Pramlintide ntsiav tshuajyog cov tshuaj tshiab ntawm qhov ncauj hypoglycemic tsim los ntawm Pramlintide. Prallin peptide yog ib qho hluavtaws amylin analog, uas zoo ib yam li amylin secreted los ntawm tib neeg lub cev hauv cov qauv thiab kev ua haujlwm, thiab qhia tau hais tias tus nqi tshwj xeeb hauv kev kho mob ntshav qab zib.
Hais txog cov pej xeem siv tau, nws tsuas yog siv tau rau cov neeg mob uas muaj hom 1 thiab hom 2 mob ntshav qab zib, tshwj xeeb tshaj yog cov neeg uas tseem muaj kev tswj tsis tau GLs tom qab kho iletin. Nws tuaj yeem siv los ua cov tshuaj pab kho mob ntawm iletin los pab ntxiv dag zog GLs.
Khoom Description
PramlintideCOA
Pramlintide ntsiav tshuajyog cov khoom sib txuas ntawm pancreatic amyloid peptide, muaj tag nrho cov haujlwm ntawm pancreatic amyloid peptide. Nws tsis yog tsuas yog siv rau hauv cov ntsiav tshuaj daim ntawv, thiab tam sim no txoj kev tswj hwm yog kev txhaj tshuaj subcutaneous ua ntej noj mov. Txawm li cas los xij, cov ntaub ntawv tseem ceeb ntawm nws qhov kev txo qhov hnyav thiab cov teebmeem yog qhov tseem ceeb rau kev nkag siab txog nws cov ntawv thov cov ntsiav tshuaj. Nws tuaj yeem inhibit qhov tso tawm ntawm glucagn, ncua kev ua pa ntawm plab thiab inhibit kev noj zaub mov. Nws tau raug pom zoo los ntawm FDA ua ib qho kev kho mob ntawm iletin therapy rau cov neeg mob uas muaj hom 1 thiab hom 2 mob ntshav qab zib mellitus, thiab tau pom tias muaj qee qhov cuam tshuam rau kev tswj qhov hnyav.
Yog xav paub ntxiv txog kev tshawb fawb, thov saib cov xwm txheej tam sim no thiab kev nce qib ntawm cov tshuaj ntshav qab zib.
Lub mechanism ntawm qhov hnyav poob
(1) Inhibition ntawm glucagon seem
Glucagn secrtion yog ib qho ntawm cov laj thawj tseem ceeb ntawm postprandial hyperglycemia. Raws li ib txwm muaj, postprandial glucagn ntu yuav raug cuam tshuam, tab sis postprandial glucagn ntu ntawm cov neeg mob ntshav qab zib hom 1 thiab hom 2 feem ntau tsis cuam tshuam tag nrho, lossis txawm tias nce ntxiv. Nws tuaj yeem cuam tshuam qhov txawv txav ntawm glucagn thiab txo qis cov piam thaj los ntawm lub siab. Lub siab yog lub cev tseem ceeb rau cov piam thaj metabolism hauv lub cev. Thaum glucagn ntu txo qis, lub siab glycogen puas thiab gluconeogenesis tsis muaj zog, yog li txo qis cov piam thaj tso rau hauv cov hlab ntsha thiab txo cov qib GLs. Nyob rau tib lub sijhawm, vim qhov txo qis hauv GLs hloov pauv, lub cev qhov kev thov rau iletin kuj txo qis, uas pab txhim kho iletin tsis kam thiab muaj txiaj ntsig zoo rau kev tswj qhov hnyav.
Cov txheej txheem no tau nthuav dav hauv cov ntaub ntawv xws li "Endocrinology thiab Metabolic Disease Diagnosis and Treatment Manual - Iiletin Linpeptide GLP".
(2) Ncua lub plab zom mov
Los ntawm kev ua ntawm lub posterior vagus paj hlwb plexus ntawm lub hlwb, nws txhawb lub plab vagal paj hlwb transduction thiab slows down gastric emptying tus nqi. Lub sij hawm nyob ntev ntawm cov zaub mov hauv plab ua rau qeeb tus nqi ntawm cov piam thaj nqus hauv cov hnyuv, ua kom lub sij hawm ntev ntawm cov piam thaj nqus mus rau hauv cov hlab ntsha, yog li txo qis cov ntshav qabzib thaum ntxov. Thaum tus nqi ntawm GLs nce qeeb, lub cev tsis ceev nrooj zais ntau ntawm iletin kom qis GLs, txo lub luag haujlwm ntawm iletin hauv kev txhawb cov rog synthesis thiab inhibiting rog rog. Tsis tas li ntawd, ncua kev ua pa ntawm lub plab tuaj yeem ua rau muaj kev nkag siab zoo thiab txo cov khoom noj. Piv txwv li, tom qab noj mov, vim qhov qeeb qeeb ntawm cov khoom noj hauv lub plab, lub plab tseem nyob hauv lub xeev ntawm kev puv, xa cov cim ntawm satiety rau lub hlwb, yog li inhibiting lub siab xav noj dua, pab tswj tag nrho cov calorie kom tsawg thiab ua tiav lub hom phiaj ntawm kev poob phaus.
