Ginseng oligopeptides(GOPs) yog ib hom me me molecule active peptide ntu nrog ib qho hnyav molecular feem ntau ntawm 200 thiab 1000 daltons (Da) tau los ntawm kev tsom cleavage ntawm cov protein los ntawm Araliaceae cog Panax ginseng CA Meyer siv enzymatic hydrolysis technology. Lawv muaj li ntawm 2-20 amino acid residues txuas nrog peptide bonds. Tsis zoo li cov khoom xyaw ib txwm muaj xws li ginsenosides, GOPs sawv cev rau kev loj hlob ntawm cov protein ntau hauv ginseng.
Cov nplua nuj nyob hauv 18 hom amino acids, suav nrog 8 qhov tseem ceeb amino acids rau tib neeg lub cev (isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine), nrog rau cov qib siab glutamic acid (Glu) thiab arginine (Arg). Glutamic acid yog qhov ua ntej tshaj plaws ntawm excitatory neurotransmitters nyob rau hauv tib neeg lub cev, thaum arginine yog tus ncaj precursor ntawm nitric oxide (NO) synthesis. Kev nplua nuj ntawm ob cov amino acids no nteg lub hauv paus molecular rau ntau - phiaj xwm lom neeg ntawm GOPs.
Ginseng OligopeptideCOA
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| Certificate of Analysis | ||
| Compound npe | Ginseng Oligopeptide | |
| Qib | Pharmaceutical qib | |
| Ntau | 72g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090066 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv | N\A | |
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.40% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.21% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.42% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 205 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 5 20 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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Ginseng, lub npe hu ua "King of Herbs", muaj keeb kwm kho mob ntau dua txhiab xyoo. Cov tshuaj suav tshuaj suav tshuaj ntseeg tau hais tias ginseng muaj cov txiaj ntsig ntawm "tonifying qi, nourishing ntshav, thiab lub neej ntev", thaum cov kev tshawb fawb niaj hnub no maj mam muab cov txiaj ntsig no rau ob lub cev muaj zog ntawm ginsenosides thiab ginseng peptides. Ntawm lawv,ginseng oligopeptide hmoov(GOP), raws li ib qho me me molecule active peptide ntu tau los ntawm kev qhia enzymatic hydrolysis ntawm ginseng protein (feem ntau muaj li ntawm 2-20 amino acid residues, molecular hnyav.<1000 Da), has attracted much attention in the fields of functional food and cosmetics in recent years due to its advantages of direct absorption through the intestine, high bioavailability, and diverse targets. Compared with commercially available synthetic beauty peptides such as palmitoyl tripeptide-1, oligopeptide-1, oligopeptide-2, etc.
GOP muab kev nyab xeeb ntawm cov khoom siv ntuj tsim nrog kev ua haujlwm siab ntawm cov tshuaj lom neeg peptides. Raws li 2026 cov ntaub ntawv cov khoom lag luam los ntawm Bloomtechz hauv Shaanxi, GOP yog nplua nuj nyob rau hauv 18 amino acids (xws li 8 qhov tseem ceeb amino acids rau tib neeg lub cev), nrog rau glutamic acid (Glu) thiab arginine (Arg) yog qhov tshwj xeeb. Glutamate ua lub zog substrate rau cov ntaub so ntswg hlwb, thaum arginine ua raws li tus thawj coj ncaj qha rau nitric oxide (NO) synthesis. Ob qho no muaj ntau cov amino acids nteg lub hauv paus molecular rau ntau - phiaj xwm lom neeg ntawm GOP.
1. GOP antioxidant kev ua: thawj kab ntawm kev tiv thaiv ntawm daim tawv nqaij tiv thaiv -aging
Oxidative kev nyuaj siab yog lub hauv paus tsav tsheb tom qab endogenous tawv nqaij laus.
Reactive oxygen hom (ROS) tsim los ntawm ultraviolet hluav taws xob, ib puag ncig muaj kuab paug, thiab kev ntxhov siab ntawm lub hlwb tuaj yeem tua cov cell membrane lipids thiab cov proteins, ua rau cov pob txha ntawm malondialdehyde (MDA), collagen breakage, pigmentation, thiab thaum kawg ua rau wrinkles, sagging, thiab dullness.
