Kev sib tham nyob ib puag ncig kev noj qab haus huv thiab kev siv roj ntsha tau txais kev sib tw ntawm cov pab pawg tshawb fawb tshawb nrhiav cov kev xaiv tshiab rau kev tswj cov ntaub so ntswg adipose. Cov lus hais txog kev tshawb fawb zaum kawg yog ua raws li me me -molecule inhibitor muaj npe5 amino 1mq peptideuas thaiv nicotinamide N-methyltransferase (NNMT).

5-Amino-1MQ Peptide Txhaj Tshuaj

1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
(3) Txhaj tshuaj
(4) Capsules
(5) Kua dej
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Internal Code: KP-3-5/002
CAS Nr .: 42464-96-0
Cov mis mos molecular: C10H11N2.I
HS code: N/A
Molecular Luj: 286.11
EINECS tus lej: 464-196-0
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4

Cov kws tshawb fawb tab tom pib tshem tawm cov txheej txheem nyuaj uas tswj hwm adipocytes 'kev cia thiab tso tawm cov roj fatty acids, thiab kev tsis ntseeg tseem nyob ntawm seb qhov peptide no puas tuaj yeem cuam tshuam cov txheej txheem ntawm cov roj cellular. Txhawm rau kom nkag siab txog cov kev sib txuas ua tau zoo no, peb yuav tsum tshuaj xyuas cov txheej txheem molecular tswj hwm lipid mobilization thiab lub zog sib npaug.

Cov koom haum tshawb fawb tau tsom mus rau cov tshuaj uas tuaj yeem hloov pauv qhov hloov pauv ntawm triglycerides khaws cia rau hauv lub zog muaj txiaj ntsig los ntawm adipocytes. Lipolysis, enzymatic hydrolysis ntawm lipids kom dawb fatty acids thiab glycerol, yog ib feem tseem ceeb ntawm cellular zog tswj. Thaiv NNMT kev ua, cov kws tshawb fawb tau pom, tuaj yeem ua rau muaj kev hloov pauv hauv metabolic uas cuam tshuam li cas cov hlwb metabolise khaws cia lipids. Qhov kev nug no tau txheeb xyuas cov 5 amino 1mq peptide ua cov molecule ntawm qhov cuam tshuam hauv kev tshawb fawb metabolic, tshwj xeeb tshaj yog nyob rau hauv kev hwm rau nws txoj kev koom tes nrog lipolytic txoj kev.

Txoj hauv kev los ntawm kev soj ntsuam hauv chav kuaj mus rau kev paub tag nrho suav nrog kev kawm txog ntau theem ntawm cellular metabolism. Kev ua haujlwm enzyme, muaj coenzyme, kev hloov pauv ntawm cov tshuaj tiv thaiv kab mob metabolic Cov kev hloov pauv cuam tshuam rau lipolysis yog ib feem ntawm lub network nyuaj. Raws li kev tshawb fawb txuas ntxiv mus, cov kws tshaj lij tseem tab tom ntsuas seb NNMT inhibition puas yog cov txheej txheem ua tau los tshawb xyuas cov ntaub so ntswg adipose thiab cov txheej txheem ntawm cov rog rog.

NNMT Txoj Kev thiab Nws Qhov Tseem Ceeb Metabolic

Nicotinamide N-methyltransferase yog ib qho enzyme uas muaj nyob hauv cov rog, siab, nqaij thiab lwm qhov chaw. Cov enzyme no catalyses hloov dua siab tshiab ntawm nicotinamide rau 1-methylnicotinamide thiab S-adenosylhomocysteine ​​siv S-adenosylmethionine ua methyl pub. Lawv tau pom tias cov neeg rog rog uas muaj teeb meem metabolic muaj kev qhia ntau dua ntawm NNMT hauv lawv cov ntaub so ntswg adipose. Cov enzyme ua haujlwm nyob rau hauv ib txoj kev uas theem ntawm NAD + hauv hlwb zoo li hloov pauv. NAD + yog ib qho coenzyme uas pab hauv kev tsim hluav taws xob thiab thauj lipid hauv lub cev.

Yog li ntawd yog li cas NNMT txuas rau metabolic muaj nuj nqi. NNMT hloov cov theem ntawm NAD+ . Ua kom nicotinamide, ib lub tsev thaiv rau NAD+, muaj zog dua, nws hloov mus rau hauv cov ntawv methylated. Qhov no yuav qhia tau tias muaj cov substrates tsawg dua los tsim NAD+. Cov kws tshawb fawb xav tias qib qis ntawm NAD + tuaj yeem cuam tshuam rau sirtuin tsev neeg cov proteins, tshwj xeeb SIRT1. SIRT1 tswj cov kev qhia ntawm cov noob metabolic.

Nws pom tau tias NNMT kev ua haujlwm muaj kev cuam tshuam loj dua ntawm cov metabolism, xws li txoj kev adipocytes khaws thiab thauj cov rog.

