Cov kws tshawb fawb tab tom kawm cov tshuaj tshiab uas cuam tshuam nrog lub cev cov txheej txheem metabolic kom pom cov kev xaiv txo cov roj ntsha. 5mq1 uapeptide txhaj tshuajyog ib qho kev tshawb fawb metabolic nrov. Qhov me me no -molecule compound tsom rau nicotinamide N-methyltransferase (NNMT) enzyme kom cuam tshuam rau lub zog ntawm tes thiab roj cia, tsis zoo li kev txwv caloric lossis stimulant- raws li txoj kev tswj kev hnyav. Kev tshuaj xyuas qhov sib txuas ntawm cov cellular metabolism thiab cov ntaub so ntswg ua haujlwm pab piav qhia tias cov tshuaj no txo cov rog li cas. Lub cev sib npaug zog khaws cia thiab siv, thiab qhov hnyav nce tshwm sim thaum khaws cia ntau tshaj kev siv . 5 amino 1mq muab kev tshawb fawb-raws li kev txo cov rog uas txawv ntawm cov qauv kev kho mob los ntawm kev tsom mus rau cov txheej txheem metabolic uas cuam tshuam qhov nyiaj tshuav no. Txoj kev tshawb no siv cov kev tshawb fawb preclinical thiab mechanical los tshawb xyuas seb cov tshuaj no cuam tshuam li cas rau cov roj metabolism thiab kev ua kom zoo ntawm cov metabolism.
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
(3) Txhaj tshuaj
(4) Capsules
(5) Kua dej
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Internal Code: KP-3-5/002
CAS Nr .: 42464-96-0
Cov mis mos molecular: C10H11N2.I
HS code: N/A
Molecular Luj: 286.11
EINECS tus lej: 464-196-0
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Yuav Ua Li Cas 5 Amino 1MQ Peptide Injection Influence Fat Metabolism Los Ntawm NNMT Pathway Regulation?
Lub luag haujlwm tseem ceeb ntawm NNMT hauv Kev Cai Metabolic
Nicotinamide N-methyltransferase yog qhov tseem ceeb rau cell metabolism. Nws muaj ntau nyob rau hauv cov ntaub so ntswg adipose thiab hloov lub zog siv. Cov enzyme no hloov nicotinamide rau methylnicotinamide. Qhov no ua rau NAD + lub tsev thaiv nyuaj rau nrhiav. Ntau cov haujlwm metabolic xav tau NAD +, coenzyme. Nws pab sirtuins, cov proteins uas tswj cov cell noj qab haus huv thiab metabolism, ua haujlwm.
Cells poob NAD+ thaum NNMT kev ua haujlwm nce. Qhov no txo qis NAD +, txo qis mitochondrial yooj thiab ua haujlwm. Qhov kev xaiv no txhawb nqa cov rog ntau dua li kev hlawv rog. NNMT nres los ntawm 5 amino 1mq peptide txhaj. Qhov no tswj cov cell NAD+. Cov kws tshawb fawb siv kev noj zaub mov-cov qauv kev rog rog pom tias txhaj tshuaj no txhua hnub ntawm 50 mg / kg rau cov nas rau yim lub lis piam txo NNMT kev ua hauv cov ntaub so ntswg dawb los ntawm 60% thiab nce NAD + ntau ntau los ntawm 2.3 npaug.
Metabolic Cascade Tom qab NNMT Inhibition
Thaum cov hlwb tau txais ntau NAD +, nws pib cov tshuaj tiv thaiv kab mob uas hloov pauv li cas adipocytes cuam tshuam nrog cov rog hauv txoj kev sib sib zog nqus. SIRT1 tau qhib thaum muaj ntau NAD + muaj. Qhov no deacetylates cov metabolism hauv tseem ceeb xws li PPAR- . Cov noob uas ua rog, xws li fatty acid synthase (FAS) thiab stearoyl-CoA desaturase-1 (SCD1), raug tso tseg los ntawm cov kev hloov pauv hauv kev sau ntawv.
Cov noob uas tswj kev tawg ntawm fatty acids kuj tau qhib. Tom qab kev kho mob, muaj ntau ntawm ob enzymes: CPT1A thiab ACOX1. Cov roj acids tuaj yeem txav mus los thiab tawg yooj yim dua hauv mitochondria vim qhov no. Yog tias koj txwv cov rog rog los ntawm kev tsim thiab ua kom lawv tawg, koj tuaj yeem poob rog yam tsis tau txiav rov qab rau calories.
