ANTIBACTERIAL PROTEIN LL-37 AMIDE (HUMAN) (LL-37) tsuas yog cationic amphipathic -helical antimicrobial peptide hauv tib neeg cathelicidin tsev neeg. Nws muaj 37 amino acids thiab dav dav hauv tib neeg cov ntaub so ntswg epithelial, lub cev tiv thaiv kab mob thiab cov kua dej hauv lub cev, ua ib qho tseem ceeb ntawm lub cev tiv thaiv kab mob. Raws li ib tug standardized koob tshuaj formulation,LL -37 5 mgmuaj cov tshuaj tiv thaiv kab mob tshwj xeeb, dav -spectrum los tiv thaiv- kis kab mob kev ua haujlwm thiab muaj txiaj ntsig zoo biocompatibility, qhia dav daim ntawv thov kev cia siab hauv thaj tsam ntawm kev tiv thaiv kab mob - kho mob.
Peb Cov Khoom Muag Khoom
ANTIBACTERIAL PROTEIN LL-37 AMIDE (HUMAN)\\LL-37COA
 |
||
| Certificate of Analysis | ||
| Compound npe | ANTIBACTERIAL PROTEIN LL-37 AMIDE (HUMAN)\\LL-37 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 597562-32-8 | |
| Ntau | 27g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090066 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
|
|
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.53% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.36% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib qho impurity | <0.8% | 0.48% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 96 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
|
|
||
Broad -Spectrum Antibacterial Effect
Lub ntsiab kom zoo dua ntawmLL -37 5 mgnyob hauv nws qhov dav -spectrum antibacterial kev ua haujlwm. Nws tuaj yeem cuam tshuam lossis tua ntau yam kab mob xws li cov kab mob, cov kab mob thiab cov kab mob, thiab ua kom muaj txiaj ntsig zoo tiv thaiv kev kho mob ntau yam tshuaj ntau yam - cov kab mob resistant. Nws kov yeej cov kev txwv ntawm cov tshuaj tua kab mob ib txwm muaj, xws li nqaim tshuaj tua kab mob spectrum thiab siab nyiam ua rau cov tshuaj tiv thaiv.
Hais txog cov kab mob kab mob, nws muab cov kab mob muaj zog tiv thaiv kab mob Gram-zoo thiab Gram- cov kab mob tsis zoo, nrog rau kev ua haujlwm zoo tshaj plaws tiv thaiv cov tshuaj tsis haum tshuaj - cov kab mob resistant. Ntawm Gram- cov kab mob zoo, nws qhia tau hais tias muaj kev cuam tshuam tseem ceeb tiv thaiv Methicillin-ResistantStaphylococcus Aureus(MRSA) thiab Vancomycin-ResistantEnterococcus(VRE).
Ob hom kab mob no yog cov kab mob loj uas ua rau cov kab mob nosocomial thiab feem ntau teb tsis zoo rau cov tshuaj tua kab mob. Nws ua tiav kev ua haujlwm zoo ntawm cov kab mob bactericidal los ntawm kev cuam tshuam cov kab mob cell membrane kev ncaj ncees thiab cuam tshuam nrog cov kab mob metabolic.
Rau Gram- cov kab mob tsis zoo, nws nthuav tawm cov txiaj ntsig zoo inhibitory ntawm cov kab mob pathogenic xws liPseudomonas Aeruginosa, Escherichia ColithiabAcinetobacter Baumannii. Ntawm lawv,Pseudomonas Aeruginosanquag ua rau cov kab mob refractory nyob rau hauv lub ntsws, urinary ib ntsuj av thiab lwm qhov chaw, thiab yooj yim tsim biofilms ua rau cov tshuaj tiv thaiv. Nws ncaj qha ua rau nws cov cell membrane thaum inhibiting biofilm tsim los txhim kho kev ua tau zoo.
Hauv kev kho cov kab mob fungal, nws muaj txiaj ntsig zoo tiv thaiv kab mob fungal xws liCandida Albicans yog cov kab mobthiabAspergillus.
