Humanin peptide bodybuildingyog ib tug me me molecule peptide encoded los ntawm mitochondrial genes, pib attracting xim rau nws lub luag hauj lwm tseem ceeb hauv neuroprotection thiab anti-aging. Nyob rau hauv xyoo tas los no, nws lub peev xwm rau daim ntawv thov nyob rau hauv kev tawm dag zog thiab kev ua kis las science tau maj mam pom, dhau los ua qhov tseem ceeb ntawm kev saib xyuas rau cov neeg nyiam kev tawm dag zog thiab ncaws pob. Antioxidant thiab anti-cov khoom muaj zog tuaj yeem txo cov kev ntxhov siab oxidative thiab inflammatory tshwm sim los ntawm kev tawm dag zog, tiv thaiv cov leeg thiab lwm yam ntaub so ntswg los ntawm kev puas tsuaj, txo qhov kev pheej hmoo ntawm overtraining, txhawb kev rov qab los ntawm lub cev sai dua, thiab pab kom cov neeg nyiam kev noj qab haus huv nkag mus rau qhov kev cob qhia tom ntej hauv lub xeev zoo dua. Txawm li cas los xij, daim ntawv thov tam sim no hauv thaj chaw qoj ib ce tseem nyob rau theem tshawb fawb, thiab nws lub sijhawm ntev - cov teebmeem thiab kev nyab xeeb tseem xav tau kev tshuaj xyuas cov ntaub ntawv pov thawj ntxiv.
Nws tau pom qhov zoo tshwj xeeb hauv cov leeg nqaij loj hlob thiab kho. Kev cob qhia kev qoj ib ce, tshwj xeeb tshaj yog siab - kev siv zog siv zog, tuaj yeem ua rau cov leeg mob micro raug mob, uas tuaj yeem txo cov leeg cell tuag los ntawm kev cob qhia thiab nrawm kho thiab rov tsim kho cov leeg nqaij puas tsuaj los ntawm kev tswj hwm apoptosis ntsig txog kev taw qhia. Nyob rau tib lub sijhawm, nws kuj tseem tuaj yeem txhawb kev ua kom muaj zog thiab loj hlob ntawm cov leeg qia hlwb (satellite cells), muab "cov ntaub ntawv raw" ntau ntxiv rau cov nqaij ntshiv loj hlob, pab cov neeg nyiam kev noj qab haus huv cuam tshuam los ntawm cov leeg nqaij, thiab ua tiav cov leeg nqaij thiab lub zog.
Hais txog kev txhim kho kev ua kis las, nws pab txhim kho lub zog metabolism. Nws tuaj yeem txhim kho mitochondrial muaj nuj nqi, txhim kho kev siv ntawm tes ntawm cov pa oxygen, ua kom cov leeg ua kom muaj zog ntau dua thaum ua haujlwm, thiab ncua qhov tshwm sim ntawm qaug zog. Rau cov kev pabcuam kev tawm dag zog uas xav tau kev txhawb nqa siab - siv zog tawm, xws li kev cob qhia ua haujlwm, kev cob qhia lub voj voog, thiab lwm yam, qhov no tuaj yeem txhim kho lub sijhawm thiab kev cob qhia zoo, pab cov neeg nyiam kev tawm dag zog ua kom tiav ntau dua thiab muaj zog dua.
Peb Cov Khoom Muag Khoom
Humanin COA
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| Certificate of Analysis | ||
| Compound npe | Tib neeg | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 330936-69-1 | |
| Ntau |
50.0g
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| Ntim txheem | 10g / hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202511150025 | |
| MFG |
Peb 15, 2025
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| EXP |
Peb 15, 2027 |
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| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim |
Dawb los yog tawm -dawb hmoov
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Dawb hmoov
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| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.41% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.26% |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.39% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 80 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 98ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -10 degree | |
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Humanin peptide bodybuildingyog luv peptide uas muaj 24 amino acids encoded los ntawm mitochondrial noob. Txij li thaum nws thawj zaug pom nyob rau hauv lub hlwb cov ntaub so ntswg ntawm Alzheimer's cov neeg mob nyob rau hauv 2001, nws tshwj xeeb cellular tiv thaiv mechanism thiab metabolic regulatory muaj nuj nqi tau maj attracted scientific xim. Txawm hais tias nws tseem tsis tau pom zoo rau tib neeg kev kho mob, nws cov peev txheej ntawm daim ntawv thov muaj txiaj ntsig tau raug lees paub ua ntej hauv thaj chaw xws li tiv thaiv - kev laus, kev noj qab haus huv metabolic, thiab kev tiv thaiv neuroprotection. Hauv kev tsim lub cev, cov ntawv thov tuaj yeem txheeb xyuas los ntawm plaub qhov loj: kev tiv thaiv ntawm tes, kev tswj cov metabolism, kev tawm dag zog rov qab, thiab kev tu lub sijhawm ntev -.