Observable metabolic tshwm sim nyob rau hauv kev tshawb fawb qauv
Tsawg NNMT hloov txoj hauv kev ua haujlwm metabolism, uas tuaj yeem pom thiab ntsuas hauv lub cev. Tsiaj txhu uas tau muab 5 amino 1mq peptide txhaj poob 18% ntawm lawv lub cev qhov hnyav, thiab cov roj pad nyob ib ncig ntawm lawv thaj chaw pubic poob 35% ntawm nws qhov hnyav dhau ntawm yim lub lis piam. Tib neeg tsis tau hloov ntau npaum li cas lawv noj, tab sis cov kev hloov no tseem tshwm sim. Qhov no qhia tau hais tias cov tshuaj hloov pauv tau txhim kho metabolic efficiency ntau dua li ua rau tib neeg xav tias tsis tshaib plab.
Cov kev ntsuas ntawm cov metabolism kuj tau zoo heev. Raws li HOMA-Kev kuaj IR, insulin rhiab heev tau nce 40%, thiab ceev cov ntshav qabzib poob qis los ntawm 22%. Cov txiaj ntsig metabolic yog ntau dua li tsuas yog poob rog, raws li cov kev tshawb pom no qhia. Cov piam thaj zoo dua thiab cov lus teb insulin kuj yog ib feem ntawm lawv. Ob qho no tseem ceeb heev rau kev noj qab haus huv metabolic.
Nkag siab lub luag haujlwm ntawm 5 Amino 1MQ Peptide Txhaj Tshuaj hauv Lipid Mobilization thiab Kev Tshawb Fawb Kev Siv Hluav Taws Xob
Mechanisms ntawm Lipid Mobilization ntawm Cellular Level
Triglycerides khaws cia rau hauv adipocytes thiab yuav tsum tau hlawv hauv cov ntaub so ntswg nrog cov metabolic siab rau cov rog kom tshwm sim. Dawb fatty acids thiab glycerol yog tsim los ntawm triglycerides hauv thawj kauj ruam ntawm cov txheej txheem. Cov kua qaub ces nkag mus rau hauv cov hlab ntsha thiab ua rau lawv txoj kev mus rau cov hlwb uas xav tau lub zog. Muaj ob peb txoj kev uas cov5 amino 1mq peptide txhajceev cov txheej txheem no.
Muaj tus tswv metabolic regulator hu ua AMPK uas kuaj xyuas lub zog ntawm cov hlwb. Thaum NAD + qib siab, AMPK tig rau. Proteins hu ua hormone-sensitive lipase (HSL) thiab perilipin txiav txim siab npaum li cas cov roj uas tau khaws cia tuaj yeem siv tau. Cov proteins no yog phosphorylated los ntawm kev ua AMPK. Cov saw hlau ntawm phosphorylations no ua rau kom lipolysis, uas tso cai rau ntau cov roj fatty acids raug hlawv. Hauv kev kho cov ntaub so ntswg adipose, cov noob uas zom cov rog thiab txav cov fatty acids nyob ib puag ncig tau pom tias tau hloov pauv ntau.
Txhim kho Mitochondrial Capacity rau Fat Oxidation
Cov roj acids tsis tuaj yeem hloov pauv ntau yog tias cov hlwb tsis muaj cov cuab yeej tsim nyog los ua. Cov no yog cov feem tseem ceeb ntawm cov cell uas hlawv fatty acids. Cov hlwb zoo npaum li cas tuaj yeem siv cov rog dawb rau lub zog nyob ntawm seb cov khoom no ua haujlwm zoo npaum li cas. Txoj kev PGC-1 / NRF1 / TFAM yog qhib los ntawm 5 amino 1mq kev kho mob, uas pab mitochondria loj hlob.
Nws tau pom tias tom qab kev kho mob, cov ntawv luam ntawm mitochondrial DNA tau nce 1.5 npaug ntawm cov ntaub so ntswg rog. Qhov no qhia tau hais tias lub network ntawm mitochondria tau loj dua. Vim tias muaj mitochondria ntau dua, beta-oxidation tuaj yeem tshwm sim tau yooj yim dua. Qhov no yog cov txheej txheem uas fatty acids hloov mus rau hauv ATP. Nws tau yooj yim dua los hloov cov electrons thiab tau txais lub zog los ntawm fatty acid qhov chaw vim tias muaj cov kab mob ua pa ntau dua.