Nws tuaj yeem rhuav tshem cov kab mob ntawm cov phab ntsa ntawm cov kab mob fungal, cuam tshuam nrog cov kab mob ntawm tes, thiab txo cov kab mob ntawm daim tawv nqaij thiab kab mob los ntawm fungi.
Hauv kev kis kab mob, nws txwv tsis pub rov ua dua thiab kis tus kabmob coronaviruses, kab mob khaub thuas, Epstein- kab mob Barr thiab ntau lwm yam kab mob. Nws cov txheej txheem tseem ceeb suav nrog kev thaiv cov kab mob txhawm rau txhawm rau tswj cov cell, cuam tshuam nrog cov kab mob nucleic acid replication, tswj lub cev tiv thaiv kab mob thiab txhim kho tus tswv tsev tiv thaiv kab mob. Cov ntaub ntawv tshawb fawb tam sim no qhia tias nws tuaj yeem cuam tshuam lossis tua ntau dua 38 hom kab mob, 16 hom fungi thiab 16 hom kab mob. Nws qhov dav -spectrum antibacterial thaj chaw muab nws qhov txiaj ntsig tseem ceeb hauv kev kho thawj zaug ntawm cov kab mob sib xyaw thiab kev sib kis ntawm cov kab mob uas tsis paub, ua kom tswj tau sai ntawm cov tsos mob ntawm tus kab mob thiab tau txais lub sijhawm rau kev kho mob tom ntej.
Cov Ntaub Ntawv Keeb Kwm: BioArt Review: Decoding LL-37: Nws Cov Txheej Txheem thiab Cov Txheej Txheem Tshuaj Tiv Thaiv Microbial hem; PMC: Tib neeg cov tshuaj tiv thaiv kab mob / tus tswv tsev tiv thaiv peptide LL-37 tuaj yeem tiv thaiv kev kis tus kab mob hauv zos los ntawm ntau lub tswv yim: kev hloov tshiab.
Anti-Biofilm nyhuv
Kev tsim cov kab mob biofilms yog ib qho tseem ceeb ua rau muaj kev cuam tshuam tsis zoo, rov tshwm sim hauv chaw kho mob thiab tshuaj tua kab mob. Many pathogenic bacteria form biofilms at infection sites to encapsulate themselves, evading the effects of antibiotics and clearance by the host immune system, resulting in persistent and unhealed infections. Nws muaj qhov tseem ceeb los tiv thaiv- biofilm kev ua haujlwm thiab ua rau muaj txiaj ntsig zoo inhibitory txawm nyob rau hauv sub-inhibitory concentrations, muab lub tswv yim tshiab los daws cov tshuaj tiv thaiv.
Cov kev tshawb fawb tau pom tias nws tuaj yeem cuam tshuam kev tsim biofilmPseudomonas Aeruginosantawm sub-inhibitory concentration ntawm 0.5 ug/mL.
Nws cov txheej txheem hauv qab no yog qhov tseem ceeb ntawm kev txo qis ntawm cov kab mob hauv pawg neeg pom cov kab mob - ib qho tseem ceeb rau kev sib txuas lus ntawm cov kab mob thiab kev sib koom ua ke ntawm biofilm. Los ntawm suppressing cov kev qhia txog cov noob caj noob ces nyob rau hauv no system, nws thaiv cov kab mob aggregation, adhesion thiab synthesis ntawm biofilm matrix, yog li cuam tshuam cov txheej txheem biofilm. Lub caij no,LL -37 5 mgtseem tuaj yeem rhuav tshem cov biofilms paub tab uas twb tau tsim, loosening thiab disintegrating lawv cov qauv kom tso cov kab mob encapsulated, yog li txhim kho cov kab mob bactericidal ntawm cov tshuaj tua kab mob thiab txo cov ciaj sia ntawm cov tshuaj - cov kab mob resistant.
Cov Ntaub Ntawv Keeb Kwm: PMC: Tiv thaiv ESKAPE kab mob biofilm tsim los ntawm antimicrobial peptides WLBU2 thiab LL37; BioArt Review: Decoding LL-37: Nws Cov Txheej Txheem thiab Cov Txheej Txheem Tshuaj Tiv Thaiv Microbial hem.
