m/z | 795.63 (100.0%), 796.63 (44.3%), 797.64 (9.6%), 796.63 (3.3%), 797.63 (1.5%), 797.64 (1.2%) |
| Elemental Analysis | C, 61.85; H, 10.26; N, 15.83; O, 12.06 |
Myristoyl pentapeptide 17 muab lipid saw hloov kho rau qhov tob pilus follicle nkag thiab cov yam ntxwv permeability
Sib txawv los ntawm cov kev txwv ntawm qhov chaw khaws cia thiab kev ua haujlwm sib sib zog nqus qis feem ntau pom muaj nyob hauv cov dej ntshiab ib txwm muaj -soluble peptides,myristoyl pentapeptide 17 rau cov plaub hau loj hlobyog hloov kho los ntawm covalent qauv ntawm davhlau ya nyob twg kaum plaub carbon saturated fatty acids. Thaum khaws cov kev ua si lom neeg ntawm cov tub ntxhais peptide ntu, nws tawg los ntawm kev txwv permeation ntawm qhov ntom ntom keratin barrier thiab txoj hauv kev sib sib zog nqus pilus follicle, thiab tuaj yeem txav mus los ntawm cov kab noj hniav ntuj thiab lipid qhov khoob kom raug mus txog qhov chaw ua haujlwm tseem ceeb ntawm pilus follicle. Los ntawm qib tsim qauv molecular, nws daws qhov teeb meem tshwm sim ntawm tsis txaus transdermal efficiency ntawm peptide cov ntaub ntawv.
01.Txoj kev nkag mus rau qhov khoom plig ntawm daim tawv nqaij stratum corneum barrier:
Tib neeg epidermal stratum corneum tsim lub hauv paus tiv thaiv kev tiv thaiv nrog classic "cib tshauv" architecture, nrog keratinocytes raws li cov txheej txheem cib thiab intercellular lipids muaj li ntawm ceramides, cholesterol, thiab dawb fatty acids li nplaum mortar, tsim ib tug ntom hydrophobic tiv thaiv network. Ordinary peptide molecules nrog cov polarity muaj zog muaj roj tsawg -dej faib coefficient, ua rau nws nyuaj rau embed rau hauv lipid bilayer qauv. Feem ntau ntawm lawv tsuas yog maj mam diffuse los ntawm qhov nqaim heev ntawm tes thiab tau yooj yim decomposed thiab inactivated los ntawm ntog metabolic enzymes. Qhov kev faib ua feem ntawm cov dej num uas tuaj yeem nkag mus rau hauv stratum corneum thiab nkag mus rau hauv cov txheej txheem sib sib zog nqus yog qhov tsawg heev. Cov pab pawg neeg nutmeg belongs rau cov kab nruab nrab ntev ntev hydrophobic lipid qauv, uas tuaj yeem tso siab rau cov ntsiab lus zoo sib xws thiab soluble physicochemical kom ntseeg nkaws rau hauv lipid gap qauv ntawm stratum corneum. Los ntawm passive diffusion, qhov cuam tshuam ntawm qhov cuam tshuam ntawm epidermal barrier yog maj mam tsis muaj zog, ua kom tiav cov qauv peptide kom nkag mus rau hauv stratum corneum thiab nkag mus rau cov txheej txheem epidermal, tso lub hauv paus rau kev tsiv teb tsaws tom qab mus rau thaj chaw dermis thiab pilus follicle.
02.Targeted tob infiltration raws cov plaub hau follicle channel
Ntxiv rau txoj hauv kev tseem ceeb ntawm kev nkag mus los ntawm cov kab mob epidermis, qhov qhib ntawm pilus follicle tsim ib qho kev cuam tshuam ntawm permeation channel nyob rau hauv daim tawv nqaij, nrog qis tsis kam tshaj qhov ntom stratum corneum, ua rau nws muaj txiaj ntsig shortcut rau cov khoom xyaw nquag mus txog qhov tob dermis. Cov peptide molecule no tuaj yeem nkag mus rau hauv cov kab noj hniav ntuj ntawm pilus follicle qhib, siv nws lipophilic kawg kom cuam tshuam nrog sebum thiab lipid membrane ntawm pilus follicle phab ntsa. Nws tsis tu ncua infiltrates downwards raws qhov zoo sib txawv ntawm lub pilus ncej thiab lub pilus follicle phab ntsa, sequentially dhau los ntawm lub funnel thiab isthmus lug ntawm lub pilus follicle, tsis txhob metabolic poob thiab barrier obstructive ntawm lub epidermal txheej, thiab ncaj qha mus txog lub core functional cheeb tsam ntawm lub dermal papilla follicle. Txoj kev nkag mus no muaj qib siab ntawm cov ntaub so ntswg lub hom phiaj, uas tuaj yeem ua kom pom tseeb ntawm cov tub ntxhais cellular lub hom phiaj ntawm kev txhim kho pilus txoj cai, ua kom muaj txiaj ntsig zoo hauv cheeb tsam ntawm pilus follicle, thaum txo qhov kev faib tawm ntawm cov khoom xyaw nquag hauv cov ntaub so ntswg uas tsis yog lub hom phiaj, txhim kho qhov tseeb thiab kev ua haujlwm ntawm qhov kev txiav txim.