Metabolic Flexibility thiab Substrate Siv Cov Qauv
Lub cev tuaj yeem hloov pauv ntawm cov roj sib txawv raws li qhov muaj thiab qhov nws xav tau. Qhov no yog hu ua metabolic yooj. Thaum ib tug neeg muaj teeb meem metabolism, feem ntau lawv hloov tsis tau. Qhov no txhais tau hais tias lawv nyob hauv qabzib - nyob ntawm seb txawm tias muaj ntau cov fatty acids nyob ib puag ncig. Thaum koj tsis noj NNMT, koj cov metabolism hloov, uas ua rau koj hloov tau dua.
Cov kws tshawb fawb uas tau soj ntsuam qhov sib piv ntawm kev ua pa (RER) ntawm cov tsiaj uas tau muab tshuaj pom tias muaj roj ntau tau hlawv thaum so thiab thaum lub teeb ua haujlwm. Cov rog tam sim no siv los ntawm cov hlwb rau lub zog es tsis txhob muaj piam thaj vim qhov hloov pauv hauv cov metabolism. Los ntawm nws tus kheej, qhov no yuav pab koj poob rog thiab ua kom cov nqaij ntshiv. Cov nyhuv tau muaj zog dua thaum koj txo qis calories lossis ua haujlwm ntau dua. Nws ua haujlwm zoo dua yog tias koj tseem ua lwm yam kev hloov pauv hauv koj lub neej.
Yuav ua li cas 5 Amino 1MQ Peptide Txhaj Tshuaj cuam tshuam rau Adipocyte Function thiab Fat Metabolism Studies?
Adipocyte Remodeling thiab Cellular Composition Hloov
Kev laus rog muaj ntau hom cell. Brown adipocytes tsim cov cua sov, thaum cov dawb khaws cia lub zog. Adipocytes uas zoo li cov rog dawb thiab xim av tau kuaj pom hauv cov kev tshawb fawb tsis ntev los no. Qee qhov xwm txheej tso cai rau cov hlwb no tsim. Lub 5 amino 1mq peptide txhaj tshuaj hloov kho adipocytes kom nyiam cov metabolism hauv kev cia.
Hauv kev kho cov ntaub so ntswg, adipocytes tau me dua. Tsawg rog nyob hauv txhua lub cell. Qhov kev txo qis hauv cell ntim yog txuam nrog cov rog poob. Gene qhia pom tias adipocytes muaj ntau dua aerobic metabolism thiab mitochondrial kev ua ub no. Qhov no qhia tau tias cov hlwb tau nrawm dua - metabolizing.
Tshuaj hloov adipocytes txawv cov kauj ruam. PPAR- kev ua haujlwm tau hloov pauv los ntawm SIRT1 deacetylation, hloov pauv cov roj synthesis genetic pathways. Qhov no ua rau ib puag ncig tsis haum rau cov rog- khaws cia adipocytes kev loj hlob thiab ua rau cov hlwb uas twb muaj lawm metabolically nquag.
Inflammatory Profile Hloov kho hauv adipose ntaub so ntswg
Cov kab mob metabolic thiab insulin tsis kam yog feem ntau tshwm sim los ntawm qhov mob uas tshwm sim los ntawm kev rog dhau. Interleukin-6 (IL-6) thiab qog nqaij hlav necrosis factor-alpha (TNF-) yog ob lub cytokines uas tawm tsam qhov mob thaum lub hlwb loj dua. Cov no ua rau tag nrho lub cev kub, uas ua rau kev sib txuas lus metabolic tsis zoo. Cov tsos mob ntawm qhov mob no poob qis heev thaum cov kws tshawb fawb siv a5mq1 uapeptide txhaj tshuaj.