Cov kev tshawb pom saum toj no muaj cov ntsiab lus ncaj qha rau cov tawv nqaij los tiv thaiv- kev laus: GOP txiav tawm cov kab mob ntawm "dawb radicals → lipid peroxidation → collagen degradation → tawv nqaij laus" los ntawm cov hauv paus hniav los ntawm cov txheej txheem bidirectional ntawm "txo MDA / PCO (txo oxidative puas) + txhim kho SOD/GSHenous defensing ". Qhov kev muaj peev xwm antioxidant no ua rau GOP muaj txiaj ntsig zoo tshaj ib qho tshuaj tiv thaiv antioxidant (xws li vitamin C thiab vitamin E) hauv kev tiv thaiv - kev laus. GOP antioxidant kev ua: thawj kab ntawm kev tiv thaiv ntawm daim tawv nqaij los tiv thaiv -aging. Oxidative kev nyuaj siab yog lub hauv paus tsav tsheb tom qab endogenous tawv nqaij laus.
Reactive oxygen hom (ROS) tsim los ntawm ultraviolet hluav taws xob, ib puag ncig muaj kuab paug, thiab kev ntxhov siab ntawm lub hlwb tuaj yeem tua cov cell membrane lipids thiab cov proteins, ua rau cov pob txha ntawm malondialdehyde (MDA), collagen breakage, pigmentation, thiab thaum kawg ua rau wrinkles, sagging, thiab dullness.
Cov kev tshawb pom saum toj no muaj cov ntsiab lus ncaj qha rau cov tawv nqaij los tiv thaiv- kev laus: GOP txiav tawm cov kab mob ntawm "dawb radicals → lipid peroxidation → collagen degradation → tawv nqaij laus" los ntawm cov hauv paus hniav los ntawm cov txheej txheem bidirectional ntawm "txo MDA / PCO (txo oxidative puas) + txhim kho SOD/GSHenous defensing ". Qhov kev muaj peev xwm antioxidant no ua rau GOP muaj txiaj ntsig zoo tshaj ib qho tshuaj tiv thaiv antioxidant (xws li vitamin C thiab vitamin E) hauv kev tiv thaiv - kev laus.
2. GOP txhawb collagen synthesis: txhawb 'cov hluas scaffold' los ntawm dermis txheej
Hom I collagen tso nyiaj ntau dua 75% ntawm qhov hnyav qhuav ntawm dermis thiab yog cov txheej txheem tseem ceeb ntawm cov protein uas txiav txim siab ntawm daim tawv nqaij firmness thiab elasticity.Thaum muaj hnub nyoog nce, kev ua haujlwm fibroblast txo qis, hom I collagen synthesis txo qis thiab degradation nrawm, ua rau tawv nqaij laxity thiab wrinkle tsim.
Ib txoj kev tshawb fawb luam tawm nyob rau hauv phau ntawv Journal Cosmetics (2022, 9 (3): 58) tau lees paub tias kev kho mob ntawm tib neeg dermal fibroblasts (HDF) nrog GOP ntawm qhov siab ntawm 100 μ g / mL rau 24 teev tuaj yeem txhim kho qhov kev qhia ntawm hom I collagen los ntawm 45%. Qhov no amplitude belongs rau qib siab tshaj plaws ntawm ntuj active peptides.
Tsis tas li ntawd, GOP tuaj yeem qhib cov synthesis ntawm fibronectin hauv fibroblasts, txhim kho cov qauv kev ncaj ncees ntawm epidermal dermal junction (DEJ). Qhov no txhais tau hais tias GOP tsis tsuas yog ua rau daim tawv nqaij "plum" (collagen ↑), tab sis kuj "ntse" (DEJ ntxiv dag zog rau), daws qhov teeb meem ntawm sagging los ntawm ib tug sib sib zog nqus theem.
Kev sib piv nrog hluavtaws peptides qhia tau hais tias txawm tias palmitoyl tripeptide-1 (oligopeptide-1) tuaj yeem txhawb collagen synthesis thiab kho cov hlwb puas, nws qhov chaw yog tshuaj synthesis; GOP tsis tsuas yog txhawb nqa collagen, tab sis kuj muaj ob qhov cuam tshuam ntawm antioxidant thiab tiv thaiv -inflammatory, tsim lub cev tiv thaiv kev laus ntawm "antioxidant + collagen txhawb nqa + tshuaj tiv thaiv".
