Oxytocin acetateyog peptide hormone uterine contraction tshuaj nrog ib qho tseem ceeb daim ntawv thov nqi nyob rau hauv obstetrics thiab gynecology soj ntsuam kev xyaum. Nws cov ntsiab lus tseem ceeb, nws yog ib qho kev hloov kho derivative ntawm -hypophamine. Los ntawm kev hloov pauv ntawm butyryl thiab thioether daim ntawv cog lus cov tswv yim, nws txhim kho cov metabolism hauv kev ruaj ntseg ntawm cov tshuaj, ncua lub sijhawm ntawm nws cov txiaj ntsig los ntawm 3-5 zaug piv rau natural -hypophamine.
Peb cov khoom tsim
Oxytocin Acetate COA
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| Certificate of Analysis | ||
| Compound npe | Oxytocin Acetate | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 6233-83-6 | |
| Ntau | 60g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202512090051 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8 Dec 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.62% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.33% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.80% |
| Ib qho impurity | <0.8% | 0.21% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 105 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 612 pwm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Chemical Formula: | C45H70N12O12S2 |
| Exact Mass: | 1066 |
| Molecular Luj: | 1067 |
| m/z: | 1066 (100.0%), 1677 (46.5%), 1068 (10.6%), 1068 (9.0%), 1067 (4.4%), 1009 (4.2%), 1008 (2.5%), 1008 (2.1%), 1007 (1.6%), 1009 (1.1%) |
| Elemental Analysis: | C, 51.28; H, 6.61; N, 16.69; O, 19.06; S, 6.37 |
Cov tshuaj no feem ntau ua rau cov receptors tshwj xeeb ntawm cov ntaub so ntswg ntawm lub tsev menyuam uas tsis yog -striated pulp hlwb, ua kom cov phospholipase C qhia txoj hauv kev kom nce intracellular calcium ion concentration, yog li ua rau lub tsev me nyuam tsis tu ncua. Nws cov ntaub ntawv kho mob suav nrog plaub thaj chaw loj:
Ib qho yog:
Induced Labor thiab Labor induction, haum rau cov xwm txheej uas yuav tsum tau ua hauj lwm xws li cev xeeb tub tas sij hawm thiab ntxov ntxov rupture ntawm daim nyias nyias;
Thib ob:
Kev tiv thaiv thiab kev kho mob ntawm cov ntshav tom qab yug me nyuam tuaj yeem cog lus rau lub tsev menyuam cov ntaub so ntswg thiab txo cov placental abruption los ntshav los ntawm kev nruam intravenous infusion;
Thib peb:
Nws txhawb nqa lub plab involution, accelerates postpartum womb ntim txo thiab lochia tawm;
Plaub
-Hypophamine stimulation test yog siv los soj ntsuam cov placental cia muaj nuj nqi los ntawm kev ua kom lub tsev menyuam tsis tu ncua.
Oxytocin acetateyog ib qho khoom siv hluavtaws peptide cov tshuaj hormones uas muaj ntau yam kev siv hauv kev kho obstetrics thiab gynecology. Nws cov txheej txheem ntawm kev ua haujlwm muaj ntau theem, suav nrog kev sib txuas ntawm molecular receptor binding, intracellular signal transduction, womb non-striated pulp contraction regulation, cervical ripening promotion, breast milk excretion, and other physiological effects.
Molecular receptor khi mechanism
Qhov kev txiav txim pib los ntawm kev khi rau qhov tshwj xeeb -hypophamine receptor (OXTR) ntawm daim nyias nyias ntawm lub tsev menyuam uas tsis yog-striated pulp cells. OXTR belongs rau G protein coupled receptor (GPCR) tsev neeg thiab muaj xya transmembrane domains. Nws yog peptide cov tshuaj hormones tsim los ntawm 9 amino acids, thiab 8th amino acid (leucine) thiab 3rd amino acid (isoleucine) hauv nws cov qauv molecular yog qhov chaw tseem ceeb rau kev lees paub thiab khi rau -hypophamine receptor. Kev khi ntawm -hypophamine acetate rau OXTR yog qhov tshwj xeeb, zoo li qhov sib tw ntawm tus yuam sij thiab lub xauv.
