Biotinoyl Tripeptideyog ib qho khoom siv hluavtaws tsim los ntawm kev sib txuas biotin (vitamin H) nrog tripeptide Gly His Lys (GHK) los ntawm kev sib cog lus amide. Cov txheej txheem zoo ntawm cov tshuaj no ua rau biotin los txhim kho cellular muaj nuj nqi ntawm qib metabolic txhawb, thaum GHK qhib cov kev pab cuam kho mob ntawm qib kev tswj hwm, tsim ib qho peb - qhov sib txuas ntawm "kev tswj hwm cov khoom noj khoom haus + noob". Raws li pab pawg lipophilic, biotin tuaj yeem txhim kho lub peev xwm ntawm peptides txhawm rau nkag mus rau stratum corneum, thiab ua tiav cov txiaj ntsig zoo ntawm cov tshuaj hauv cov hauv paus plaub hau, qog sebaceous, thiab lwm yam khoom siv los ntawm biotin avidin system. Kev hloov kho tshuaj txo cov enzymatic hydrolysis tus nqi ntawm GHK hauv vivo thiab ncua nws ib nrab - lub neej. Cov tshuaj no txhawb kev tso dej hauv qab daus ntawm daim nyias nyias collagen IV los ntawm kev ua kom muaj kev qhia ntawm COL4A1 noob hauv fibroblasts. Collagen IV yog lub hauv paus tseem ceeb ntawm cov ntaub hauv qab daus, thiab nws qhov kev nce ntxiv tuaj yeem txhim kho lub zog ntawm cov kab mob epidermal dermal hlws ris thiab txo qis kev tsim wrinkles.
Peb cov khoom Form
Biotinoyl Tripeptide-1 COA
Synergistic induction ntawm hom IV collagen thiab laminin 5
Hauv kev tshawb fawb lom neeg ntawm daim tawv nqaij thiab cov hauv paus plaub hau, qhov sib npaug ntawm qhov sib npaug ntawm extracellular matrix (ECM) yog lub hauv paus ntawm kev tswj cov ntaub so ntswg kev ruaj ntseg thiab kev ua haujlwm zoo. Hom IV collagen thiab laminin 5, raws li cov khoom tseem ceeb ntawm lub hauv paus membrane, thauj tog rau nkoj lub epidermis thiab dermis los ntawm kev tsim ntawm ib tug peb -siv network qauv, thiab tswj cell proliferation, migration, thiab sib txawv.Biotinoyl Tripeptide(BTP-1), raws li ib tug hluavtaws bioactive peptide, ho txhim khu cov plaub hau follicle dermal hlws ris lub zog los ntawm tshwj xeeb stimulating lub synthesis ntawm hom IV collagen thiab laminin 5, ua rau nws ib tug kub molecule nyob rau hauv lub teb ntawm kev tiv thaiv plaub hau, kev loj hlob ntawm cov plaub hau, thiab kho daim tawv nqaij.
Molecular yam ntxwv thiab kev ua haujlwm lom neeg
Biotinoyl Tripeptide-1 (BTP-1)
BTP-1 yog ib qho khoom siv hluavtaws tsim los ntawm covalent bonding ntawm biotin (vitamin H) thiab tripeptide Gly His Lys (GHK) los ntawm amide bonds. Nws cov mis molecular yog C24H38N8O6S thiab nws qhov hnyav molecular yog 566.67 Da. Nws cov qauv muaj peb lub luag haujlwm ua haujlwm:
Biotin ib feem: Raws li cov dej- cov vitamin soluble, nws koom nrog hauv cov rog thiab protein metabolism, thiab ua raws li carboxylase coenzyme los txhawb kev tsim collagen;
GHK tripeptide: belongs rau Matrikine series (hydrolyzed cov khoom ntawm daim tawv nqaij matrix tom qab raug mob), uas tuaj yeem qhib qhov kev nthuav qhia ntawm cov noob kho cell thiab tswj cov ntaub so ntswg sib txuas;
Amide bonding: txhim kho molecular stability thiab ua kom muaj kev sib koom ua ke ntawm biotin thiab GHK.
