Raws li ib tug natural sourced cationic active peptide,melittin tshuaj tsuagmuab cov teebmeem lom neeg muaj zog heev nyob ib puag ncig ntawm ob qhov tseem ceeb ua haujlwm. Ob qho khoom siv los ntawm nws cov qauv molecular tshwj xeeb thiab cov kev ua haujlwm tshwj xeeb, ua rau nws ua kom muaj kev sib txawv ntawm lub cev. Qhov tshwj xeeb zoo li no tsis tsuas yog qhia txog nws qhov kev teeb tsa zoo tshaj plaws ntawm cov molecular tab sis kuj tseem tsim lub hauv paus ruaj khov rau nws txoj kev txhim kho ntxiv, kev siv tswv yim thiab kev hloov pauv kev lag luam. Sib txawv los ntawm ntau yam ntuj active peptides uas tsuas muaj ib tug ua hauj lwm vaj tse, ob tug yam ntxwv tseem ceeb ntawm no ua hauj lwm nyob rau hauv nws tus kheej kuj tseem featuring muaj peev xwm molecular correlations. Lawv muaj peev xwm ua tau zoo ntawm ob theem cellular thiab qib systemic ntawm tib neeg lub cev. Nyob rau hauv cov ntsiab lus hauv qab no, peb yuav ua ib qho kev nthuav dav hauv - qhov tob ntawm ob qhov tseem ceeb ntawm cov kev xav no los ntawm ntau qhov kev xav xws li cov txheej txheem molecular, cov txheej txheem ua kom ntxaws thiab cov ntawv thov yav tom ntej, txhawm rau ua kom meej meej lawv cov kev ua haujlwm sab hauv thiab cov txiaj ntsig ua haujlwm tau zoo.
Peb Cov Khoom Muag Khoom
Melittin COA
Melittin nqi & nws cov kev cai ntawm inflammatory mediators thiab antagonism rau prostaglandin synthesis
Qhov tseem ceeb ntawm kev ua tau zoo ntawmmelittin tshuaj tsuagNyob rau hauv lub teb ntawm phlogistic kev cai yog tsuas yog xav nyob rau hauv lub hom phiaj inhibition ntawm tej phlogistic mediators thiab blockade ntawm prostaglandin biosynthesis. Cov txheej txheem no suav nrog ntau qhov ntev xws li molecular theem teeb liab kev tswj hwm kev tswj hwm thiab qib cellular secretion inhibition, thiab txhua qhov txuas ua haujlwm ua ke los tsim cov kev tswj hwm phlogistic tiav. Qhov tshwj xeeb thiab kev nkag siab ntawm nws cov txheej txheem ntawm kev ua haujlwm ua rau nws yog ib qho kev tshawb fawb tseem ceeb hauv cov tshuaj phlogistic tswj hwm ntuj.
01.Lub hom phiaj kev tswj hwm txheej txheem ntawm TNF - .
TNF - , raws li cov tub ntxhais phlogistic mediator hauv pro-phlogistic teb, nws overexpression tuaj yeem ua rau lub cev tsis zoo ntawm cov lus teb phlogistic, exacerbate cov ntaub so ntswg puas thiab phlogistic infiltration. Mellttin tuaj yeem ua tiav lub hom phiaj inhibition ntawm TNF - los ntawm kev tswj cov kev ua haujlwm ntawm cov khoom siv hluav taws xob nuclear kappa B (NF - κ B) qhia txoj hauv kev. Tshwj xeeb, mellttin tuaj yeem khi rau qhov tseem ceeb ntawm kev tswj hwm hauv NF - κ B signaling txoj hauv kev, tiv thaiv lawv txoj kev hloov mus rau hauv lub nucleus, yog li txo qis cov kev hloov pauv thiab kev qhia theem ntawm TNF - noob thiab txo lawv qhov tso tawm thiab tso tawm. Txoj cai no tsis yog ib qho yooj yim inhibitory nyhuv, tab sis nthuav tawm cov koob tshuaj meej - nyob ntawm cov yam ntxwv ntawm kev tswj hwm.