Piv rau cov tsiaj uas tsis tau kho, cov uas kho tau 53% tsawg dua IL-6 hauv lawv cov ntshav thiab 47% tsawg TNF- . Cov tshuaj tiv thaiv kab mob no yuav tshwm sim nyob rau ntau txoj hauv kev, suav nrog kev ntxhov siab tsawg dua ntawm adipocytes, zoo dua mitochondrial muaj nuj nqi (uas txo qis kev tsim cov pa oxygen reactive hom), thiab kev hloov pauv ntawm cov ntaub so ntswg zoo dua hauv maadi. Nyob rau hauv tus po, tus nqi ntawm kev tswj T hlwb nce los ntawm 31%. Qhov no txhais tau hais tias lub cev tiv thaiv kab mob tag nrho hloov.
Adipokine Secretion thiab Metabolic Signaling
Adipokines yog cov tshuaj xa xov uas hloov lub cev metabolism. Lawv raug tso tawm los ntawm cov ntaub so ntswg adipose, uas yog cov kab mob endocrine. Ob qho tseem ceeb adipokines, leptin thiab adiponectin, ua haujlwm sib txawv. Leptin qhia tias lub cev muaj zog txaus, tab sis yog tias nws nyob ntev ntev, nws tuaj yeem ua rau mob. Ntawm qhov tod tes, adiponectin hloov txoj kev insulin ua haujlwm thiab txo qhov mob. Qhov sib npaug ntawm adipokines no hloov pauv rau qhov zoo dua thaum siv cov khoom sib xyaw.
Cov kws tshawb fawb tau pom tias txwv tsis pub NNMT ua rau ntau dua adiponectin tawm thaum ua kom cov qib leptin zoo li qub. Lub siab thiab cov leeg muaj peev xwm teb tau zoo dua rau insulin thaum lawv muaj adiponectin ntau dua. Qhov no ua rau nws yooj yim dua rau lub cev kom nkag mus thiab siv cov piam thaj, thiab nws kuj pab lub cev hlawv rog. Muaj cov teebmeem ntawm cov nqaij rog, tab sis qhov kev nce metabolic no kuj ua rau cov xwm txheej hauv lwm qhov ntawm lub cev uas zoo rau kev rog thiab kev noj qab haus huv.
Kev sib txuas ntawm 5 Amino 1MQ Peptide Txhaj thiab Cellular Zog Ntsuas Mechanisms
NAD + Metabolism raws li Central Regulatory Hub
NAD + yog qhov tseem ceeb rau cell metabolism. Nws pab cov hlwb tswj kev ntxhov siab, tsim lub zog, thiab kho DNA ntawm ntau tshaj 100 txoj hauv kev enzyme. NAD + yuav tsum ua ntau tshaj ferry electrons thaum glycolysis thiab oxidative phosphorylation. Nws kuj tsim sirtuins thiab PARPs, enzymes uas tswj cov metabolism thiab cell noj qab haus huv.
Cov neeg laus uas muaj teeb meem metabolic muaj qis NAD + qib. Qhov no ua rau muaj kev pheej hmoo ntawm mitochondrial tsis ua hauj lwm thiab metabolic nruj. Lub 5 amino 1mq peptide txhaj tiv thaiv kev hloov kho nicotinamide los ntawm kev thaiv NNMT. Qhov no khaws cia NAD + txoj kev khaws cia lub peev xwm los kho qhov tseem ceeb ntawm coenzyme. Vim li no, cell NAD + qib nce, txhim kho cov metabolism.
Qhov no txawv cov molecule los ntawm lwm yam NAD + precursor ntxiv txoj kev. Thaiv NNMT kho cov kab mob metabolic uas khiav tawm ntawm NAD + pas dej es tsis txhob ntxiv cov substrate. NNMT cuam tshuam cov metabolism hauv adipose thiab lwm cov ntaub so ntswg nrog ntau ntawm nws; yog li ntawd, qhov kev txiav txim kom haum no yuav pab tau.
SIRT1 Ua kom thiab Metabolic Reprogramming
NAD+-dependent sirtuins deacetylate histones thiab metabolic enzymes. Qhov no cuam tshuam rau kev qhia gene thiab kev siv lub zog ntawm tes. SIRT1, feem ntau kawm SIRT, tswj ntau txoj hauv kev metabolic uas pab koj hlawv rog thiab tswj lub zog. Cov molecule no yuav tsum tau NAD + ua haujlwm; Yog li ntawd, nws cov txheej txheem cuam tshuam cov metabolism tom qab.