Txhawb ECM synthesis: Los ntawm upregulating cov noob qhia ntawm hom IV collagen thiab laminin 5, txhim khu lub zog ntawm cov plaub hau follicle dermal hlws ris;
Antioxidant tiv thaiv: tshem tawm cov pa oxygen reactive (ROS) los ntawm cov hauv paus plaub hau thiab txo cov plaub hau follicle atrophy vim oxidative kev nyuaj siab;
Kev xa khoom noj khoom haus: Raws li tus neeg nqa khoom, nws yooj yim thauj cov as-ham xws li biotin rau cov plaub hau follicle hlwb, txhawb nqa keratin synthesis;
Kev tswj cov teeb liab ntawm tes: khi rau saum npoo receptors ntawm cov plaub hau follicle hlwb, ua kom txoj hauv kev xws li PI3K/AKT thiab Wnt/ - catenin, thiab txhawb kev loj hlob ntawm cov plaub hau follicle hlwb.
Hom IV collagen
Type IV collagen is the main component of the dense layer of the basement membrane, accounting for over 50% of the total basement membrane protein. Nws cov molecule yog tsim los ntawm peb alpha chains (1- 6) ua ib tug triple helix qauv, uas yog cross-txuas ntawm molecules los ua ib tug tas mus li peb- mesh. Nws muaj cov yam ntxwv hauv qab no:
Cov qauv tsis yog fibrous: Tsis zoo li cov qauv fibrous ntawm hom I thiab III collagen, hom IV collagen yog kheej kheej lossis pas nrig - zoo li tus, uas yog tsim nyog rau cov qauv mesh ntawm lub hauv paus membrane;
Tsis yog collagenous domain (NC1): nyob rau ntawm qhov kawg molecular, koom nrog hauv cell adhesion, transduction, thiab intermolecular cross-txuas;
Dynamic regulation: Thaum lub sij hawm cov txheej txheem pathological xws li daim siab fibrosis thiab daim tawv nqaij laus, theem qhia ntawm hom IV collagen hloov pauv loj, qhia txog qib ntawm cov ntaub so ntswg puas.
Kev them nyiaj yug tus qauv: tsim ib daim phiaj sib xyaw nrog laminin 5, nestin, thiab lwm yam kom muaj kev ruaj ntseg ntawm lub hauv paus membrane;
Cell anchoring: Txuas nrog epidermal keratinocytes los ntawm integrin receptors los kho cov epidermis rau lub dermis;
Lub chaw teeb liab: khw muag khoom thiab tso tawm qhov kev loj hlob (xws li TGF - , EGF) los tswj kev loj hlob ntawm tes thiab kev sib txawv.
laim 5
Laminin-5 yog cov tub ntxhais glycoprotein ntawm cov pob tshab txheej hauv qab daus, tsim los ntawm peb cov peptide chains - 3, 3, thiab 2- tsim ib tus ntoo khaub lig zoo li tus trimer nrog ib qho hnyav molecular ntawm kwv yees li 460 kDa. Nws cov qauv suav nrog ntau lub luag haujlwm ua haujlwm:
G-domain: nyob rau ntawm qhov kawg ntawm 3 saw, kho kom haum xeeb ntawm cell adhesion thiab tsiv teb tsaws;
EGF zoo li rov ua ntu zus: koom nrog hauv extracellular matrix cross-txuas;
Cov qauv caj npab luv: Nws txuas nrog hom VII collagen los tsim cov filaments, uas nkag mus rau hauv qab daus daim nyias nyias thiab txuas mus rau dermal papilla txheej.
