Raws li chav kawm tshwj xeeb bioactive molecules nrog lub hom phiaj tswj kev muaj peev xwm,CilengitideQhov kev ua tau zoo yog tsom mus rau ob qhov tseem ceeb: thaiv thiab tswj cov kab mob neoplastic lesion ntxeem tau thiab kev nthuav tawm, thiab kev cuam tshuam meej hauv cov kab mob ntawm lub qhov muag. Ua ke, lawv tsim cov kev taw qhia tseem ceeb ntawm nws cov kev tshawb fawb soj ntsuam thiab kev tshawb nrhiav daim ntawv thov. Piv nrog rau cov txheej txheem kev cuam tshuam ib txwm muaj uas feem ntau nthuav tawm ib lub hom phiaj thiab ib txoj hauv kev ntawm kev ua, cov molecule no tso siab rau nws qhov tshwj xeeb ncig peptide saw qauv los muab nws nrog cov yam ntxwv sib luag, uas tuaj yeem txheeb xyuas thiab khi rau cov hom phiaj tshwj xeeb. Nws nthuav tawm cov txiaj ntsig tshwj xeeb hauv inhibiting neoplasm cell invasion thiab tsiv teb tsaws hla cov ntaub so ntswg, txwv tsis pub kis tus kab mob, thiab txo cov kab mob cuam tshuam los ntawm qhov txawv txav ntawm neovascularization nyob rau hauv lub qhov muag, uas txawv ntawm cov pa formulations. Nws qhov tseeb thiab qhov tshwj xeeb tsis yog tsuas yog txhim kho cov txiaj ntsig kev cuam tshuam, tab sis kuj txo qis qhov cuam tshuam ntawm qhov tsis yog - cov teebmeem tshwj xeeb.
Peb cov khoom Description
Cilengitide COA
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| Certificate of Analysis | ||
| Compound npe | Cilengitide | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 188968-51-6 | |
| Ntau | 38g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090078 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib qho impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia |
Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree |
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| Tshuaj Formula | C27H40N8O7 |
| Exact Mass | 588.30 |
| Molecular Luj | 588.67 |
| m/z | 588.30 (100.0%), 589.31 (29.2%), 590.31 (4.1%), 589.30 (3.0%), 590.31 (1.4%) |
| Elemental Analysis | C, 55.09; H, 6.85; N, 19.04; O, 19.02 |
Blocking thiab diffusion limiting los ntawm cov tshuaj nontawm neoplasm infiltration thiab metastasis
Lub hauv paus tseem ceeb ntawm neoplastic lesion infiltration thiab metastasis yog nyob rau hauv kev tawg ntawm cov kab mob hlwb los ntawm cov ntaub so ntswg teeb meem thiab lub realization ntawm cross site colonization. Nws tsim ib qho kev thaiv peb -qhov kev thaiv ntawm cov txheej txheem no los ntawm kev sib txuas ntau txoj cai, thiab nws cov yam ntxwv ntawm lub hom phiaj muaj zog thiab kev cuam tshuam dav tuaj yeem ua los ntawm cov hauv qab no:
(I) cuam tshuam nrog adhesion thiab colonization muaj peev xwm ntawm lesion cells.
Lub infiltration ntawm neoplastic lesion hlwb ua ntej tso siab rau lawv cov adhesion thiab khi rau ib puag ncig matrix, thiab cov txheej txheem khi no yuav tsum muaj kev sib koom ua ke ntawm cov receptors tshwj xeeb thiab ligands.Cilengitidetuaj yeem sib tw khi rau qhov chaw receptor cuam tshuam, thaiv qhov kev sib raug zoo ntawm cov kab mob qog nqaij hlav thiab cov khoom siv ntawm cov kab mob extracellular matrix, ua rau lub cev tsis muaj zog ntawm cov hlwb, thiab txo qhov muaj peev xwm ntawm cov hlwb neoplasm detaching los ntawm thawj qhov txhab los ntawm qhov chaw, nteg lub hauv paus rau thaiv infiltration thiab metastasis. Cov kev tshawb fawb ntsig txog tau pom tias nyob rau hauv ntau yam khoom siv neoplastic lesion qauv, cov molecule no tuaj yeem txo qhov kev ua kom zoo ntawm cov kab mob thiab cov matrix, thiab txo qhov tshwm sim ntawm cell shedding.