Cov txheej txheem no tau piav qhia hauv cov ntaub ntawv xws li "Kev kuaj mob endocrinology thiab Metabolic Disease Diagnosis and Treatment Manual - Insulin Linpeptide GLP".
(3) Inhibition ntawm kev pub mis
Nws tuaj yeem khi rau pancreatic amyloid receptor rau ntawm daim nyias nyias ntawm lub paj hlwb neurons, thiab ua rau lub chaw noj zaub mov hypothalamic los ntawm receptor-kev hloov pauv hloov pauv hloov pauv, ua rau muaj txiaj ntsig satiety. Lub hypothalamus yog qhov chaw tseem ceeb rau kev tswj hwm tus cwj pwm noj zaub mov, tau txais ntau yam teeb meem ntawm sab hauv thiab sab nraud lub cev, xws li qib GLs, qib tshuaj hormones, thiab lwm yam, thiab tswj kev noj qab haus huv raws li cov cim no. Tom qab ua haujlwm ntawm hypothalamus, cov haujlwm neural ntawm qhov chaw pub mis yog hloov pauv, ua rau lub cev xav tias tag nrho thiab txo qhov kev ntshaw thiab kev noj zaub mov. Nyob rau lub sijhawm ntev, qhov kev hloov pauv ntawm kev noj zaub mov no pab tsim cov qauv kev noj haus tshiab, txo cov calorie kom tsawg, thiab txhawb kev poob phaus.
Cov txheej txheem ntawm kev txiav txim no tau hais nyob rau hauv "Txoj Cai thiab Kev Txhim Kho ntawm Cov Tshuaj Kho Mob Ntshav Qab Zib" thiab lwm yam ntaub ntawv.
Clinical tshawb fawb pov thawj ntawm kev poob phaus
(1) Kawm txog cov neeg mob ntshav qab zib hom 1
Hauv kev tshawb fawb ntawm cov neeg mob ntshav qab zib hom 1, cov neeg mob tau muab faib ua pawg kho mob thiab pab pawg placebo. Pab pawg kho mob ntxiv pranylin peptide (ob zaug ib hnub, 120 μ g txhua lub sijhawm) raws li iletin, nrog rau kev txhaj tshuaj subcutaneous ua ntej noj mov. Tom qab 26 lub lis piam ntawm kev kho mob, cov txiaj ntsig tau pom qhov poob ntawm 2.0kg hauv pab pawg kho mob, thaum pab pawg placebo nce 0.5kg. Hauv lwm txoj kev tshawb fawb 52 lub lis piam, cov neeg mob hauv pab pawg kho mob kuj tau txais kev kho mob nrog prallintide (ob zaug hauv ib hnub, 120 μ g txhua lub sijhawm), ua rau poob phaus ntawm 1.4kg, uas txawv ntawm cov placebo pawg (P.<0.05). These studies show that it has a significant weight loss effect in type 1 diabetes patients, and the effect is better than placebo.
Cov ntaub ntawv tshawb fawb ntsig txog tuaj yeem xa mus rau cov ntaub ntawv xws li "Lub Ntiaj Teb Tshiab Tshuaj Dynamics thiab Kev Ntsuam Xyuas ntawm Lindeplan Ntshav Glucose".
(2) Kawm txog cov neeg mob ntshav qab zib hom 2
Rau cov neeg mob uas muaj ntshav qab zib hom 2, ntau qhov kev tshawb fawb kuj tau lees paub qhov kev poob phaus ntawm Pranin. Piv txwv li, hauv ib txoj kev tshawb fawb, lub cev hnyav ntawm cov neeg mob ntshav qab zib hom 2 tuaj yeem raug txo los ntawm 1.5kg tom qab 120 μ g ntawm prallin peptide tau siv. Hauv lwm txoj kev tshawb fawb, cov neeg mob tau muab faib ua pawg sib txawv thiab kho nrog cov tshuaj sib txawv ntawm cov tshuaj. Cov txiaj ntsig tau pom tias nrog qhov nce ntawm cov koob tshuaj, cov txiaj ntsig ntawm kev poob phaus tau pom tseeb dua. Cov kev tshawb fawb no qhia tau hais tias nws muaj txiaj ntsig zoo rau kev tswj qhov hnyav ntawm cov neeg mob ntshav qab zib hom 2, thiab nws qhov kev poob phaus tuaj yeem cuam tshuam nrog cov koob tshuaj.
Cov kev tshawb fawb ntsig txog tuaj yeem xa mus rau "kev mob ntshav qab zib kom hnyav tswj kev txhaj tshuaj Lintipram" thiab lwm yam ntaub ntawv.