Kev ua SIRT1 nce nrog NAD +, deacetylating transcription yam xws li PPAR-, PGC-1, thiab FOXO proteins. Cov noob uas tswj cov lipid metabolism, cov zis mitochondrial, thiab cov lus teb ntawm tes raug cuam tshuam los ntawm cov kev hloov pauv no. Qhov no nws thiaj li txhim kho cov metabolism, uas txhim kho mitochondrial muaj nuj nqi, rog hlawv, thiab metabolic kev nyuaj siab teb.
SIRT1 ua kom muaj lub luag haujlwm rau ntau qhov cuam tshuam ntawm metabolic ntawm NNMT inhibition, raws li kev tshawb fawb. Kev kho mob nrog SIRT1 inhibitors ua rau cov rog poob thiab cov kev hloov pauv ntawm metabolic nyuaj dua. Qhov no qhia tau hais tias txoj kev no tswj tau ntau yam ntawm cov tshuaj biochemical. Txoj kev tshawb fawb no piav qhia txog yuav ua li cas txhaj tshuaj pab lub cev txo cov rog ib txwm los ntawm txoj hauv kev ntawm tes.
Energy Sensing thiab AMPK Pathway Activation
Thaum lub zog ntawm tes poob qis, AMP-activated protein kinase ua haujlwm metabolic los ntawm kev txheeb xyuas qhov piv ntawm AMP/ATP. AMPK ua kom nrawm nrawm nrawm los tsim ATP thiab ncua kev tsim cov molecule kom siv lub zog. Cov kev hloov pauv no cuam tshuam rau kev poob rog los ntawm kev ua kom cov rog ua kom yooj yim dua thiab cov lipoprotein ntau dua nyuaj.
5 amino 1mq hloov lub zog sib npaug ntawm NAD + metabolism thiab AMPK signaling. AMPK kev ua haujlwm yuav raug nce ncaj qha lossis tsis ncaj. Ncaj nraim nce nws yuav tsum hloov cov kinases sab saud. Thaum AMPK qhib, nws ua haujlwm nrog SIRT1 los hloov cov metabolism hauv kev siv rog.
Cov kev sim cuam tshuam tau qhia tias inhibiting NNMT thiab5mq1 uapeptide txhaj tshuajpab kev tawm dag zog. Tsiaj txhu nrog kev kho mob thiab kev tawm dag zog muaj 60% muaj zog tuav lub zog. Nce los ntawm 20% thaum tsuas muaj kev kho mob lossis 40% thaum tsuas yog ua haujlwm tawm. Thaum ob txoj kev kho mob tau ua ke, mitochondrial ATP tiam tau nce 45%. Qhov no qhia tias cov metabolism ntau dua. Cov tshuaj no txhim kho metabolic adaptation, raws li cov kev tshawb fawb no. Qhov no yuav qhia tau tias kev hloov kho lub neej ua haujlwm zoo dua.
Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Metabolic ntawm 5 Amino 1MQ Peptide Txhaj rau Kev Tswj Fat
Cov ntaub so ntswg-Tshwj xeeb Metabolic Effects Beyond adipose ntaub so ntswg
Ntau cov kev tshawb fawb tsom rau cov ntaub so ntswg adipose; Txawm li cas los xij, NNMT kuj tseem muaj nyob hauv daim siab, nqaij, hlwb, thiab lwm yam ntaub so ntswg. Cov qauv ntawm kev nthuav tawm no qhia tias cov tshuaj boosts metabolism thoob plaws hauv lub cev, tsis yog nyob rau hauv cov rog rog. Peb tuaj yeem nkag siab zoo dua cov txiaj ntsig metabolic hauv cov qauv tshawb fawb los ntawm kev txheeb xyuas cov ntaub so ntswg - cov teebmeem tshwj xeeb.
Kev tswj NNMT cuam tshuam rau daim siab ua haujlwm. Lub siab tswj cov piam thaj, lipids, thiab lipoprotein rhuav tshem. Kev kho mob rau cov rog rog uas tsis yog- dej cawv fatty siab kab mob tuaj yeem txo cov lipids hauv siab thiab txhim kho daim siab ua haujlwm. Qhov no pab cov neeg muaj tus mob no. Cov txheej txheem no txo cov rog rog hauv daim siab thiab ua kom cov rog rog ntau ntxiv.