Inhibit kev txav chaw
(II) Lub peev xwm tsiv teb tsaws ntawm cov qog hlwb yog tus yuam sij kom ua tiav kev sib kis nyob deb, thiab cov txheej txheem no tau tswj hwm los ntawm txoj hauv kev hauv lub cev.
Qhov no tuaj yeem cuam tshuam qhov kev txav ntawm cov kab mob qog nqaij hlav, txo qis kev tsiv teb tsaws ntawm cov hlwb, tiv thaiv lawv cov kev nkag mus rau hauv cov ntaub so ntswg ib puag ncig, thiab txwv tsis pub lawv nkag mus rau hauv cov ntshav ncig, lymphatic ncig, thiab lwm txoj hauv kev sib kis los ntawm kev tswj hwm cov haujlwm ntawm cov teeb meem cuam tshuam, yog li txo qhov tsim ntawm metastases nyob deb. Hauv kev sim ntawm tes ntawm kev mob qog noj ntshav ntawm zes qe menyuam, mob qog noj ntshav mis thiab lwm yam kab mob neoplastic, cov molecule no tuaj yeem cuam tshuam qhov muaj peev xwm tsiv teb tsaws ntawm cov hlwb neoplasm thiab nqaim cov migration ntau yam.
(III) Kev tswj cov pro metastatic zog ntawm qog microenvironment.
Cov hlwb muaj feem cuam tshuam thiab cov xwm txheej hauv cov kab mob neoplastic microenvironment muab kev txhawb nqa rau neoplasm infiltration thiab metastasis, thiab nws tuaj yeem thim rov qab nws txoj kev nyiam metastatic los ntawm kev tswj cov kev qhia ntawm cov khoom cuam tshuam hauv microenvironment. Piv txwv li, nws tuaj yeem cuam tshuam qhov tso tawm ntawm cov kab mob metastatic los ntawm kev mob qog noj ntshav- ntsig txog fibroblasts, txo cov kev hloov pauv txawv txav ntawm extracellular matrix, cuam tshuam cov microenvironmental tej yam kev mob uas yuav tsum tau rau neoplastic lesion infiltration thiab metastasis, ntxiv dag zog rau qhov limiting nyhuv ntawm cov qog nqaij hlav, thiab tsim ib tug dual intervention muaj peev xwm ntawm lub cell 'blocking.
Cov ntaub ntawv hauv tshooj no yog los ntawm:
Zhu F, Yuan S, Li J, et al. no peptide inhibits Neovascularization nyob rau hauv tus luav Abdominal Aortic Plaque Model los ntawm Impairing VEGF Signaling. Biomed Res Int, 2021, 2021: 5954757.
Xiang Peng, Yang Yang Combination inhibition ntawm nto CD51 thiab gamma secretase mediated CD51 cleavage txhim kho cov nyhuv ntawm kev sim metastatic daim siab mob cancer [J]. Suav Journal of Hepatology, 2024, 32 (2): 189-196
Cov yam ntxwv ntawm daim ntawv thov thiab cov tshuaj tiv thaiv angiogenic ntawm nws hauv cov kab mob ophthalmic
Hauv cov kab mob ophthalmic, daim ntawv thov tseem ceeb ntawm qhov no tsom mus rau kev cuam tshuam ntawm cov hnub nyoog ntub dej - ntsig txog macular degeneration. Nws lub luag haujlwm tseem ceeb yog txhawm rau txhawm rau tsim qhov txawv txav ntawm neovascularization nyob rau hauv lub qhov muag, txo cov kab mob, thiab tiv thaiv kev ua haujlwm ntawm qhov muag. Nws cov yam ntxwv ntawm kev ua yog ob qho tib si tsom thiab nyab xeeb. Kev tsom xam tshwj xeeb yog raws li hauv qab no:
Qhov tseeb tsom qhov txawv txav neovascularization hauv qhov muag
Cov kev hloov pauv tseem ceeb ntawm cov hnub nyoog ntub dej- ntsig txog macular degeneration yog qhov txawv txav ntawm choroidal neovascularization, uas yog cov txheej txheem tsis yooj yim thiab nws yooj yim rau to, ua rau macular edema, los ntshav, thiab thaum kawg ua rau pom kev ua haujlwm tsis zoo. Qhov no tuaj yeem ua tshwj xeeb rau cov receptors uas cuam tshuam rau ntawm cov kab mob endothelial hauv cov hlab ntsha tshiab, thaiv kev khi ntawm cov receptors thiab ligands, inhibit qhov kev loj hlob, kev tsiv teb tsaws, thiab lumen tsim ntawm endothelial hlwb, yog li tiv thaiv kev loj hlob ntawm cov hlab ntsha tshiab txawv txav, txo cov kab mob pathological, thiab zam kev puas tsuaj ntxiv rau kev ua haujlwm.
