Calcitonin Salmon Txhaj(salcatonin) yog ib qho tshuaj tiv thaiv polypeptide uas muaj zog heev rau kev tswj cov pob txha metabolism. Tsim los ntawm 32 amino acids, nws muaj ntau dua receptor affinity dua li mammalian calcitonin, nrog rau qhov pib sai thiab ntev - cov teebmeem. Nws cov txheej txheem tseem ceeb cuam tshuam nrog kev muaj peev xwm inhibiting osteoclast kev ua si, thaiv cov pob txha resorption, txo qis cov ntshav calcium sai, thiab ua rau cov teebmeem hauv nruab nrab thiab peripheral analgesic. Clinically, nws yog qhia rau Paget tus kab mob ntawm pob txha, hypercalcemia txuam nrog malignant pob txha metastasis, thiab mob dystrophy.
Peb Cov Khoom Muag Khoom
Calcitonin salmon COA
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| Certificate of Analysis | ||
| Compound npe | Calcitonin salmon | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 47931-85-1 | |
| Ntau | 37g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090056 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 1.21% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.07% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.25% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 313 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Tshuaj Formula | C145H240N44O48S2 |
| Exact Mass | 3429.71 |
| Molecular Luj | 3431.90 |
| m/z | 3430.72(100.0%), 3431.72(77.9%), 3429.71(63.8%), 3432.72(40.1%), 3431.71(16.3%), 3432.72(12.3%), 3430.71(10.4%), 3432.72(9.9%), 3432.71(9.0%), 3433.73(8.8%), 3433.72(7.7%), 3433.72(7.0%), 3433.73(6.6%), 3431.72(6.3%), 3431.71(5.8%), 3433.72(5.0%), 3434.73(3.2%), 3434.73(3.0%), 3434.72(3.0%), 3431.72(2.8%), 3432.73(2.1%), 3431.72(1.8%), 3430.72(1.8%), 3434.73(1.7%), 3433.72(1.6%), 3431.72(1.6%), 3433.72(1.5%), 3433.71(1.5%), 3432.72(1.4%), 3434.72(1.3%), 3432.71(1.3%), 3432.72(1.2%), 3434.72(1.2%), 3430.72(1.2%), 3434.72(1.2%), 3434.71(1.1%), 3432.71(1.0%), 3430.71(1.0%) |
| Elemental Analysis | C,50.75; H,7.05; N,17.96; O,22.38; S,1.87 |
Daim ntawv thov hauv Kev Kho Mob ntawm Hypercalcemia
Calcitonin Salmon Txhaj is a synthetic polypeptide hormone drug with a structure highly consistent with natural calcitonin in salmon. Compared with endogenous human calcitonin and other mammalian calcitonins, it features stronger receptor affinity, faster onset, and longer duration of action, making it one of the key clinical drugs for hypercalcemia. Hypercalcemia is a pathological condition defined as a corrected total serum calcium concentration exceeding 2.55 mmol/L (or ionized calcium >1.3 mmol / L. Nws tuaj yeem tshwm sim los ntawm ntau yam kab mob thiab tuaj yeem ua rau muaj sia nyob -kev hem thawj hypercalcemic ntsoog hauv cov xwm txheej hnyav.
Clinical Classification ntawm Hypercalcemia thiab Indications
Hypercalcemia muaj cov etiologies nyuaj thiab ntau hom kev kho mob sib txawv, nrog cov kab mob sib txawv, kev kho mob tshwm sim, thiab kho qhov tseem ceeb ntawm ntau hom. Vim nws qhov pib sai thiab kev nyab xeeb siab, cov khoom siv tau siv los tswj ntau hom hypercalcemia, tshwj xeeb tshaj yog rau kev kho mob xwm txheej ceev thiab cov neeg mob tshwj xeeb. Nws cov lus qhia sib raug rau cov kev faib tawm hauv chaw kho mob yog raws li hauv qab no.
