Hauv kev kuaj mob thiab kev kho mob niaj hnub no, kev siv cov tshuaj ntau yam yog qhov tseem ceeb rau kev txhim kho kev kuaj mob thiab kev kho mob kom zoo thiab txhim kho cov neeg mob. Ntawm lawv, cov tshuaj nrog ob tus nqi ntawm kev cuam tshuam thiab kev kuaj mob nyob hauv txoj haujlwm tseem ceeb hauv kev tswj kab mob tshwj xeeb vim lawv qhov tshwj xeeb zoo.
Txhaj tshuaj desmopressinyog ib tug neeg sawv cev ntawm hom tshuaj no. Raws li lub hom phiaj bioactive tshuaj, cov tshuaj no ua lub luag haujlwm tsis tuaj yeem hloov kho hauv ob qhov chaw tseem ceeb ntawm kev cuam tshuam hemorrhage thiab kev kuaj mob raum los ntawm kev tswj hwm lub cev lub cev hemostasis thiab cov txheej txheem physiological cuam tshuam rau lub raum dej metabolism. Piv nrog rau cov tshuaj ib txwm siv, nws daim ntawv thov scenarios yog lub hom phiaj heev, thiab nws cov yam ntxwv ua haujlwm kuj qhia qhov tseem ceeb tshwj xeeb. Nws tuaj yeem hloov kho raws li qhov xav tau ntawm kev cuam tshuam ntawm cov kab mob tshwj xeeb, thiab muab kev txhawb nqa kev ntseeg siab rau kev kuaj mob. Nws muab kev pabcuam tseem ceeb rau cov kws kho mob txhawm rau txhim kho kev kuaj mob thiab cov phiaj xwm kho mob thiab txhim kho kev kuaj mob thiab kho cov txheej txheem. Cov hauv qab no yuav muab cov ncauj lus kom ntxaws los ntawm ntau qhov ntev thiab qib sib sib zog nqus kom paub meej nws cov kev thov tshwj xeeb thiab cov yam ntxwv tseem ceeb.
Peb Cov Qauv Khoom
Desmopressin COA
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| Certificate of Analysis | ||
| Compound npe | Desmopressin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 16679-58-6 | |
| Ntau | 36g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090082 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib qho impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia |
Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav ntawm 0 degree |
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| Tshuaj Formula | C46H64N14O12S2 |
| Exact Mass | 1068.43 |
| Molecular Luj | 1069.22 |
| m/z | 1068.43 (100.0%), 1069.43 (49.8%), 1070.43 (12.1%), 1070.42 (9.0%), 1069.42 (5.2%), 1071.43 (4.5%), 1070.43 (2.6%), 1070.43 (2.5%), 1069.43 (1.6%), 1071.43 (1.2%), 1071.44 (1.1%), 1072.43 (1.1%) |
| Elemental Analysis | C, 51.67; H, 6.03; N, 18.34; O, 17.96; S, 6.00 |
Clinical intervention thov ntawmhemorrhage thiabhemorrhage nyiam
Txhaj tshuaj desmopressinyog tsim rau ntau yam xwm txheej tshwj xeeb hauv kev soj ntsuam kev cuam tshuam ntawm hemorrhage thiab hemorrhage nyiam vim nws lub hom phiaj kev ua yeeb yam, tshwj xeeb tshaj yog rau cov kev cai ntawm me me mus rau nruab nrab cov kab mob hemorrhage. Nyob rau tib lub sijhawm, nws tuaj yeem tiv thaiv kev pheej hmoo hemorrhage hauv ntau cov txheej txheem invasive. Qhov tshwj xeeb daim ntawv thov scenarios thiab cov yam ntxwv yog raws li nram no:
01.Intervention rau me me mus rau nruab nrab yam VIII deficiency
