Walnut oligopeptides muaj(WOPs) yog ib chav kawm ntawm me me molecules nrog cov kev ua haujlwm lom neeg tseem ceeb tau muab rho tawm los ntawm walnuts (Juglans regia L.) los ntawm kev siv tshuab enzymatic hydrolysis. Nws cov ntsiab lus yog ib qho luv luv saw peptide ntu uas muaj li ntawm 2 txog 10 amino acids, nrog rau qhov hnyav molecular feem ntau tsawg dua 500 daltons, coexisting nyob rau hauv daim ntawv ntawm dawb amino acids, oligopeptides, peptides, thiab ib tug me me ntawm cov proteins.
Nws walnut peptide muaj 18 amino acids, suav nrog 8 qhov tseem ceeb amino acids, ntawm cov glutamic acid muaj cov ntsiab lus siab tshaj plaws, ua raws li arginine. Glutamate, raws li ib qho ntawm cov amino acids tseem ceeb hauv tib neeg cov metabolism hauv nitrogen, tshwj xeeb tshaj yog rau cov ntaub so ntswg hlwb - cov ntaub so ntswg hlwb tsuas tuaj yeem oxidize thiab siv glutamate es tsis txhob siv lwm cov amino acids. Yog li, glutamate tuaj yeem ua lub zog rau cov ntaub so ntswg hlwb, muab lub zog rau lub hlwb.
Walnut OligopeptideCOA
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| Certificate of Analysis | ||
| Compound npe | Walnut Oligopeptide | |
| Qib | Pharmaceutical qib | |
| Ntau | 44g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090066 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv | N\A | |
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.40% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.21% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.42% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 205 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 5 20 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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Cov qauv me me no ua rau WOPs muaj txiaj ntsig zoo: lawv tuaj yeem nqus tau ncaj qha los ntawm tib neeg lub cev yam tsis muaj kev zom zaub mov, thiab lawv qhov kev nqus tau zoo dua li ntawm ib qho amino acids lossis cov protein tsis zoo. Cov yam ntxwv no tau nyiam ntau yam hauv cov khoom noj khoom haus thiab kev noj qab haus huv.
Cov ntaub ntawv Source:
Lub vev xaib raug cai ntawm Shaanxi Baichuan Biotechnology Co., Ltd;
Shaanxi ShineHerb Biotech Product Description (tso tawm rau Lub Ib Hlis 29, 2026)
Walnut oligopeptides muaj, cov tshuaj lom neeg muaj txiaj ntsig tau muab rho tawm los ntawm "lub hlwb nourishing txiv hmab txiv ntoo" ntawm walnuts, tau dhau los ua ib qho tseem ceeb tshaj plaws lub hnub qub raw cov ntaub ntawv hauv cov khoom noj khoom haus thiab kev noj qab haus huv kev lag luam nrog rau nws cov kev cuam tshuam tseem ceeb ntawm neuroprotection, kev tiv thaiv kab mob plawv, kev tiv thaiv kab mob, kev tu plab hnyuv, tawv nqaij tiv thaiv - laus, tiv thaiv qaug zog thiab tiv thaiv oxidation.{1}
1. Lub hlwb noj qab haus huv thiab neuroprotection - lub hnub qub dazzling tshaj plaws
Kev ua tau zoo ntawm walnut oligopeptides hauv kev noj qab haus huv ntawm lub hlwb yog qhov zoo kawg nkaus.
(1) Txhim kho kev kawm thiab kev nco muaj peev xwm
Ib qho kev sim rau cov nas me me (48 txiv neej C57BL / 6J nas) pom tias cov nas tau muab faib ua pawg tswj hwm dawb paug thiab peb pawg pab cuam walnut peptide: qis (110mg / kg · bw), nruab nrab (220mg / kg · bw), thiab siab (440mg / kg · bw).
