Ib qho Kev Txiav Txim Rau Peptide Raw Material Hmoov Los Ntawm Ib Tus Neeg Siv Khoom Lavxias

Tsis ntev los no, peb tau txais kev txiav txim los ntawm cov neeg siv khoom hauv tebchaws Russia. Cov neeg yuav khoomTIAB SA 9604thiabGHK-CUraw khoom hmoov, thiab teev tshwj xeeb ntim yuav tsum tau. Lawv thov kom AOD 9604 hmoov muab faib ua plaub feem.
Peb nruj me ntsis ua raws li cov neeg siv khoom xav tau los ua haujlwm. Peb raug ntim cov AOD 9604 hmoov kom ntseeg tau tias txhua pob tau raws li cov qauv. Tom qab lub ntim tiav lawm, peb muab cov duab ntawm cov khoom ntim thiab xa cov duab rau cov neeg siv khoom kom paub meej txog cov xwm txheej ntim khoom. Tom qab ntawd, peb tau ntim cov khoom kom zoo thiab npaj xa lawv mus rau tus neeg siv khoom qhov chaw nyob. Tag nrho cov txheej txheem aims kom muaj kev ruaj ntseg thiab kev nyab xeeb ntawm cov khoom thaum lub sij hawm thauj mus los, thiaj li ua tau raws li cov neeg siv khoom xav tau.

AOD 9604 yog ib qho khoom siv peptide fragment uas muaj 30 amino acid residues. Nws cov qauv tshuaj yog muab los ntawm C- thaj tsam thaj tsam ntawm tib neeg kev loj hlob hormone (amino acids 176-191), nrog rau tyrosine residues ntxiv los txhim kho kev ruaj ntseg. Raws li "lipolytic domain" ntawm kev loj hlob hormone, AOD 9604 yog tsim los rau lub hom phiaj thiab tswj cov roj metabolism. Nws cov txheej txheem tseem ceeb nyob rau hauv kev ua kom muaj roj tawg (lipolysis) thiab inhibiting rog ntau lawm, thaum tsis txhob muaj cov kab mob endocrine tshwm sim los ntawm kev kho cov tshuaj hormones loj hlob.

Kev tshawb nrhiav keeb kwm yav dhau thiab kev tshuaj xyuas tshuab

Thaum xyoo 1990s lig, cov kws tshawb fawb tau siv cov noob hloov kho thev naus laus zis los cais cov ntu tshwj xeeb hauv hGH uas yog lub luag haujlwm rau cov roj metabolism. Lawv pom tias ntu no (xws li AOD 9604) tuaj yeem ua haujlwm ntawm nws tus kheej ntawm kev loj hlob hormone receptor. Cov kev sim tsiaj tau pom tias AOD 9604 txhim kho qhov kev qhia ntawm lipolytic receptors hauv cov ntaub so ntswg adipose, txhawb kev tawg ntawm triglycerides rau hauv cov roj fatty acids dawb, thaum inhibiting cov haujlwm ntawm cov noob ntsig txog kev sib txawv ntawm cov roj ntsha sib txawv, yog li txo cov rog rog. Tsis zoo li qhov ua tiav cov tshuaj hormones loj hlob, AOD 9604 tsis txhawb kev tso tawm ntawm insulin -zoo li kev loj hlob zoo -1 (IGF-1), yog li zam tsis txhob muaj kev pheej hmoo metabolic xws li ntshav qab zib siab thiab insulin tsis kam uas yuav tshwm sim los ntawm kev siv cov tshuaj loj hlob mus ntev.

Kev tshawb fawb soj ntsuam thiab kev soj ntsuam kev nyab xeeb

Hauv kev sim tshuaj thaum ntxov, AOD 9604 tau qhia txog cov txiaj ntsig tseem ceeb hauv cov qauv nas rog rog: thaum noj qhov ncauj ntawm koob tshuaj 500 micrograms ib kilogram rau 19 hnub sib law liag, AOD 9604 txo qhov hnyav nce ntawm cov nas rog rog los ntawm ntau dua 50%, thaum txhim kho kev qhia ntawm cov roj oxidation. Hauv kev sim tib neeg, tom qab ib qho kev tswj hwm qhov ncauj ntawm 1 milligram ntawm AOD 9604, cov tsos mob ua npaws (xws li hnoos thiab ua npaws) tau txo qis hauv 24 teev, qhia tias nws tuaj yeem cuam tshuam kev tiv thaiv kab mob los ntawm kev tswj cov kab mob metabolic. Txawm li cas los xij, tom qab loj- nplai Phase IIb kev sim tshuaj tsis tuaj yeem rov ua dua qhov kev poob phaus, ua rau ncua kev loj hlob. Txawm li cas los xij, AOD 9604 tseem raug cais raws li cov khoom txwv tsis pub los ntawm cov koom haum tiv thaiv -doping, uas cuam tshuam txog qhov tsis sib haum xeeb ntawm nws txoj kev tswj hwm metabolic muaj peev xwm hauv kev sib tw kis las.