factor VIII deficiency, raws li ib tug hereditary hemostasis disorder, yog yus muaj los ntawm tsis txaus synthesis los yog kev ua ub no ntawm hemostatic factor VIII. Nws cov tsos mob tshwm sim muaj xws li cov ntshav tawm los yog tsis tu ncua tom qab mob me, thiab feem ntau pom muaj nyob rau hauv pob qij txha, mucous daim nyias nyias, thiab cov ntaub so ntswg mos. Acetic acid antidiuretic hormone tuaj yeem txhawb nqa cov hlwb hauv lub cev kom tso tawm hemostatic factor VIII, nce qib kev ua haujlwm ntawm qhov tseem ceeb hauv cov ntshav peripheral, yog li them nyiaj rau qhov tsis txaus ntawm tus neeg mob lub cev thiab ua tiav lub hom phiaj ntawm kev tswj cov ntshav thiab txo cov tsos mob. Daim ntawv thov scenario no muaj qhov hloov tau yooj yim thiab tsuas yog tsim nyog rau cov neeg mob me thiab nruab nrab. Cov neeg mob no tseem khaws tau qee lub peev xwm los ua ke cov khoom hemostatic, thiab cov tshuaj tuaj yeem tswj tau zoo los ntawm kev txhawb nqa nruab nrab yam tsis muaj kev cia siab rau exogenous yam infusion. Piv nrog rau cov kev cuam tshuam ib txwm muaj, nws yooj yim dua thiab tsis tshua muaj peev xwm ua rau lub cev tiv thaiv kab mob tsis zoo. Tib lub sijhawm, nws tuaj yeem txo qhov cuam tshuam ntawm cov xwm txheej hemorrhage ntawm cov neeg mob kev sib koom ua haujlwm thiab lub neej zoo.
02.Intervention rau vascular hemophilia
Von Willebrand tshwm sim los ntawm qhov txawv txav lossis kev ua haujlwm tsis zoo ntawm von Willebrand yam, uas yog ib qho tseem ceeb hauv cov txheej txheem hemostasis. Qhov zoo tshaj plaws no tuaj yeem kho cov platelet adhesion, sib sau ua ke, thiab tiv thaiv hemostatic factor VIII los ntawm degradation. Nws qhov txawv txav tuaj yeem ua rau muaj qhov cuam tshuam loj rau cov ntshav hauv cov neeg mob, feem ntau tshwm sim raws li daim tawv nqaij bruising thiab mucosal hemorrhage.Txhaj tshuaj desmopressintuaj yeem txhawb kev tso tawm thiab khaws cia ntawm von Willebrand factor thiab hemostatic factor VIII los ntawm endothelial hlwb, ib txhij ua kom cov ntshav peripheral concentration ntawm ob yam tshuaj thiab txhim kho hemostasis muaj nuj nqi ntawm cov neeg mob. Nws yog qhov tshwj xeeb tshaj yog rau kev tswj ntshav ntshav txhua hnub thiab kev tiv thaiv kab mob perioperative hemorrhage nyob rau hauv cov neeg mob uas mob me mus rau nruab nrab tus kab mob von Willebrand. Txoj kev cuam tshuam no muaj cov yam ntxwv ntawm lub hom phiaj muaj zog thiab pib sai. Tom qab kev tswj hwm, nws tuaj yeem nce qib ntawm cov xwm txheej cuam tshuam sai sai, txo cov tsos mob ntawm hemorrhage raws sijhawm, thiab hloov kho lub sijhawm thiab cov txheej txheem ntawm kev tswj hwm raws li tus neeg mob qhov xwm txheej hemorrhage, hloov mus rau ib tus neeg sib txawv ntawm cov neeg mob sib txawv.
Lub hauv paus ntawm cov ntaub ntawv saws nyob rau hauv nqe lus saum toj no yog:
Li Li, Zhao Yang Kev soj ntsuam ntawm kev kho cov nyhuv ntawm antidiuretic hormone acetate hauv kev tiv thaiv hemorrhage thaum lub sij hawm me thiab nruab nrab -sized surgeries Journal of Clinical surgical operation, 2022, 30 (10): 987-990
Garcí a R, et al. Qhov no Acetate: Kev Ntsuam Xyuas ntawm Nws Lub Luag Haujlwm hauv Hemostasis thiab Kev Ntsuas Lub Raum Kev Ua Haujlwm. Tshuaj, 2022, 82(12): 1345-1362.
