Acetyl hexapeptide-38 peptide(PAW- ) yog ib qho hluavtaws high-kev ua kom zoo nkauj polypeptide tsim los ntawm 6 amino acids hloov ntawm acetylation. Featuring lub hom phiaj xa khoom, lub zog me me thiab kev nyab xeeb zoo dua, nws yog ib qho khoom siv tshiab uas siv tau dav siv hauv kev kho mob zoo nkauj thiab tiv thaiv - kev laus ntawm daim tawv nqaij. Tsis zoo li cov khoom xyaw volumizing ib txwm ua haujlwm los ntawm lub cev plumping, qhov peptide no ua rau muaj kev cuam tshuam los ntawm kev tswj cov kab mob lom neeg. Nws muab xoom txawv teb chaws- lub cev hnov qab thiab khaus tsawg, haum rau txhua hom tawv nqaij nrog rau cov tawv nqaij rhiab heev. Nws cov txiaj ntsig tseem ceeb ntawm kev tu tawv nqaij yog nyob rau hauv adipogenesis thiab cov ntaub so ntswg mos volumization, uas tshwj xeeb alleviates aging kev txhawj xeeb xws li poob ntawm subcutaneous lub ntsej muag rog, lub ntsej muag hollowness, daim tawv nqaij atrophy thiab sagging. Nws kuj muab kev pabcuam soothing thiab tiv thaiv -wrinkle teebmeem.
Peb Cov Khoom Muag Khoom
Acetyl Hexapeptide-38COA
Mechanism ntawm Action
Core Function: Lub hom phiaj txhawb nqa ntawm Adigenesis rau cov ntaub so ntswg mos Volumization
Nyob rau hauv lub hauv paus ntawm daim tawv nqaij laus lies atrophy ntawm subcutaneous rog pads, nrog rau tsawg thiab tsawg active adipocytes, uas ua rau sunken lub puab tsaig, deflated lub ntsej muag contours thiab tsis muaj zog ntawm daim tawv nqaij. Cov khoom xyaw tshuaj pleev ib ce feem ntau tsom rau kev kho collagen nyob rau hauv cov epidermis thiab dermis, tsis ua rau cov txheej txheem adipose. Lub zog tseem ceeb ntawmacetyl hexapeptide-38 peptideNws yog nws lub peev xwm los txhawb adipogenesis thiab ua kom cov nqaij mos mos zoo nkauj.Raws li ib qho kev taw qhia txog kev lom neeg, cov peptide no nkag mus rau hauv cov epidermis thiab cov dermis kom ncav cuag cov ntaub so ntswg subcutaneous adipose, qhov twg nws lub hom phiaj preadipocytes thiab ua rau cov kev pab cuam physiological adipogenic.
Qhov txawv ntawm hyaluronic acid uas plumps ntawm daim tawv nqaij los ntawm lub cev dej nqus thiab o, nws cov nyhuv volumizing originates los ntawm endogenous adipocyte proliferation thiab lipid tsub zuj zuj, yielding ntuj, ntev -cov txiaj ntsig kav ntev uas ua raws li cov tawv nqaij ib txwm muaj.Rau cov ntsiab lus ntawm kev ua haujlwm tshwj xeeb, PAW- kev xaiv lub ntsej muag muaj zog thiab kev ua kom muaj zog caj dab tsis inducing systemic rog nce.
Nws raug kho kom raug cov rog hauv cheeb tsam kom rov tsim kho tag nrho, ruaj khov ntawm lub ntsej muag contours, thickens subcutaneous adipose txheej los txhawb cov tawv nqaij barrier, thiab boosts tawv nqaij softness thiab elasticity. Nws pab txo qis ntau cov cim kev laus xws li hollowness, sagging thiab kab zoo.
Txoj hauv kev tseem ceeb: PGC-1 / PPAR / C / EBP Adipogenic Differentiation Pathway
Lub hauv paus molecular los ntawm PAW- tsav adipogenesis thiab volumization yog nws qhov kev ua kom raug thiab kev hloov kho ntawm peb -tiered txuas PGC-1 / PPAR / C / EBP adipogenic sib txawv taw qhia txoj hauv kev.Qhov txoj hauv kev no ua haujlwm raws li lub hauv paus kev tswj hwm cascade tswj kev ua neej nyob thiab kev sib txawv, kev sib txawv ntawm lub neej thiab kev ua haujlwm, Kev txiav txim siab adipocyte maturation efficiency thiab adipose cov ntaub so ntswg ntim.Txoj kev ua haujlwm nyob rau hauv kev loj hlob, synergistically activated hierarchical logic.Raws li tus dej ntws tawm activator, PAW- sequentially tswj cov kev qhia ntawm cov ntsiab lus ntawm cov proteins thiab cov noob kom tag nrho pib ua tiav lub cev adipogenic cascade.
