Secretin yog thawj lub plab zom mov cov tshuaj hormones pom nyob rau hauv tib neeg, feem ntau secreted los ntawm S hlwb nyob rau hauv lub duodenum thiab ua hauj lwm raws li ib tug tseem ceeb txoj cai molecule nyob rau hauv kev tswj cov kev ua ntawm lub digestive system.Secretin Txhaj, nws Feem ntau qhov tseem ceeb ntawm lub cev muaj zog yog ob npaug: ua ntej, txhawb cov txiav txiav kom zais cov kua txiv kab ntxwv alkaline, ua haujlwm zoo neutralizing gastric acid uas nkag mus rau hauv cov hnyuv; thiab thib ob, inhibiting gastric acid secretion thaum ncua lub plab khoob. Ob lub tswv yim no ntxiv rau ib leeg, sib koom ua ke tsim kom muaj kev tiv thaiv kab mob rau plab hnyuv acid- puag ncig.
Cov txheej txheem no tuav qhov tseem ceeb physiological tseem ceeb: ntawm ib sab, nws tsim ib qho chaw alkaline tsim nyog rau kev ua kom lub plab zom mov enzymes, kom ntseeg tau tias digestive efficiency; Ntawm qhov tod tes, nws tiv thaiv cov kua qaub ntau dhau los ntawm kev ua rau lub plab hnyuv mucosa, yog li khaws cia kev ncaj ncees ntawm txoj hnyuv. Kev ua haujlwm ntawm nws tsis raug cais tawm - nws ua haujlwm sib koom ua ke nrog cov tshuaj hormones xws li cholecystokinin thiab tswj hwm los ntawm lub paj hlwb, sib sau ua ke tswj kev zom zaub mov homeostasis.
Yog li ntawd, los ntawm kev tswj hwm cov kua qaub- puag ncig, nws ua lub luag haujlwm tseem ceeb hauv kev zom zaub mov. Kev ua haujlwm zoo ntawm secretin yog lub hauv paus tseem ceeb rau kev zom zaub mov zoo thiab nqus tau cov zaub mov.
Peb cov khoom Description
Secretin COA
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| Certificate of Analysis | ||
| Compound npe | Secretin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 17034-35-4 | |
| Ntau | 30g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090077 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.97% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Tshuaj Formula | C130H220N44O41 |
| Exact Mass | 3053.65 |
| Molecular Luj | 3055.46 |
| m/z | 3054.65 (100.0%), 3053.65 (71.1%), 3055.65 (69.8%), 3056.66 (23.9%), 3055.65 (16.3%), 3056.65 (9.3%), 3056.66 (8.4%), 3056.66 (8.3%), 3054.65 (6.6%), 3057.66 (6.0%), 3055.65 (6.0%), 3057.66 (5.9%), 3057.66 (5.0%), 3054.65 (5.0%), 3057.66 (2.9%), 3055.66 (2.5%), 3057.66 (2.4%), 3058.67 (2.3%), 3056.65 (2.0%), 3058.66 (2.0%), 3054.65 (1.8%), 3056.66 (1.8%), 3055.66 (1.6%), 3057.65 (1.4%), 3058.66 (1.2%), 3054.65 (1.1%), 3056.66 (1.1%), 3056.65 (1.1%) |
| Elemental Analysis | C, 51.10; H, 7.26; N, 20.17; O, 21.47 |
Cov nyhuv ntawm Secretin rau stimulating pancreatic secretion ntawm alkaline pancreatic kua txiv
Lub luag haujlwm ntawm cov tshuaj no yog qhov tseem ceeb ntawm kev siv tshuaj kho mob thiab kev tshawb fawb tshawb fawb txij li nws tshawb pom. Raws li cov txiaj ntsig physiological no, txoj kev tshawb nrhiav paub tab, cov phiaj xwm kho mob ntxiv, thiab txiav - cov lus qhia tshawb fawb txog kev tshawb fawb tau txuas ntxiv.