Kev tiv thaiv ntawm tes: tiv thaiv oxidative kev nyuaj siab thiab mob tshwm sim los ntawm kev cob qhia
Kev cob qhia cev nqaij daim tawv yog nyob ib puag ncig siab - kev siv zog ua haujlwm tawm dag zog, uas tseem ceeb ua rau cov leeg nqaij pob txha raug mob los ntawm kev ntxhov siab thiab ua rau cov txheej txheem ntawm kev rov ua haujlwm ntau dhau. Txawm li cas los xij, cov txheej txheem no yog nrog los ntawm cov tiam ntawm ntau cov dawb radicals thiab tso tawm ntawm cov teeb meem inflammatory. Yog tias tsis kho raws sijhawm, nws tuaj yeem ua rau cell apoptosis lossis cov ntaub so ntswg fibrosis.
Anti-kev nyuaj siab oxidative
Nws tuaj yeem ncaj qha tshem tawm cov pa oxygen reactive (ROS) xws li superoxide anions thiab hydrogen peroxide, thiab txhim kho cellular antioxidant muaj peev xwm los ntawm kev tswj cov dej num ntawm superoxide dismutase (SOD) thiab glutathione peroxidase (GPx). Cov kev sim tsiaj tau pom tias kev kho mob Humanin tuaj yeem ua rau kom muaj sia nyob ntawm cov hlwb myocardial los ntawm 40% tom qab hypoxia / reoxygenation raug mob, thiab nws cov nyhuv yog piv rau N-acetylcysteine (cov tshuaj antioxidant classic). Hauv kev cob qhia bodybuilding, qhov kev tiv thaiv no tuaj yeem txo cov lipid peroxidation ntawm cov leeg cell daim nyias nyias, tswj cov membrane kev ncaj ncees, thiab ua kom cov protein synthesis thiab metabolism.
Antiapoptosis
Tom qab siab - kev cob qhia siv zog, intracellular calcium overload nyob rau hauv cov leeg nqaij activates txoj kev mitochondrial apoptosis, ua rau txo cov nqaij fibers. Los ntawm inhibiting qhov translocation ntawm Bax protein mus rau mitochondrial membrane, thaiv kev tso tawm ntawm cytochrome c thiab caspase-3 ua kom, kev cob qhia induced nqaij cell apoptosis yuav txo tau. Kev tshawb fawb qhia tau hais tias nyob rau hauv cov txiv neej uas muaj ntshav qab zib ua ntej, 12 lub lis piam ntawm kev kawm tiv thaiv tuaj yeem nce qib ntawm Humanin protein nyob rau hauv cov leeg ncej puab los ntawm 27%, nrog rau cov leeg nqaij thiab txhim kho insulin rhiab heev.
Anti-cov nyhuv inflammatory
Nws tuaj yeem cuam tshuam rau NF - κ B signaling txoj hauv kev thiab txo qhov kev tso tawm ntawm cov pro-inflammatory yam xws li TNF - thiab IL-6. Lub sij hawm ntev siab - kev siv zog ntawm cov neeg tsim lub cev tuaj yeem ua rau mob qis qis - qib o, cuam tshuam rau cov leeg rov qab thiab cov roj metabolism. Cov tshuaj tiv thaiv kab mob tuaj yeem txhawb kev kho cov ntaub so ntswg thiab txo cov leeg nqaij protein los ntawm kev tswj hwm macrophage polarization (los ntawm M1 txog M2).
Cov txheej txheem metabolic: optimizing kev siv lub zog thiab kev tswj lub cev muaj pes tsawg leeg
Ib qho ntawm cov hom phiaj tseem ceeb ntawm kev tsim lub cev yog kom txo qis lub cev rog feem pua thaum ua kom lub cev tsis muaj zog, uas yuav tsum muaj kev tswj xyuas meej ntawm qhov sib npaug ntawm kev siv zog thiab kev siv nyiaj. Lub luag haujlwm hauv kev tswj hwm metabolic feem ntau yog tshwm sim hauv cov hauv qab no:
Lub peev xwm ntawm cov leeg pob txha kom txhawb nqa cov piam thaj tuaj yeem txhim kho los ntawm kev ua kom AMPK / PI3K / Akt signaling pathway. Cov kev sim tsiaj tau pom tias txhaj tshuaj Humanin analogs (HNG) ob zaug hauv ib lub lis piam mus rau hauv nruab nrab - cov nas muaj hnub nyoog tuaj yeem txo cov ntshav qabzib sai li 15% thiab tseem txo qis cov roj visceral. Hauv tib neeg cov kev tshawb fawb, tom qab kev kawm tiv thaiv rau cov neeg mob ntshav qab zib ua ntej, theem ntawm cov leeg Humanin yog qhov tseem ceeb thiab muaj kev cuam tshuam zoo nrog insulin rhiab heev, tawm tswv yim tias nws tuaj yeem txhawb lub cev rog los ntawm kev txhim kho cov leeg ntshav qabzib metabolism.