2.1 Hypercalcemia ntawm Malignancy
Hypercalcemia ntawm malignancy (HCM) yog ib hom kev kho mob ntau tshaj plaws ntawm hypercalcemia, suav txog 40% -50% ntawm tag nrho cov mob. Nws feem ntau yog tshwm sim los ntawm cov pob txha metastasis los ntawm cov qog nqaij hlav cancer mis, mob ntsws cancer, lub raum cell carcinoma, thiab ntau yam myeloma, thiab tej zaum yuav tshwm sim los ntawm qog qog ntawm cov tshuaj hormones parathyroid- cuam tshuam nrog cov protein thiab lwm yam kev sib kho. Hom hypercalcemia no muaj qhov pib mob hnyav thiab nce nrawm, feem ntau nrog cov ntshav calcium uas nce siab, ua rau muaj cov tsos mob hnyav xws li xeev siab, ntuav, thiab tsis meej pem, thiab tuaj yeem ua rau muaj sia nyob - hem.
Cov khoom lag luam yog thawj - kab tus neeg sawv cev rau hypercalcemia ntawm malignancy, tshwj xeeb tshaj yog rau cov neeg mob uas raug mob los ntawm cov pob txha metastasis. Los ntawm inhibiting osteoclast sai sai thiab thaiv kev tso tawm ntawm cov pob txha calcium, nws txo cov ntshav calcium hauv lub sijhawm luv luv thiab txo cov tsos mob hypercalcemic. Nws cov nyhuv analgesic kuj zoo alleviates cov pob txha mob hnyav tshwm sim los ntawm malignant pob txha metastasis, yuav lub sij hawm rau tom qab los tiv thaiv - qog noj ntshav. Nws yog qhov kev hloov pauv uas nyiam tshaj plaws rau cov neeg mob intolerant rau bisphosphonates lossis ua ntej bisphosphonates siv.
2.2 Hypercalcemia Associated nrog Hyperparathyroidism
Hyperparathyroidism (thawj thiab theem nrab) yog lwm qhov ua rau hypercalcemia. Thawj hyperparathyroidism tshwm sim los ntawm cov kab mob parathyroid qog ua rau cov tshuaj parathyroid ntau dhau lawm, thaum theem nrab hyperparathyroidism feem ntau tshwm sim los ntawm cov kab mob raum, vitamin D tsis txaus, thiab lwm yam. Hom hypercalcemia no feem ntau tshwm sim nrog kev pheej hmoo hypercalcemia nyuaj los ntawm osteoporosis, lub raum calculi, peptic ulcer, thiab lwm yam comorbidities.
Cov khoom siv tuaj yeem siv los kho cov tsos mob ntawm hypercalcemia cuam tshuam nrog hyperparathyroidism, tshwj xeeb tshaj yog rau kev npaj ua ntej, cov neeg mob tsis tuaj yeem ua haujlwm, lossis ua ib qho ntxiv rau kev tswj xyuas lub sijhawm ntev. Los ntawm inhibiting osteoclast kev ua si thiab txhawb cov urinary calcium excretion, nws zoo tswj cov ntshav calcium, txo cov tsos mob xws li osteoporosis thiab pob txha mob, thiab txo cov teeb meem. Qhov tseem ceeb, nws tsis tuaj yeem hloov cov tshuaj parathyroid hormone inhibitors lossis kev kho phais thiab yuav tsum muaj kev cuam tshuam etiological.
2.3 Hypercalcemia ntsig txog Vitamin D Intoxication thiab Immobilization
Cov vitamin D intoxication tshwm sim los ntawm kev noj cov vitamin D ntau dhau los yog qhov txawv txav ntawm cov vitamin D metabolism, ua rau cov plab hnyuv nqus calcium ntau thiab nce cov ntshav calcium. Immobilization-txog hypercalcemia feem ntau tshwm sim nyob rau hauv cov neeg mob nyob rau hauv lub txaj ntev so los yog nrog post- pob txha fixation, qhov uas txo skeletal kev ua ub no ua rau kuj txhim khu kev qha osteoclast kev ua si thiab ua kom cov pob txha calcium tso, tsa cov ntshav calcium. Ob hom no feem ntau me me mus rau nruab nrab tab sis tuaj yeem ua rau hypercalcemia hnyav yam tsis muaj kev cuam tshuam raws sijhawm.
