Biotinoyl Tripeptide-1yog ib qho tshiab tripeptide compound tsim los ntawm chemically combining vitamin H (biotin) nrog ib tug signaling tooj liab peptide (GHK, a Matrikine). Nws feem ntau muaj nyob rau hauv daim ntawv ntawm cov hmoov dawb, los yog muaj peev xwm ua ntej yaj nyob rau hauv cov kuab tshuaj los ua kua tov rau siv nyob rau hauv cov tshuaj pleev ib ce thiab cov khoom tu tus kheej. Feem ntau yog siv los txhawb cov plaub hau kev loj hlob, tiv thaiv cov plaub hau tsis zoo, txhim kho cov plaub hau kev noj qab haus huv, thiab txhawb cov tawv nqaij kho thiab rov tsim dua tshiab. Muaj cov biotin thiab peb cov amino acid residues (glycine, histidine, lysine). Biotin, tseem hu ua vitamin H lossis vitamin B7, yog dej- cov vitamin soluble uas tseem ceeb heev rau tib neeg txoj kev loj hlob, kev loj hlob, thiab lub cev ua haujlwm, tshwj xeeb tshaj yog ua lub luag haujlwm tseem ceeb hauv cov metabolism hauv cov rog thiab cov protein. GHK tripeptide yog ib qho luv luv peptide nrog cov haujlwm lom neeg uas tuaj yeem khi nrog biotin los ua ib qho kev ua haujlwm zoo ntawm cov plaub hau peptide.
Peb cov khoom Form
Biotinoyl Tripeptide-1 COA
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| Certificate of Analysis | ||
| Compound npe | Biotinoyl tripeptide-1 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 299157-54-3 | |
| Ntau | 15g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202512090055 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8 Dec 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.47% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.55% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib qho impurity | <0.8% | 0.26% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 70 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Tshuaj Formula | C24H38N8O6S | |
| Exact Mass | 566.26 | |
| Molecular Luj | 566.68 | |
| m/z | 566.26 (100.0%),567.27(26.0%),568.26(4.5%),568.27(3.2%),567.26(3.0%),568.27(1.2%),569.26(1.2%) | |
| Elemental Analysis | C,50.87;H,6.76;N,19.77;O,16.94;S,5.66 | |
Biotinoyl Tripeptide-1yog ib qho tshuaj lom neeg molecule tsim los ntawm covalent khi ntawm biotin (vitamin B7) nrog glycyl-L-histidyl-L-lysine (GHK) tripeptide. Nws cov qauv molecular yog C24H38N8O6S, nrog rau qhov hnyav molecular ntawm 566.67. Nws zoo nkaus li dawb rau cov hmoov dawb uas muaj purity ntau dua 99%. Cov molecule no tau nyiam ntau yam vim nws cov teebmeem tseem ceeb hauv kev noj qab haus huv ntawm cov plaub hau, tab sis muaj qhov sib txawv tseem ceeb ntawm nws cov teebmeem hauv vitro thiab hauv vivo, ua rau muaj kev nyuaj rau kev tshawb fawb thiab kev siv tshuaj kho mob.
Molecular mechanism: synergistic nyhuv ntawm biotin thiab GHK
Nws cov haujlwm yog los ntawm kev sib koom ua ke ntawm biotin thiab GHK tripeptide:
Biotin yog ib qho tseem ceeb coenzyme hauv keratin synthesis, koom nrog cov metabolism hauv fatty acids, qabzib, thiab amino acids. Hauv cov hauv paus plaub hau, biotin txhawb kev tsim cov fatty acid los ntawm kev ua kom acetyl CoA carboxylase (ACC), muab lub hauv paus zog rau cov plaub hau loj hlob. Tsis tas li ntawd, biotin tuaj yeem txhim kho lub peev xwm antioxidant ntawm cov plaub hau follicle thiab txo UV induced DNA puas.
Kev khi ntawm biotin rau GHK ua kom muaj kev ruaj ntseg ntawm cov molecule (11 npaug siab dua GHK ib leeg) thiab cov hom phiaj ntawm cov plaub hau follicle. Biotin ua raws li "kev taw qhia molecule" coj GHK rau hauv cov plaub hau follicle hlwb, thiab GHK ncaj qha ua rau lub hom phiaj tseem ceeb ntawm cov plaub hau follicle loj hlob los ntawm nws cov kev ua ub no.