Regulating lipid metabolism
Nws tuaj yeem cuam tshuam kev ua haujlwm ntawm cov tshuaj hormones lipase (HSL) hauv cov ntaub so ntswg adipose, txo qhov tso tawm ntawm cov roj fatty acids dawb (FFA) los ntawm cov khoom siv rog rog, thiab yog li txo qis cov uptake thiab oxidation ntawm FFA los ntawm cov leeg nqaij. Cov txheej txheem no tuaj yeem pab txo qis ectopic lipid deposition hauv cov leeg tom qab kev cob qhia thiab tswj cov leeg purity. Tsis tas li ntawd, Humanin tuaj yeem txhawb lub siab beta oxidation thiab ntxiv dag zog rau lub cev lipid faib los ntawm kev txhawb nqa PPAR - kev qhia.
Txhawb nqa protein synthesis
Txhim kho cov leeg nqaij protein synthesis los ntawm kev ua kom lub mTOR signaling pathway. Hauv kev sim ntawm tes, kev kho mob tuaj yeem ua kom cov protein synthesis ntawm C2C12 myotubes los ntawm 30%, uas yog sib npaug rau leucine stimulation. Cov yam ntxwv no yog qhov sib xws nrog qhov xav tau kom rov qab ua haujlwm ntau dhau tom qab kev cob qhia lub cev, thiab tuaj yeem ua kom muaj txiaj ntsig kev cob qhia los ntawm kev sib koom ua ke.
Kev Ua Si Rov Qab: Txhim kho qhov mob nrawm thiab ua haujlwm rov ua haujlwm
Qhov zoo ntawm kev rov qab los tom qab kev cob qhia bodybuilding ncaj qha cuam tshuam rau kev cob qhia zaus thiab cov nqaij ntshiv kev loj hlob. Lub luag haujlwm ntawm Humanin nyob rau hauv lub cev muaj zog rov qab yog qhov tseem ceeb hauv cov hauv qab no:
Txhawb kev ua haujlwm satellite cell
Satellite cells yog cov qia hlwb tseem ceeb rau cov nqaij ntshiv, thiab lawv txoj kev ua haujlwm yog nyob ntawm kev ua kom lub Hedgehog signaling pathway. Upregulation ntawm Shh (Sonic Hedgehog) qhia tuaj yeem txhawb nqa satellite cell proliferation thiab sib txawv, ua kom cov nqaij fiber ntau kho. Cov kev sim tsiaj tau pom tias kev kho mob Humanin tuaj yeem ua rau muaj kev pheej hmoo ntawm cov nqaij ntshiv ntawm 50%, thaum txo cov kab mob fibrosis.
Regulating mitochondrial biogenesis
Kev cob qhia siab siv zog tuaj yeem ua rau mitochondrial DNA puas thiab kev ua haujlwm tsis zoo, cuam tshuam rau lub zog. Kev ua kom PGC-1 qhia tuaj yeem txhawb nqa mitochondrial biogenesis thiab nce mitochondrial ntom hauv cov leeg nqaij. Kev tshawb fawb tau pom tias kev kho mob nrog cov tshuaj analogues tuaj yeem ua rau muaj kev ua haujlwm ntawm mitochondrial respiratory chain complex IV hauv nas pob txha pob txha los ntawm 25%, yog li txhim kho kev ua haujlwm siab.
Relieve qeeb pib mob nqaij mob (DOMS)
DOMS yog mob nqaij uas tshwm sim 24-72 teev tom qab kev cob qhia, uas cuam tshuam nrog kev tso tawm ntawm cov kab mob inflammatory thiab micro puas rau cov leeg nqaij. Cov tshuaj tiv thaiv kab mob thiab kev tiv thaiv ntawm tes tuaj yeem txo qhov hnyav ntawm DOMS. Hauv kev tshawb fawb tib neeg, cov kev kawm uas tau txais kev txhaj tshuaj ntawm Humanin analogs tau ntsib 40% txo qis hauv DOMS cov qhab nia thiab 30% nce hauv cov leeg nqaij rov qab.