Nws hom kev nqis tes ua nthuav dav thoob plaws peb txoj kev sib txuas nruj, kev sib koom ua ke txhawb nqa cov qib uas sib koom ua ke rov qab cov ntaub so ntswg ntim los ntawm lub cev rog ntxiv.
Qib 1: Kev ua kom nce toj thiab kev cai ntawm PGC-1 - Lub Hom Phiaj Tseem Ceeb
PGC-1 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1) yog ib qho tseem ceeb tshaj plaws ntawm cov khoom siv hluav taws xob uas tswj hwm cov roj metabolism thiab kev sib txawv ntawm adipocytes, tswj hwm cov cellular zog metabolism thiab pib ntawm adipogenesis. Nyob rau hauv tej yam kev mob laus, cutaneous PGC-1 qhia tsis tu ncua poob, ncaj qha ntes preadipocyte sib txawv thiab impairing lipid synthesis muaj peev xwm. Cov ntaub ntawv soj ntsuam xyuas tias PAW- tshwj xeeb khi rau receptors ntawm preadipocyte daim nyias nyias los ua intracellular teeb liab transduction, markedly elevating mRNA{7} thiab protein qhia
Ntawm qhov concentration ntawm 0.5 mg / mL, PGC-1 qhia tau nce los ntawm 61.1%, tag nrho qhib cov kab hluav taws xob adipogenic pib pib rau lub hnub nyoog thim rov qab-txog adipogenic stagnation thiab nteg hauv paus rau tom qab adipocytes maturation thiab lipid deposition} ntxiv rau, cov kev sib cuam tshuam {6. txoj hauv kev xws li Wnt / -catenin, stabilizing PGC-1 ua kom cov cim qhia thiab tiv thaiv ntxov ntxov ntawm kev sib txawv ntawm adipogenic.
Qib 2: Kev Sib Haum Xeeb thiab Kev Cai ntawm PPAR - Lub Chaw Tseem Ceeb rau Kev Qhia Adipocyte Sib Txawv
Thaum qhib ua haujlwm, PGC-1 xaiv khi rau thiab qhib cov khoom xa tawm hauv qab tus lej PPAR (Peroxisome Proliferator-Activated Receptor Gamma).
Raws li lub hauv paus tswj hwm noob ntawm adipogenic sib txawv, PPAR dictates seb preadipocytes undergo coj maturation mus rau functional adipocytes, ua hauj lwm raws li ib tug indispensable mediator ntawm adipogenesis.acetyl hexapeptide-38 peptide, qhib PGC-1 ua kom muaj kev sib txuas lus ua haujlwm ruaj khov nrog PPAR, ua kom muaj zog ntau dua PPAR cov dej num. Qhov no prompts dormant preadipocytes tawm mus quiescence thiab tso tawm qhia kev sib txawv cov kev pab cuam, suppresses cellular apoptosis thiab fibrosis, thiab khaws cia proliferative tseem ceeb ntawm adipocytes.Qhov no mechanism fundamentally txawv los ntawm ib tug zoo moisturizing thiab anti- kev laus actives los ntawm regenerating thiab kho adipose cov ntaub so ntswg sib txawv nyob rau hauv ib ntus. lub hauv paus ntawm lub sij hawm ntev volumization.
Hauv vitro cellular kev soj ntsuam pom tau hais tias kev kho mob nrog PAW- txhawb nqa PPAR kev hloov pauv hauv tib neeg cov kab mob preadipocytes los ntawm ntau dua 50%, ua kom nce qhov sib txawv ntawm cov kab mob adipogenic. Cov hlwb sib txawv khaws cov lipids cia muaj peev xwm nrog xoom pheej hmoo ntawm kev loj hlob txawv txav, lees paub qhov tshwj xeeb kev nyab xeeb profiles.