Calcitonin Salmon Txhajmuaj feem xyuam rau ob hom hypercalcemia. Nws sai txo cov ntshav calcium los ntawm inhibiting pob txha calcium tso tawm thiab txhawb nqa cov calcium tso zis thaum txo cov tsos mob. Rau cov neeg mob uas muaj vitamin D intoxication, nws siv accelerates normalization ntawm cov ntshav calcium thaum txiav cov vitamin D. Rau immobilization-txog hypercalcemia, ua ke nrog cov kev kho kom zoo, nws zoo tiv thaiv hypercalcemia rov tshwm sim.
2.4 Kev Tswj Xyuas Thaum Muaj Xwm Ceev ntawm Hypercalcemic Crisis
Hypercalcemic ntsoog yog ib qho teeb meem loj ntawm hypercalcemia, txhais tau tias yog cov calcium hauv cov ntshav siab tshaj 3.5 mmol / L nrog rau lub neej - cov tsos mob hem xws li tsis nco qab, mob plawv, thiab lub raum tsis ua haujlwm. Cov neeg tuag coob heev yog tsis muaj resuscitation sai. Cov khoom lag luam yog tus neeg sawv cev tseem ceeb rau kev tswj hwm kev kub ntxhov ntawm hypercalcemic ntsoog vim nws qhov pib sai.
Hauv hypercalcemic ntsoog resuscitation, cov khoom tuaj yeem siv los ntawm kev txhaj tshuaj hauv cov hlab ntsha lossis kev txhaj tshuaj bolus kom ua kom cov calcium sai sai - txo cov teebmeem. Kev txo cov ntshav calcium feem ntau pom tau 30 feeb mus rau 2 teev tom qab kev tswj hwm, yuav lub sijhawm rau kev rov ua kom cov kua dej ntxiv thiab diuresis. Kev siv ua ke nrog bisphosphonates ua tiav cov txiaj ntsig zoo ntawm "kev txo qis calcium sai ntxiv nrog rau lub sijhawm ntev- kev saib xyuas", txhim kho cov txiaj ntsig zoo ntawm resuscitation.
Cov ntaub ntawv qhov chaw: Cov Lus Qhia rau Kev Ntsuam Xyuas thiab Kev Tswj Xyuas Hypercalcemia (2025 Edition); Tuam Tshoj Cov Ntaub Ntawv Kho Mob Query Platform, Calcitonin Salmon; Pob ntawv ntxig rau Calcitonin Salmon, National Medical Products Administration; VIP Journal, Kev Saib Xyuas Kev Ua Haujlwm ntawm Salmon Calcitonin hauv Kev Kho Mob Hypercalcemia Teeb meem los ntawm Kev Kho Mob Hemodialysis.
Kev ntsuam xyuas ntawm Kev Kho Mob Ua Haujlwm hauv Hypercalcemia
Cov khoom lag luam tau lees paub qhov ua tau zoo hauv hypercalcemia, nrog cov txiaj ntsig zoo hauv kev txo cov calcium sai thiab pab pob txha mob. Nws qhov kev ua tau zoo yog ntsuas raws li cov kev hloov pauv hauv cov ntshav calcium concentration, txhim kho cov tsos mob hauv chaw kho mob, thiab kev kwv yees ntev ntev, txhawb nqa los ntawm cov ntaub ntawv tshawb fawb soj ntsuam thiab kev coj ua raws li cov lus qhia hauv qab no.
4.1 Ntshav Calcium Control
Cov tshuaj muaj qhov pib sai: qhov siab tshaj plaws plasma concentration yog mus txog 1 teev tom qab txhaj tshuaj subcutaneous lossis intramuscular, nrog kev tshem tawm ib nrab- lub neej ntawm 70-90 feeb. Kev txo cov ntshav calcium feem ntau pom tau 30 feeb mus rau 2 teev tom qab kev tswj hwm, thiab qib poob mus rau qhov muaj kev nyab xeeb tsis pub dhau 24-48 teev. Rau cov neeg mob uas muaj mob hypercalcemia, kev noj tshuaj tsis tu ncua zoo tswj cov normocalcemia thiab txo cov kev hloov pauv. Rau hypercalcemic ntsoog, kev tswj hwm hauv cov hlab ntsha sai txo cov calcium kom tiv thaiv kev kis kab mob.