Tom qab kev cuam tshuam tas mus li rau 30 hnub, Morris dej maze, dhia platform sim, thiab shuttle box sim tau ua. Cov txiaj ntsig qhia:
Morris dej maze: Kev khiav tawm latency ntawm siab - pawg koob tshuaj tau luv luv piv rau pawg tswj hwm (P<0.05), and the residence time and number of passes in the target quadrant were significantly increased in the medium and high-dose groups (P<0.05);
Jumping Platform Experiment: Cov pab pawg qis thiab qib siab tau pom qhov txo qis ntawm qhov yuam kev thaum lub sijhawm 24-teev xeem (P<0.05), while all three intervention groups had an increase in latency (P<0.05). The medium dose group had a slower memory loss of electric shocks (P<0.05);
Shuttle box sim: Cov pab pawg qis, nruab nrab, thiab siab koob tshuaj pom tau tias muaj kev nce ntxiv ntawm cov kev sim zam (P<0.05) and a decrease in the number of electric shocks received (P<0.05).
Cov lus xaus yog qhov tseeb: nws tuaj yeem txhim kho kev kawm thiab kev nco qab muaj peev xwm, muaj peev xwm ua kom muaj zog thiab tsis muaj peev xwm zam, thiab tuaj yeem ncua kev poob ntawm kev kawm thiab kev nco hauv cov nas me.
Cov txheej txheem muaj feem cuam tshuam nrog kev ua haujlwm antioxidant - pawg walnut peptide koob tshuaj muaj ntau dua cov ntshav T-SOD thiab GSH Px kev ua ub no dua li pawg tswj hwm, thiab txo qis MDA ntau dua li pawg tswj hwm (P<0.05).
Tsis tas li ntawd, ib txoj kev tshawb fawb luam tawm nyob rau hauv Food & Function ntse cais cov tshiab oligopeptide AQ los ntawm hydrolyzate ntawm defatted walnut pluas noj, thiab txheeb xyuas nws cov qauv tshuaj raws li AASDCQ. Cov peptide no nthuav tawm cov peev xwm zoo tshaj plaws dawb radical scavenging ntawm qhov concentration ntawm 1mg / mL: O ₂⁻ dawb radical scavenging tus nqi ntawm 81.00%, DPPH dawb radical scavenging tus nqi ntawm 79.40%, thiab ABTS dawb radical scavenging tus nqi ntawm 67.09%.
Qhov tseem ceeb tshaj, AQ muaj kev tiv thaiv zoo tiv thaiv H-SY5Y neuronal puas tsuaj los ntawm H ₂ O ₂, txo cov cell puas thiab apoptosis. Hauv vivo thwmsim kuj tau qhia tias AQ tuaj yeem txhawb nqa angiogenesis hauv quail chorioallantoic membrane thiab txo ROS tsub zuj zuj thiab ua kom lub neej ntev hauv C. elegans qauv.
Lwm qhov kev tshawb fawb soj ntsuam tau pom tias nws tuaj yeem txhim kho lub hnub nyoog - cuam tshuam txog kev kawm thiab kev nco, thiab suav tias yog qhov muaj peev xwm thiab muaj txiaj ntsig zoo.
Cov ntaub ntawv Source:
Kev sim hauv phau ntawv Journal of Peptide Nutrition and Health;
Cov ntawv tshawb fawb txog Khoom Noj & Kev Ua Haujlwm (RSC Publishing);
Kev tshawb fawb ntawm Walnut Oligopeptide ncua kev txhim kho kev laus ntsig txog kev kawm
(2) Sib sib zog nqus mechanisms ntawm neuroprotection
AQ oligopeptides kuj tseem muaj peev xwm tiv thaiv - mob thiab neuroprotective teebmeem: hauv LPS stimulated RAW264.7 hlwb, AQ zoo inhibits qhov tso tawm ntawm pro-inflammatory yam NO (IC ₅₀=46.03 ± 0.32 μ M) thiab suppresses cov lus qhia ntawm Western {7} ntau {TN} {6} nws anti-inflammatory mechanism. Zuag qhia tag nrho, AQ muaj plaub txheej ntawm neuroprotective zog: antioxidant, tiv thaiv -inflammatory, pro angiogenic, thiab tiv thaiv kev laus.