NNMT thaiv kuj cuam tshuam rau cov leeg pob txha, lwm cov ntaub so ntswg tseem ceeb. Cov kws tshawb fawb pom tau tias qhov kev kho mob nce cov leeg mitochondria thiab kev siv oxygen. Qhov no txhim kho cell fueling nrog fatty acids. Cov kev hloov pauv no pab txhawb cov leeg nqaij, uas ua rau feem ntau ntawm lub cev hnyav, kom txo cov rog thiab ua kom cov metabolism sai.
Kev sib tham nrog kev tawm dag zog thiab kev noj zaub mov zoo
Metabolism hloov nrog 5 amino 1mq peptide txhaj, ua kom muaj sia nyob ntau dua rau kev hloov pauv. Ntau txoj hauv kev cuam tshuam los ntawm NNMT txo qis kuj tau hloov kho los ntawm kev tawm dag zog. Piv txwv suav nrog AMPK ua kom, PGC-1 nce, thiab mitochondrial biogenesis. Tag nrho cov xwm txheej no muaj kev cuam tshuam ntau dua ua ke dua li ib leeg.
Qhov no tau tshwm sim nyob rau hauv kev tshawb fawb uas tshuaj xyuas cov tsiaj uas tau muab tshuaj sedatives, cov tsiaj siv zog, thiab cov tsiaj muab ob qho tib si. Cov ob - pab pawg kev cuam tshuam muaj cov cim mitochondrial tshaj plaws. Qhov no qhia tau hais tias kev txiav NNMT txhim kho kev tawm dag zog metabolism. Kev tshawb pom tias kev sib xyaw ua ke tuaj yeem txhim kho cov txiaj ntsig kev tawm dag zog yog qhov tseem ceeb rau lub neej tiag tiag.
Yam koj haus kuj tuaj yeem hloov pauv li cas cov tshuaj cuam tshuam rau cov metabolism. Rog- noj cov qauv tau txais txiaj ntsig ntau dua los ntawm kev kho mob. Kev ntxhov siab xav tias nce qib NNMT mRNA. Yog li, cov neeg uas muaj teeb meem metabolic hnyav tuaj yeem pom cov teebmeem feem ntau. Kev kho mob nce metabolic yooj. Qhov no ua rau cov zaub mov lipids yooj yim dua rau kev siv thiab tsis tshua muaj peev xwm khaws cia.
Ntev -Lub Sijhawm Metabolic Health Implications
Thaiv NNMT tuaj yeem pab koj hlawv rog sai thiab tiv thaiv cell aging thiab metabolic tsis ua haujlwm.
Kev kho mob qhib NAD+- txoj hauv kev, tshwj xeeb tshaj yog cov cim sirtuin, uas txhawb kev noj qab haus huv thiab kev ua neej ntev. Cov tshuaj tuaj yeem pab cov kab ke no ua haujlwm los daws qhov tseeb ua rau kev laus metabolic qeeb.
Kev kho mob ntev -lub sij hawm khaws cia cov leeg nqaij, kev paub txog kev ua haujlwm, thiab cov cim ua mob hauv cov qauv tsiaj laus. Cov txheej txheem pab kho cell, sib npaug ntawm cov protein, thiab kev ua mitochondrial. Cov ntaub ntawv no qhia tias kev txhim kho metabolic txhawb kev noj qab haus huv tshaj li kev rog.
Vim muaj kev hloov pauv ntawm kev tswj hwm epigenetic, cov tshuaj yuav muaj kev cuam tshuam ntev -. SIRT1 hloov histones los hloov cov noob qhia rau kev noj qab haus huv metabolic. Cov kev hloov pauv no tuaj yeem tshwm sim tom qab kho. Qhov kev rov pib dua tshiab no qhia tau tias luv luv li cas - hloov pauv lub sijhawm yuav ua rau ntev - cov txiaj ntsig metabolic, tab sis peb yuav tsum nkag siab ntau ntxiv.
Xaus
Cov kws tshawb fawb pom tias5 amino 1mq peptide txhajcuam tshuam cov roj metabolism ntawm cov cell sib sib zog nqus. Los ntawm lub hom phiaj NNMT thiab ua kom ntseeg tau tias muaj NAD +, txoj kev no pib hloov pauv metabolic uas txo qhov mob, hloov pauv rog, thiab ntxiv dag zog rau mitochondria. Cov kev tshawb fawb thaum ntxov qhia tias nws cuam tshuam rau lub cev qauv, cov ntsuas metabolic, thiab kev noj qab haus huv ntawm tes.