Kev tshawb fawb soj ntsuam pom tau hais tias intramuscular salmon calcitonin muab rau 12 lub lis piam mus rau 28 tu cov neeg mob hemodialysis nrog hypercalcemia ua rau txo qis hauv cov ntshav calcium thiab calcium-phosphorus cov khoom ntawm lub lim tiam 4 (P < 0.05), ua kom pom cov calcium uas muaj txiaj ntsig zoo - txo qis cov pej xeem. Nco ntsoov, qee tus neeg mob tuaj yeem tsim "qhov tshwm sim khiav tawm" nrog kev siv sijhawm ntev -, tus cwj pwm los ntawm kev ua tau zoo zuj zus. Hauv cov xwm txheej zoo li no, kev kho mob yuav tsum tau cuam tshuam ib ntus ua ntej rov pib dua, lossis hloov kho thiab ua ke nrog lwm tus neeg sawv cev.
4.2 Kev txhim kho hauv cov tsos mob
Cov tsos mob tshwm sim los ntawm hypercalcemia, suav nrog xeev siab, ntuav, kiv taub hau, mob osteoarticular, thiab kev tsis sib haum xeeb, tau txais txiaj ntsig zoo los ntawmCalcitonin Salmon Txhaj. Kev mob pob txha yog qhov tshwj xeeb tshaj yog: cov kev tshawb fawb soj ntsuam qhia pom tias mob pob txha tshem tawm ntau dua 70% rau cov pob txha mob qog nqaij hlav - mob ntsig txog. Ntawm kev saib xyuas cov neeg mob hemodialysis nrog hypercalcemia, txhua tus tau ntsib ib feem ntawm kev mob osteoarticular thiab kev tsis sib haum xeeb ntawm lub lim tiam 4, nrog cov tsos mob yuav luag daws hauv 23 tus neeg mob thaum kawg ntawm kev kho mob.
Tsis tas li ntawd, cov tshuaj pab txhim kho cov tsos mob ntawm lub paj hlwb xws li tsis meej pem thiab chim siab los ntawm hypercalcemia, pab txhawb kev nco qab thiab txhim kho kev kho mob. Txawm li cas los xij, nws tsis tuaj yeem thim rov qab ua ntej- muaj teeb meem xws li metastatic calcification, uas yuav tsum tau ua ke nrog kev kho mob thawj zaug.
4.3 Qhov cuam tshuam rau lub sijhawm ntev -Tsev Kawm Ntawv
Rau cov mob hypercalcemia, ntev - siv cov khoom siv tau zoo tswj cov ntshav calcium, txo kev puas tsuaj rau lub raum, lub plawv, pob txha, thiab lwm yam kabmob, txo cov kev pheej hmoo ntawm cov teeb meem xws li lub raum calculi, arrhythmias, thiab osteoporosis, thiab txhim kho lub neej ntev -. Rau cov neeg mob uas muaj hypercalcemia ntawm malignancy, nws alleviates cov tsos mob, prolongs ciaj sia taus, thiab tsim tej yam kev mob rau tom ntej no anti{3}} kho qog.
Raws li kev kho mob rau hypercalcemia, cov tshuaj tsis kho qhov tshwm sim. Yog li ntawd, kev tswj tus kab mob tseem ceeb (piv txwv li, qog resection, phais parathyroid, txiav tawm cov vitamin D ntau dhau) yuav tsum tau ua raws li kev tswj hwm mus ntev -.
Cov ntaub ntawv qhov chaw: VIP Journal, Kev soj ntsuam ntawm kev ua tau zoo ntawm Salmon Calcitonin hauv kev kho mob hypercalcemia nyuaj los ntawm Kev Kho Mob Hemodialysis; Cov Lus Qhia rau Kev Ntsuas thiab Kev Tswj ntawm Hypercalcemia (2025 Edition); Tuam Tshoj Cov Ntaub Ntawv Kho Mob Query Platform, Calcitonin Salmon rau Txhaj Tshuaj; Tuam Tshoj Cov Ntaub Ntawv Kho Mob Query Platform, Calcitonin Salmon.