Daim ntawv thov teb thiab cov lus qhia yav tom ntej

Tam sim no, AOD 9604 feem ntau yog siv los ua cov cuab yeej tshawb fawb los tshawb txog cov txheej txheem molecular ntawm cov nqaijrog metabolism. Piv txwv li, nyob rau hauv ib tug luav qauv ntawm lub hauv caug sib koom tes osteoarthritis, intrajoint kab noj hniav txhaj tshuaj ntawm AOD 9604 ua ke nrog hyaluronic acid tuaj yeem txhawb nqa pob txha mos, thiab nws cov txiaj ntsig zoo dua li ntawm ib qho - kev kho mob. Ntxiv mus, daim ntawv thov muaj peev xwm ntawm AOD 9604 nyob rau hauv cov cheeb tsam xws li kho pob txha mos thiab kev tswj cov kab mob metabolic tseem tab tom tshawb nrhiav. Txawm hais tias nws tseem tsis tau pom zoo los ntawm cov koom haum tswj hwm rau kev kho mob, nws lub hom phiaj tsim muab cov ntaub ntawv tseem ceeb rau kev txhim kho cov tshuaj tiv thaiv tshiab - rog rog.

GHK-Cu (ib txwm tshwm sim tripeptide- tooj liab complex, hu ua "blue tooj liab peptide" vim nws cov xim xiav hauv cov kua dej) yog tooj liab - khi tripeptide compound. Xyoo 1973, biochemist Loren Picard tau cais GHK tripeptide los ntawm tib neeg cov ntshav thawj zaug thiab pom tias nws muaj kev sib raug zoo rau tooj liab ions thiab tuaj yeem tsim ib qho bioactive GHK-Cu complex. Qhov kev tshawb pom no tau qhib ntau daim ntawv thov ntawm tooj liab peptides hauv thaj chaw xws li kev kho mob zoo nkauj thiab kho cov ntaub so ntswg.

GHK-Cu yog tsim los ntawm kev sib txuas ntawm peb amino acids - glycine, histidine, thiab lysine - los ntawm peptide bonds. Nws kuj tsim ib qho chaw ruaj khov nrog tooj liab ions (Cu²⁺) los ntawm lub nplhaib imidazole ntawm histidine sab saw thiab nitrogen atom hauv peptide daim ntawv cog lus. Cov qauv no endows GHK-Cu nrog ntau yam kev ua haujlwm lom neeg:

 

 

Txij li thaum xyoo 1999, thaum muaj qee lub tuam txhab tau tshaj tawm cov tshuaj tiv thaiv - cov tshuaj tiv thaiv kev laus uas muaj GHK-Cu, cov khoom xyaw no tau siv dav hauv cov khoom tu tawv nqaij xws li cov ntshav qab zib thiab lub qhov ncauj qhov ntswg. Cov kev tshawb fawb soj ntsuam tau lees paub tias kev siv cov tshuaj nplaum uas muaj GHK-Cu rau 12 lub lis piam sib law liag tuaj yeem txhim kho daim tawv nqaij laxity, kab zoo thiab pigmentation. Nws cov txiaj ntsig yog qhov zoo tshaj plaws ntawm cov tshuaj tiv thaiv kev laus - cov khoom xyaw xws li vitamin C. Txhawm rau kov yeej cov teeb meem ntawm GHK-Cu ua rau tsis muaj zog thiab nkag mus tsis zoo, cov kws tshawb fawb tau tsim cov thev naus laus zis xws li liposome encapsulation thiab nano carriers. Piv txwv li, GHK{11}}Cu liposomes npaj los ntawm txoj kev rov qab evaporation tuaj yeem ua rau muaj kev ruaj ntseg ntau dua 40%.

Daim ntawv thov ntawm GHK-Cu tau dhau mus dhau qhov kev zoo nkauj thiab tau txuas ntxiv mus rau kev kho mob thiab biotechnology teb.

Kho qhov txhab mob

Cov kev hnav khaub ncaws ntse uas muaj GHK-Cu tuaj yeem ua kom kho tau qhov nyuaj ntawm -kom- kho qhov txhab xws li mob ntshav qab zib ko taw los ntawm nws cov tshuaj tua kab mob antioxidant, tiv thaiv- mob thiab tshuaj tua kab mob.

Kev kho mob pulmonary fibrosis

Cov kev sim tsiaj tau pom tias GHK-Cu tuaj yeem cuam tshuam bleomycin-induced pulmonary fibrosis thiab txo cov theem ntawm inflammatory yam, muab txoj kev kho mob rau cov kab mob ntsws interstitial.

Hom tshiab ntawm biomaterial

Kev sib txuas thev naus laus zis ntawm GHK-Cu thiab 316L kev kho mob stainless hlau tuaj yeem tswj hwm nws cov haujlwm metabolic hauv cov xwm txheej ua neej nyob, nthuav dav nws cov peev xwm siv hauv cov khoom siv hnav.

AOD 9604 thiab GHK-Cu feem ntau sawv cev rau kev siv tshiab ntawm cov peptides hluavtaws thiab cov peptides ntuj hauv thaj chaw biomedicine. Cov qub tshawb nrhiav txoj hauv kev tshiab rau kev tiv thaiv- rog dhau los ntawm kev tsom cov roj metabolism, thaum lub sijhawm tom kawg tau dhau los ua "lub hnub qub muaj khoom" hauv kev zoo nkauj thiab cov tshuaj kho dua tshiab vim nws cov khoom siv ntau- cuam tshuam kev kho. Txawm hais tias ob qho tib si ntsib cov teeb meem hauv kev kho mob txhais lus, lawv cov txiaj ntsig kev tshawb fawb thiab kev lag luam muaj peev xwm txuas ntxiv thawb cov ciam teb ntawm peptide kev tshawb fawb thiab kev loj hlob, coj ntau txoj hauv kev rau tib neeg kev noj qab haus huv thiab kev zoo nkauj.