Kev tiv thaiv thiab tswj cov hemorrhage hauv kev phais thiab hniav rho tawm scenarios
Cov txheej txheem invasive xws li kev phais thiab kev tshem tawm cov hniav inevitably ua rau cov hlab ntsha ntawm lub cev. Rau cov neeg mob uas muaj qhov txawv txav ntawm hemostasis los yog hemorrhage nyiam, cov haujlwm no tuaj yeem yooj yim ua rau muaj kev cuam tshuam loj heev los yog tsis tu ncua tom qab kev ua haujlwm hemorrhage, ua rau muaj kev pheej hmoo ntawm kev kuaj mob thiab kev kho mob.
Txhaj tshuaj desmopressintuaj yeem siv los tiv thaiv kev cuam tshuam rau cov xwm txheej zoo li no. Los ntawm kev tswj hwm nws tsim nyog ua ntej kev phais mob, kev ua haujlwm ntawm hemostasis cuam tshuam rau hauv tus neeg mob lub cev tuaj yeem nce ntxiv ua ntej, txhim kho lub cev lub peev xwm hemostasis thiab txo tag nrho cov nyiaj ntawm intraoperative hemorrhage; Rau cov tsos mob hemorrhage uas tau tshwm sim thaum lub sij hawm thiab tom qab kev phais, kev siv tshuaj raws sij hawm tuaj yeem siv los tswj kev ua haujlwm ntawm hemostasis sai, tiv thaiv hemorrhage, thiab txhawb lub qhov txhab hemostasis thiab kho. Nws daim ntawv thov scenarios npog ntau yam me me thiab nruab nrab- cov kev phais me me nrog rau kev ua haujlwm ntawm qhov ncauj, tshwj xeeb tshaj yog tsim rau cov neeg mob uas tsis muaj hemostasis me. Cov laj thawj tseem ceeb rau qhov no yog tshwm sim hauv cov hauv qab no:
Cov tshuaj lub zog ntawm kev ua yog tsim rau me me txawv txav thiab tsis tas yuav muaj kev cuam tshuam ntau dhau.
Cov neeg mob uas muaj tus mob no tsis tau poob tag nrho lawv cov hemostasis system ua haujlwm thiab tsuas yog muaj qhov tsis txaus ntawm kev ua haujlwm hemostatic lossis ib qho me me ntawm vascular haemophilia tsis txaus. Acetate antidiuretic hormone tuaj yeem maj mam txhawb lub cev kom tso tawm cov yam tseem ceeb hemostatic, uas ua rau muaj txiaj ntsig zoo rau qhov tsis txaus, tsis muaj hemostasis ntau dhau lossis tsis txaus hemostasis;
Kev zam qhov tsis zoo ntawm kev cuam tshuam loj, kev nyab xeeb yog siab dua.
Piv nrog rau cov exogenous hemostatic factor infusion xav tau rau cov neeg mob hnyav, cov tshuaj no tsis tas yuav tsum tau siv cov tshuaj exogenous, txo cov kev pheej hmoo ntawm kev tiv thaiv kab mob, tshuaj tiv thaiv kab mob, thiab lwm yam. Nws yog qhov tsim nyog rau luv luv - kev cuam tshuam los yog ntev - lub sij hawm tu cov neeg mob me me;
Kev tswj hwm yooj yim, tsim nyog rau kev kuaj mob thiab kho cov neeg mob me me txawv txav.
Nws tuaj yeem ua tau sai sai los ntawm luv luv- kev tswj hwm ua ntej ua ntej, ua haujlwm yooj yim, tsis xav tau ntev- kev saib xyuas hauv tsev kho mob, thiab ua tau raws li qhov xav tau ntawm "ntawm- kev thov cuam tshuam thiab hemostasis sai"; Qhov thib plaub yog kom tsis txhob muaj kev kho mob ntau dhau, txo cov nqi kho mob thiab lub cev lub cev, ua kom muaj hemostasis ib ntus lossis kev tiv thaiv ib ntus, tsis tas yuav siv sijhawm ntev - siv tshuaj, thiab txo cov nqi kho mob thiab lub nra hnyav ntawm cov tshuaj ntawm daim siab thiab lub raum ua haujlwm.
