Yuav ua li cas 5 Amino 1MQ Peptide Targets NNMT Pathway

Cov tshuaj tshiab uas cuam tshuam li cas cov hlwb ua kom lub zog tau txais kev saib xyuas ntau dua vim tias muaj kev txaus siab rau kev ua haujlwm hauv metabolic. 5 amino 1MQ peptide yog ib qho ntawm cov tshuaj tshiab no uas tau txais kev pom zoo los ntawm cov kws tshawb fawb thiab kws kho mob vim tias txoj kev ua haujlwm. Cov tshuaj no ua haujlwm los ntawm kev mus tom qab qee cov enzymes uas tseem ceeb heev rau yuav ua li cas cov hlwb tswj lub zog thiab cov txheej txheem methylation. Tshawb nrhiav kev sib txuas ntawm cov peptide no thiab nws lub hom phiaj ntawm tes yog qhov muaj txiaj ntsig zoo rau kev tsim cov kev daws teeb meem kev noj qab haus huv metabolic. Cov kws tshawb fawb tau pom tias qee txoj kev enzymatic muaj qhov cuam tshuam loj rau lub cev txuag thiab siv zog li cas. Ib qho ntawm cov kab ke no yog nicotinamide N-methyltransferase txoj hauv kev, uas cuam tshuam rau txhua yam ntawm cov tshuaj methylation ntawm cov hlwb mus rau qhov ceev ntawm cov metabolism. Thaum cov txheej txheem no ua haujlwm hnyav dhau, nws tuaj yeem ua rau muaj teeb meem ntawm tes. Kev tshawb pom tias qee cov molecules me tuaj yeem hloov txoj hauv kev no tau ua rau muaj kev kawm ntau ntxiv thiab kev loj hlob hauv kev tshawb fawb ntawm metabolic. Daim ntawv no saib ntawm kev sib raug zoo ntawm 5-amino-1MQ peptide thiab enzyme uas nws lub hom phiaj. Nws kuj tseem saib seb qhov kev sib raug zoo no cuam tshuam li cas rau cov tshuaj ua haujlwm ntawm cov hlwb. Txawm hais tias koj ua haujlwm rau kev lag luam kws tshuaj uas xav tau cov khoom xyaw tshuaj muaj txiaj ntsig zoo lossis cov pab pawg tshawb fawb uas xav tau kev txheeb xyuas cov yam ntxwv ntxaws ntxaws, koj yuav tsum nkag siab txog cov txheej txheem no txhawm rau txhawm rau txhawm rau txhawm rau txhim kho koj txoj haujlwm..

 

5-Amino-1MQ hmoov

1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
(3) Txhaj tshuaj
(4) Capsules
(5) Kua dej
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Internal Code: KP-3-5/001
CAS Nr .: 42464-96-0
Cov mis mos molecular: C10H11N2.I
HS code: N/A
Molecular Luj: 286.11
EINECS tus lej: 464-196-0
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R & D Dept.-4

Peb muab 5-Amino-1MQ hmoov, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.

Khoom siv:https://www.kpeptide.com/peptides-healthy/5-amino-1mq-powder.html

To taub Nicotinamide N-Methyltransferase Function

 

Qhov no yog ib qho luv luv rau nicotinamide N-methyltransferase, uas yog ib qho cytosolic enzyme uas feem ntau pom muaj nyob rau hauv cov nqaij rog, daim siab, thiab cov leeg pob txha. Cov enzyme no pab hloov nicotinamide rau hauv N-methylnicotinamide thiab S-adenosylhomocysteine ​​los ntawm kev muab S-adenosylmethionine los ua methyl qhov chaw. Tus nqi ntawm cov enzyme uas tau nthuav tawm txawv ntau ntawm cov ntaub so ntswg. Hauv qee lub xeev metabolic, cov ntaub so ntswg rog muaj qhov tshwj xeeb ntawm kev ua haujlwm siab. Cov kws tshawb fawb tau pom tias NNMT qhia tau nce ntau hauv cov nqaij rog thaum tib neeg rog dhau lossis muaj teeb meem metabolic. Kev ua haujlwm siab dua NNMT txo qis tus nqi ntawm nicotinamide adenine dinucleotide intermediates hauv hlwb, uas tuaj yeem hloov pauv li cas mitochondria ua haujlwm thiab lawv siv zog npaum li cas. Lub enzyme ua ntau tshaj li cov txheej txheem methylation; nws kuj tseem cuam tshuam rau cov xov tooj biochemical loj dua uas tswj qhov sib npaug ntawm lub zog hauv cov hlwb thiab cov rog rog.