Kev ua haujlwm ntawm GHK tripeptide
GHK tripeptides muaj ntau yam haujlwm lom neeg:
Kev txhawb nqa ntawm tes: Los ntawm kev ua kom lub MAPK / ERK signaling txoj hauv kev, nws txhawb kev loj hlob ntawm dermal papilla hlwb (DPC). Nyob rau hauv vitro thwmsim pom tau hais tias lub cell proliferation tus nqi mus txog 148.24% ntawm ib tug concentration ntawm 0.625%.
Antioxidant tiv thaiv: Chelate tooj liab ions (Cu ² ⁺), inhibit lawv cov tshuaj tiv thaiv catalytic los tsim cov pa oxygen reactive (ROS), thiab txo cov oxidative kev nyuaj siab rau cov hauv paus plaub hau.
Anti amyloid protein aggregation: inhibiting kev tsim khoom thiab sib sau ua ke ntawm carbonylated amyloid beta protein (A) tuaj yeem ua tiav los ntawm kev tswj cov hlau ion tshuav.
Kev tshawb fawb hauv vitro: mechanism validation thiab koob tshuaj - teb kev tshuaj xyuas
Cov nyhuv loj hlob: Hauv tib neeg dermal papilla hlwb (HHDPCs) kab lis kev cai hauv vitro, tom qab kev kho mob nrog 0.625% thiab 1.25% cov ntsiab lus ntawm cov tshuaj rau 72 teev, cov cell proliferation nce mus txog 148.24% thiab 143.59%, feem, tsis muaj qhov sib txawv tseem ceeb piv rau qhov zoo tswj minoxidil (1.5%). Tab sis qhov kev loj hlob zuj zus tau poob qis mus rau 102.31% ntawm qhov concentration ntawm 2.5%, qhia txog koob tshuaj - nyob ntawm cov nyhuv saturation.
Antioxidant mechanism: Los ntawm chelating Cu ² ⁺, nws tuaj yeem inhibit oxidation ntawm ascorbic acid (ASC) induced los ntawm Cu-Ib qho nyuaj thiab txo ROS tiam. Nyob rau hauv A 1-16 carbonylation qauv induced los ntawm acrolein, tus nqi inhibition ntawm A aggregation mus txog 65% ntawm ib tug concentration ntawm 20 μ M, qhia nws cov neuroprotective nyhuv los ntawm hlau ion kev cai.
Molecular Interaction: Streptomycin Binding thiab Copper Chelation
Streptomycin binding: Qhov kev sib raug zoo ntawm cov tshuaj no rau streptavidin (IC ₅₀=30 μ M) yog qhov siab dua li cov biotin dawb (IC ₅₀=1.2 μ M), uas tej zaum yuav cuam tshuam nrog nws qhov kev ua kom zoo ntawm qhov chaw. Txawm li cas los xij, qhov kev sib raug zoo siab no yuav raug txwv hauv vivo vim muaj cov kab mob lom xws li stratum corneum ntawm daim tawv nqaij.
Copper chelation muaj peev xwm: GHK tripeptides tuaj yeem ua tau zoo chelate Cu ² ⁺ (Kd=10 ⁻¹ ² M) los ntawm imidazole pawg ntawm histidine residues, tsim kom ruaj khov Cu GHK complexes. Qhov chelation no tuaj yeem cuam tshuam tag nrho ASC oxidation catalyzed los ntawm Cu ² ⁺ hauv vitro, tab sis qhov sib npaug sib npaug thiab kev sib tw ntawm tooj liab ions yuav tsum tau txiav txim siab hauv vivo.
Hauv vivo cov teebmeem: kho mob txhais lus thiab txwv
Cov plaub hau ceev nce: kev soj ntsuam kev sim ntawm cov ntsiab lus uas muaj 1% ntawm cov khoom pom tau tias cov plaub hau ceev tau nce 29% tom qab 16 lub lis piam, thiab qhov feem pua ntawm cov plaub hau hauv lub sij hawm loj hlob nce 35% (cov plaub hau follicle microscope nrhiav tau). Txawm li cas los xij, lwm txoj kev tshawb fawb pom tau tias tsuas yog 12% nce ntawm qhov ntom ntom tau pom ntawm 8 lub lis piam, qhia txog qhov sib txawv ntawm tus kheej hauv lub sijhawm pib.