Kev cuam tshuam muaj lub koom haum tshwj xeeb
Lub physiological qauv ntawm lub qhov muag cov ntaub so ntswg yog tshwj xeeb, thiab siab tshwj xeeb yog yuav tsum tau rau cov neeg ua hauj lwm cuam tshuam.Cilengitidetuaj yeem xaiv ua qhov txawv txav ntawm neovascularization nyob rau hauv lub qhov muag, tsis muaj kev cuam tshuam tseem ceeb ntawm cov hlab ntsha ntawm lub qhov muag thiab cov ntaub so ntswg. Nws tuaj yeem zam kev puas tsuaj rau lub qhov muag ib txwm ua haujlwm ntawm lub cev los ntawm kev cuam tshuam thiab txo qhov kev pheej hmoo ntawm kev tsis zoo. Cov yam ntxwv no ua rau nws muaj txiaj ntsig zoo hauv kev cuam tshuam cov kab mob ophthalmic, thiab piv rau cov uas tsis yog - cov tshuaj tiv thaiv angiogenic tshwj xeeb, nws muaj kev nyab xeeb ntau dua.
Kev sib koom tes pab txo cov tsos mob ntsig txog qhov txhab
Cov neeg mob uas muaj hnub nyoog ntub dej- ntsig txog macular degeneration feem ntau tshwm sim nrog cov kev kho mob ib txwm muaj xws li macular edema, exudation, thiab hemorrhage, uas ua rau lub cev puas tsuaj loj thiab ua rau muaj kev cuam tshuam loj rau qhov pom. Cov tshuaj muaj peev xwm ua tau zoo inhibit qhov tsim ntawm choroidal neovascularization txawv txav, indirectly txo vascular permeability thiab to, txo retinal edema, thiab txo exudative lesions.
Los ntawm kev txhim kho microenvironment ntawm thaj av macular, nws ua kom pom kev pom kev zoo thiab lub neej zoo ntawm cov neeg mob. Tsis tas li ntawd, nws cov txiaj ntsig kho tau ruaj khov thiab kav ntev, uas tuaj yeem cuam tshuam tsis tu ncua kev loj hlob ntawm neovascular, ncua kev hloov pauv ntawm cov kab mob pathological, thiab muab kev tiv thaiv ruaj khov thiab txhim khu kev qha rau lub sijhawm ntev - kev saib xyuas ntawm cov neeg mob kev ua haujlwm pom.
Cov ntaub ntawv hauv tshooj no yog los ntawm:
Zhang Y, Li L, Wang H. Targeted inhibition ntawm integrin V 3 los ntawm peptide suppresses zes qe menyuam qog noj ntshav cell migration thiab spheroid tsim. Int J Oncol, 2023, 62(3):112.
Li J, Wang Y, Chen F. peptide ua ke nrog trastuzumab kov yeej trastuzumab tsis kam nyob rau hauv HER2-zoo mob cancer mis los ntawm lub hom phiaj ITGB3 heterogeneity. Ib., 2025, 14(1:9.
