Peptide Humanin

Peptide neegyog luv peptide encoded los ntawm mitochondrial genome, muaj 24 amino acids,
Nws cov kab ke yog Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Th r-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala. Raws li thawj mitochondrial derived peptide (MDP) nrhiav pom, Humanin tau txais txiaj ntsig zoo hauv kev hloov pauv thiab muaj nyob rau hauv ntau hom xws li tib neeg, liab qab mole nas, nematodes, thiab lwm yam. Nws qib qis dua nrog lub hnub nyoog, tab sis tseem ceeb nce hauv cov xeeb ntxwv ntawm centenarians, qhia txog kev sib raug zoo nrog lub neej. Cov kev tshawb fawb hauv tsev kho mob kuj tau qhia tias nws muaj feem cuam tshuam nrog kev saib xyuas ntawm mitochondrial kev ua haujlwm, thiab qhov txo qis hauv nws qib yog cuam tshuam nrog kev pheej hmoo ntawm hnub nyoog nce ntxiv -cov kab mob xws li AD thiab mitochondrial encephalomyopathy. Txawm hais tias nws daim ntawv thov kev kho mob tseem txwv rau kev tshawb fawb txog kev tshawb fawb, nws lub peev xwm los tiv thaiv - kev laus thiab kab mob kev cuam tshuam lub hom phiaj tau nyiam thoob plaws, thiab tuaj yeem muab cov tswv yim tshiab rau kev kho cov kab mob neurodegenerative, kab mob plawv, thiab metabolic syndrome yav tom ntej.

 

Peb Cov Khoom Muag Khoom

 

Raws li chav kawm ntawm neuroprotective peptides lossis cov khoom xyaw nquag,peptide neeg(tib neeg lub cev) tau pom muaj txiaj ntsig tseem ceeb hauv kev tswj xyuas lub hlwb, txhim kho kev paub txog kev ua haujlwm, tiv thaiv thiab kho cov kab mob neurodegenerative, thiab lwm yam.

Daim ntawv thov hauv kev paub txog kev noj qab haus huv npog tag nrho cov kev cuam tshuam los ntawm kev puas hlwb me me (MCI) mus rau Alzheimer's disease (AD), txhim kho kev nco, kev saib xyuas, thiab kev ua haujlwm los ntawm ntau yam - lub hom phiaj ua.

ncua kev txawj ntse poob

 

Nws cov tshuaj tiv thaiv antioxidant (xws li KOXpqq thiab ergotamine) tuaj yeem tshem tawm cov dawb radicals thiab txo oxidative kev nyuaj siab puas tsuaj rau kev nco txog cov paj hlwb xws li hippocampus. Piv txwv li, TG hom Omega-3 tivthaiv nyob rau hauv Swisse siab concentration ntses roj yuav txo tau amyloid deposition nyob rau hauv lub hlwb, uas yog ib tug ntawm cov tseem ceeb pathological cim ntawm AD. Kev noj qab haus huv ntev tuaj yeem txo qhov kev pheej hmoo ntawm MCI lossis AD hloov pauv hauv cov neeg laus noj qab haus huv, muab kev tiv thaiv ntev rau lub hlwb.

Txhim khu kev kawm thiab kev nco muaj peev xwm

 

Txhim kho kev kawm thiab kev nco qab los ntawm kev txhim kho synaptic plasticity thiab neurotransmitter tso tawm. Piv txwv li, phosphatidylserine hauv enkephalin tuaj yeem txhawb cov kua dej ntawm cov hlwb hauv hlwb thiab ua kom cov teeb liab kis tau tus mob neural; DHA algae roj txhawb kev ncaj ncees ntawm cov qauv neuronal membrane thiab txhim kho cov ntaub ntawv ua haujlwm. Cov kev tshawb fawb soj ntsuam tau pom tias tom qab noj cov khoom siv tshuaj tiv thaiv neuroprotective rau 3 lub hlis, cov neeg kawm cov qhab nia hauv cov kev ntsuam xyuas kev txawj ntse xws li cov lus nco thiab cov laj thawj kev xav tau zoo dua qub, txheeb xyuas cov txiaj ntsig hauv kev txhim kho kev txawj ntse.