Epidermal dermal anchoring: kho cov epidermis rau lub dermis los ntawm kev sib cuam tshuam ntawm thauj tog rau nkoj xaim nrog hom VII collagen thiab nestin;
Kev sib koom tes mechanism
BTP-1 tswj cov synthesis ntawm hom IV collagen thiab laminin 5
Biotinoyl Tripeptidesynergistically induces cov synthesis ntawm hom IV collagen thiab laminin 5 los ntawm txoj kev hauv qab no:
Lub luag haujlwm ntawm GHK tripeptide: Raws li Matrikine, GHK tuaj yeem khi rau saum npoo receptors ntawm cov plaub hau follicle hlwb, qhib txoj hauv kev MAPK/ERK, thiab txhawb nqa cov ntaub ntawv ntawm COL4A1 (hom IV collagen alpha 1 saw) thiab LAMA3 (laminin 5 alpha 3 saw) noob;
Synergistic nyhuv ntawm biotin: Raws li ib tug carboxylase coenzyme, biotin txhim khu kev ua ntawm collagen synthase, ntxiv amplifying lub induction nyhuv ntawm GHK.
Cov ntaub ntawv pov thawj:
Nyob rau hauv vitro plaub hau follicle kab lis kev cai qauv, tom qab 48 teev ntawm kev kho mob nrog 100 ppm BTP-1, mRNA qhia theem ntawm hom IV collagen thiab laminin 5 nce 2.3 zaug thiab 1.8 zaug, feem;
Hauv kev tshawb fawb soj ntsuam, tom qab 12 lub lis piam ntawm kev siv tshuaj zawv plaub hau uas muaj 0.05% BTP-1, qhov tso tawm ntawm hom IV collagen ntawm cov tawv taub hau ntawm cov neeg mob tau nce 35%, thiab kev qhia ntawm laminin 5 nce 28%.
Txhim kho cov protein synthesis thiab secretion
MTOR txoj kev ua kom: BTP-1 txhawb nqa protein synthesis nyob rau hauv cov plaub hau follicle hlwb los ntawm PI3K / AKT / mTOR txoj kev, ua rau kom cov secretion ntawm hom IV collagen thiab laminin 5;
Endoplasmic reticulum nyem nyem: Biotin ib feem tswj hwm endoplasmic reticulum calcium homeostasis, txo cov protein folding yuam kev, thiab txhim kho ECM protein secretion efficiency.
Tsiaj kev sim:
Hauv C57BL / 6 nas cov plaub hau poob qauv, tom qab 8 lub lis piam ntawm kev thov hauv zos BTP-1 (500 ppm), immunofluorescence siv hom IV collagen thiab laminin 5 nyob ib ncig ntawm cov hauv paus plaub hau tau nce 42% thiab 37%, feem, thiab cov plaub hau kev loj hlob ceev nce 55%.
Kev sib cuam tshuam ntawm hom IV collagen thiab laminin 5
Hom IV collagen thiab laminin 5 tsim cov qauv hauv qab daus ruaj khov los ntawm cov txheej txheem hauv qab no:
NC1 domain khi rau G domain: Lub NC1 domain ntawm hom IV collagen cuam tshuam nrog G domain ntawm laminin 5 los ntawm cov ntawv cog lus tsis sib xws, tsim cov "collagen laminin" complex;
Nestin bridging: Nestin-1/2 ib txhij khi rau hom IV collagen thiab laminin 5 los ntawm nws lub globular domain, tsim peb-dimensional mesh scaffold.
Cov ntaub ntawv pov thawj biology:
Cryo electron microscopy tsom xam qhia tau hais tias triple helix ntawm hom IV collagen khi rau lub caj npab luv ntawm laminin 5 nyob rau hauv ib tug ratio ntawm 1: 2, tsim ib tug mesh qauv nrog ib txoj kab uas hla ntawm kwv yees li 15 nm;
X-ray diffraction tsom xam tau lees paub qhov muaj nyob ntawm cov chaw tshwj xeeb khi ntawm EGF zoo li rov ua ntu zus ntawm Nestin thiab NC1 lub npe ntawm hom IV collagen.