3. GOP inhibits matrix metalloproteinases (MMPs): khaws collagen los ntawm kev poob
Txhawb nqa collagen synthesis yog qhov 'kev tawm tsam', thaum inhibiting collagen degradation yog 'tiv thaiv'. Matrix metalloproteinases (MMPs) yog ib tsev neeg tseem ceeb enzyme koom nrog kev degradation ntawm extracellular matrix. MMP-1 (collagenase) tshwj xeeb cleaves hom I thiab III collagen, thaum MMP-3 (matrix metalloproteinase) tuaj yeem ua rau lwm yam MMPs, ua tus "pib" ntawm collagen degradation cascade.
Ib txoj kev tshawb fawb 2022 los ntawm Tshuaj pleev ib ce tau qhia tias GOP tuaj yeem cuam tshuam qhov kev qhia ntawm MMP-1 thiab MMP-3. Raws li cov ntaub ntawv dhau los uas GOP txhawb nqa hom I collagen synthesis los ntawm 45%, ua tiav "kev tawm tsam thiab tiv thaiv" qauv tuaj yeem tsim: ntawm ib sab, GOP activates fibroblasts thiab txhawb kev tsim collagen; Ntawm qhov tod tes, GOP inhibits MMP-1/3 thiab thaiv kev degradation ntawm collagen uas twb muaj lawm.
Qhov kev sib tw ob lub cev no yog qhov kev sib tw tseem ceeb ntawm GOP piv rau ib qho kev txhawb nqa collagen (xws li cov vitamin C ntshiab -induced collagen synthesis).
4. GOP cov kev tiv thaiv kev yees duab: qhov kawg nemesis ntawm ultraviolet hluav taws xob
Ultraviolet (UV) hluav taws xob yog ib qho loj tshaj plaws uas ua rau exogenous tawv nqaij laus. UV irradiation tuaj yeem ua rau muaj ntau ntawm ROS ntau lawm, qhib tyrosinase los txhawb melanin synthesis, thiab upregulate MMP qhia kom ceev collagen degradation, thaum kawg ua rau photoaging manifestations xws li wrinkles, pigmentation, thiab so.
ginseng oligopeptide hmoov, nrog nws muaj zog antioxidant muaj peev xwm (SOD ↑, GSH Px ↑, MDA ↓), tuaj yeem tshem tawm UV induced ROS thiab thaiv cov txheej txheem ntawm kev yees duab los ntawm qhov chaw. Nyob rau tib lub sij hawm, GOP indirectly inhibits tyrosinase kev ua si thiab melanin overproduction los ntawm kev txo oxidative kev nyuaj siab theem, ua tiav cov nyhuv ntawm brightening ntawm daim tawv nqaij laus thiab fading pigmentation.
Nws tsim nyog sau cia tias GOP muaj peev xwm ua haujlwm nrog Astaxanthin (los ntawm Haematococcus pluvialis). Astaxanthin feem ntau tshem tawm cov pa oxygen, thaum GOP ua tiav kev txhim kho endogenous antioxidant enzyme system.
Kev sib xyaw ua ke ntawm ob tuaj yeem ua tiav qhov kev tiv thaiv kev yees duab ua ke ntawm "kev tiv thaiv sab nraud (astaxanthin) + kho sab hauv (GOP)".
5. GOP's anti-kev ua kom mob thiab rov ua haujlwm: tua hluav taws tsis pom ntawm daim tawv nqaij
Kev mob qis qis -qib o yog lwm qhov zais cia ntawm cov tawv nqaij laus. Cov kab mob ua paug (TNF - , IL-6, IL-1 ) tsis tsuas yog txo qis collagen ncaj qha, tab sis kuj cuam tshuam cov tawv nqaij teeb meem thiab ua kom cov pigmentation.Cov tshuaj tiv thaiv kab mob ntawm GOP tau ua tiav hauv ntau yam qauv.
Nyob rau hauv LPS stimulated RAW264.7 macrophage qauv, GOP inhibited NO secretion nyob rau hauv ib koob -dependent yam, nrog IC ₅₀=46.03 ± 0.32 μ M, thaum IL-6 thiab TNF - qhia tau inhibited heev. Hauv BV2 microglial cell qauv, GOP inhibited kev ua haujlwm ntawm NF - κ B signaling txoj kev, txo TNF - los ntawm 58%, IL-1 los ntawm 47%, thiab IL-6 los ntawm 62% (tag nrho P<0.01). In a rat model of alcoholic liver injury, GOP significantly reduced serum levels of TNF - α and IL-6. In the liver of db/db mice, GOP also downregulated the expression of TNF - α and IL-6.