Cov tshuaj no ua haujlwm nrog lub cev tswj cov txheej txheem los pab tib neeg hauv qhov hnyav, tsis zoo li cov metabolism hauv- hloov tshuaj. Zoo li ua haujlwm tawm thiab noj tsawg dua, SIRT1, AMPK, thiab txoj hauv kev cuam tshuam tau qhib. Cov tshuaj zoo li pab koj lub cev noj qab haus huv metabolic xeev es tsis ua rau lawv.
Txhawm rau txiav txim siab lawv cov teebmeem thiab siv rau tib neeg, cov txiaj ntsig ntawm cov metabolism tseem raug kawm. Kawm txog cov xov tooj ntawm tes-tsuas yog qhov cuam tshuam, lawv cuam tshuam li cas rau koj lub neej, thiab ntev- cuam tshuam rau kev noj qab haus huv. Tam sim no peb paub ntau ntxiv, peb yuav tsum tau kawm yuav ua li cas cov khoom me me no cuam tshuam rau cov txheej txheem metabolic los pab lub cev poob rog.
FAQ
1. Dab tsi ua rau 5 Amino 1MQ Peptide Txhaum txawv ntawm cov tshuaj noj rog rog?
5 amino 1mq ua haujlwm los ntawm kev tso tseg NNMT enzyme, uas ua rau cov hlwb ib txwm ua ntau NAD+. Thiab qhov no tsis zoo ib yam li cov tshuaj uas siv cov tshuaj stimulants ua rau koj cov metabolism sai dua. Cov txheej txheem no pib ua rau lub cev cov txheej txheem metabolic, xws li SIRT1 thiab AMPK signalling, kom mitochondria ua haujlwm zoo dua thiab hlawv roj ntau dua. Txoj kev no hloov koj cov metabolism hauv txoj hauv kev uas zoo ib yam li qhov tshwm sim thaum koj txwv calories thiab ua haujlwm tawm. Nws tuaj yeem yog qhov ntev dua - txoj kev kav ntev thiab noj qab nyob zoo los pab kev tshawb fawb txog kev poob rog.
2. Yuav ua li cas cov compound cuam tshuam cov cim metabolic tshaj li qhov hnyav?
Cov kws tshawb fawb tau pom tias txwv tsis pub NNMT hloov cov metabolism hauv ntau txoj hauv kev, thiab nws tsis yog hais txog kev poob rog xwb. Cov kws tshawb fawb tau pom tias qhov kev nkag siab zoo ntawm insulin tau txhim kho ntau heev (40% nce hauv HOMA-IR Performance index), ceev cov piam thaj poob qis (22%), thiab cov cim mob tau ploj mus (53% poob hauv IL-6). Cov teebmeem metabolic dav no qhia tau hais tias cov compound ua ntau tshaj li tsuas yog txo cov rog rog; nws kuj kho cov teeb meem metabolic uas yog nyob rau hauv lub hauv paus ntawm qhov teeb meem. Qhov no tuaj yeem pab cov kws tshawb fawb kawm paub ntau ntxiv txog cov kab mob metabolic thiab lwm yam mob zoo li nws uas tau cim los ntawm insulin tsis kam thiab mob ntev.
3. 5 Amino 1MQ Peptide Txhaj Tshuaj Puas tuaj yeem txhim kho kev tawm dag zog thiab kev noj zaub mov zoo?
Muaj pov thawj los ntawm kev tshawb fawb preclinical uas NNMT inhibition thiab kev tawm dag zog tuaj yeem ua haujlwm ua ke kom pab tau. Cov kws tshawb fawb tau saib qhov sib txawv ntawm ib txoj hauv kev thiab cov txheej txheem uas tau siv ua ke. Lawv pom tias cov tsiaj uas tau txais kev kho mob thiab kev tawm dag zog tau txais 60% zoo dua ntawm lawv lub cev kev ua tau zoo, piv rau 20% zoo dua thaum lawv tsuas tau txais kev kho mob lossis 40% zoo dua thaum lawv tsuas tau txais kev tawm dag zog. Zoo dua mitochondrial ntau lawm thiab metabolic yooj yog ib feem ntawm cov txheej txheem. Qhov no ua rau kuv xav tias cov tshuaj tau txais cov tshuab hauv cov hlwb npaj ua kom muaj zog ntau dua rau cov teeb liab metabolic. Nws zoo nkaus li tias kev hloov pauv rau koj txoj kev ua neej yuav ntxiv rau cov txiaj ntsig ntawm kev tshawb fawb metabolic es tsis txhob coj lawv mus.