Cov kev ceev faj
Kev kuaj tawv nqaij: Raws li cov tshuaj polypeptide, cov tshuaj tiv thaiv kab mob yuav tshwm sim. Yuav tsum tau kuaj daim tawv nqaij ua ntej siv tshuaj kho mob. Cov txheej txheem: kos 0.2 mL (50 IU / vial) ntawm cov tshuaj, dilute mus rau 1 mL nrog saline ib txwm, thiab txhaj 0.1 mL (kwv yees li 1 IU) subcutaneously. Saib rau 15 feeb. Cov tshuaj tiv thaiv tsis muaj ntau tshaj li qhov nruab nrab liab ntawm qhov chaw txhaj tshuaj yog qhov tsis zoo; Nruab nrab lossis hnyav liab yog qhov zoo, thiab cov tshuaj yog contraindicated nyob rau hauv qhov zoo.
Cov tshuaj sib cuam tshuam: Kev siv cov tshuaj antacids los yog laxatives tuaj yeem ua rau tsis haum rau kev nqus vim lawv cov calcium lossis hlau ion (magnesium, hlau) cov ntsiab lus. Kev siv ua ke nrog cov tshuaj tua kab mob aminoglycoside tuaj yeem ua rau hypocalcemia thiab yuav tsum zam; yog tias kev tswj hwm yog tsim nyog, cov calcium hauv ntshav yuav tsum tau saib xyuas kom zoo.
Dosage Control: Tsis txhob noj ntau dhau. Siab - koob tshuaj luv luv- lub sij hawm kho yuav ua rau cov hypoparathyroidism thib ob thiab hypocalcemia hauv cov neeg mob tsawg, yuav tsum tau txais calcium thiab vitamin D ntxiv.
Cov pejxeem tshwj xeeb: Cov neeg mob laus thiab cov neeg mob siab lossis lub raum tsis zoo yuav tsum tau siv cov tshuaj raws li kev saib xyuas kho mob; Kev hloov tshuaj rau lub raum tsis zoo yog ua raws li lub raum ua haujlwm. Cov neeg mob uas tau pw ntev ntev yuav tsum tau txais kev kho mob kom zoo los tiv thaiv cov pob txha calcium ntxiv.
Cov ntaub ntawv qhov chaw: Pob Ntxig rau Calcitonin Salmon, National Medical Products Administration; Tuam Tshoj Cov Ntaub Ntawv Kho Mob Query Platform, Miacalcic Calcitonin Salmon; Gutongning® Calcitonin Salmon, Beijing Shuanglu Pharmaceutical Co., Ltd.; Tuam Tshoj Cov Ntaub Ntawv Kho Mob Query Platform, Calcitonin Salmon rau Txhaj.
FAQ
Puas yog calcitonin muab los ntawm cov ntses?
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Salmon calcitonin (sCT) yog hom calcitonin hormone pom nyob rau hauv salmon.
Koj puas tuaj yeem tau txais calcitonin los ntawm kev noj salmon?
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Ntau qhov chaw exogenous ntawm calcitonin muaj nyob, ntawm cov ntses salmon yog cov muaj zog tshaj plaws. Calcitonin tau pom zoo rau kev kho mob osteoporosis thiab lwm yam kab mob uas cuam tshuam nrog cov pob txha nrawm.
Leej twg yuav tsum tsis txhob noj calcitonin salmon?
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Calcitonin salmon tuaj yeem ua rau muaj kev tsis haum tshuaj, uas tuaj yeem ua rau mob hnyav. Tsis txhob siv calcitonin salmon thiab tau txais kev pab tam sim yog tias koj muaj cov tsos mob hauv qab no ntawm kev tsis haum tshuaj loj. Tsawg Calcium Qib (Hypocalcemia).
Cim npe nrov: Tuam Tshoj calcitonin salmon txhaj tshuaj manufacturers, lwm tus neeg