03.Piv rau qhov ua tau zoo ntawm cov peptides zoo tib yam
Cov dej tsis hloov pauv tsis zoo- soluble peptides raug txwv los ntawm ntau yam xws li molecular polarity, spatial loj, thiab thaiv kev nkag mus, ua rau nws yuav luag tsis tuaj yeem ncav cuag qhov tob dermal papilla cov ntaub so ntswg ntawm pilus follicles. Feem ntau ntawm cov dej num yog khaws cia nyob rau hauv lub superficial txheej ntawm lub stratum corneum thiab sai metabolized, ua rau ib tug ntiav thiab tsis muaj zog cov nyhuv. Lub liposoluble hloov qauv ntawmmyristoyl pentapeptide 17 rau cov plaub hau loj hlobdaws cov kev lag luam cov ntsiab lus mob ntawm qhov nyuaj transdermal nkag thiab sib sib zog nqus lub hom phiaj enrichment peptide raw cov ntaub ntawv los ntawm kev xav ntawm molecular tsim. Nws cov pilus follicle lub hom phiaj kev xa khoom tuaj yeem txhim kho tau zoo dua piv rau cov peptides tsis hloov pauv ntawm tib lub sijhawm, thiab lub sijhawm khaws cia ntawm lub hom phiaj kev ua haujlwm kuj tseem ntev. Tsis zoo li cov peptides zoo tib yam uas tso siab rau kev nkag mus rau sab nraud thiab cov txheej txheem qhia lub cev kom ua tiav cov txiaj ntsig sib sib zog nqus, cov khoom xyaw no tso siab rau nws tus kheej cov qauv molecular kom ua tiav cov khoom xa tuaj zoo yam tsis tas yuav tsum tau ntxiv cov khoom ntxiv rau qhov khaus, ua tiav qhov sib npaug ntawm kev ua tau zoo thiab kev siv me me.
Lub hom phiaj kev tswj hwm ntawm pilus follicles rau kev tu tawv taub hau thiab kev txhim kho pilus zoo
Raws li cov txiaj ntsig tseem ceeb ntawm kev sib sib zog nqus pilus follicle infiltration, qhov peptide tivthaiv no tuaj yeem cuam tshuam rau lub cev kev ua haujlwm ntawm pilus follicles, thiab tswj kev loj hlob zoo, pilus zoo li, thiab pilus follicle ciaj sia taus ntawm tawv taub hau pilus. Nws yog qhov tsim nyog rau cov kev xav tau ntawm ntau yam tawv taub hau thiab cov khoom siv los tiv thaiv pilus.
Extending lub ntuj loj hlob voj voog ntawm pilus
Txoj kev loj hlob thiab so hauv lub xeev ntawm cov hauv paus plaub hau ncaj qha txiav txim siab qhov kev loj hlob thiab txo qis ntawm pilus. Cov khoom xyaw no tuaj yeem maj mam cuam tshuam rau hauv lub cev ntawm lub cev ntawm pilus follicles, zoo ncab lub sijhawm ntawm lub sijhawm loj hlob ntawm pilus, txo qhov kev faib ua feem ntawm lub sijhawm so ntawm pilus follicles, awaken dormant pilus follicles, thiab tso cai rau ntau pilus follicles kom muaj kev loj hlob tsis tu ncua thiab nquag.
Txhim kho zoo thiab mos pilus tsis xws luag
Nyob rau hauv teb rau cov teeb meem ntawm congenital nplua thiab mos pilus, cov hauv paus hniav tsis txaus, thiab flattened thiab nyias pilus,myristoyl pentapeptide 17 rau cov plaub hau loj hlobmuaj peev xwm tswj cov kev ua ntawm pilus follicle hlwb, optimize lub synthesis efficiency ntawm pilus structural tshuaj, solidify lub hauv paus qauv ntawm pilus shafts, txhim khu lub fullness thiab kev txhawb nqa ntawm ib tug neeg pilus strands, thiab fundamentally txhim kho cov tsos ntawm zoo thiab mos pilus adhesion, tawv taub hau adhesion, thiab tsis txaus fluffiness.
Kev ua haujlwm ruaj khov pilus follicle thiab txo qis qhov tshwm sim
Daim ntawv thov ntev tuaj yeem txhim kho microenvironment ntawm pilus follicle ciaj sia, txhim khu kev loj hlob thiab kev ua siab ntev ntawm pilus follicle hlwb, alleviate qhov teeb meem ntawm pilus follicle tsis muaj zog los ntawm lwm tus neeg ib puag ncig stimuli thiab metabolic poob, zoo txhim kho tag nrho cov ciaj sia taus ntawm pilus follicles, thiab txo cov teeb meem xws li cov kab mob sib kis. pilus loss.