Qib 3: Kev Tswj Xyuas Chaw Ua Haujlwm ntawm C / EBP - Ua tiav Lipid Accumululation thiab Volumization
C/EBP (CCAAT/Enhancer{0}}Binding Protein Alpha) yog lub hom phiaj tseem ceeb ntawm cov noob caj noob ces ntawm PPAR thiab lub davhlau ya nyob twg tswj kev tswj hwm adipocytes maturation thiab lipid synthesis. Nws feem ntau tswj intracellular fatty acid synthesis, triglyceride deposition thiab adipocyte morphological maturation, ncaj qha dictating incremental adipose ntaub so ntswg ntim.
PPAR kev ua kom muaj zog ntxiv ua rau muaj kev qhia siab ntawm C / EBP gene, ob npaug ntxiv txoj hauv kev ua haujlwm kom tsav cov lipid synthesis thiab khaws cia hauv cov adipocytes sib txawv.
Ua kom tiav lipid droplet tsim ua kom loj adipocytes loj thiab tsis tu ncua ua rau cov cell suav, thaum kawg ua rau lub cev hnyav thiab ntim cov ntaub so ntswg subcutaneous adipose. Tsis tas li ntawd, txhawb nqa siab C / EBP qhia stabilizes cov qauv thiab kev ua haujlwm ntawm cov laus adipocytes, txuas ntxiv cellular rau kev muaj sia nyob ntev dua - volumizing teebmeem.Cov ntaub ntawv pov thawj qhia tau hais tias PAW- kev kho mob txhawb nqa cov kab mob lipid hauv cov adipocytes txog li 32.4%. Ib 14-hnub tib neeg lub ntsej muag sim sau tseg 11.9% nce hauv cov ntim hauv zos, thiab daim ntawv thov mus sij hawm ntev zoo txhawb nqa cov tawv nqaij, tag nrho.
Tag nrho PGC-1 / PPAR / C / EBP txoj hauv kev suav nrog kev kaw- lub voj voog kev tswj hwm: kev pib dej ntws, kev sib kho nruab nrab thiab kev ua tiav ntawm lub davhlau ya nyob twg. Los ntawm kev ua kom tiav qhov peb -tiered cascade, PAW- orchestrates tag nrho cov spectrum ntawm adipocytes sib txawv, lipid synthesis thiab cov ntaub so ntswg volumization. Nws daws cov rog subcutaneous thiab lub ntsej muag hollowness ntawm qib cellular thiab molecular kom xa khoom ntuj, nyab xeeb, ntev -ntev volumizing los tiv thaiv -cov txiaj ntsig kev laus - nws cov txiaj ntsig tseem ceeb tshaj li kev sib tw polypeptides.Qhov tseem ceeb, cov txheej txheem kev tswj hwm no ua tiav nrog tib neeg lub cev metabolic mechanisms. Nws yuav tsum tsis muaj exogenous muab tub lim los yog hormonal cuam tshuam, tshem tawm cov kev phiv tshwm sim xws li txawv txav rog hyperplasia, daim tawv nqaij liab thiab ua xua, ua rau nws haum rau ntev - lub sij hawm los tiv thaiv kev laus ntawm daim tawv nqaij.
Efficacy on Barrier Repair for Sensitive Skin
Acetyl hexapeptide-38 peptideyog haum rau cov tawv nqaij rhiab heev featuring fragility, flushing thiab cuam tshuam ntawm daim tawv nqaij teeb meem, nrog ntxiv me ntsis anti-inflammatory thiab soothing bioactivities. Cov polypeptide no inhibits kev tso tawm ntawm pro-inflammatory mediators IL-6 thiab TNF- nyob rau hauv lub stratum corneum, mitigates kev ntxhov siab cov lus teb nrog rau kub hnyiab, stinging thiab redness tshwm sim los ntawm sab nraud irritants, thiab alleviates daim tawv nqaij intolerance induced los ntawm caij nyoog hloov los yog khaus tawv nqaij cov khoom nyob rau hauv rhiab heev.
Hloov kho los ntawm acetylation, nws boasts ib tug nruab nrab molecular hnyav nrog maj mam nkag mus rau ntawm daim tawv nqaij.Nws zam dhau - nkag mus los ntawm lub stratum corneum uas yuav irritate dermal paj hlwb, nqa tsis muaj kev pheej hmoo ntawm stinging los yog rhiab heev. Tsis muaj qhov tshwm sim ntawm kev tsis haum tshuaj tiv thaiv hauv tib neeg kev soj ntsuam thaj chaw.