Clinical Formulation Development
Ntuj LL-37 muaj qhov txwv tsis pub siv rau kev kho mob ncaj qha, suav nrog kev cuam tshuam rau protease degradation, luv luv hauv vivo ib nrab-lub neej thiab qee yam cytotoxicity ntawm siab concentrations. Kev hloov kho cov qauv ntawm LL-37 thiab kev txhim kho ntawm nws cov derivative formulations tuaj yeem txhim kho nws cov tshuaj pharmacokinetic thiab txhim kho cov txiaj ntsig ntawm daim ntawv thov. Ntawm cov derivatives, OP-145 (hloov ntawm acetylation thiab amidation) muaj cov ntaub ntawv kho mob tshaj plaws thiab tau tsim los ua pob ntseg poob, feem ntau yog rau kev kho mob ntawm cov kab mob otitis media.
Cov ntaub ntawv tshawb fawb soj ntsuam pom tau tias OP-145 pob ntseg tee ua tiav cov kab mob bactericidal txog li 90% tiv thaiv MRSA thiab 85% tshem tawm tus nqi biofilms tsim nyob rau hauv nruab nrab pob ntseg, zoo dua rau cov pob ntseg pob ntseg. Nws kuj muaj qhov tshwm sim tsis zoo ntawm cov tshuaj tiv thaiv thiab kev nyab xeeb zoo. Tsis tas li ntawd, OP-145 tuaj yeem siv los kho otitis externa thiab myringitis, ntxiv rau kev nthuav dav hauv kev soj ntsuam cov xwm txheej ntawm cov khoom tsim khoom. Tam sim no, lwm cov qauv tsim tawm ntawm LL-37, suav nrog cov tshuaj nplaum, qhov muag tee thiab nqus tau pa, tab tom tshawb nrhiav thiab txhim kho, thiab xav tias yuav siv tshuaj kho mob hauv thaj chaw kis kab mob ntau dua.
Cov Ntaub Ntawv Keeb Kwm: MedChemExpress: OP-145; PMC: Tshawb nrhiav cov tshuaj tua kab mob tshiab rau kev kho mob qhov txhab: all-hydrocarbon stapling optimization ntawm LL-37.
Kev kho mob hauv zos
Nws thiab nws cov derivative formulations yog dav siv nyob rau hauv kev kho mob ntawm lub zos kab mob, tshwj xeeb tshaj yog rau cov kab mob nyob rau hauv lub qhov muag, pob ntseg, qhov ncauj kab noj hniav, kab mob ua pa, daim tawv nqaij thiab cov ntaub so ntswg mos. Lawv muaj lub hom phiaj muaj zog, muaj txiaj ntsig zoo kawg li kho mob thiab ob peb qhov kev cuam tshuam tsis zoo, muaj peev xwm ua ncaj qha rau ntawm qhov chaw kis kab mob, tswj cov tsos mob sai thiab txhawb kev kho cov ntaub so ntswg.
Hauv cov kab mob ocular,LL -37 5 mgNws tuaj yeem siv los kho keratitis, conjunctivitis thiab lwm yam kab mob. Nws cov tshuaj tua kab mob zoo inhibits cov kab mob ocular xws liStaphylococcus Aureus, Pseudomonas AeruginosathiabCandida Albicans yog cov kab mob. Nws kuj tseem siv qee yam tshuaj tiv thaiv - inflammatory teebmeem los txo qhov muag liab, mob thiab ua kom muaj kuab paug, nrog rau qhov khaus qis rau cov ntaub so ntswg ntawm lub qhov muag thiab kev nyab xeeb zoo. Nws xav tias yuav hloov cov tshuaj tua kab mob qhov muag tshuaj thiab txo cov tshuaj tiv thaiv kab mob hauv qhov muag.
Nyob rau hauv pob ntseg kab mob, sib nrug los ntawm OP-145 pob ntseg tee rau cov kab mob ntev otitis media, nws qab zib tuaj yeem siv rau otitis externa, ncaj qha ua haujlwm ntawm qhov chaw kis kab mob los tua cov kab mob thiab txhawb kev kho cov kwj dej sab nraud.