Peptide neegRaws li mitochondrial derived peptide (MDP), qhov kev tshawb pom thiab kev tshawb fawb ntawm Humanin tsis tsuas yog nthuav tawm lub luag haujlwm tshiab ntawm mitochondria hauv cell biology, tab sis kuj coj kev cia siab tshiab rau cov teb xws li kev tiv thaiv - laus, neuroprotection, thiab kev kho kab mob metabolic. Cov hauv qab no yog cov ncauj lus kom ntxaws txog kev tshawb pom thiab kev txhim kho keeb kwm ntawm Humanin.

Qhov kev tshawb pom tuaj yeem rov qab mus rau lub xyoo pua 21st thaum ntxov, thaum cov kws tshawb fawb tau ua haujlwm nrhiav cov proteins uas tuaj yeem tiv thaiv cov neurons los ntawm cov tshuaj lom neeg cuam tshuam nrog Alzheimer's disease (AD). Alzheimer's disease yog ib yam kab mob loj heev uas tshwm sim los ntawm kev tuag neuronal loj heev, thiab cov tshuaj lom xws li beta amyloid (A) yog suav tias yog qhov tseem ceeb ua rau neuronal apoptosis. Xyoo 2001, peb pawg tshawb fawb ywj pheej yuav luag ib txhij nrhiav pom Humanin.

Peb qhov kev tshawb pom no ua ke qhia txog qhov muaj nyob ntawm mitochondrial derived peptides ua tus neeg saib xyuas neuroprotective. Encoded los ntawm mitochondrial 16S ribosomal RNA gene (MT-RNR2), nws yog ib qho me me molecule polypeptide muaj li ntawm 24 amino acids. Nws cov qauv muaj peb tig alpha helix uas tsis muaj symmetry, uas muab lub hauv paus rau nws cov kev sib cuam tshuam nrog ntau yam cellular receptors thiab ua rau nws ua tau ntau yam kev lom nyob rau hauv lub cell.

Tom qab kev tshawb pom ntawm Humanin, cov kws tshawb fawb tau pib kawm nws txoj haujlwm lom neeg. Cov kev tshawb fawb thaum ntxov tau pom tias Humanin muaj zog tiv thaiv apoptotic muaj peev xwm thiab tuaj yeem tiv thaiv cov neurons los ntawm AD cov tshuaj lom neeg xws li A, APP mutants, thiab presenilin 1 thiab 2 uas ua rau apoptosis. Cov tshuaj lom no sib sau ua ke hauv lub hlwb ntawm cov neeg mob AD, ua rau kev tuag neuronal thiab kev paub tsis meej, thiab qhov tshwm sim ntawm Humanin muab lub tswv yim tshiab los tawm tsam cov tshuaj lom no.

Tsis tas li ntawd, Humanin tuaj yeem tiv thaiv cov hlwb los ntawm ntau yam kev ntxhov siab raug mob los ntawm inhibiting oxidative kev nyuaj siab, txo cov inflammatory teb, thiab lwm yam mechanisms. Oxidative stress thiab inflammatory teb yog cov txheej txheem tseem ceeb rau kev puas tsuaj ntawm tes thiab kab mob tshwm sim, thiab Humanin tuaj yeem tswj cov txheej txheem no kom tswj tau cellular homeostasis thiab noj qab haus huv.

Raws li kev tshawb fawb tob zuj zus, cov kws tshawb fawb tau tshawb pom tias Humanin tsis yog nyob hauv tib neeg nkaus xwb, tab sis kuj muaj nyob hauv ntau hom xws li liab qab mole nas thiab nematodes, thiab nthuav tawm kev txuag siab ntawm ntau hom. Qhov kev saib xyuas no qhia tias Humanin tuaj yeem ua lub luag haujlwm tseem ceeb hauv cov txheej txheem evolutionary, thiab nws cov haujlwm yuav muaj qhov sib xws ntawm ntau hom, muab cov qauv dav dav rau kev kawm txog kev ua haujlwm lom neeg ntawm Humanin.