Tshaj li kev tiv thaiv -mob thiab soothing teebmeem, cov khoom muaj thickens subcutaneous rog pads los ntawm boosting adipocytes sib txawv los txhawb cov tawv nqaij txhawb nqa barrier los ntawm tob txheej. Muaj ntau subcutaneous rog cushions epidermal kev puas tsuaj los ntawm lwm yam kev ntxhov siab xws li kub hloov pauv, kev sib txhuam thiab UV hluav taws xob, txo qhov cuam tshuam kev puas tsuaj thiab cov dej tsis zoo transepidermal (TEWL).
Lub caij no, cov adipocytes paub tab secrete lipid-cov tshuaj nquag los pab txhawb lipid synthesis nyob rau hauv lub stratum corneum, sau intercellular khoob ntawm keratinocytes, qeeb cutaneous dej poob, thiab txo cov tsos mob ntawm daim tawv nqaij rhiab heev xws li dryness, tev thiab pruritus.
Nws txoj kev tswj hwm txoj cai tso siab rau tag nrho ntawm endogenous physiological cellular modulation yam tsis muaj cov tshuaj hormones lossis irritating volumizing agents. Ntev- daim ntawv thov lub sij hawm maj mam txhim kho daim tawv nqaij kam rau ntawm cov tawv nqaij rhiab heev, muab ob qho txiaj ntsig ntawm kev kho qhov teeb meem thiab cov ntaub so ntswg volumization.
Keeb kwm Discovery
Nws yog cov khoom siv tseem ceeb rau kev tiv thaiv kev tiv thaiv- kev laus hauv cov khoom siv tshuaj pleev ib ce polypeptide, tshwj xeeb uas tsim los ntawm pab pawg R&D ntawm Lipotec, Spain. Cov tshuaj pleev ib ce polypeptides feem ntau ua rau ntawm daim tawv nqaij thiab dermis, tsuas yog txo cov kev txhawj xeeb ntawm daim tawv nqaij xws li wrinkles thiab dullness, tab sis tsis kho cov teeb meem kev laus nrog rau lub ntsej muag hollowness thiab cov nqaij mos sagging induced los ntawm subcutaneous rog atrophy.
Txhawm rau ua tiav qhov kev sib txawv no, pab pawg tshawb fawb tau txais siab - dhau los ntawm kev tshuaj ntsuam xyuas molecular thiab cellular txoj kev siv thev naus laus zis los xaiv cov tshuaj bioactive polypeptide ib ntus uas muaj peev xwm tswj hwm adipogenesis. Tom qab rov ua kom zoo dua qub, PAW muaj zog heev - tau txais, thiab nws txoj haujlwm tseem ceeb ntawm kev ua kom PGC-1 / PPAR / C / EBP adipogenic sib txawv txoj hauv kev tau txheeb xyuas.
Cov khoom xyaw no tau ua tiav tag nrho cov kev ntsuam xyuas kev nyab xeeb thiab kev ua tau zoo thiab tau raug tso tawm mus rau hauv kev ua lag luam hauv xyoo 2010, kos npe rau thawj daim tawv nqaij polypeptide featuring physiological fat volumization. Pib txij xyoo 2018, kev sib koom ua ke hauv cheeb tsam thiab loj - nplai daim ntawv thov ntawm cov khoom xyaw no tau maj mam pom hauv Suav teb, thiab nws tau siv dav rau hauv siab - kawg tiv thaiv - kev laus ntawm daim tawv nqaij formulations.
Cov ntaub ntawv
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- Suzhou Ruijia Biotechnology Co., Ltd. Phau ntawv qhia kev qhia ntawm Acetyl Hexapeptide-38[EB/OL]. 2026.
- ChemicalBook. Database of Efficacy and Physicochemical Properties of Acetyl Hexapeptide-38 (CAS No. 1400634-44-7)[DB/OL]. 2026.
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- Hangzhou Chuangpeptide Biotechnology Co., Ltd. Kev tshuaj xyuas ntawm R&D Keeb Kwm thiab Daim Ntawv Thov ntawm Cosmetic Polypeptide Acetyl Hexapeptide-38[EB/OL]. 2024.
Cim npe nrov: Tuam Tshoj acetyl hexapeptide-38 peptide manufacturers, lwm tus neeg