Cov ntaub ntawv Source:Khoom noj khoom haus & Kev Ua Haujlwm (RSC Publishing)
2. Kev noj qab haus huv ntawm lub plawv - cov ntaub thaiv npog ntuj uas tiv thaiv lub plawv
Cov nyhuv tiv thaiv ntawmwalnut oligopeptides ntawm cov txiv ntoontawm cov hlab plawv system tau validated los ntawm ntau qhov chaw. Nws mechanism ntawm kev txiav txim muaj xws li:
Txo cov qib "phem" cholesterol (LDL);
Regulating ntshav siab;
Txhim kho cov ntshav ncig.
Cov txiaj ntsig no yog los ntawm kev sib koom ua ke ntawm cov rog noj qab haus huv, antioxidants, thiab cov amino acids tseem ceeb hauv WOPs. Nyob rau hauv cov ntsiab lus ntawm cov kab mob plawv thoob ntiaj teb hnyav zuj zus, qhov kev tiv thaiv lub plawv zoo li no muaj txiaj ntsig zoo rau pej xeem kev noj qab haus huv.
Qhov chaw:Xov xwm - Uncovering the Nutrition Miracle: Walnut Oligopeptides
3. Kev tswj kev tiv thaiv kab mob - qhib rau tib neeg tiv thaiv corps
Kev tshawb fawb tau pom tias nws tuaj yeem txhim kho kev lom zem thiab kev tiv thaiv ntawm tes - cov lus teb tiv thaiv kab mob sib kis, pom tau tias:
Txhim kho macrophage phagocytic muaj nuj nqi: Hauv cov qauv zebrafish, hmoov tau pom los txhawb cov macrophage phagocytosis (WO2017124921A1 patent record);
Txhim khu kev ua haujlwm ntawm ntuj tua cov hlwb (NK hlwb).
Qhov no txhais tau hais tias nws tsis yog tsuas yog "kev noj haus ntxiv", tab sis kuj yog lub cev tiv thaiv kab mob uas tuaj yeem ua kom lub cev tsis muaj zog ntawm tib neeg lub cev hauv txhua yam.
Cov ntaub ntawv Source:
Immunomodulatory teebmeem ntawm kev tshawb fawb walnut oligopeptides;
WO2017124921A1 patent
4. Gut Health - Probiotic zoo li "Nourishing Bacteria" Effect
WOPs muaj cov khoom siv prebiotic thiab tuaj yeem ua cov khoom noj khoom haus rau cov plab hnyuv microbiota, txhawb kev loj hlob thiab kev loj hlob ntawm "tus phooj ywg kab mob" xws li bifidobacteria thiab lactobacilli. Txoj kev tshawb no tseem pom tau tias WOPs tuaj yeem txhawb cov kab mob loj hlob thiab kev loj hlob, ua kom cov kab mob biofilm thiab extracellular polysaccharide (EPS) tso tawm. Los ntawm kev tswj hwm lub plab microbiota kev noj qab haus huv, nws tsis ncaj qha txhim kho kev zom zaub mov thiab kev noj zaub mov zoo.
Cov ntaub ntawv Source:
Cov txiaj ntsig zoo thiab cov txheej txheem ntawm WOP kev tshawb fawb (PMC, T Ding, 2021);
Xov xwm - Uncovering the Nutrition Miracle
5. Daim tawv nqaij noj qab haus huv - Lub Anti Aging Code los ntawm Sab Hauv
Hauv kev lag luam tshuaj pleev ib ce,walnut oligopeptides ntawm cov txiv ntookuj ci ntsa iab:
Txhawb nqa kev loj hlob ntawm keratinocytes: Cov hlwb no yog lub luag haujlwm tsim cov keratin, cov ntsiab lus tseem ceeb ntawm daim tawv nqaij tiv thaiv kev tiv thaiv, uas txhawb kev kho tawv nqaij thiab rov tsim dua tshiab;
Txhawb cov synthesis ntawm collagen thiab elastin: Cov proteins ob no yog qhov tseem ceeb ntawm kev tswj cov tawv nqaij elasticity thiab firmness, thiab tuaj yeem tiv thaiv cov tawv nqaij sagging thiab laus;
Dual tiv thaiv antioxidant thiab tiv thaiv - mob: txo qhov kev puas tsuaj ntawm cov dawb radicals rau ntawm daim tawv nqaij thiab ncua kev laus ntev.
