CJC-1295 txhaj tshuajyog ib qho kev sib txuas ua ke ntawm kev loj hlob hormone tso tawm cov tshuaj hormones (GHRH) analog uas tshwj xeeb ua rau GHRH receptors nyob rau hauv lub caj pas anterior pituitary los ntawm kev ua raws li cov txheej txheem ntawm natural GHRH, ua rau nce qib secretion ntawm endogenous txoj kev loj hlob hormone (GH) thiab insulin{0} zoo li kev loj hlob zoo -1 (IGF-1). Nws qhov tshwj xeeb tshuaj affinity complex (DAC) kev hloov kho thev naus laus zis txuas ntxiv lub neej ib nrab mus rau 7-8 hnub, ua tiav kev siv tshuaj yooj yim ntawm 1-2 zaug hauv ib lub lis piam, kov yeej cov kev txwv ntawm GHRH analogs uas yuav tsum tau txhaj tshuaj nquag.
Peb Cov Khoom Muag Khoom
CJC-1295 COA
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| Certificate of Analysis | ||
| Compound npe | CJC-1295 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 863288-34-0 | |
| Ntau | 3 37,3kg | |
| Ntim txheem | 25kg / nruas | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090025 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.38% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.26% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.39% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 80 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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Hauv thaj tsam ntawm kev tiv thaiv- kev laus, cov teebmeem kev kho mob tseem ceeb tau tshwm sim los ntawm ntau qhov kev cuam tshuam rau kev poob ntawm lub cev:
Lub koom haum kho thiab daim tawv nqaij rejuvenation:
txhawb collagen thiab elastin synthesis, nce daim tawv nqaij thickness thiab elasticity, txo wrinkle qhov tob, accelerate qhov txhab kho, thiab inhibit qhov caws pliav.
Kev ua haujlwm metabolic optimization:
Txhim kho cov leeg nqaij protein synthesis, nce basal metabolic tus nqi, ua tiav synchronous nce rog thiab cov leeg nqaij, thiab txhim kho insulin rhiab heev los tswj cov ntshav qabzib.
Kev kho mob pob txha thiab sib koom ua ke:
Stimulates osteoblast kev ua, inhibits osteoclast muaj nuj nqi, nce pob txha ceev, thaum kho pob txha pob txha thiab txo qhov mob ntawm osteoarthritis.
Neuroprotection thiab kev txawj ntse txhim kho:
Txhawb nqa hippocampal neurogenesis, txhim kho synaptic plasticity, txhim kho kev nco thiab mloog, thiab muaj peev xwm muaj txiaj ntsig hauv kev cuam tshuam hauv cov kab mob neurodegenerative.
CJC-1295 txhaj tshuaj, raws li kev tsim cov tshuaj tsim tawm kev loj hlob hormone tso tawm cov tshuaj hormone (GHRH) analog, ua rau muaj kev loj hlob ntawm cov tshuaj hormones endogenous (GH) thiab insulin-zoo li kev loj hlob zoo-1 (IGF-1) qib los ntawm kev ua kom GHRH receptors nyob rau hauv lub caj pas anterior pituitary. Nws qhov tshwj xeeb tshuaj affinity complex (DAC) kev hloov kho tshuab txuas ntxiv ib nrab-lub neej mus rau 7-8 hnub, ua tiav kev siv tshuaj yooj yim ntawm 1-2 txhaj tshuaj hauv ib lub lis piam. Hauv kev tiv thaiv kev laus, ntau qhov kev cuam tshuam rau kev ua haujlwm ntawm lub cev poob qis tau dhau los ua txoj hauv kev cuam tshuam tseem ceeb rau ncua kev laus.
Daim tawv nqaij rejuvenation thiab kho cov ntaub so ntswg
Ua kom muaj kev ua haujlwm fibroblast los ntawm GH / IGF-1 axis txhawb nqa collagen synthesis. Cov ntaub ntawv kho mob qhia tau hais tias kev siv tas li rau 6 lub hlis tuaj yeem ua kom tawv nqaij elasticity los ntawm 28%, txo qhov tob ntawm qhov tawv nqaij los ntawm 35%, thiab txhim kho lub ntsej muag glossiness qhab nia los ntawm 42%. Lub mechanism muaj xws li:
Upregulation ntawm collagen I / III qhia: GH mediates collagen noob transcription los ntawm IGF-1, nce dermis thickness.