Nyob rau hauv qhov tsim nyog ntau yam, nws muaj peev xwm tshwj xeeb inhibit qhov overexpression ntawm TNF - yam tsis muaj kev cuam tshuam cov phlogistic tiv thaiv cov lus teb ntawm lub cev. Qhov cuam tshuam hauv vitro macrophage kab lis kev cai tau txheeb xyuas tias tom qab kev kho mob nrog melttin, qhov tso tawm ntawm TNF - tuaj yeem raug txo los ntawm 40% -60%, thiab tsis muaj kev cuam tshuam loj rau kev ua haujlwm ntawm lub cev ntawm macrophages. Tsis tas li ntawd, melttin kuj tseem tuaj yeem hloov pauv nws qhov kev sib haum xeeb thiab txo nws cov kev ua haujlwm lom neeg los ntawm kev khi rau TNF - molecules lawv tus kheej, ntxiv rau nws cov kev tiv thaiv tsis muaj zog thiab tsim kom muaj kev tswj hwm kev tswj hwm ob.
02.Inhibition thiab txuas ntxiv ntawm IL-6 secretion.
IL-6, raws li lwm tus tseem ceeb pro-phlogistic mediator, ua haujlwm sib koom ua ke nrog TNF - los txhawb qhov tshwm sim thiab txhim kho cov lus teb phlogistic, thiab ua lub luag haujlwm tseem ceeb hauv kev txhim kho kev mob ntev. Kev tswj hwm ntawm IL-6 los ntawm qhov no feem ntau tsom rau qib cellular secretion, thiab tuaj yeem tsom qhov inhibition ntawm IL-6 secretion hauv phlogistic cov hlwb xws li synovial fibroblasts thiab macrophages. Nws txoj hauv kev ntawm kev nqis tes ua yog ua tiav los ntawm inhibiting Janus kinase / signal transducer thiab activator of transcription (JAK / STAT) signaling pathway.
Thaiv cov kev cai ntawm IL-6 noob, thiab txo cov synthesis thiab tso tawm ntawm IL-6.Meanwhile,melittin tshuaj tsuagtseem tuaj yeem cuam tshuam qhov kev qhia ntawm IL-6 receptors, txo cov kev sib txuas ntawm IL-6 thiab receptors, ua rau tsis muaj zog ntawm kev sib kis ntawm cov kab hluav taws xob pro-phlogistic, thiab yog li txo IL-6 cov lus teb phlogistic xws li cov ntaub so ntswg edema thiab phlogistic cell infiltration. Hauv cov qauv mob ntev, nws tuaj yeem txo qhov concentration ntawm IL-6 hauv cov ntaub so ntswg hauv zos, txo cov phlogistic puas tsuaj, thiab cov nyhuv inhibitory tsis tu ncua, muaj txiaj ntsig ncua kev loj hlob ntawm kev mob ntev.
03.Blocking txoj kev ntawm prostaglandin synthesis.
Prostaglandins, raws li tus neeg nruab nrab tseem ceeb hauv cov tshuaj tiv thaiv kab mob, vam khom feem ntau ntawm kev ua haujlwm catalytic ntawm cyclooxygenase (COX) hauv lawv cov txheej txheem biosynthesis. COX-2, raws li ib tug inducible cyclooxygenase, yog heev qhia nyob rau hauv phlogistic stimulation, txhawb lub synthesis ntawm prostaglandins thiab exacerbating o thiab cov nqaij mos mob. Mellttin tuaj yeem tiv thaiv kev ua haujlwm ntawm COX-2 thiab thaiv cov biosynthesis ntawm prostaglandins. Tshwj xeeb, mellttin tuaj yeem khi rau qhov chaw nquag ntawm COX-2, inhibit nws txoj haujlwm catalytic, txo cov kev hloov pauv ntawm arachidonic acid rau prostaglandins.