1. Kev tshawb fawb los tiv thaiv kev laus

Nyob rau hauv xyoo tas los no, muaj kev vam meej tseem ceeb hauv kev tshawb fawb los tiv thaiv- kev laus. Kev tshawb fawb tau pom tias theem ntawm Humanin txo qis nrog lub hnub nyoog, tab sis nce ntau hauv centenarians thiab lawv cov xeeb ntxwv. Cov kev sib koom ua ke tam sim no tuaj yeem cuam tshuam nrog kev tswj hwm lub neej. Tsiaj thwmsim tau pom tias nematodes overexpressing Humanin ho ncua lawv lifespan, thiab qhov kev ncua no nyob ntawm daf-16/FoxO signaling pathway. Daf-16/FoxO yog ib qho tseem ceeb ntawm kev hloov pauv uas ua lub luag haujlwm tseem ceeb hauv cov lus teb ntawm tes, kev tswj cov metabolism, thiab kev tswj lub neej. Nws tuaj yeem txhawb nqa cellular kev ntxhov siab thiab kev noj qab haus huv hauv metabolic los ntawm kev ua haujlwm ntawm daf-16 / FoxO signaling txoj hauv kev, yog li txuas ntxiv lub neej.

Tsis tas li ntawd, exogenous supplementation ntawm Humanin analogs (xws li HNG) tuaj yeem txhim kho cov kab mob metabolic, txo cov cim inflammatory, thiab ncua kev paub txog cov nas. Cov kev tshawb fawb no muab kev txhawb zog rau kev txhim kho cov tshuaj tiv thaiv - laus. Piv txwv li, hauv cov metabolism, nws cov analogues tuaj yeem txhim kho insulin rhiab heev thiab qabzib kam rau cov nas, txo cov ntshav qab zib thiab qib lipid, thiab yog li tiv thaiv qhov tshwm sim ntawm cov kab mob metabolic xws li ntshav qab zib. Nyob rau hauv cov nqe lus ntawm kev paub, nws cov analogues yuav txo tau A deposition thiab neuroinflamation nyob rau hauv nas hlwb, tiv thaiv neurons los ntawm kev puas tsuaj, thiab yog li ncua kev txawj ntse poob thiab tshwm sim ntawm Alzheimer's kab mob.

2. Neuroprotection thiab Kev Kho Mob

Cov nyhuv neuroprotective ua rau nws muaj peev xwm sib tw tshuaj rau kev kho cov kab mob neurodegenerative xws li AD, Parkinson's disease, thiab lwm yam. Kev tshawb fawb tau pom tias Humanin tuaj yeem tiv thaiv cov neurons los ntawm kev puas tsuaj los ntawm inhibiting neuronal apoptosis, txo oxidative kev nyuaj siab, thiab inflammatory teb. Hauv AD qauv, nws tuaj yeem txo A - induced neuronal tuag thiab synaptic poob, thiab txhim kho kev txawj ntse hauv nas. Tsis tas li ntawd, Humanin tuaj yeem txhawb kev loj hlob thiab kev sib txawv ntawm cov kab mob neural qia hlwb, ua kom cov hlab ntsha kho thiab rov tsim dua tshiab. Neural qia hlwb muaj tus kheej- rov ua dua tshiab thiab muaj peev xwm sib txawv ntau yam, thiab tuaj yeem sib txawv rau hauv cov neurons, astrocytes, oligodendrocytes, thiab lwm yam, koom nrog kev kho thiab rov tsim dua tshiab ntawm lub paj hlwb. H tuaj yeem txhawb kev kho thiab rov tsim dua tshiab ntawm lub paj hlwb los ntawm kev tswj cov kev loj hlob thiab kev sib txawv ntawm cov kab mob neural, yog li kho cov kab mob neurodegenerative.