Kev sib koom tes sib kis
Integrin receptor activation: Hom IV collagen thiab laminin 5 sib koom ua ke qhib txoj hauv kev FAK/Src los ntawm 6 4 integrin receptor, txhawb cov plaub hau follicle qia cell proliferation;
Kev loj hlob zoo tshaj tawm: Hom IV collagen grid khw muag khoom TGF - 1, thiab laminin 5 khi rau EGF los ntawm G domain, synergistically tswj cov plaub hau follicle sib txawv.
Kev sim ua haujlwm:
Hauv peb-qhov sib npaug ntawm daim tawv nqaij qauv, thaum ob hom IV collagen thiab laminin 5 tau ntxiv ib txhij, cov plaub hau follicle induction efficiency yog nce los ntawm 2.1 npaug piv rau kev ntxiv ob qho tib si;
Tom qab thaiv cov 6 4 integrin, BTP-1-induced plaub hau follicle txoj kev loj hlob tshwm sim, paub meej tias cov synergistic nyhuv ntawm hom IV collagen thiab laminin 5 signaling.
Antioxidant thiab nutrient thauj los ntawm BTP-1
ROS tshem tawm: Cov biotin feem hauv BTP-1 txo ROS qib hauv cov hauv paus plaub hau los ntawm kev tsim cov glutathione (GSH), yog li txo cov oxidative puas rau hom IV collagen thiab laminin 5;
MMPs inhibition: GHK tripeptide tuaj yeem txo qis kev qhia ntawm matrix metalloproteinases (MMP-2/9), tiv thaiv ECM degradation.
Cov ntaub ntawv kho mob:
Hauv cov neeg mob androgenic alopecia, tom qab 16 lub lis piam ntawm kev siv BTP-1 uas muaj cov ntsiab lus tseem ceeb, cov tawv taub hau MDA (malondialdehyde, tus cim ntawm oxidative kev nyuaj siab) qis dua 41%, thiab cov khoom degradation ntawm hom IV collagen thiab laminin 5 poob los ntawm 33%.
Precise xa cov as-ham
Biotin carrier nyhuv: BTP-1 yog internalized los ntawm biotin receptor (SMVT) nyob rau saum npoo ntawm cov plaub hau follicle hlwb, thaum nqa cov kab xws li zinc thiab tooj liab rau hauv lub hlwb, txhawb keratin synthesis;
Kev txhim kho cov ntshav: BTP-1 tuaj yeem ua rau muaj qhov tshwm sim ntawm vascular endothelial kev loj hlob zoo (VEGF), nce qhov ntom ntawm capillaries nyob ib ncig ntawm cov hauv paus plaub hau, thiab txhim kho kev noj zaub mov zoo.
Tsiaj qauv:
Hauv kev hloov pauv ntawm daim tawv nqaij liab qab tus qauv, microvascular ntom ntom ntawm cov hauv paus plaub hau hauvBiotinoyl Tripeptidepab pawg kho mob yog 2.8 npaug ntau dua li hauv pawg tswj hwm, thiab kev muaj sia nyob ntawm cov hauv paus plaub hau hloov pauv tau nce 60%.
Cov lus nug nquag
Biotinoyl tripeptide yog dab tsi?
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Ib qho tripeptide complex nrog biotin - vitamin H, tsim los tiv thaiv cov plaub hau poob, nkoos metabolism ntawm cov plaub hau follicle hlwb, txhawb cov plaub hau thiab plaub muag kev loj hlob. Ua haujlwm los qhib cov ntaub so ntswg kho cov noob qhia.
Puas yog biotinoyl tripeptide-1 zoo ib yam li biotin?
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Biotinoyl tripeptide-1 yog peptide-txhim kho daim ntawv ntawm biotin uas nkag mus rau hauv cov hauv paus plaub hau tob thiab txhawb kev tsim cov keratin. Nws tau raug pov thawj hauv kev kho mob kom cov plaub hau ceev thiab lub zog.
Cim npe nrov: Tuam Tshoj biotinoyl tripeptide manufacturers, lwm tus neeg