Thaum cev xeeb tub, qib kev qhia ntawm OXTR ntawm lub tsev menyuam uas tsis yog -striated pulp hlwb nce ntxiv nrog lub hnub nyoog gestational, tshwj xeeb tshaj yog mus txog qhov siab tshaj thaum lub sij hawm cev xeeb tub. Qhov no zoo heev txhim khu lub rhiab heev ntawm lub tsev menyuam rau cov khoom, muab lub hauv paus physiological rau cov tshuaj siv nws cov teebmeem ntawm induction thiab zog. Piv txwv li, thaum ntxov cev xeeb tub, vim hais tias tsis tshua muaj kev qhia ntawm OXTR, lub tsev menyuam yog insensitive rau -hypophamine; Thaum cev xeeb tub lig, txawm tias qis dua ntawm -hypophamine tuaj yeem ua rau mob plab loj.
Intracellular signaling pathways
Thaum nws khi rau OXTR, nws qhib qhov sib txuas ntawm G protein (G q / 11), ua rau muaj cov xwm txheej hauv lub cev ntawm lub cev:
Phospholipase C activation: Lub tshuab ua G protein ntxiv activates phospholipase C - (PLC -), txhawb nqa cov hydrolysis ntawm phosphoinositol diphosphate (PIP2) ntawm cell membrane rauCov tshuaj oxytocin acetateinositol triphosphate (IP3) thiab diacylglycerol (DAG).
Calcium ion tso tawm: IP3 khi rau cov receptors tshwj xeeb ntawm sarcoplasmic reticulum (SR), ua rau SR tso cov calcium ions (Ca{1}}) mus rau hauv cytoplasm, ua rau muaj kev nce sai hauv intracellular Ca2+ concentration. Lub intracellular Ca2+ concentration tuaj yeem nce los ntawm lub xeev so ntawm 10 ⁻⁷ M txog 10 ⁻⁵ M.
Ua kom cov protein kinase C: DAG tseem nyob rau ntawm lub cell membrane, activating protein kinase C (PKC). Kev ua haujlwm ntawm PKC txuas ntxiv ua rau cov mitogen activated protein kinase (MAPK) cascade, ua rau kev ua kom phospholipase A2 (PLA2) thiab tsim cov prostaglandin E2 (PGE2). PGE2 tsis tsuas yog txhawb nqa lub tsev menyuam ncaj qha tsis yog -striated pulp contraction, tab sis kuj tswj cov kev ua haujlwm hauv lub cev ntawm lub tsev menyuam hauv plab los ntawm paracrine signaling, txhim kho cov nyhuv ntawm lub plab contraction.
Uterine non{0}}striated pulp contraction regulation
Qhov nce hauv intracellular Ca2+ concentration yog qhov ncaj qha ua rau lub cev tsis muaj -striated pulp contraction. Cov txheej txheem tshwj xeeb yog raws li hauv qab no:
Calcium calmodulin complex formation: Ca2+ khi rau calmodulin (CaM) los ua Ca2+- CaM complex.
Myosin light chain kinase activation: Ca2+- CaM complex activates myosin light chain kinase (MLCK).
Myosin phosphorylation: MLCK catalyzes phosphorylation ntawm myosin teeb saw (MLC).
Kev sib cuam tshuam ntawm Actin myosin: Phosphorylated MLC cuam tshuam nrog actin los tsim lub voj voog hla hla, ua kom muaj kev cog lus thiab ua rau lub plab tsis yog -striated pulp kom cog lus.
Lub plab contractions nws ua rau yog koob tshuaj -nyob ntawm:
Cov koob tshuaj tsawg: feem ntau ua rau lub tsev menyuam muaj zog, nrog rau kev sib cog lus ntawm li 2-4 zaug / 10 feeb, thiab txhua qhov kev cog lus yuav kav li 30-60 vib nas this. Cov qauv kev cog lus no zoo ib yam li kev cog lus ntawm lub cev, uas yuav pab txhawb kev ua haujlwm ntawm kev ua haujlwm thiab pab txhawb kev sib luag ntawm tus menyuam hauv plab.
Cov koob tshuaj ntau: tuaj yeem ua rau lub tsev menyuam tsis muaj zog, ua kom lub plab hnyuv hauv lub cev tsis tu ncua. Qhov kev cog lus no tuaj yeem ua rau cov hlab ntsha hauv lub tsev menyuam cov ntaub so ntswg sai sai, kaw cov ntshav sinuses ntawm lub placental detachment nto, txo cov ntshav tom qab yug me nyuam, thiab ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv thiab kho ntshav tom qab yug menyuam.