Cov ntaub ntawv Source:
Unveiling the Marvelous Benefits of Walnut Extract in Skincare - Morganna's Alchemy Skin Care
6. Los tiv thaiv kev qaug zog thiab kev ua haujlwm antioxidant
Nws kuj tau raug pov thawj tias muaj peev xwm tiv thaiv qaug zog thiab muaj zog antioxidant muaj peev xwm. Cov kws tshawb fawb tau pom tias nws tuaj yeem tshem tawm hydroxyl radicals thiab superoxide anion radicals, uas yog lub hauv paus molecular rau nws ntau yam txiaj ntsig kev noj qab haus huv.
Cov ntaub ntawv qhov chaw: Shaanxi Shanhe Biotechnology Product Description (2026-01-29)
Kev npaj ntawm WOPs feem ntau yog siv ntau- cov txheej txheem xws li enzymolysis - ultrafiltration - gel filtration chromatography. Tshwj xeeb tshaj yog, cov khoom noj khoom haus uas tsis muaj qab zib yog thawj zaug siv los ua cov khoom siv raw, enzymatically hydrolyzed los ntawm protease, tom qab ntawd cov khoom uas muaj qhov sib txawv molecular hnyav tau sib cais los ntawm ultrafiltration membrane, thiab thaum kawg lub hom phiaj oligopeptides tau purified los ntawm gel filtration chromatography.
Noj cov txheej txheem kev npaj ntawm cov tshuaj ntsuam xyuas piav nyob rau hauv patent WO2017124921A1 ua piv txwv: Yog 10mg ntawm WOP hmoov, muab tso rau hauv 50mL xim av volumetric hwj, ntxiv 30mL ntawm ethanol, sonicate rau 5 feeb, dilute nrog ethanol rau lub cim, thiab co zoo. Qhov no qhia tias WOP hmoov muaj ethanol solubility zoo.
Hais txog cov khoom lag luam, kev lag luam feem ntau muab faib ua plaub hom: hom kua, hom hmoov qhuav, hom peptide, thiab hom oligopeptide. Cov kua dej muaj cov dej solubility zoo heev thiab tsim nyog rau cov dej haus thiab kev noj qab haus huv, nrog rau kev nqus sai; Qhuav hmoov hom (ieWalnut oligopeptidehmoov) yog ib qho yooj yim rau khaws thiab thauj, haum rau cov qauv zaub mov thiab cov khoom noj khoom haus. Nws zoo nkaus li cov hmoov dawb dawb rau cov hmoov daj daj, tsis muaj clumping lossis impurities, nrog rau purity ntau dua 95% lossis txawm tias 99%.
Cov ntaub ntawv Source:
WO2017124921A1 patent;
European Walnut Protein Peptide Market Report (2026-2033);
Shaanxi Shanhe Biotechnology Product Description
Cov ntsiab lus tseem ceeb ntawm cov ntaub ntawv:
Khoom noj khoom haus&Function (RSC Publishing) - Neuroprotective Study of a Novel Oligopeptide AQ
Phau ntawv Journal of Peptide Nutrition and Health - Kev Kawm thiab Kev Nco Txog Cov Me Nyuam Yaus
PMC (T Ding, 2021) - Probiotic cuam tshuam ntawm walnut oligopeptides ntawm plab microbiota
WO2017124921A1/MY193780A - Cov ntaub ntawv Patent
Shaanxi ShineHerb Biological (ShineHerb) Khoom Nplooj (2026-01-29)
Shaanxi Baichuan Biotechnology Official Lub Vev Xaib (Lub Cuaj Hli 9, 2025)
European Walnut Protein Peptide Market Report (2026-2033, CAGR 14.9%)
Ntiaj teb no Walnut Peptide Kev Lag Luam Tshaj Tawm (2026-2033)
Morgana's Alchemy Skin Care - Walnut Extract Skincare Benefits
Kev tshawb fawb ntawm Walnut Oligopeptide ncua kev txhim kho kev laus ntsig txog kev kawm
Immunomodulatory teebmeem ntawm Walnut oligopeptides kev tshawb fawb
Cim npe nrov: Walnut Oligopeptide, Tuam Tshoj Walnut Oligopeptide manufacturers, lwm tus neeg