Lub Cim Tseem Ceeb ntawm NNMT hauv Metabolism

 

NNMT tseem ceeb heev vim nws cuam tshuam ntau npaum li cas methylation tuaj yeem tshwm sim hauv hlwb thiab ntau npaum li cas NAD + muaj. NNMT hloov txoj kev khaws cia uas cov hlwb siv los ua NAD +, coenzyme uas xav tau rau ntau cov txheej txheem metabolic, los ntawm kev noj nicotinamide. Thaum NNMT kev ua haujlwm nce mus, cov hlwb yuav muaj tsawg dua NAD + tsim, uas tuaj yeem cuam tshuam li cas mitochondria ua haujlwm thiab ntau npaum li cas cov hlwb ua. Cov kws tshawb fawb uas tau saib ntawm NNMT knockout qauv tau pom cov txiaj ntsig zoo ntawm metabolic. Cov tsiaj uas tsis muaj txiaj ntsig NNMT siv lub zog ntau dua, muaj kev nkag siab zoo rau insulin, thiab tsis hnyav thaum lawv noj tsawg. Los ntawm cov kev tshawb pom no, nws zoo li thaiv NNMT yuav yog ib txoj hauv kev zoo los kho cov kab mob metabolic. Vim tias lub kaw lus tseem ceeb heev, nws tau dhau los ua lub hom phiaj nrov rau kev cuam tshuam tshuaj, tshwj xeeb tshaj yog rau cov tebchaw xws li 5-amino-1MQ peptide, uas.5 amino 1MQ peptidetuaj yeem hloov pauv nws ua haujlwm li cas.

Mechanism ntawm Enzymatic Inhibition

 

Lub 5-amino-1MQ peptide ua haujlwm ua ib qho me me-molecule inhibitor uas txwv tsis pub NNMT enzyme ua nws txoj haujlwm los ntawm kev sib tw inhibition. Cov molecule no muaj cov qauv uas zoo ib yam li cov enzyme lub cev substrate, uas tso cai rau nws nkag mus rau hauv lub active site yam tsis tau methylated. Cov peptide blocks nicotinamide los ntawm kev nkag mus rau lub tshuab methylation los ntawm kev txuas mus rau catalytic domain. Qhov no ua rau cov enzyme ua haujlwm tsawg dua. Kev ntsuam xyuas siv biochemistry tau pom tias cov tshuaj no tuaj yeem nres qhov kev ua ntawm cov ntshiab NNMT enzyme npaj. Tus inhibitor txo qis kev ua enzyme nyob rau hauv ib txoj kev uas nyob ntawm tus nqi, thiab nws cov teebmeem tuaj yeem pom ntawm cov koob tshuaj micromolar. Nws yog ib qho tseem ceeb heev uas yuav tsum xav txog qhov txwv qhov kev txwv no rau kev siv tshuaj, vim tias nws ua rau tsis xav tau qhov tsawg kawg nkaus, uas tuaj yeem ua rau kev kho mob tsis zoo.

Pharmacological yam ntxwv thiab Bioavailability

 

Cov tshuaj profile ntawm 5-amino-1MQ peptide muaj ntau yam uas muaj txiaj ntsig zoo hauv lub neej tiag tiag. Nyob rau hauv physiological chaw, lub molecule yog zoo nkauj ruaj khov, thiab nws cov qauv nyob twj ywm tib yam ntev txaus rau enzyme kev tshwm sim tshwm sim. Nws qhov hnyav molecular thiab cov tshuaj lom neeg muaj txiaj ntsig cuam tshuam li cas nws faib hauv cov ntaub so ntswg. Nws nyhav tsim nyob rau hauv cov ntaub so ntswg metabolically active, uas yog qhov twg NNMT qhia muaj zog tshaj. Cov yam ntxwv nqus tau qhia peb tias qhov sib xyaw ua ke tau zoo npaum li cas rau cov hom phiaj tom qab muab. Lub bioavailability ntawm peptide nyob ntawm ntau yam, xws li kev tswj hwm nws li cas, nws raug tsim li cas, thiab tus neeg nws tus kheej cov yam ntxwv lom neeg. Cov tuam txhab lag luam uas tab tom tsim cov tshuaj nrog cov khoom xyaw nquag no yuav tsum ua tib zoo xav txog cov xwm txheej no kom tau txais cov txiaj ntsig kev kho mob zoo tshaj plaws thaum khaws cov ntaub ntawv kev nyab xeeb uas tsim nyog rau kev siv lawv tau tsim rau.