Mechanism ntawm ncauj tsev menyuam maturation nce
Cov ntsiab lus siab ntawm -hypophamine acetate tuaj yeem txhawb kev loj hlob ntawm ncauj tsev menyuam los ntawm kev txhawb nqa kev ua haujlwm ntawm prostaglandin synthase hauv cov ntaub so ntswg hauv tsev menyuam, ua kom lub cev degradation ntawm collagen fibers thiab matrix remodeling.
Ua kom cov synthesis ntawm prostaglandins: Kev ua kom zoo dua ntawm prostaglandin synthase ua rau muaj kev nce hauv prostaglandin synthesis. Prostaglandins tuaj yeem tswj cov metabolism ntawm lub ncauj tsev menyuam extracellular matrix, txhawb kev ua haujlwm ntawm collagenase, thiab rhuav tshem collagen fibers hauv lub ncauj tsev menyuam.
Cervical softening thiab dilation: Tib lub sijhawm, prostaglandins tuaj yeem ua kom cov dej noo thiab elastin ntawm lub ncauj tsev menyuam, yog li softening thiab dilating nws. Cov txheej txheem no tsim cov kev mob zoo rau qhov chaw mos, tso cai rau tus menyuam hauv plab hla lub ncauj tsev menyuam ntau dua. Piv txwv li, thaum lub sij hawm induction ntawm txoj kev ua hauj lwm, nws tsis tau tsuas yog ncaj qha mus rau lub non- striated pulp ntawm lub tsev menyuam kom induce lub tsev menyuam contractions, tab sis kuj txhawb lub tsev me nyuam maturation, shortening txoj kev ua hauj lwm, thiab txhim kho qhov kev vam meej ntawm qhov chaw mos.
Mechanism ntawm Breast Excretion
Nws kuj muaj cov nyhuv contractile ntawm cov hlwb myoepithelial nyob ib puag ncig cov qog mammary acini. Cov ceg lobular ntawm lub mis yog nyob ib puag ncig los ntawm cov qog nqaij hlav myoepithelial, uas yog cov rhiab heev rau -hypophamine acetate. Thaum nws ua rau cov hlwb myoepithelial, nws ua rau lawv sib cog lus, ua rau muaj kev sib haum xeeb ntawm cov ducts thiab sarcomeres. Qhov kev cog lus no pab cov mis nyuj ntws los ntawm acini mus rau hauv cov kua mis, ua kom tiav cov txheej txheem ntawm cov kua mis ejection reflex thiab txhawb cov kua mis excretion. Thaum lub sij hawm lactation, daim ntawv thov tsim nyog tuaj yeem txhawb nqa cov kua mis tso tawm, tab sis hauv kev kho mob, nws feem ntau yog siv ntau dua rau nws lub cev lactation txhawb nqa cov nyhuv ntau dua li txhob txwm lactation. Tab sis qee zaus cov mis stasis yog tshwm sim los ntawm cov hlab ntsha ntawm lub mis, kev siv tsim nyog yuav pab txhim kho cov kua mis tawm.
Lwm yam teebmeem physiological
Cov teebmeem ntawm lub plawv: Cov koob tshuaj tsawgCov tshuaj oxytocin acetateNws tuaj yeem nthuav cov hlab ntsha peripheral thiab ua rau reflex tachycardia. Qhov no yog vim hais tias nws ua rau cov receptors ntawm vascular tsis yog -striated pulp hlwb, ua kom cov kev taw qhia hauv lub hlwb, ua rau vasodilation. Txawm li cas los xij, thaum siv tshuaj ntau lossis ntev, nws tuaj yeem qhib OXTR ntawm lub raum tubules, tsim cov nyhuv antidiuretic, ua rau dej thiab sodium tuav, thiab ua rau muaj kev pheej hmoo ntawm "dej lom".
Cov nyhuv Neuromodulatory: Nws tuaj yeem ua rau cov neurons nyob rau hauv paraventricular nucleus thiab supraoptic nucleus ntawm hypothalamus, cuam tshuam rau kev coj tus cwj pwm thiab kev sib raug zoo ntawm tus me nyuam mos los ntawm limbic system. Hauv kev sim tsiaj, nws tau pom tias yuav txhim khu kev noj qab haus huv ntawm niam thiab txiv thiab txhawb kev sib raug zoo ntawm niam thiab tus menyuam.
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