Thiab yog li txo qis cov concentration ntawm prostaglandins hauv lub cev. Tsis tas li ntawd, mellttin tuaj yeem txo qis kev qhia theem ntawm COX-2 noob, txo COX-2 synthesis, thiab thaiv kev tsim cov prostaglandins los ntawm lub hauv paus, tsim ib qho kev thaiv ob qho ntawm "kev ua haujlwm inhibition + synthesis inhibition". Cov nyhuv thaiv no yog qhov tshwj xeeb thiab tsuas yog lub hom phiaj COX-2. Nws tsis muaj qhov cuam tshuam tseem ceeb ntawm COX-1, uas yog koom nrog hauv kev tswj hwm kev ua haujlwm ntawm lub cev. Nws tuaj yeem cuam tshuam phlogistic cov tshuaj tiv thaiv thaum tsis txhob cuam tshuam nrog lub cev cov txheej txheem physiological metabolic.
04.Lub synergistic nyhuv ntawm inflammatory kev cai thiab kev sim ua pov thawj.
Qhov inhibition ntawm TNF - thiab IL-6 los ntawm mellttin thiab blockade ntawm prostaglandin synthesis tsis muaj nyob rau hauv kev sib cais, tab sis muaj kev cuam tshuam tseem ceeb.
Peb ua hauj lwm ua ke los inhibit qhov tshwm sim thiab kev loj hlob ntawm phlogistic tshwm sim nyob rau hauv ntau theem, tsim ib tug tiav phlogistic regulatory network.In vivo thwmsim tau lees paub tias malittin kev kho mob yuav txo tau cov theem ntawm inflammatory mediators nyob rau hauv phlogistic qauv tsiaj, alleviate edema thiab infiltration ntawm inflammatory cov ntaub so ntswg, thiab alleviate mob teb los ntawm o. Nws cov tshuaj tiv thaiv kab mob yog piv rau cov tshuaj tiv thaiv kab mob - cov tshuaj tiv thaiv kab mob, thiab tsis muaj kev phiv loj heev. Tsis tas li ntawd, kev sim molecular docking tau pom tias mellttin tuaj yeem tsim kev ruaj khov nrog TNF - , IL-6, thiab COX-2, ntxiv kev lees paub nws cov phiaj xwm kev cai tshwj xeeb thiab kev ntseeg siab, muab lub hauv paus khoom molecular rau nws cov kev tswj hwm phlogistic.
Cov kev ua ub no ntawm lub cev muaj zog ntawm Mellitin: cardiotonic, antiarrhythmic, tiv thaiv hluav taws xob, thiab kev tiv thaiv kab mob
Melittin tshuaj tsuagmuaj ntau qhov kev ua haujlwm ntawm lub cev muaj zog, feem ntau yog tsom rau hauv kev tswj hwm lub plawv, kev tiv thaiv hluav taws xob, thiab kev tiv thaiv kab mob.
Txhua yam kev ua haujlwm tso siab rau cov txheej txheem molecular tshwj xeeb los ua kom nws cov teebmeem, thiab muaj kev ywj pheej ntawm ib leeg yam tsis muaj kev sib koom ua ke lossis antagonistic cuam tshuam.Cov nyhuv cardiotonic activates cov kev taw qhia los ntawm kev khi rau cov receptors tshwj xeeb ntawm myocardial cell membrane, txhawb calcium influx thiab optimizing myocardial zog metabolism, thaum inhibiting myocardial cell apoptosis.
Ntawm cov koob tshuaj uas tsim nyog, nws tuaj yeem txhim kho lub plawv dhia ua haujlwm yam tsis muaj tshuaj lom tseem ceeb thiab yog koob tshuaj - nyob ntawm. Cov teebmeem antiarrhythmic tuaj yeem ua tiav los ntawm kev tswj cov haujlwm ntawm myocardial ion channels.