Cov kev sib tw ntawm cov ntawv thov ntsiav tshuaj muaj peev xwm
Nws yog cov tshuaj peptide uas yuav cuam tshuam los ntawm cov yam ntxwv xws li gastric acid thiab digestive enzymes hauv plab hnyuv, ua rau cov tshuaj degradation thiab cuam tshuam rau nws txoj kev nqus thiab bioavailability. Yuav ua li cas txhawm rau txhim kho kev ruaj ntseg ntawm cov ntsiav tshuaj hauv plab hnyuv los ntawm kev tsim cov thev naus laus zis thiab ua kom muaj txiaj ntsig zoo ntawm cov tshuaj yog ib qho ntawm cov teeb meem tseem ceeb hauv kev txhim kho.pramlintide ntsiav tshuaj.
Txoj kev loj hlob ntawm cov ntaub ntawv ntau npaum li cas rau cov tshuaj peptide ua rau muaj teeb meem qee yam. Tsim nyog excipients thiab cov txheej txheem npaj yuav tsum tau xaiv los xyuas kom meej qhov zoo thiab ruaj khov ntawm cov ntsiav tshuaj. Nyob rau tib lub sijhawm, nws tseem yuav tsum xav txog qhov tso tawm cov yam ntxwv ntawm cov tshuaj, kom cov tshuaj tuaj yeem maj mam thiab tsis tu ncua tso tawm hauv lub cev, ua tiav cov txiaj ntsig kho mob xav tau. Tsis tas li ntawd, qhov tsos, saj, thiab lwm yam ntawm cov ntsiav tshuaj kuj yuav tsum tau ua kom zoo dua los txhim kho kev lees paub ntawm tus neeg mob.
Kev sib piv nrog lwm cov tshuaj poob phaus
(1) Kev sib piv nrog GLP-1 receptor agonists
GLP-1 receptor agonists xws li semaglutide kuj tseem siv cov tshuaj poob phaus. Piv nrog rau pramlintide, GLP-1 receptor agonists feem ntau siv lawv cov teebmeem los ntawm kev ua kom GLP-1 receptors, uas muaj cov teebmeem ntawm inhibiting qab los noj mov thiab ncua kev noj plab. Hais txog kev poob phaus, cov kev tshawb fawb tau pom tias semaglutide tuaj yeem pab cov neeg mob poob 15% -18% ntawm lawv qhov hnyav hauv 68 lub lis piam, nrog rau qhov hnyav hnyav. Qhov poob phaus ntawm prallintide yog qhov me me, feem ntau nyob ib ncig ntawm ob peb kilograms. Txawm li cas los xij, thaum txo qhov hnyav, prallintide kuj tseem muaj qee yam kev txhim kho ntawm cov ntsuas metabolic xws li GLs thiab ntshav lipids, thiab nws cov txheej txheem ntawm kev ua haujlwm txawv ntawm GLP-1 receptor agonists. Kev sib xyaw ua ke ntawm ob yuav muaj kev sib koom ua ke, txhim kho qhov hnyav poob.
Cov ntaub ntawv sib piv uas cuam tshuam tuaj yeem xa mus rau cov ntaub ntawv xws li "Kev Tshawb Fawb Kawg|Kev Tshawb Fawb Txog Qhov Zoo thiab Kev Pom Zoo Qhia Txog Kev Xaiv Cov Tshuaj Noj Qab Haus Huv".
(2) Muab piv rau orlistat
Orlistat txo cov calories kom tsawg thiab ua kom poob phaus los ntawm inhibiting lipase kev ua haujlwm hauv plab hnyuv, tiv thaiv kwv yees li 30% ntawm kev noj zaub mov kom tsis txhob nqus. Kev siv Orlistat ntev tuaj yeem pab tswj qhov hnyav ntawm 5% -10% thiab txhim kho cov ntshav lipid txawv txav. Piv nrog rau cov tshuaj no, cov txheej txheem ntawm kev txiav txim ntawm orlistat feem ntau yog tsom rau kev nqus rog, thaum prallintide siv nws cov teebmeem hauv ntau yam xws li inhibiting glucagn secrtion, ncua kev ua pa ntawm plab, thiab inhibiting noj. Orlistat tuaj yeem ua rau qee qhov tsis zoo hauv plab hnyuv, xws li cov quav oily, plab zom mov, thiab lwm yam.pramlintide ntsiav tshuajFeem ntau suav nrog cov tsos mob ntawm plab hnyuv xws li xeev siab thiab ntuav, nrog rau kev pheej hmoo ntawm hypoglycemia. Ob leeg muaj lawv tus kheej cov yam ntxwv ntawm kev poob phaus thiab kev tsis zoo, thiab cov kws kho mob tuaj yeem xaiv cov tshuaj tsim nyog raws li qhov xwm txheej tshwj xeeb ntawm tus neeg mob.
Rau cov ntaub ntawv sib piv uas cuam tshuam, thov xa mus rau cov ntaub ntawv xws li "Tsis yog Nyias! Cov Khoom Uas Nyuaj Siab Ntev Ntev Li Cas tuaj yeem Pab Koj Hloov Metabolism thiab Hais Goodbye rau Yo Yo Effect".
Cim npe nrov: Tuam Tshoj pramlintide ntsiav tshuaj manufacturers, lwm tus neeg