Kev cuam tshuam rau S-Adenosylmethionine Metabolism

 

5-amino-1MQ peptide lub peev xwm los thaiv NNMT muaj kev cuam tshuam ncaj qha rau lub voj voog methylation ntawm cov hlwb los ntawm kev hloov pauv li cas S-adenosylmethionine siv. Thaum NNMT kev ua haujlwm poob qis, hlwb siv S-adenosylmethionine tsawg dua rau nicotinamide methylation. Qhov no tuaj yeem ua rau ntau qhov methyl thoob ntiaj teb no muaj rau lwm cov txheej txheem biochemical. Qhov kev hloov pauv hauv kev sib kis ntawm methylation muaj peev xwm tuaj yeem cuam tshuam rau ntau cov txheej txheem cellular uas vam khom kom muaj qhov zoo ntawm methylation. S-adenosylmethionine muab methyl pawg rau ntau pua cov txheej txheem enzyme uas tshwm sim hauv cov hlwb. DNA methylation, histone hloov, protein methylation, thiab zus tau tej cov phospholipids tag nrho xav tau txaus S-adenosylmethionine. Cov peptide tuaj yeem pab tsis ncaj rau cov txheej txheem methylation tseem ceeb los ntawm kev txwv NNMT los ntawm kev siv cov khoom noj tseem ceeb no. Qhov no tuaj yeem ua rau kev ua haujlwm ntawm cellular zoo dua hauv ntau qhov chaw.

Methylation Capacity thiab Epigenetic Regulation

 

Kev hloov pauv hauv lub peev xwm ntawm cov hlwb rau methylate5 amino 1MQ peptidetuaj yeem cuam tshuam cov qauv ntawm kev tswj hwm epigenetic uas tswj cov kev qhia gene. DNA methyltransferases thiab histone methyltransferases tuaj yeem siv tau ntau dua ntawm cov substrates thaum NNMT thaiv kom S-adenosylmethionine muaj. Qhov no muaj peev xwm ua rau methylate tuaj yeem, hauv txoj kev xav, hloov cov noob qes qes tsim, uas tuaj yeem cuam tshuam rau cov txheej txheem metabolic thiab txoj kev sib txawv ntawm cov hlwb.NNMT txo tau cuam tshuam rau epigenetics uas dhau mus dhau ntawm kev hloov cov noob rau lossis tawm. Cov qauv ntawm cov tshuaj methylation hloov cov duab ntawm chromatin, uas hloov pauv li cas cov tshuab luam ntawv khi rau genomic DNA. Cov qauv no tuaj yeem hloov pauv, uas tuaj yeem cuam tshuam li cas cov hlwb teb rau cov lus hauv metabolic thiab tej zaum txawm tias cov cell reprogramme kom nyob rau hauv lub xeev metabolic zoo dua. Cov kws tshawb fawb tseem tab tom saib yuav ua li cas cov tshuaj uas hloov cov metabolism hauv methylation tuaj yeem siv cov txheej txheem epigenetic kom ua tau zoo dua.

NAD + Biosynthesis thiab Mitochondrial Function

 

Qhov kev sib txuas ntawm kev thaiv NNMT thiab kev tsim hluav taws xob feem ntau yog nyob ntawm seb nws cuam tshuam li cas rau kev tsim cov nicotinamide adenine dinucleotides. Thaum NNMT kev ua haujlwm poob qis, nicotinamide uas ib txwm ua rau methylated tseem muaj rau txoj hauv kev uas cawm NAD+. Qhov no ua rau NAD + precursors muaj, uas tuaj yeem nce NAD + hauv hlwb, uas pab mitochondria ua haujlwm thiab ua kom muaj zog. Rau cov kab mob ua pa kom ua haujlwm zoo, mitochondria yuav tsum muaj NAD + txaus. Oxidative phosphorylation, txoj kev uas mitochondria ua rau feem ntau ntawm lub zog hauv lub cell, xav tau cov coenzyme no los nqa electrons. Yog tias NNMT raug thaiv, ntau NAD + tej zaum yuav muaj, uas yuav ua rau mitochondria ua haujlwm zoo dua. Qhov no tuaj yeem ua rau cov hlwb siv zog ntau dua thiab ua kom lawv cov metabolism.