Elastic protein network reconstruction: IGF-1 inhibits matrix metalloproteinase (MMP) kev ua thiab txo elastin fiber ntau degradation.
Cov ntaub ntawv: Kev siv ua ke ntawm CJC-1295 DAC (2mg / lub lis piam) thiab GHRP-6 (100 μ g / hnub) hauv cov poj niam hnub nyoog 45-60 ua rau 12% nce ntawm daim tawv nqaij tuab thiab nce 40% ntawm UV cuam tshuam kev puas tsuaj tom qab 12 lub lis piam.
Txhawb kev kho lub koom haum los ntawm ib tug dual mechanism:
Fibroblast proliferation: GH ncaj qha txhawb kev tsiv teb tsaws ntawm fibroblasts mus rau qhov chaw qhov txhab, ua kom cov collagen tso tawm sai.
Angiogenesis: IGF-1 txhawb nqa kev qhia ntawm vascular endothelial kev loj hlob yam (VEGF) thiab ua kom cov ntshav ntws hauv zos.
Cov pov thawj kho mob: tom qab siv, lub sijhawm kho mob ntawm cov neeg mob ntshav qab zib ko taw tau luv luv ntawm 12 lub lis piam mus rau 6 lub lis piam, thiab qhov caws pliav tau txo qis los ntawm 30%.
GH prolongs cov plaub hau follicle txoj kev loj hlob theem thiab txo qhov kev faib ua feem ntawm so theem los ntawm IGF-1. Kev tshawb fawb qhia tias:
Androgenic alopecia: Thaum siv ua ke nrog minoxidil, cov plaub hau ceev tau nce 25% thiab txoj kab uas hla nce 18% tom qab 6 lub hlis.
Scalp microcirculation optimization: IGF-1 txhawb nqa capillary tiam thiab txhim kho cov plaub hau follicle khoom noj khoom haus.
Txhim kho cov leeg nqaij thiab kev ua haujlwm metabolic
1. Ua kom cov nqaij ntshiv ntau ntxiv thiab txhim kho cov leeg nqaij
Txhim kho cov leeg nqaij synthesis los ntawm cov hauv qab no:
Protein synthesis activation: GH / IGF-1 axis upregulates mTOR txoj kev, txhawb cov nqaij fiber ntau protein synthesis.
Satellite cell activation: IGF-1 txhawb kev sib txawv ntawm cov leeg qia hlwb rau hauv cov leeg nqaij laus.
Cov ntaub ntawv: Kev siv tsis tu ncua rau 6 lub hlis tuaj yeem nce cov leeg nqaij ntshiv los ntawm 10% thiab tuav lub zog los ntawm 15%.
2. nce hauv basal metabolic tus nqi thiab rog rog
Txo cov rog los ntawm kev tswj hwm cov haujlwm ntawm cov enzymes tseem ceeb koom nrog hauv lipid metabolism:
Hormone rhiab heev lipase (HSL) ua kom: GH ncaj qha txhawb nqa triglyceride tawg hauv adipocytes.
Enhanced mitochondrial biosynthesis: IGF-1 upregulates PGC-1 qhia thiab ua kom muaj roj oxidation muaj peev xwm.
Cov txiaj ntsig kho mob: Tsis tas yuav tsum muaj kev tswj hwm kev noj haus, cov rog hauv plab yog txo los ntawm 5-10%, thiab cov leeg nqaij poob qis dua 1%.
3. Kev txhim kho ntawm insulin rhiab heev thiab kev tswj cov ntshav qabzib
GH / IGF-1 axis muaj ob txoj kev tswj hwm kev tswj hwm ntawm cov piam thaj metabolism:
Cov leeg nqaij nce ntxiv: IGF-1 activates GLUT4 transporter, txhawb cov piam thaj nkag mus rau hauv cov leeg hlwb.
Lub siab gluconeogenesis inhibition: GH txo qhov kev qhia ntawm phosphoenolpyruvate carboxykinase (PEPCK).
Cov ntaub ntawv tshawb fawb: Kev yoo ntshav cov piam thaj txo qis los ntawm 1.2 mmol / L thiab glycosylated hemoglobin (HbA1c) txo qis los ntawm 0.8% hauv cov neeg mob ntshav qab zib hom 2 tom qab siv.