(I) Kev kuaj mob: Cov ntaub ntawv ntxaws ntxaws ntawm Secretin Stimulation Test
Qhov kev sim tshuaj stimulation tam sim no yog ib qho ntawm cov txheej txheem kub rau kev ntsuam xyuas pancreatic exocrine muaj nuj nqi. Nws tsim yog tag nrho raws li classic physiological luag hauj lwm ntawm nws. Cov txheej txheem xeem yog raws li nram no: nyob rau hauv kev yoo mov, hluavtaws exogenoustxhaj tshuaj secretinyog muab tso rau hauv cov hlab ntsha kom meej meej qhib cov receptors ntawm pancreatic ductal epithelial hlwb. Tom qab ntawd, kua txiv pancreatic secreted nyob rau hauv ib lub sij hawm teev yog sau los ntawm endoscopic pancreatic duct catheterization los yog duodenal aspiration. Kev ntsuas ntau yog tom qab ntawd ua tiav ntawm tag nrho cov ntim ntawm pancreatic secretion, bicarbonate concentration hauv cov kua txiv pancreatic, thiab qib ntawm cov enzymes digestive xws li pancreatic amylase, lipase, thiab trypsin.
Nyob rau hauv ib txwm muaj lub cev muaj zog, exogenous secretin nkoos pancreas los tsim cov kua txiv pancreatic txaus nrog siab bicarbonate concentration. Txawm li cas los xij, thaum txiav txiav raug cuam tshuam los ntawm cov kab mob organic, nws txoj haujlwm exocrine yuav raug cuam tshuam rau ntau qib. Los ntawm kev txheeb xyuas qhov txawv txav ntawm cov kev txwv no, qhov kev sim muab kev pabcuam kev kuaj mob tseem ceeb rau cov xwm txheej xws li mob pancreatitis, mob qog noj ntshav, cystic fibrosis, thiab pancreatic exocrine insufficiency. Tshwj xeeb tshaj yog rau cov kab mob pancreatic thaum ntxov, qhov kev sim no tuaj yeem kuaj pom qhov ua haujlwm tsis zoo ua ntej qhov txawv txav tseem ceeb tshwm sim ntawm kev tshawb fawb duab, yog li txhim kho cov kab mob thaum ntxov.
(II) Kev Kho Mob: Kev Pab Cuam Tshuam rau Pancreatic Exocrine Insufficiency
Txoj kev kho no tsuas yog siv tau rau cov neeg mob tshwj xeeb uas muaj qhov tsis zoo ntawm pancreatic exocrine muaj nuj nqi, feem ntau pom nyob rau hauv cov xwm txheej xws li pancreatic resection, mob siab heev pancreatitis, lossis cystic fibrosis nrog pancreatic puas. Hauv cov neeg mob no, endogenous secretin secretion tsis txaus, lossis qhov rhiab heev ntawm pancreatic ductal epithelial hlwb rau nws txo, ua rau tsis txaus tso kua txiv kua txiv kua txiv pancreatic. Exogenous supplementation ntawm cov tshuaj no ncaj qha nkoos cov ntaub so ntswg pancreatic secrete bicarbonate, tsa lub duodenal pH thiab neutralizing gastric acid nkag mus rau hauv cov hnyuv. Ntawm ib sab tes, qhov no yuav pab tiv thaiv kom tsis txhob muaj zog gastric acid tsis tu ncua eroding lub plab hnyuv mucosa, txo txoj kev pheej hmoo ntawm plab hnyuv ulcers thiab los ntshav.
Ntawm qhov tod tes, nws muab qhov kev pom zoo nruab nrab- rau- ib puag ncig alkaline rau kev ua haujlwm ntawm exogenous pancreatic enzyme npaj. Hauv kev xyaum kho mob,txhaj tshuaj secretinfeem ntau yog siv ua ke nrog exogenous pancreatic enzyme tshuaj pab kom txo tau cov tsos mob xws li steatorrhea, tsam plab, thiab tsis qab los noj mov los ntawm pancreatic enzyme inactivation thiab impaired digestive function. Txoj hauv kev no txhim kho kev nqus ntawm cov rog, cov protein, thiab carbohydrates, txhim kho tus neeg mob noj zaub mov zoo. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qhov kev kho mob no tsuas yog ib qho kev pab cuam nkaus xwb thiab tsis tuaj yeem thim rov qab cov organic pancreatic puas los yog hloov cov kev kho mob xws li kev hloov pauv hauv pancreatic.