Adipocyte muaj nuj nqi thiab lub zog cia

 

Vim tias adipocytes yog cov hlwb tseem ceeb uas tsim NNMT, lawv muaj kev nkag siab zoo rau cov tshuaj uas thaiv cov enzyme no. Thaum NNMT raug thaiv hauv adipocytes, lawv cov khoom metabolic tuaj yeem hloov pauv mus rau txoj kev loj. Kev tshawb pom los ntawm cov kev tshawb fawb tau pom tias thaiv NNMT hauv cov ntaub so ntswg adipose tuaj yeem hloov pauv lipids khaws cia, li cas adipokines raug tso tawm, thiab cov tshuaj insulin ua haujlwm li cas. Adipocytes 'kev hloov pauv metabolic tshwm sim los ntawm kev thaiv NNMT tuaj yeem pab txhim kho lub zog sib npaug hauv lub cev tag nrho. Cov ntaub so ntswg adipose tsis yog tsuas yog lub khw muag khoom tsis muaj zog xwb; Nws kuj yog ib qho active endocrine kab mob uas cuam tshuam cov metabolism hauv tag nrho lub cev. Thaum NNMT raug thaiv, kev hloov pauv hauv txoj kev ua haujlwm adipocytes tuaj yeem xa cov lus metabolic mus rau lwm cov ntaub so ntswg, uas tuaj yeem pab ntau lub cev hloov pauv uas zoo rau lawv.

5 amino 1MQ peptideLub hom phiaj ntawm NNMT txoj kev hauv txoj kev nyuaj heev. Qhov no yog ib qho piv txwv ntawm yuav ua li cas cov tshuaj me me tuaj yeem hloov cov enzyme tshwj xeeb los hloov cov hlwb siv lub zog. Los ntawm kev thaiv NNMT kev sib tw, cov peptide no khaws cov nicotinamide rau kev ua NAD + thiab ua kom lub peev xwm ntawm cov hlwb rau methylate. Cov kev hloov pauv no tuaj yeem tshwm sim hauv kev sib txuas hauv metabolic thiab tej zaum yuav muaj kev cuam tshuam rau ntau npaum li cas lub zog siv, mitochondria ua haujlwm li cas, thiab seb adipocytes siv lub zog li cas. Cov tuam txhab tshuaj, cov pab pawg kawm, thiab CDMOs ua haujlwm ntawm cov kev daws teeb meem kev noj qab haus huv tuaj yeem tau txais txiaj ntsig los ntawm kev nkag siab txog cov ntsiab lus molecular ntawm kev sib raug zoo no. Cov peptide qhov tshwj xeeb khi, nws qhov cuam tshuam rau enzyme kinetics, thiab nws cov teebmeem metabolic ntawm qhov loj dua txhua qhov ua rau nws muaj txiaj ntsig zoo li kev tshawb fawb thiab cov tshuaj kho tau. Raws li kev tshawb fawb txog cov metabolism hauv kev loj hlob, cov tshuaj uas tsom rau txoj hauv kev enzyme tshwj xeeb, zoo li NNMT, xav tias yuav dhau los ua qhov tseem ceeb hauv kev daws teeb meem metabolic. Txoj kev tshawb no ntawm 5-amino-1MQ peptide thiab NNMT tseem loj hlob, qhia txog qhov tshiab ntawm qhov kev sib raug zoo molecular no thiab nws txhais li cas rau lub cev. Rau lawv txoj haujlwm txhim kho kom mus tau zoo, cov koom haum ua haujlwm nrog qhov sib xyaw no yuav tsum muaj peev xwm tso siab rau cov khoom siv uas muab cov ntaub ntawv siab dawb huv rau lawv, tag nrho cov ntaub ntawv txheeb xyuas, thiab cov kws tshaj lij pab.