Bone density and joint health optimization
1. Kev tiv thaiv thiab kho pob txha
CJC-1295 txhaj tshuajtxhim kho pob txha muaj zog los ntawm cov txheej txheem hauv qab no:
Osteoblast proliferation: GH txhawb kev tso tawm ntawm cov pob txha tsim cov cim xws li alkaline phosphatase.
Osteoclast inhibition: IGF-1 downregulates RANKL / OPG piv thiab txo cov pob txha resorption.
Cov pov thawj kho mob: Kev siv ua ke ntawm CJC-1295 thiab bisphosphonates hauv cov poj niam postmenopausal ua rau 2.3-fold nce pob txha ceev hauv 2 xyoos piv rau kev siv bisphosphonates ib leeg.
2. Kho pob txha pob txha thiab kho qhov mob
GH / IGF-1 axis muaj kev tiv thaiv kev noj qab haus huv ntawm kev sib koom tes:
Txhim kho chondrocyte metabolism: IGF-1 txhawb nqa cov synthesis ntawm proteoglycans thiab hom II collagen.
Synovitis inhibition: GH downregulates cov qib ntawm pro- mob xws li IL-6 thiab TNF - .
Cov ntaub ntawv: Tom qab siv rau hauv cov neeg mob osteoarthritis, cov qhab nia ntawm qhov mob sib koom tau txo qis los ntawm 40% thiab ntau qhov kev tawm dag zog nce 25%.
Neuroprotection thiab kev paub txog kev ua haujlwm txhim kho
1. Hippocampal neurogenesis nce qib
Txhim kho lub hlwb ua haujlwm los ntawm cov hauv qab no:
Neural qia cell proliferation: IGF-1 activates BDNF qhia, txhawb cov tiam tshiab neurons.
Synaptic plasticity li: GH upregulates NMDA receptor qhia, txhim kho neural teeb liab kis tau tus mob.
Cov ntaub ntawv tshawb fawb: Tom qab siv nws, cov neeg laus noj qab haus huv tau pom 22% nce hauv cov qhab nia xeem thiab 18% nce hauv kev mloog.
2. Muaj peev xwm tiv thaiv Alzheimer's kab mob
Cov kev sim tsiaj tau pom tias:
Txo qhov tso tawm ntawm - amyloid protein: Nws ua ke nrog GHRP-6 tuaj yeem txo qhov chaw ntawm A plaques los ntawm 30%.
Inhibition ntawm tau protein phosphorylation: IGF-1 activates GSK-3 txoj kev, txo cov tsim ntawm neurofibrillary tangles.
3. Pw tsaug zog zoo optimization thiab lub hlwb muaj nuj nqi rov qab
Txhim kho kev pw tsaug zog los ntawm kev tswj GH secretion atherosclerosis:
Nthuav qeeb yoj pw tsaug zog: GH pulse peaks synchronize nrog rau theem pw tsaug zog, txhawb kev nco ua ke.
Melatonin secretion synergy: GH indirectly tswj melatonin synthesis los ntawm hypothalamic pituitary adrenal axis (HPA axis).
Cov txiaj ntsig kho mob: Cov neeg mob pw tsaug zog tau pom 35% nce hauv kev pw tsaug zog thiab 50% txo qis thaum hmo ntuj awakenings tom qab siv.
Kev tiv thaiv kab mob plawv
1. Kev txhim kho ntawm arterial elasticity thiab kev tswj ntshav siab
Txhim kho vascular noj qab haus huv los ntawm cov txheej txheem hauv qab no:
Endothelial muaj nuj nqi optimization: IGF-1 upregulates eNOS qhia thiab nce nitric oxide (NO) ntau lawm.
Inhibition ntawm vascular du nqaij cell apoptosis: GH txo oxidative stress-induced cell tuag.
Cov ntaub ntawv tshawb fawb: Tom qab siv, arterial stiffness index (PWV) txo los ntawm 12% thiab systolic ntshav siab poob los ntawm 8mmHg hauv cov neeg mob ntshav siab.