Kev loj hlob lub voj voog txoj cai: Nws tuaj yeem txhim kho lub voj voog plaub hau los ntawm kev ncua sij hawm ntev ntawm cov plaub hau (Anagen) thiab ua kom lub sijhawm so (Telogen). Cov kev sim tsiaj tau pom tias daim ntawv thov hauv zos tuaj yeem ua rau muaj kev nthuav qhia ntawm cov plaub hau follicle qia cell cim (xws li CD34, K15), tab sis cov txheej txheem molecular tshwj xeeb (xws li Wnt / - catenin) tsis tau qhia meej.
Kev soj ntsuam kev nyab xeeb: kev raug kaw thiab kev kam rau lub zos
Cov kab mob toxicity: Txawm tias muaj ntau npaum li cas (0.6% biotin sib npaug), qhov nqus ntawm daim tawv nqaij tsuas yog kwv yees li 10%, thiab biotin yog metabolized sai sai rau hauv dihydrobiotin thiab biotin sulfide, tsis muaj kev pheej hmoo ntawm tsub zuj zuj. Tsis tas li ntawd, biotin tsis tau pom muaj cov tshuaj tua kab mob, mutagenicity, lossis teratogenicity thiab tsim nyog rau kev siv sijhawm ntev -.
Kev khaus hauv zos: Hauv qhov ntau ntawm 0.5% -3%, cov tshuaj tsis ua rau muaj kev phiv xws li erythema, khaus, lossis flaking. Txawm li cas los xij, qee tus neeg muaj kev ntxhov siab tuaj yeem ua rau muaj kev hnov mob me ntsis, uas tej zaum yuav cuam tshuam nrog pH qhov tseem ceeb (pom zoo 5.5-6.5) lossis cov qauv sib xyaw.
Cov laj thawj rau kev cuam tshuam ntawm kev tshawb fawb hauv vitro thiab hauv vivo cuam tshuam
Qhov sib txawv ntawm bioavailability
Kev nkag mus ntawm daim tawv nqaij: Hauv vitro thwmsim feem ntau ua ncaj qha rau cov hlwb lossis cov ntaub so ntswg, thaum nyob rau hauv vivo, nws yuav tsum nkag mus rau hauv lub stratum corneum (thickness ntawm li 10-20 μ m) thiab cov epidermal dermal hlws ris. Txawm hais tias qhov hnyav molecular ntawmBiotinoyl Tripeptide-1(566.67 Da) yog tsawg dua qhov permeation pib ntawm 500 Da, nws polarity (logP ≈ -2.5) yuav txwv tsis pub transmembrane thauj.
Metabolic degradation: Nyob rau hauv lub cev, proteases (xws li elastase thiab collagenase) thiab esterases nyob rau hauv daim tawv nqaij yuav degrade peptide los yog ester bonds ntawm cov khoom, txo nws cov kev ua. Cov dej ntshiab-cov kab lis kev cai dawb siv hauv kev sim tshuaj vitro tsis tuaj yeem sim ua qhov enzyme ib puag ncig.
Qhov sib txawv ntawm koob tshuaj
Cov nyhuv hauv vitro saturation: Cov concentrations siab (xws li 2.5%) inhibit cell proliferation hauv vitro, uas tej zaum yuav muaj feem xyuam rau receptor saturation lossis tsis yog- tshwj xeeb khi. Nyob rau hauv lub cev, vim muaj kev txwv permeation, qhov tseeb concentration ncav cuag cov hauv paus plaub hau tej zaum yuav qis dua qhov zoo concentration hauv vitro.
Internal dynamic tshuav nyiaj li cas: Qhov concentration ntawm tooj liab ions nyob rau hauv lub cev yog tswj los ntawm ntau yam xws li kev noj haus thiab kab mob, thiab nws cov tooj liab chelation yuav tsis muaj zog vim tooj liab deficiency. Tsis tas li ntawd, lwm yam tshuaj antioxidant hauv lub cev, xws li glutathione thiab vitamin C, tuaj yeem cuam tshuam lawv cov teebmeem.