(III) Daim Ntawv Thov Kev Tshawb Fawb: Ib qho tseem ceeb txhawb rau Pancreatic Physiology thiab Kev Txhim Kho Tshuaj
Cov txheej txheem physiological no ua haujlwm ua qhov tseem ceeb nkag rau kev tshawb fawb txog kev ua haujlwm ntawm pancreatic. Cov kws tshawb fawb siv cov qauv tsiaj (xws li nas thiab nas) nrog pancreatic dysfunction thiab hauv vitro cell qauv ntawm pancreatic ductal epithelial hlwb los tswj cov kev cuam tshuam secretin, yog li tshawb xyuas cov txheej txheem ntawm ion thauj, teeb liab hloov, thiab kev tswj kev zais cia hauv cov hlwb. Tsis tas li ntawd, cov kev tshawb fawb tsom mus rau txoj hauv kev uas nws kho cov plab hnyuv acid- kev tswj hwm kev sib npaug thiab txheeb xyuas cov tswv yim tawm tswv yim nrog rau cov kua qaub hauv plab, secretin, thiab pancreatic secretion. Tsim los ntawm lub hauv paus no, cov tshuaj no thiab nws txoj kev cuam tshuam yog lub hom phiaj rau kev tshuaj xyuas tshuaj.
Ntawm ib sab tes, kev tshuaj xyuas rau agonists uas ua raws li cov txiaj ntsig ntawm nws pab txhim kho kev nyab xeeb thiab ua haujlwm zoo dua cov tshuaj hloov pauv pancreatic. Ntawm qhov tod tes, kev tshuaj xyuas rau cov kev hloov pauv xws li secretin receptor antagonists tshawb nrhiav lawv cov kev siv peev xwm hauv cov kab mob cuam tshuam nrog pancreatic hypersecretion, muab theoretical thiab kev sim hauv paus rau kev txhim kho cov tshuaj tshiab tsom rau kev mob pancreatic.
Inhibit gastric acid secretion thiab ncua lub plab khoob
Lub luag haujlwm ntawm nws ua lub luag haujlwm pabcuam hauv kev tiv thaiv thiab kev kho mob ntawm plab hnyuv los ntawm kev tswj cov kua qaub thiab motility ntawm txoj hnyuv, thiab muab cov lus qhia tseem ceeb rau kev tshawb fawb txog cov tshuaj hormones gastrointestinal.
Adjuvant Kev Kho Mob ntawm plab hnyuv Fistulas: Pancreatic fistulas, biliary fistulas, thiab enteric fistulas yog ib qho teeb meem loj heev tom qab mob plab lossis phais plab. Cov fistulas tsis tu ncua tso cov kua dej hauv plab, uas muaj cov tshuaj corrosive xws li gastric acid thiab kua txiv pancreatic. Cov kua dej no tsis tu ncua ua rau cov ntaub so ntswg nyob ib puag ncig, exacerbating cov ntaub so ntswg necrosis, kab mob, thiab impeding fistula kho. Cov tshuaj no txo cov kev tso tawm tag nrho ntawm gastric acid los ntawm ntau txoj hauv kev, suav nrog kev cuam tshuam ncaj qha ntawm parietal cell acid secretion thiab inhibition ntawm gastrin tso tawm. Nyob rau tib lub sijhawm, nws txo qis tag nrho secretory load ntawm gastrointestinal digestive kua. Qhov txo qis hauv ob qho tib si ntim thiab acidity ntawm cov kua hauv plab ua rau txo qis corrosion thiab inflammatory stimulation rau cov ntaub so ntswg fistula, tswj cov kab mob hauv zos txaus ntshai, thiab tsim cov ntaub so ntswg hauv zos rau kev kho mob fistula los yog tom qab phais kho. Qhov no ua rau secretin ib qho tseem ceeb adjunctive tivthaiv nyob rau hauv cov kev tswj ntawm gastrointestinal fistulas.