Koom tes nrog BLOOM TECH-Koj Trusted 5 Amino 1MQ Peptide Txhaj Muag Khoom
BLOOM TECH sawv ua tus thawj coj5 amino 1mq peptide txhajtus neeg muag khoom nrog ntau dua 12 xyoos ntawm kev paub hauv cov organic synthesis thiab kev tsim tshuaj nruab nrab. Peb GMP-cov chaw tsim khoom tau ntawv pov thawj raws li US-FDA, EU-GMP, JP-GMP, thiab CFDA cov qauv, kom ntseeg tau cov khoom zoo tshaj plaws rau koj cov kev tshawb fawb thiab kev tsim kho. Raws li cov neeg tsim khoom tsim nyog rau 24 thoob ntiaj teb kws tshuaj thiab R&D cov koom haum, peb muab cov nqi sib tw nrog kev tswj xyuas kom zoo-featuring triple- txheej tsom xam los ntawm lub Hoobkas QC, peb lub koom haum tshwj xeeb QA / QC, thiab thib peb- cov koom haum muab ntawv pov thawj.
Peb qhov kev cog lus txuas ntxiv dhau ntawm cov khoom lag luam zoo rau kev txhawb nqa cov neeg siv khoom, pob tshab tus nqi nrog cov nyiaj tau los ruaj khov, thiab cov sijhawm xa khoom raug tswj los ntawm peb lub platform ERP. Txawm hais tias koj xav tau kev tshawb fawb ntau lossis kev tsim khoom ntau, BLOOM TECH muab kev ntseeg siab, cov ntaub ntawv pov thawj, thiab kev txawj ntse uas koj xav tau. Txuas nrog peb pab neeg los tham txog yuav ua li cas peb 5 amino 1mq peptide txhaj tshuaj thiab cov khoom siv tshuaj lom neeg ntau tuaj yeem ua kom koj cov hom phiaj tshawb fawb metabolic. Tiv tauj peb hnub no ntawmSales@bloomtechz.comkom tau txais cov ncauj lus kom ntxaws cov khoom tshwj xeeb, cov lus sib tw, thiab cov kws tshaj lij kev sib tham ntawm koj cov kev xav tau tshwj xeeb.
Cov ntaub ntawv
1. Komatsu M, Kanda T, Urai H, et al. Kev ua kom NNMT tuaj yeem pab txhawb kev txhim kho cov kab mob rog rog los ntawm kev hloov kho NAD + cov metabolism. Kev Tshaj Tawm Txog Kev Tshawb Fawb . 2018; 8(1): 8637.
2. Kraus D, Yang Q, Kong D, et al. Nicotinamide N-methyltransferase knockdown tiv thaiv kev noj haus- ntxias rog rog. Xwm . 2014;508(7495):258-262.
3. Ulanovskaya OA, Zuhl AM, Cravatt BF. NNMT txhawb nqa kev hloov kho epigenetic hauv kev mob qog noj ntshav los ntawm kev tsim cov kab mob metabolic methylation dab dej. Nature Chemical Biology. 2013;9(5):300-306.
4. Hong S, Moreno-Navarrete JM, Wei X, et al. Nicotinamide N-methyltransferase tswj cov metabolism hauv hepatic nutrient los ntawm Sirt1 protein stabilization. Tshuaj kho mob xwm txheej . 2015;21(8):887-894.
5. Brandacher G, Winkler C, Aigner F, thiab al. Kev phais Bariatric tsis tuaj yeem tiv thaiv tryptophan depletion vim lub cev tsis muaj zog hauv cov neeg mob rog rog. Obesity Surgery. 2006;16(5):541-548.
6. Cantó C, Menzies KJ, Auwerx J. NAD + metabolism thiab tswj lub zog homeostasis: ib qho kev ntsuas ntsuas ntawm mitochondria thiab cov nucleus. Cell Metabolism. 2015;22(1:31-53.