Cov kev txwv ntawm kev sim ua qauv
Cell qauv simplification: Hauv vitro thwmsim feem ntau siv ib hom cell (xws li HHDPCs), thaum nyob rau hauv vivo plaub hau follicles yog ib tug complex system ntawm ntau lub hlwb (xws li keratinocytes, melanocytes) thiab matrix Cheebtsam (xws li collagen, hyaluronic acid). Cov nyhuv ntawm cov tshuaj no tuaj yeem nyob ntawm kev sib cuam tshuam ntawm cov cell lossis microenvironment ntawm matrix.
Tsiaj qauv sib txawv: lub voj voog ntawm cov plaub hau follicle (txog 20 hnub) hauv kev sim tsiaj (xws li nas) yog qhov sib txawv ntawm cov tib neeg (3-7 xyoo), thiab cov tawv nqaij ntawm cov tsiaj (xws li cov plaub hau ntom ntom thiab sebum secretion) txawv ntawm qhov hauv tib neeg, uas yuav ua rau muaj kev tsis ncaj ncees ntawm cov txiaj ntsig.
Kev daws teeb meem thiab cov lus qhia yav tom ntej
Delivery system optimization
Nanocarriers: Los ntawm encapsulatingBiotinoyl Tripeptide-1nrog liposomes, polymer nanoparticles, los yog hlau organic moj khaum (MOFs), nws cov tawv nqaij permeability thiab stability tuaj yeem txhim kho. Piv txwv li, liposome encapsulation tuaj yeem nce permeability los ntawm 3-5 zaug.
Micro koob tshuab: xa ncaj qha mus rau txheej dermis los ntawm kev sib xyaw micro koob array, nws tuaj yeem hla lub stratum corneum barrier thiab ua tiav lub hom phiaj meej. Cov kev sim tsiaj tau pom tias kev xa cov microneedle tuaj yeem ua rau cov tshuaj muaj zog hauv cov hauv paus plaub hau los ntawm 10 npaug.
Cov qauv kev txhim kho
Kev hloov kho PH: Kev tswj cov mis pH ntawm 5.5-6.5 (ze rau ntawm daim tawv nqaij pH) tuaj yeem txo qis peptide nqi rejection thiab txhim kho permeability. Lub caij no, ntxiv kev nkag mus rau kev txhim kho xws li propylene glycol thiab azone tuaj yeem txhim kho cov nyhuv.
Stabilizer ntxiv: Ntxiv cov tshuaj antioxidants (xws li vitamin E) lossis protease inhibitors (xws li EDTA) tuaj yeem tiv thaiv lawv cov degradation hauv cov mis thiab ua rau lub neej ntev.
Combination therapy zoo
Ua ke nrog minoxidil: Minoxidil txhawb cov plaub hau follicle khoom noj khoom haus los ntawm vasodilation, thaum txhim kho cov plaub hau follicle vitality los ntawm cell proliferation thiab antioxidant teebmeem. Cov kev tshawb fawb hauv tsev kho mob tau pom tias kev sib xyaw ntawm 1% Biotinoyl Tripeptide thiab 2% Minoxidil tuaj yeem ua rau cov plaub hau ntom ntom 42%, zoo dua li kev kho mob monotherapy.
Ua ke nrog caffeine: Caffeine tuaj yeem inhibit 5 - reductase, txo dihydrotestosterone (DHT) ntau lawm, thiab tiv thaiv cov plaub hau follicle miniaturization. Kev sib xyaw ua ke ntawm cov tshuaj no thiab caffeine tuaj yeem txhim kho androgenic alopecia, nrog rau kev sim tsiaj uas qhia txog 25% nce ntawm cov plaub hau txoj kab uas hla hauv pawg ua ke.
Nyob rau hauv qhov tob kawm ntawm mechanisms
Tib lub xov tooj sib txuas: Siv ib zaug - xov tooj ntawm tes RNA sequencing thev naus laus zis los tshuaj xyuas qhov sib txawv ntawm cov tshuaj no ntawm cov plaub hau follicle qia hlwb, dermal papilla hlwb, thiab keratinocytes, nthuav tawm nws txoj hauv kev tshwj xeeb hauv kev tswj cov plaub hau.
Organoid qauv: Tsim tib neeg cov plaub hau follicle organoids los simulate cov qauv complex thiab kev ua haujlwm ntawm cov hauv paus plaub hau hauv vivo, uas tuaj yeem ntsuas qhov tseeb dua lawv cov teebmeem thiab tshuaj lom.
Cim npe nrov: Tuam Tshoj biotinoyl tripeptide-1 manufacturers, lwm tus neeg