Kev Tiv Thaiv Kev Nyuaj Siab-Induced Gastric Mucosal Injury: Nyob rau hauv kev ntxhov siab xws li kev raug mob hnyav, kub hnyiab, kev phais loj, lossis kev kis kab mob tseem ceeb, kev ua kom lub paj hlwb ua rau txo qis hauv plab mucosal cov ntshav ntws thiab nce gastric acid secretion, ua rau muaj kev ntxhov siab -ua rau muaj kev puas tsuaj rau cov hlab ntsha thiab ua rau lub plab zom mov ntau ntxiv. tej zaum. Nws tuaj yeem cuam tshuam kev cuam tshuam los ntawm inhibiting gastric acid secretion ntau dhau thaum muaj kev ntxhov siab thiab ua rau lub plab khoob. Qhov no txo qis kev ua xua ntawm lub plab mucosa los ntawm acidic chyme, txhim kho lub peev xwm tiv thaiv mucosal, thiab txo qis kev pheej hmoo ntawm kev ntxhov siab- raug mob plab hnyuv.
(II) Kev Tshawb Fawb Cov Ntawv Thov: Cov Kabmob Kabmob Cov Kabmob Cov Kabmob Kev Tswj Xyuas Network thiab Kev Tsim Tshuaj Tshiab
Lub secretory thiab lub cev muaj zog ua haujlwm ntawm lub plab zom mov yog tswj los ntawm kev sib koom ua ke ntawm ntau yam kab mob hauv plab, nrog rau nws ua lub luag haujlwm tseem ceeb hauv lub network no. Cov kws tshawb fawb tsom mus rau kev kawm txog kev sib cuam tshuam thiab kev tawm tswv yim tswj hwm cov txheej txheem ntawm cov tshuaj hormones xws li secretin, gastrin, thiab somatostatin. Gastrin yog ib qho tseem ceeb ntawm cov tshuaj hormones uas txhawb nqa cov kua qaub hauv plab thiab ua kom lub plab zom mov, thaum somatostatin yog ib qho dav -spectrum inhibitor ntawm gastrointestinal secretion.
Kev txhaj tshuaj secretinua nyob rau hauv antagonistic thiab synergistic yam nrog cov tshuaj hormones los tswj lub homeostasis ntawm gastric acid secretion thiab gastric motility. Los ntawm kev tshawb xyuas qhov kev tswj hwm lub network no, cov kws tshawb fawb tuaj yeem nkag siab tob rau hauv cov kab mob ntawm cov kab mob xws li gastric ulcers, functional dyspepsia, qeeb gastric emptying, thiab gastrinomas, thiab elucidate cov qauv ntawm gastrointestinal hormone imbalances thaum lub sij hawm tus kab mob. Tsis tas li ntawd, kev tsom mus rau secretin-txoj hauv kev muaj feem cuam tshuam rau kev txhim kho cov kua qaub tshiab- txwv tsis pub siv tshuaj thiab kev hloov pauv hauv plab hnyuv. Piv nrog rau cov tshuaj acid ib txwm siv -tshuaj xyuas cov tshuaj, cov tshuaj tsim los ntawm nws tuaj yeem tswj hwm cov kab mob hauv plab hnyuv ntau dua, ib txhij inhibiting gastric acid secretion thiab modulating gastrointestinal motility. Qhov no tuav cov lus cog tseg rau kev muab cov tswv yim kho tshiab tshiab rau cov teeb meem ntawm gastric acid secretion thiab gastrointestinal motility dysfunction.