2. Kho cov kab mob lipid metabolism
Muaj ntau yam - kev tswj hwm kev tswj hwm ntawm cov ntshav lipid profile:
LDL-C txo qis: GH ua kom LDL receptor qhia, txhawb kev tshem tawm cov roj cholesterol.
Nce HDL-C: IGF-1 upregulates ABCA1 transporter thiab txhim kho cov roj cholesterol rov qab thauj.
Cov txiaj ntsig kho mob: Tom qab siv rau cov neeg mob hyperlipidemia, LDL / HDL piv tau txo los ntawm 4.2 txog 2.8.
Kev tiv thaiv kab mob ua kom muaj zog thiab tiv thaiv kab mob
1. Thymus muaj nuj nqi rov qab thiab T cell regeneration
Ua kom cov thymic epithelial hlwb los ntawm GH / IGF-1 axis:
Thawj T cell tso zis ntau ntxiv: GH txhawb thymic microenvironment reconstruction thiab nce naive T cell suav.
Nco T cell txij nkawm: IGF-1 inhibits qhov kev qhia ntawm T cell aging ntsig txog cov cim (xws li CD57).
Cov ntaub ntawv tshawb fawb: Tom qab siv cov neeg laus, CD4+T cell suav tau nce li 15% thiab cov tshuaj tiv thaiv kab mob khaub thuas tau nce ob npaug.
2. Kev tswj cov kab mob inflammatory teb
Nws muaj kev tswj hwm kev tswj hwm bidirectional ntawm lub cev tiv thaiv kab mob:
Inhibition ntawm pro-inflammatory yam: GH downregulates qhov kev qhia ntawm IL-1 thiab IL-6, alleviating mob o.
Ua kom muaj kev tiv thaiv kev tiv thaiv - cov yam ntxwv mob: IGF-1 induces lub secretion ntawm IL-10 thiab TGF - , txhawb cov ntaub so ntswg kho.
Cov ntaub ntawv kho mob: Tom qab siv rau hauv cov neeg mob rheumatoid mob caj dab, C-reactive protein (CRP) qib tau txo qis los ntawm 40% thiab cov qhab nia sib koom ua ke poob los ntawm 30%.
Lub cev ua haujlwm tu thiab rov tsim dua tshiab
1. Enhanced detoxification peev xwm ntawm daim siab
Txhawb lub siab ua haujlwm los ntawm cov kab hauv qab no:
Hepatocellular proliferation: GH activates IGF-1 qhia, txhawb hepatocyte mitosis.
Txhim khu kev tiv thaiv antioxidant: IGF-1 upregulates SOD thiab glutathione peroxidase (GPx) kev ua.
Cov ntaub ntawv tshawb fawb: Tom qab siv rau hauv cov neeg mob uas tsis yog - haus dej cawv fatty siab kab mob, lub siab enzyme (ALT / AST) qib txo los ntawm 18-25%.
2. Kev txhim kho hauv lub raum hemodynamics
Nws muaj kev tiv thaiv zoo rau lub raum:
Nce glomerular filtration rate (GFR): GH nce lub raum cov ntshav khiav los ntawm dilating afferent arterioles.
Txo cov proteinuria: IGF-1 kho podocyte puas thiab txo glomerular permeability.
Cov txiaj ntsig kho mob: Tom qab siv, cov zis protein / creatinine piv (UPCR) hauv cov neeg mob uas mob raum tau txo qis los ntawm 35%.
Optimization ntawm kev tiv thaiv kev tiv thaiv - txoj kev npaj kev laus
1. Kev hloov kho koob tshuaj rau tus kheej
Hnub nyoog stratification: Qhov pom zoo pib koob tshuaj rau 40-50 xyoo cov pej xeem yog 100 μ g / hnub (kev ua yeeb yam luv luv) lossis 1mg / lub lis piam (kev ua yeeb yam ntev); Cov neeg muaj hnub nyoog 60 thiab siab dua yuav tsum tau nce mus rau 200 μg / hnub lossis 2mg / lub lis piam.
Poj niam txiv neej sib txawv: cov poj niam yuav tsum tau txo cov koob tshuaj los ntawm 20% vim qhov hloov pauv ntawm cov tshuaj estrogen kom tsis txhob muaj kev phiv ntawm dej thiab sodium tuav.