Hauv cov ntsiab lus, nws tsis yooj yim pom los ntawm cov ncauj lus kom ntxaws ntawm ntau qhov ntev hauv cov ntawv nyeem dhau los uasCilengitidetau ua kom pom qhov tsis muaj txiaj ntsig tshwj xeeb hauv ob qhov kev thov tseem ceeb ntawm kev thaiv thiab tswj cov kab mob neoplastic lesion infiltration thiab metastasis, thiab tshuaj tiv thaiv angiogenic rau cov hnub nyoog ntub dej{0}} ntsig txog macular degeneration. Nws cov txiaj ntsig tseem ceeb khiav los ntawm tag nrho cov txheej txheem ntawm kev ua haujlwm, kev cuam tshuam, thiab kev nyab xeeb ntawm daim ntawv thov. Cov yam ntxwv tshwj xeeb ntawm cov molecule no, xws li lub hom phiaj muaj zog, kev cuam tshuam meej, thiab kev nyab xeeb zoo, ua rau nws txawv ntawm cov txheej txheem kev cuam tshuam ib txwm muaj thiab dhau los ua cov txheej txheem tseem ceeb hauv kev tshawb fawb txog kab mob tam sim no, muab cov khoom tseem ceeb thiab kev txhawb nqa rau kev tshawb fawb soj ntsuam thiab kev tshawb nrhiav tom ntej. Tshwj xeeb tshaj yog, nyob rau theem ntawm kev cuam tshuam neoplasm, nws tsim ib qho peb - qhov ntev thaiv qhov system rau cov qog infiltration thiab metastasis los ntawm kev cuam tshuam nrog cov adhesion ntawm cov kab mob hlwb, inhibiting cell migration, thiab tswj cov neoplasm microenvironment, zoo txwv cov malignant kis ntawm cov kab mob sib txawv.
Nyob rau theem ntawm kev cuam tshuam cov kab mob ophthalmic, nws tso siab rau lub hom phiaj meej ntawm qhov txawv txav neovascularization nyob rau hauv lub qhov muag, thaum inhibiting txawv txav vascular proliferation, synergistically alleviating nrog rau cov tsos mob xws li macular edema thiab exudation, maximizing kev tiv thaiv ntawm cov neeg mob lub qhov muag kev ua hauj lwm, thiab tsis muaj kev puas tsuaj rau lub qhov muag tseem ceeb ntawm cov ntaub so ntswg. Txawm hais tias nws yog qhov sib txuas ntau thiab ntau- lub hom phiaj txwv kev kis kab mob neoplastic, lossis qhov tshwj xeeb inhibition ntawm qhov txawv txav ntawm lub qhov muag, qhov no rhuav tshem cov kev txwv ntawm cov qauv kev cuam tshuam ib txwm muaj, muab cov tswv yim tshiab thiab cov lus qhia rau kev kho mob ntsig txog kab mob, thiab tseem muab cov ntaub ntawv tseem ceeb rau kev txhim kho cov phiaj xwm kho mob. Nrog rau qhov txuas ntxiv txuas ntxiv ntawm cov kev tshawb fawb txog kev tshawb fawb thiab kev sim tshuaj ntsuam xyuas, nws cov txheej txheem ntawm kev ua haujlwm yuav raug nthuav dav ntxiv, thiab nws cov xwm txheej thov yuav nthuav dav ntxiv. Nws daim ntawv thov muaj peev xwm yuav tsum tau tshawb nrhiav thiab tso tawm tag nrho, ua rau muaj kev cia siab kho tshiab rau cov neeg mob ntau yam kab mob.
Cov ntaub ntawv hauv tshooj no yog los ntawm:
Wang Min, Li Li, Zhang Tao Lub inhibitory nyhuv ntawm peptide ntawm choroidal neovascularization nyob rau hauv tus nas qauv ntawm lub hnub nyoog ntub-txog macular degeneration [J]. New Advances in Ophthalmology, 2024, 44 (5): 361-365
Cov ntaub ntawv
Peterson A, Smith J, Jones C. Anti-kev kho mob sib xyaw nrog peptide rau cov kab mob retinovascular: cov pov thawj preclinical thiab cov kev xav yav tom ntej. J Ocul Pharmacol Ther, 2023, 39(4): 289-298.
Zhao H, Liu Z, Zhang L. qhov no inhibits neoplastic lesion ntxeem tau los ntawm kev tswj cov CD51-ICD/OXPHOS axis nyob rau hauv hepatocellular carcinoma. J Hepatol, 2023, 79(2): 287-299.
Schmidt M, Mü ller K, Weber S. peptide ua tus kws kho mob muaj peev xwm rau cov hnub nyoog ntub dej - ntsig txog macular degeneration: kev kawm ua ntej. Graefes Arch Clin Exp Ophthalmol, 2022, 250(11): 1879-1888.
Chen W, Li M, Zhang H. Lub luag haujlwm ntawm peptide hauv inhibiting neoplasm metastasis los ntawm kev hloov kho cov qog microenvironment. Cancer Biol Ther, 2024, 25(3): 189-198.
Cim npe nrov: Tuam Tshoj cilengitide manufacturers, lwm tus neeg