Txheej txheem cej luam ntawm ob classic physiological teebmeem
Ob qho kev cuam tshuam ntawm lub cev ntawm nws txoj kev txhaj tshuaj: txhawb lub txiav ua kom zais alkaline pancreatic kua txiv rau neutralize gastric acid nyob rau hauv cov hnyuv thiab inhibiting gastric acid secretion thaum ncua lub plab khoob, sib sau ua ib lub tswv yim tseem ceeb rau kev tswj cov kua qaub- puag ncig thiab mucosal tiv thaiv hauv plab hnyuv.
Nyob rau hauv daim ntawv thov kev kho mob, leveraging cov nyhuv qub, cov tshuaj stimulation test tau dhau los ua ib txoj hauv kev rau kev ntsuam xyuas pancreatic exocrine muaj nuj nqi. Nws muaj txiaj ntsig zoo hauv kev kuaj mob ntxov thiab kev ntsuas kab mob ntawm cov mob xws li mob pancreatitis, mob qog noj ntshav, thiab cystic fibrosis. Tsis tas li ntawd, kev cuam tshuam ntawm exogenous secretin cuam tshuam zoo txhim kho plab zom mov hauv cov neeg mob uas muaj tus kab mob pancreatic exocrine insufficiency, txhim kho kev nqus cov as-ham.
Tsis tas li ntawd, nws lub luag haujlwm hauv inhibiting gastric acid secretion thiab tswj lub plab hnyuv motility plays lub luag haujlwm tseem ceeb thiab kev tiv thaiv kev ua haujlwm hauv kev kho cov plab hnyuv fistulas thiab tiv thaiv kev raug mob plab hnyuv hauv cov kev ntxhov siab. Hauv kev tshawb fawb hauv kev tshawb fawb, ob txoj haujlwm no yog cov ntsiab lus tseem ceeb rau kev tshawb nrhiav cov kab mob pancreatic secretion regulation thiab gastrointestinal hormone signaling networks. Lawv nteg lub hauv paus ruaj khov rau deciphering lub pathogenesis ntawm plab hnyuv thiab pancreatic kab mob thiab txheeb xyuas cov hom phiaj tshiab tshuaj.
Nrog rau kev nce qib txuas ntxiv ntawm kev tshawb fawb ntsig txog, kev siv tshuaj kho mob muaj peev xwm thiab cov txiaj ntsig kev tshawb fawb ntawm nws yuav tsum tau nthuav tawm ntxiv, muab txoj hauv kev tshiab rau kev tiv thaiv thiab kho cov kab mob hauv plab thiab pancreatic.
Cov lus nug nquag
- Dab tsi yog secretin?
Qhov kev txhaj tshuaj no yog siv rau kev txhawb nqa ntawm pancreas secretions los pab kuaj lossis pom cov teeb meem hauv txiav txiav thiab pab txheeb xyuas lub ampulla ntawm Vater thiab cov khoom siv papilla thaum lub sijhawm endoscopy. Nws kuj tseem siv tau los pab hauv kev kuaj mob ntawm gastrinoma (cov qog nqaij hlav hauv plab lossis txiav txiav).
- Yuav ua li cas secretin tswj?
Nws muab rau tus neeg mob los ntawm kev txhaj tshuaj rau hauv cov hlab ntsha. Tom qab qee lub sijhawm, cov qauv ntawm cov kua dej tau muab los ntawm cov hnyuv me los ntawm lub raj thiab xa mus rau ib lub chaw kuaj mob los kuaj cov lus teb.
- Lub hom phiaj secretin yog dab tsi?
Secretin lub hom phiaj tseem ceeb ntawm lub cev yog lub txiav, txhawb nws kom tso tawm bicarbonate - cov kua dej nplua nuj kom tshem tawm cov kua qaub hauv plab hauv duodenum, tab sis nws kuj cuam tshuam rau daim siab, plab, thiab ob lub raum, txhawb cov kua tsib, inhibiting acid, thiab tswj cov dej sib npaug, feem, nrog cov receptors kuj pom nyob rau hauv lub hlwb.
Cim npe nrov: Tuam Tshoj secretin txhaj tshuaj manufacturers, lwm tus neeg