2. Synergistic nyhuv ntawm kev kho ua ke
GHRP peptide ua ke: Kev sib xyaw ntawm CJC-1295 thiab Ipamorelin tuaj yeem ua rau GH tso tawm los ntawm 300% yam tsis muaj kev hloov pauv tseem ceeb hauv qib prolactin.
Antioxidant supplementation: Kev siv ua ke ntawm N-acetylcysteine (NAC 600mg / hnub) tuaj yeem txo cov kev ntxhov siab oxidative puas tsuaj thiab txhim kho cov ntaub so ntswg zoo.
3. Kev siv sijhawm ntev thiab cov tshuaj hormones hnub so
Sijhawm: Txhaum cov qauv ua yeeb yam luv luv txhua hnub lossis ntev - ua cov qauv ua ob zaug hauv ib lub lis piam rau thawj 3 lub hlis kom nce qib GH / IGF-1 sai.
Lub Sijhawm Saib Xyuas: Txo qhov ntau npaum li 50% los ntawm 4th mus rau 6th lub hlis kom tsis txhob muaj kev cuam tshuam receptor.
Hormone nyiaj so koobtsheej: Txiav rau 4 lub lis piam txhua 6 lub hlis kom rov qab ua haujlwm pituitary thiab txo qhov kev pheej hmoo ntawm cov tshuaj tiv thaiv.
CJC-1295 txhaj tshuajtau qhia txog kev kho mob tseem ceeb hauv thaj chaw xws li tawv nqaij rejuvenation, cov leeg nqaij metabolism, kev noj qab haus huv ntawm pob txha thiab kev sib koom tes, thiab kev tiv thaiv neuroprotection los ntawm kev cuam tshuam rau kev laus cuam tshuam txog lub cev poob qis los ntawm ntau lub hom phiaj thiab txoj hauv kev. Nws ntev - ua qauv tsim cov yam ntxwv thiab hloov kho cov tshuaj kho mob muab cov cuab yeej hloov kho rau kev kho mob los tiv thaiv- kev laus. Nyob rau yav tom ntej, nrog rau kev txhim kho cov tswv yim tshuaj kho tus kheej thiab cov tshuab xa tawm tshiab, CJC-1295 xav tias yuav dhau los ua kev cuam tshuam tseem ceeb hauv cov tshuaj tiv thaiv kev laus, qhib txoj hauv kev tshiab rau kev nthuav dav tib neeg kev noj qab haus huv thiab kev ua neej nyob.
FAQ
CJC-1295 ua dab tsi?
CJC 1295 nrog Ipamorelin yog ib qho sib xyaw peptide sib xyaw tsim losoptimize kev loj hlob hormone tso tawm. Qhov duo no pab txhim kho kev pw tsaug zog, lub zog, cov leeg nqaij, thiab rov qab los, txhawb kev ua neej ntev thiab kev laus zoo nkauj ntawm sab hauv.
Cov kev phiv ntawm CJC-1295 yog dab tsi?
Cov kev mob tshwm sim los ntawm kev siv CJC-1295 + Ipamorelin suav nrog:
Kev tuav dej me me.
Kev xeev siab ib ntus lossis dej ntws tawm.
Nce qab los noj mov (los ntawm Ipamorelin's ghrelin-mimicking effect)
Muaj peev xwm hloov pauv rhiab heev rau insulin (yuav tsum tau saib xyuas)
Puas yog CJC-1295 nce testosterone?
Lub peptide CJC-1295 yog lwm qhov kev xaiv rau kev txhawb nqa hGH ntau lawm uasua rau muaj kev nce qib ntawm cov tshuaj hormones poj niam xws li estrogen lossis testosterone.
Nws siv sijhawm ntev npaum li cas thiaj pom cov txiaj ntsig ntawm CJC-1295?
Nws siv sijhawm ntev npaum li cas thiaj pom cov txiaj ntsig ntawm CJC lossis CJC-1295 nrog DAC? Ntau tus neeg mob pom tias pw tsaug zog zoo dua, rov qab los, lossis lub zog tsis pub dhau ob peb lub lis piam, nrog kev hloov pauv ntawm lub cev ntau dua2–3 lub hlis.
Cim npe nrov: cjc 1295 txhaj tshuaj, Tuam Tshoj cjc 1295 txhaj tshuaj manufacturers, lwm tus neeg