Txhim kho hluav taws xob conductivity, inhibiting myocarditis cov tshuaj tiv thaiv, stabilizing myocardial hluav taws xob kev ua si, txo qhov txawv txav pacing thiab hluav taws xob teeb liab thaiv. Nws yog haum rau ntau yam arrhythmias thiab muaj kev zam zoo.
Cov nyhuv tiv thaiv hluav taws xob tau cuam tshuam los ntawm kev tshem tawm cov pa oxygen reactive uas tsim los ntawm hluav taws xob, txhawb kev kho DNA puas, txhim kho lub cev hluav taws xob tiv thaiv hluav taws xob, thiab txo cov hluav taws xob puas tsuaj rau lub cev tseem ceeb. Kev tswj hwm lub cev tiv thaiv kab mob yog bidirectional, uas tuaj yeem ua kom lub cev tiv thaiv kab mob hauv lub cev, txhawb cov lus teb phlogistic, tswj kev hloov pauv ntawm lub cev tiv thaiv kab mob, kev sib txawv, thiab tshuaj tiv thaiv qog noj ntshav, thaum inhibiting kev tiv thaiv kab mob ntau dhau. Ntawm cov koob tshuaj tsim nyog, nws tuaj yeem tswj lub cev tiv thaiv kab mob homeostasis.
Melittin kev muag khoom: Kev ua kom lub cev muaj zog ntawm cardiotonic, antiarrhythmic, tiv thaiv - hluav taws xob thiab kev tiv thaiv kab mob
Kev cia siab rau nws qhov tseem ceeb phlogistic tswj kev ua tau zoo,melittin tshuaj tsuagmuaj peev xwm ua tau zoo hauv kev cuam tshuam ntawm cov kab mob sib kis xws li mob caj dab rheumatoid, osteoarthritis, thiab dermatitis. Nrog kev pab los ntawm muv koob kho kom haum tus me nyuam, nws ua tiav lub hom phiaj kev ua tau zoo thiab muaj qhov zoo ntawm lub hom phiaj muaj zog thiab ruaj khov. Nws yog ib qho tseem ceeb cov lus qhia rau ntuj active peptide kev cuam tshuam nyob rau hauv inflammatory kab mob.
01.Bee koob cuam tshuam rau rheumatoid mob caj dab.
Raws li tus kab mob autoimmune phlogistic, nws cov kab mob tseem ceeb yog kev sib koom ua ke, pob txha mos, thiab deformity.
Bee koob tuaj yeem xa cov khoom melltin mus rau cov pob qij txha cuam tshuam, txo cov synovitis thiab pob txha mos degradation los ntawm inhibiting phlogistic mediators xws li TNF - thiab IL-6, nrog rau MMP-1 thiab MMP-8 kev ua, alleviating joint redness, o, thiab mob.
Qhov kev ua tau zoo yog piv rau cov tshuaj tiv thaiv ib txwm muaj - cov tshuaj tiv thaiv kab mob thiab tsis muaj kev phiv tshuaj hormonal. Nws tseem tuaj yeem tswj cov kab mob metabolic kom txhim kho kev cuam tshuam zoo.
02.Kev cuam tshuam hauv zos rau cov kab mob dermatitis.
Cov kab mob dermatitis feem ntau cuam tshuam nrog kev mob hauv zos thiab kev tiv thaiv kab mob. Mellttin tuaj yeem xa los ntawm muv stings lossis hauv zos infiltration, inhibiting kev qhia ntawm lub zos TNF - thiab IL-6 kom txo tau qhov mob infiltration, txo qhov liab, o, thiab khaus, thaum tswj cov tawv nqaij barrier, txhawb kev kho ntawm tes, txo flaking thiab dryness, thiab sai sai siv. Nws kuj tseem tuaj yeem txo qhov kev pheej hmoo ntawm kev raug mob thiab txo qhov rov tshwm sim.
03.Txoj kev cuam tshuam rau osteoarthritis.