Cov ntaub ntawv
Zhang Yuqing, Liu Jianing Kev Tshawb Fawb ntawm daim ntawv thov txheej txheem thiab cov qauv ntawm kev ua haujlwm lipopeptides hauv tawv taub hau pilus follicle txij nkawm Txhua Hnub Kev Lag Luam Tshuaj, 2023, 53 (8): 526-531
Hwang J, Park S. Penetration mechanism thiab pilus follicle targeting effect ntawm myristoylated peptide derivatives. Phau ntawv Journal of Cosmetic Science, 2022, 73(4): 211-218.
Chen Zeyu Kev Tshawb Fawb txog kev sib raug zoo thiab kev ruaj ntseg ntawm peptide anti stripping active cov khoom xyaw hauv formulations Fine and Specialty Chemicals, 2024, 32 (2): 45-50
FAQ
Q1: Puas muaj qhov sib txawv ntawm kev saib xyuas ntawm cov tshuaj zawv plaub hau uas muaj myristoyl pentapeptide-17 thiab cov neeg nyob hauv cov ntsiab lus?
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Muaj qhov sib txawv tseem ceeb hauv kev ua tau zoo ntawm ob. Cov tshuaj zawv plaub hau yog luv luv - lub sij hawm ntxuav cov khoom, nrog cov khoom xyaw uas nyob ntawm tawv taub hau rau lub sijhawm luv luv. Nws tsuas tuaj yeem ua lub luag haujlwm tseem ceeb hauv stabilizing cov hauv paus plaub hau thiab me ntsis ntxiv dag zog rau cov plaub hau; Thaum cov plaub hau tu cov ntsiab lus, tawv taub hau ampoule thiab lwm yam khoom siv nyob hauv tuaj yeem ua rau cov khoom xyaw lo rau ntawm tawv taub hau ntev thiab txuas ntxiv mus, uas tuaj yeem ua tau zoo dua rau lub sijhawm loj hlob ntawm cov hauv paus plaub hau, txhim kho cov plaub hau kev ntxhib los mos, thiab ntev - lub sij hawm tu thiab tiv thaiv stripping nyhuv yuav zoo dua.
Q2: Cov khoom xyaw no tso siab rau nws tus kheej cov qauv kom ua tiav qhov tob tob. Puas yog nws tsim nyog rau cov tawv taub hau rhiab nrog kev puas tsuaj?
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Lub permeation ntawm myristoyl pentapeptide-17 tso siab rau nws tus kheej lub cev muaj zog, tsis tas yuav muaj kev txhawb nqa permeation mediators. Cov khoom molecular yog me me thiab ruaj khov, thiab yuav tsis ua kom cov tawv nqaij puas tsuaj. Nws cov txheej txheem nkag mus yog me me thiab tsis cuam tshuam, tsom rau cov plaub hau follicle nkaus xwb yam tsis muaj kev puas tsuaj rau saum npoo keratin qauv ntawm tawv taub hau. Nws tuaj yeem siv tau los ntawm cov tawv taub hau rhiab heev thiab cov neeg muaj kev cuam tshuam tsis zoo, thiab tsim nyog rau kev saib xyuas tawv taub hau ntawm ntau hom tawv nqaij.
Q3: Puas yog qhov dav - spectrum formula compatibility ntawm cov khoom xyaw no txhais tau tias nws tuaj yeem sib xyaw ua ke nrog txhua cov khoom xyaw ntxuav thiab tu?
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Nws cov mis muaj kev sib raug zoo heev tab sis tsis txwv kev sib xyaw ua ke, haum rau feem ntau ntawm cov pa moisturizing, nourishing, thiab soothing active cov khoom xyaw. Txawm li cas los xij, nws yog ib qho tsim nyog yuav tsum tsis txhob ua ke nrog cov khoom muaj zog acidic thiab alkaline. Ib puag ncig acidic thiab alkaline heev tuaj yeem ua rau cov qauv molecular ntawm nws niam nws txiv, ua rau tsis ua haujlwm ntawm nws cov permeability thiab kev saib xyuas zoo. Tsuav yog cov mis tswj tau cov kua qaub me me - puag ncig, nws tuaj yeem ua kom ruaj khov nrog cov plaub hau thiab cov khoom siv tu plaub hau feem ntau thiab ua tiav cov txiaj ntsig zoo.
Cim npe nrov: myristoyl pentapeptide 17 rau cov plaub hau kev loj hlob, Tuam Tshoj myristoyl pentapeptide 17 rau cov plaub hau kev loj hlob manufacturers, lwm tus neeg