3. Kev kho cov kab mob metabolic

Nws kuj tau pom muaj peev xwm hauv kev kho mob metabolic. Kev tshawb fawb qhia tau hais tias nws tuaj yeem txhawb kev nkag siab ntawm insulin, tswj kev hloov pauv hauv metabolic, thiab muaj txiaj ntsig zoo rau cov kab mob metabolic xws li ntshav qab zib. Insulin rhiab heev yog hais txog lub peev xwm ntawm cov hlwb los teb rau insulin. Kev poob qis ntawm insulin rhiab heev yog ib qho ntawm cov txheej txheem tseem ceeb ntawm cov kab mob metabolic xws li ntshav qab zib. Nws tuaj yeem txhim kho kev tswj ntshav qabzib los ntawm kev tswj cov insulin signaling txoj hauv kev thiab nce cell rhiab heev rau insulin. Tsis tas li ntawd, nws tuaj yeem tiv thaiv kab mob plawv los ntawm oxidative kev nyuaj siab thiab kev puas tsuaj, thiab txo cov kev pheej hmoo ntawm cov kab mob plawv xws li atherosclerosis. Kab mob plawv yog ib qho teeb meem tseem ceeb ntawm cov kab mob metabolic, thiab nws cov tshuaj antioxidant thiab tiv thaiv - cov teebmeem inflammatory tuaj yeem tiv thaiv cov hlab plawv ntawm kev puas tsuaj thiab tiv thaiv qhov tshwm sim ntawm cov kab mob plawv.

Txawm hais tias nws tau pom muaj peev xwm zoo hauv kev tiv thaiv- kev laus, kev tiv thaiv kab mob, thiab kev kho mob ntawm cov kab mob metabolic, nws daim ntawv thov kev kho mob tseem ntsib ntau yam teeb meem. Cov kev tshawb fawb yav tom ntej yuav tsum tau qhia ntxiv txog cov ncauj lus ntxaws ntxaws ntawm kev ua, cov yam ntxwv ntawm cov khoom sib txuas, thiab cov khoom siv tshuaj pharmacokinetic txhawm rau txhim kho nws cov tswv yim tswj hwm thiab cov qauv peptide. Piv txwv li, nws yog ib qho tsim nyog los txiav txim siab txog cov hom phiaj tshwj xeeb thiab kev taw qhia txoj hauv kev hauv lub xov tooj ntawm tes, nrog rau lawv txoj kev sib txuas thiab kev sib raug zoo nrog cov receptors sib txawv. Cov ntaub ntawv no tseem ceeb heev rau kev txhim kho Humanin analogs thiab tshuaj zoo dua.

Tsis tas li ntawd, cov kev tshawb fawb loj ntawm -cov neeg coob coob yog qhov tseem ceeb rau kev txheeb xyuas tus nqi raws li biomarkers txhim khu kev qha. Los ntawm kev sau ntau tus qauv thiab cov ntaub ntawv los ntawm cov pej xeem, tshuaj xyuas kev sib raug zoo ntawm qib thiab hnub nyoog, kab mob, thiab lwm yam, nws tuaj yeem txiav txim siab seb nws puas tuaj yeem siv los ua biomarker rau kev kwv yees kev laus thiab kab mob. Qhov no yuav muab lub hauv paus kev tshawb fawb ntau dua rau kev siv tshuaj kho mobpeptide neeg.

Lub caij no, nrog rau kev txhim kho txuas ntxiv ntawm cov thev naus laus zis xws li kev kho cov noob caj noob ces thiab kev kho ntawm tes, daim ntawv thov kev cia siab yuav yog qhov dav dua. Piv txwv li, gene kho thev naus laus zis tuaj yeem siv los qhia nws cov noob rau hauv cov hlwb tshwj xeeb rau kev hais tawm, yog li siv sijhawm ntev - tiv thaiv cov teebmeem. Tsis tas li ntawd, cov txheej txheem kho cell tuaj yeem siv los hloov cov hlwb qhia nws mus rau hauv cov ntaub so ntswg puas, txhawb cov ntaub so ntswg kho thiab rov tsim dua tshiab. Cov thev naus laus zis tshiab no yuav muab tau ntau dua rau kev siv tshuaj kho mob Humanin.

Cim npe nrov: Tuam Tshoj peptide humanin manufacturers, lwm tus neeg