Tus kab mob no tshwm sim los ntawm degenerative hloov nyob rau hauv articular pob txha mos thiab synovitis. Mellttin xa los ntawm muv stings tuaj yeem tsom thiab inhibit synovial o, txo qhov kev tso tawm ntawm cov kab mob sib kis, txhawb chondrocyte proliferation thiab kho, inhibit apoptosis thiab matrix degradation, txhim kho kev sib koom ua ke hauv zos, txo cov tsos mob, ncua cov kab mob, thiab muab cov tswv yim tsis muaj tshuaj kho mob rau me me mus rau nruab nrab osteoarthritis.
Cov ntaub ntawv
Liu Fang, Chen Jing, Zhang Lei Molecular txoj kev kawm ntawm melitin inhibiting prostaglandin synthesis Progress in Biochemistry thiab Biophysics, 2023, 50 (9): 1876-1884
Li M, Zhang H, Chen L. Lub luag hauj lwm ntawm melttin nyob rau hauv regulating NF-κB signaling pathway thiab inflammatory teb. Phau ntawv Journal of Biomolecular Structure and Dynamics, 2024, 42(7): 3690-3702.
Wang Hao, Li Jing, Zhao Wei Daim ntawv thov ntawm muv koob tshuaj kho mob rheumatoid mob caj dab thiab lub luag hauj lwm ntawm malittin Suav Journal of Rheumatology, 2023, 27 (8): 521-527
Helical Structure ntawm Recombinant Mellttin (https://pmc.ncbi.nlm.nih.gov/articles/PMC6465175/)
Pro-Apoptotic and Cytotoxic Effects of Mellttin on HL-60 Acute Promyelocytic Leukemia Cells: Implications for Retinoid-Independent Therapy(https://pmc.ncbi.nlm.nih.gov/articles/PMC12566567/)
FAQ
Lub supernatant tom qab ntawd raug rau thawj gel filtration chromatography nrog pH 3.0 rau pH 4.0 acetate tsis rau cais mellittin Ces, ib txoj kev ntawm kev sib cais malittin xws li phospholipase A2, uas yog ib tug enzyme lub luag hauj lwm rau kev ua xua tiam, yog cais los ntawm neutralizing lub sib cais ntawm Omalittin.
Los ntawm kev xav txog kev xav thiab kev coj tus cwj pwm kev xav, kev txhaj tshuaj subcutaneous ntawm malittin tuaj yeem ua rau pom tseeb thiab ntev - mob tonic ntev hauv tib neeg lub cev thiab cov tsiaj sim. Qhov kev mob tshwm sim tsis tu ncua no yuav ua rau muaj ntau yam kev mob tshwm sim -txoj kev coj cwj pwm, xws li limb retraction, restlessness thiab txo kev ua si, uas yog intuitive sab nraud manifestations ntawm qhov mob. Ntawm qib microscopic cellular, malittin exerts complex pharmacological teebmeem ntawm thawj nociceptor hlwb. Nws tuaj yeem qhib cov paj hlwb no los ntawm ob hom kev ua haujlwm sib txawv. Ntawm ib sab tes, malittin ua ncaj qha rau ntawm cov qauv saum npoo thiab cov khoom siv sab hauv ntawm cov hlwb nociceptor los pib ua kom cov cellular excitation. Ntawm qhov tod tes, nws kuj ua haujlwm tsis ncaj los ntawm kev tswj hwm ib puag ncig microenvironments thiab cuam tshuam cov teeb liab molecules. Kev sib xyaw ua ke ncaj qha thiab tsis ncaj qha cuam tshuam sib koom ua ke ua haujlwm ntawm thawj cov nociceptor hlwb, thiab tom qab ntawd xa cov cim mob ib kauj ruam los ua ib txoj hauv kev ua tiav qhov mob hauv lub cev.
Cim npe nrov: Melittin Spray, Tuam Tshoj Melittin Spray manufacturers, lwm tus neeg