Rau daim tawv nqaij, GOP suppresses NF - κ B teeb liab txoj hauv kev, "tua" qhov kev hloov pauv ntawm cov gene qhia theem, tso cai rau daim tawv nqaij rov qab mus rau lub xeev siab thiab hluas. Cov txheej txheem no ua rau GOP tshwj xeeb yog tsim rau cov leeg nqaij rhiab los tiv thaiv - kev laus, tiv thaiv - kho mob tom qab kho mob kos duab thiab lwm yam xwm txheej.
Cov txheej txheem kev npaj thiab kev tswj kom zoo
Kev npaj ua lag luam ntawm GOPs feem ntau ua raws li cov txheej txheem hauv qab no:
Cov ntsiab lus tseem ceeb ntawm cov txheej txheem txheej txheem:
Raw khoom pretreatment ntawm ginseng keeb kwm → tu → ziab → crushing → defatting (tshem cov rog soluble impurities) particle loj<60 mesh.
Enzymatic hydrolysis yog nqa tawm siv alkaline protease (Alcalase) lossis tsw protease (Flavourzyme) rau kev qhia hydrolysis ntawm qhov kub ntawm 50-55 C, pH 8.0-9.0, enzyme puag piv ntawm 3000-5000 U / g, thiab lub sijhawm ntawm 3-5 teev.
Kub lub enzyme ntawm 100 ° C rau 10-15 feeb kom tshem tawm cov tshuaj tiv thaiv.
Separation and purification ultrafiltration (membrane cut-off molecular weight 1000Da/3000Da) → nanofiltration → freeze-drying recovery rate>85%.
Hmoov purity tau los ntawm kev ziab kom qhuav lossis khov kom qhuav ntawm cov khoom tiav Ntau dua lossis sib npaug li 95%, noo noo tsawg dua lossis sib npaug li 5%.
Raws li Suav invention patent CN112813268B (tso cai nyob rau hauv 2021), ib tug optimized npaj txoj kev siv ib tug composite enzyme (alkaline protease + nruab nrab protease nyob rau hauv ib tug ratio ntawm 3: 1) enzymatically hydrolyze GOPs ntawm 55℃C thiab pH 8.5 rau 4 teev. DPPH dawb radical scavenging tus nqi ntawm cov tauginseng oligopeptide hmoovtuaj yeem ncav cuag 82.3%, thiab ACE inhibitory kev ua IC ₅ yog qis li 0.38 mg / mL, zoo dua li ntawm ib qho khoom siv enzymatic hydrolysis.
Cov ntaub ntawv Source:CN112813268B; Shaanxi Shanhe Biotechnology Product Page (2026-01-29); GB 2762 National Food Safety Standard
Cov ntsiab lus tseem ceeb ntawm cov ntaub ntawv:
1. 《Journal of Ginseng Research》2020, 44(3): 456-464
2 . 《Food & Function》(RSC Publishing) 2022, 13: 11234-11245
3 . 《Nutrients》(MDPI)2023, 15(4): 892
4 . 《Food Chemistry》2021, 348: 129105
5 . 《International Immunopharmacology》2020, 89: 107066
6 . 《Journal of Ethnopharmacology》2021, 278: 114306
7. 《 Food and Chemical Toxicology》2021, 156: 112456
8. CN112813268B/CN114606283B/CN114213507B
9. WO2017124921A1/MY193780A
10. Shaanxi ShineHerb Biological (ShineHerb) Khoom Nplooj (2026-01-29)
11. Shaanxi Baichuan Biotechnology Official Lub Vev Xaib (Lub Cuaj Hli 9, 2025)
12. Grand View Research 2026 Ginseng Peptide Market Report
13. European Plant Protein Peptide Market Report (2026-2033)
14. Morganna's Alchemy Skin Care
15. GB 2762 National Food Safety Standard
Cim npe nrov: Tuam Tshoj ginseng oligopeptide manufacturers, lwm tus neeg