Cov tshuaj no tuaj yeem txo qhov kev pheej hmoo ntawm hemorrhage thaum cov txheej txheem cuam tshuam, txo qhov kev xav tau ntawm cov ntshav, thiab zam cov teeb meem tshwm sim los ntawm cov ntshav ntau dhau, ua kom muaj kev nyab xeeb thiab du ntawm kev kuaj mob thiab kev kho mob. Tsis tas li ntawd, hauv cov txheej txheem ntawm qhov ncauj xws li kev tshem tawm cov hniav, nws tuaj yeem ua ke nrog cov kev ntsuas hemostatic hauv zos kom ntxiv dag zog rau cov nyhuv hemostatic thiab txo lub sijhawm kho qhov txhab.
Miller A, et al. Lub luag haujlwm ntawm Acetate no hauv kev kuaj mob sib txawv ntawm Mob Ntshav Qab Zib Insipidus: Kev Hloov Kho Kev Kho Mob. Endocrinology thiab Metabolism Clinics ntawm North America, 2023, 52(3): 567-582.
Liu Jing, Wang Hao Lub chaw kho mob tus nqi ntawm cov tshuaj acetate antidiuretic tshuaj ntsuam xyuas hauv kev ntsuas lub raum concentration muaj nuj nqi Suav Journal of Practical Internal Medicine, 2022, 42 (8): 689-692
Cov ntaub ntawv
Hoffmann M, et al. Kev ua tau zoo thiab kev nyab xeeb ntawm Acetate nyob rau hauv me me mus rau nruab nrab qhov tsis muaj peev xwm VIII: Kev Tshawb Fawb Txog Kev Tshawb Fawb. Phau ntawv Journal of Thrombosis thiab Haemostasis, 2022, 20(7): 1689-1700.
Zhang Min, Li Juan Kev soj ntsuam ntawm daim ntawv thov ntawm antidiuretic hormone acetate hauv perioperative hemorrhage tswj cov neeg mob hemophilia Suav Journal of Hemorheology, 2023, 33 (2): 215-218
de Jong J, et al. Desmopressin rau hemorrhage Prophylaxis nyob rau hauv Hniav Extractions: Ib Randomized Controlled Trial. Phau ntawv Journal of Oral and Maxillofacial surgical operation, 2021, 79(11): 2456-2465.
Peterson L, et al. Desmopressin nyob rau hauv kev tswj ntawm Spontaneous hemorrhage nyob rau hauv cov neeg mob uas muaj hom 1 Von Willebrand kab mob. Haemophilia, 2021, 27(4): 678-685.
Schmidt C, et al. Lub raum Concentrating Capacity Assessment Siv Desmopressin nyob rau hauv cov neeg laus uas muaj mob raum mob. Nephrology Dialysis Transplantation, 2023, 38(5): 890-897.
FAQ
- Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm no?
Basolateral membrane of the collecting duct in the kidneys –> insertion of aquaporin (AQP-2) water channels into the apical membrane –> increases water reabsorption. Vascular endothelium –> releases von Willebrand factor and factor VIII –>Txo lub sij hawm hemorrhage.
- Qhov no puas yog antidiuretic?
Desmopressin (dDAVP), hluavtaws analogue ntawm 8-arginine antidiuretic hormone (ADH), yog ib qho tshuaj antidiuretic peptide hloov kho los ntawm deamination ntawm 1-cysteine thiab hloov pauv ntawm 8-L-arginine los ntawm 8-D-arginine. ADH yog ib qho endogenous pituitary hormone uas muaj lub luag haujlwm tseem ceeb hauv kev tswj cov dej hauv lub cev.
- Nws puas txwv tsis pub koj tso zis?
Desmopressin yog ib qho tshuaj uas 'sups' lub cev cov qib ntawm cov tshuaj hormone antidiuretic hormone. Qhov no yog cov tshuaj hormones uas qhia rau lub raum kom tsim tsawg wee thaum hmo ntuj. Feem ntau cov neeg pw ib hmos tsis xav tau ib tug wee vim yog cov tshuaj no.
Cim npe nrov: Tuam Tshoj txhaj tshuaj desmopressin manufacturers, lwm tus neeg