Kev saib xyuas kev noj qab haus huv mus sij hawm ntev: tiv thaiv kev pheej hmoo ntawm kev tsim lub cev
Cov kws tsim lub cev feem ntau ntsib qhov ntev - cov kev pheej hmoo ntawm kev noj qab haus huv xws li kev cob qhia ntau dhau, metabolic ntshawv siab, thiab kab mob plawv. Lub peev xwm tiv thaiv kev cuam tshuam ntawm Humanin feem ntau yog tshwm sim hauv cov hauv qab no:
Tiv thaiv kab mob plawv
Humanin peptide bodybuildingtuaj yeem inhibit qhov apoptosis ntawm vascular endothelial hlwb induced los ntawm oxidized low density lipoprotein (oxLDL) thiab txo qhov tsim ntawm atherosclerotic plaque. Cov kev sim tsiaj tau pom tias kev kho mob tuaj yeem txo thaj tsam ntawm aortic plaques hauv apolipoprotein E deficiency nas los ntawm 35%, thaum txhim kho vasodilation muaj nuj nqi. Cov yam ntxwv no tseem ceeb tshwj xeeb rau cov neeg tsim lub cev uas siv cov tshuaj steroids lossis cov tshuaj hormones loj hlob ntev, vim tias nws tuaj yeem txo qhov kev pheej hmoo ntawm cov teeb meem plawv.
Regulating hormonal tshuav nyiaj li cas
Kev cob qhia siab siv zog thiab qis lub cev rog feem pua tuaj yeem ua rau inhibition ntawm hypothalamic pituitary gonadal axis, ua rau txo qis hauv qib testosterone. Hormonal tshuav nyiaj li cas tuaj yeem tswj hwm los ntawm kev tswj hwm GnRH secretion thiab inhibiting cortisol tso tawm. Kev tshawb fawb tau pom tias kev kho mob nrog analogues tuaj yeem txo qhov kev ntxhov siab -induced cortisol nce los ntawm 50% thiab txhawb testosterone synthesis.
Ncua qhov poob ntawm kev laus cuam tshuam txog kev ua haujlwm
Cov qib no txo qis nrog lub hnub nyoog, thiab nws qhov tsis muaj peev xwm cuam tshuam nrog cov leeg nqaij atrophy, metabolic syndrome, thiab kev paub tsis meej. Los ntawm exogenous supplementation, nws yuav ncua lub hnub nyoog lom acceleration ntawm bodybuilders tshwm sim los ntawm ntev - lub sij hawm siab - siv kev cob qhia. Tsiaj thwmsim tau pom tias overexpression tuaj yeem ncua lub neej ntawm nas los ntawm 12% thaum tswj cov leeg nqaij thiab kev txawj ntse.
Daim ntawv thov kev sib tw thiab cov lus qhia yav tom ntej
Txawm hais tias nws tau pom muaj peev xwm zoo hauv kev tsim lub cev, nws cov kev siv tau zoo tseem ntsib cov teeb meem hauv qab no:
Txoj kev tswj hwm thiab bioavailability
Kev tswj hwm qhov ncauj tau yooj yim degraded los ntawm txoj hnyuv thiab tam sim no tso siab rau kev txhaj tshuaj, uas txwv nws qhov chaw. Kev txhim kho ntawm cov tshuab xa tawm tshiab xws li nanocarriers lossis cov khoom siv hloov pauv tuaj yeem txhim kho bioavailability.
Dos optimization thiab kev nyab xeeb
Cov koob tshuaj muaj txiaj ntsig zoo ntawm Humanin hauv kev sim tsiaj yog qhov nqaim, thiab cov koob tshuaj ntau dhau tuaj yeem cuam tshuam kev ua haujlwm ntawm cov cell killer ntuj. Tib neeg txoj kev tshawb fawb yuav tsum tau qhia meej txog lub qhov rais tshuaj nyab xeeb kom tsis txhob muaj peev xwm tiv thaiv kab mob.
Kev sib txawv ntawm tus kheej thiab cov noob caj noob ces polymorphism
Lub genetic polymorphism ntawmhumanin peptide bodybuildingreceptors (xws li Formylpeptide receptor 2, FPR2) tuaj yeem cuam tshuam rau lawv txoj kev kho mob. Cov txheej txheem tshuaj kho tus kheej yuav tsum tau tsim ua ke nrog kev tshuaj ntsuam genetic technology.
Cim npe nrov: Tuam Tshoj humanin peptide bodybuilding manufacturers, lwm tus neeg