BLOOM TECH npaj txhij los pab koj nrog koj cov kev tshawb fawb thiab kev tsim kho kev xav tau los ntawm kev muab tshuaj rau koj -qib5 amino 1MQ peptide, nrog rau ntau qhov kev lees paub zoo thiab cov ntaub ntawv raug cai. Peb cov chaw tsim khoom yog GMP- ntawv pov thawj thiab ua tau raws li cov qauv thoob ntiaj teb xws li cov txheej txheem los ntawm US FDA, EU, thiab PMDA. Qhov no ua kom paub tseeb tias txhua pawg ua tau raws li qhov yuav tsum tau ua kom huv huv nruj (peb yog 5-amino-1MQ peptide tus neeg muag khoom, thiab peb muab tag nrho cov kev txheeb xyuas tus yam ntxwv, suav nrog HPLC, huab hwm coj spectrometry, thiab cov ntaub ntawv sib xws los txhawb koj cov cai CMC).

Thaum nws los txog rau cov kev tshawb fawb metabolic, peb pab neeg paub txog cov tuam txhab tshuaj, cov tuam txhab biotechnology, thiab kev cog lus tsim kho thiab tsim cov koom haum (CDMOs) xav tau. Peb tuaj yeem muab cov kev daws teeb meem hloov pauv hloov pauv txij li qhov me me rau kev tshawb fawb mus rau qhov loj -tej ntau lawm, txhawb nqa los ntawm peb qhov dej zoo- tsim cov saw hlau thiab kev tswj kom zoo. BLOOM TECH tau ua cov organic synthesis rau ntau tshaj 12 xyoo thiab tau ua haujlwm nrog 24 lub tuam txhab tshuaj loj thoob ntiaj teb, yog li koj tuaj yeem paub tseeb tias koj cov haujlwm yuav raug tswj xyuas nrog kev ntseeg siab thiab kev txawj ntse uas lawv xav tau. Hu rau peb pab neeg tam sim ntawd los tham txog koj cov kev xav tau tshwj xeeb rau 5-amino-1MQ peptide thiab nrhiav seb peb qhov kev pabcuam ib-nres tuaj yeem ua kom koj lub sijhawm txhim kho. Email rau peb ntawmSales@bloomtechz.comkom tau cov ncauj lus kom ntxaws cov khoom specifications, quotes, thiab technical support uas haum rau koj cov hom phiaj kev tshawb fawb.

1. Kraus D, Yang Q, Kong D, et al. Nicotinamide N-methyltransferase knockdown tiv thaiv kev noj haus- ntxias rog rog. Xwm . 2014;508(7495):258-262.

2. Ulanovskaya OA, Zuhl AM, Cravatt BF. NNMT txhawb kev hloov kho epigenetic hauv cov ntaub so ntswg adipose los ntawm kev hloov NAD + metabolism thiab S-adenosylmethionine dynamics. Kev Ua Haujlwm ntawm National Academy of Sciences. 2013; 110(16): 6512-6517.

3. Komatsu M, Kanda T, Urai H, et al. Kev ua kom NNMT tuaj yeem pab txhawb kev txhim kho cov kab mob rog rog los ntawm kev hloov kho NAD + cov metabolism. Kev Tshaj Tawm Txog Kev Tshawb Fawb . 2018; 8(1): 8637-8648.

4. Hong S, Moreno-Navarrete JM, Wei X, et al. Nicotinamide N-methyltransferase tswj cov metabolism hauv hepatic nutrient los ntawm Sirt1 protein stabilization. Tshuaj kho mob xwm txheej . 2015;21(8):887-894.

5. Parsons RB, Smith ML, Williams AC, et al. Kev nthuav qhia ntawm nicotinamide N-methyltransferase hauv Parkinsonian hlwb. Phau ntawv Journal of Neuropathology thiab Experimental Neurology. 2002;61(2):111-124.

6. Neelakantan H, Vance V, Wetzel MD, et al. Selective thiab daim nyias nyias-permeable me me molecule inhibitors ntawm nicotinamide N-methyltransferase thim rov qab cov zaub mov muaj roj ntau-induced rog rog nyob rau hauv cov nas. Biochemical Pharmacology. 2018; 147:141-152.