Hauv cov kab mob ntawm qhov ncauj, nws muaj feem xyuam rau cov kab mob peritonitis feem ntau tshwm sim los ntawm anaerobes thiab streptococci. Nws inhibits kev loj hlob ntawm cov kab mob no, tswj lub cev tiv thaiv kab mob ntawm cov ntaub so ntswg periodontal, alleviates gingival redness, los ntshav thiab periodontal hnab tshos tsim, thiab txhawb nqa periodontal cov ntaub so ntswg kho. Nws tseem tuaj yeem ua haujlwm sib koom ua ke nrog kev kho mob hauv zos xws li scaling thiab hauv paus npaj los txhim kho kev ua tau zoo.
Hauv cov kab mob ua pa, nws nqus tau tuaj yeem kho bronchitis, mob ntsws thiab lwm yam kab mob, tshwj xeeb tshaj yog mob ntsws uas tshwm sim los ntawm ntau yam tshuaj - cov kab mob resistant. Nws ncaj qha lub hom phiaj ntawm cov kab mob pulmonary, inhibits kev loj hlob ntawm cov kab mob thiab cov kab mob, txhawb kev kho ntawm pulmonary epithelial hlwb, thiab relieves hnoos, expectoration thiab hauv siab nruj.
Hauv cov kab mob ntawm daim tawv nqaij thiab cov nqaij mos, nws cov tshuaj nplaum tuaj yeem siv rau cellulitis, kab mob hauv lub qhov txhab thiab mob ntshav qab zib ko taw ulcers. Nws cov tshuaj tua kab mob zoo tua cov kab mob ntawm daim tawv nqaij, thaum nws ua kom cov tawv nqaij kho cov tawv nqaij thiab txo cov kab mob rov qab los ntawm kev txhawb nqa qhov txhab zoo. Cov kev tshawb fawb soj ntsuam pom tau hais tias LL-37 qab zib tuaj yeem txhim kho qhov kho tau zoo ntawm cov kab mob me me ntawm cov kab mob ntshav qab zib ko taw, txo cov kab mob colonization ntawm qhov txhab, thiab tswj kev nyab xeeb zoo.
Cov Ntaub Ntawv Keeb Kwm: PubMed: Kev ua tau zoo ntawm LL-37 qab zib hauv kev txhim kho kev kho mob ntshav qab zib ko taw rwj: kev sim ntsuas ob qhov muag tsis pom kev; PMC: Tib neeg cov tshuaj tiv thaiv kab mob / tus tswv tsev tiv thaiv peptide LL-37 tuaj yeem tiv thaiv kev kis tus kab mob hauv zos los ntawm ntau lub tswv yim: kev hloov tshiab.
FAQ
LL-37 peptide ua dab tsi?
+
-
LL-37 yog ib qho tseem ceeb ntawm tib neeg tus tswv tsev tiv thaiv peptide uas ua raws li cov tshuaj tua kab mob ntuj, rhuav tshem cov kab mob, kab mob, thiab fungi thaum hloov kho lub cev tiv thaiv kab mob thiab txhawb kev kho qhov txhab. Nws tua cov kab mob ncaj qha los ntawm kev cuam tshuam lawv cov phab ntsa ntawm tes, rhuav tshem cov kab mob biofilms, thiab tuaj yeem txhawb lossis txo qhov mob raws li cov ntsiab lus.
Cov kab mob dab tsi cuam tshuam nrog LL-37?
+
-
Lawv txhawb nqa myeloid dendritic cell maturation thiab ua kom cov lymphocytes thiab natural killer cells (36). Hom I IFNs kuj tau nce siab hauv ntau yam kab mob autoimmune xws lilupus, dermatomyositis thiab psoriasisthiab tej zaum yuav ua rau muaj kab mob pathogenesis (37).
Cim npe nrov: ll-37 5mg, Tuam Tshoj ll-37 5mg manufacturers, lwm tus neeg