5 amino 1mq peptide yog ib yam tshuaj uas thaiv NNMT hauv ib txoj kev. Cov kws tshawb fawb tau saib cov tshuaj no kom pom tias nws tuaj yeem ua rau NAD + qib siab hauv cov hlwb los ntawm kev txwv tsis pub muaj enzyme los ntawm methylating. Cov kws tshawb fawb tau siv cov qauv kuaj xyuas seb qhov kev txo qis no tuaj yeem pib cov txheej txheem uas vam khom NAD + thiab hloov lipids puas lawm. Lub tswv yim tom qab nws yog tias ua kom NAD + qib siab tuaj yeem pab mitochondria ua haujlwm zoo dua thiab tuaj yeem hloov pauv cov rog li cas thiab tawg hauv adipocytes.

Cellular Mechanisms Tom qab Fat Storage thiab tso tawm

Adipocytes yog cov hlwb tshwj xeeb uas tuaj yeem khaws thiab tso cov rog raws li lub cev xav tau. Cov hlwb no khaws cov rog thaum lawv muaj zog ntau dua li lawv xav tau. Cov txheej txheem no hu ua lipogenesis. Yog tias koj lub cev xav tau lub zog ntau dua li nws tuaj yeem tau txais los ntawm zaub mov,

Cov kws tshawb fawb pom cov noob muaj feem xyuam rau lipolysis thiab mitochondrial fatty acid oxidation ua haujlwm ntau dua, thaum cov noob uas ua rau muaj roj tsawg hauv kev ua haujlwm. Cov kws tshawb fawb xav tias peptide tuaj yeem hloov pauv li cas adipocytes cuam tshuam nrog cov rog hauv txoj hauv kev no, tab sis lawv tseem yuav tsum txheeb xyuas qhov tseeb ua rau-thiab- cuam tshuam kev sib txuas.

Hormone-Sensitive Mechanisms thiab Metabolic Signaling

Muaj ntau yam tshuaj uas ua haujlwm ua ke kom nruj tswj lipolysis. Cov no suav nrog catecholamines, insulin, natriuretic peptides, thiab lwm yam. Protein kinase A tau qhib thaum catecholamines khi rau beta-adrenergic receptors ntawm daim nyias nyias ntawm adipocytes. Qhov no pib tsim cov cyclic AMP. Hormone-sensitive lipase thiab perilipin proteins, uas npog cov lipid tee, yog phosphorylated los ntawm cov tshuaj tiv thaiv kab mob no. Enzymes tuaj yeem khaws cia triglycerides yooj yim dua li no. Insulin ua haujlwm rau lwm txoj kev. Nws ua rau phosphodiesterases ua haujlwm, uas rhuav tshem cov AMP cyclic thiab qeeb lipolysis.

Tsis tsuas yog ua cov kev tswj hwm ceev ceev tswj cov tshuaj hormones, lawv kuj tau teeb tsa lub peev xwm ntawm adipocytes kom zom cov rog. Enzymes uas zom cov rog yog qhib thiab tawm los ntawm cov receptors nuclear thiab cov khoom siv hloov pauv xws li peroxisome proliferator-activated receptors. Coenzymes, xws li NAD +, hloov txoj kev tswj hwm cov proteins, xws li sirtuins, ua haujlwm thaum lawv nyob. Cov proteins no tshem tawm tus nqi los ntawm cov khoom siv transcription thiab histone proteins.

Qhov no hloov txoj kev noob tau qhia nyob rau hauv txoj kev uas tseem ceeb rau cov metabolism. Los ntawm kev kawm cov5 amino 1mq peptide, cov kws tshawb fawb tau sim nrhiav seb puas yog NNMT txo qis hloov cov txheej txheem tswj hwm no. Cov kws tshawb fawb uas siv cov adipocytes loj hlob tau pom tias cov tshuaj tau hloov pauv ntawm cov khoom siv hloov pauv uas pab zom cov rog. Cov kev hloov pauv uas tau pom yog nyob rau hauv txoj kab nrog kev hloov pauv hauv cov metabolism uas ua rau nws hlawv rog zoo dua thiab khaws cia tsawg dua. Cov kws tshawb fawb xav tias txwv tsis pub NNMT yuav pab tau metabolic yooj, uas yog lub cev muaj peev xwm hloov pauv sai sai ntawm kev txuag thiab siv lipids raws li nws cov kev xav tau. Qhov no yog vim nws khaws NAD + qib siab.

Adipocyte Differentiation thiab Metabolic Phenotype

Adipocyte sib txawv nyob ntawm kev sib koom ua ke PPAR thiab C / EBP cov kev pabcuam kev hloov pauv, nrog NNMT kev nthuav qhia nce thaum lub sijhawm txhim kho. Cov kev tshawb fawb qhia tias NNMT inhibition nrog 5 amino 1mq txo cov cim adipogenic thiab triglyceride tsub zuj zuj, ua rau qeeb adipocyte tsim. Qhov no tuaj yeem hloov pauv cov rog- cov nqaij mos loj hlob, cov cellular muaj pes tsawg leeg, thiab kev ua haujlwm metabolic, txawm hais tias cov txheej txheem tseem nyob hauv kev tshawb nrhiav.

NAD + Muaj thiab Mitochondrial Fat Oxidation

NAD + muaj nyob rau hauv sirtuin -kev tswj hwm metabolic thiab mitochondrial fatty acid oxidation. Peb pom tias inhibiting NNMT nrog 5 amino 1mq yuav txhawb nqa cellular NAD + qib, mitochondrial ua pa thiab fatty acid oxidation, thiab lipid utilisation. Cov txiaj ntsig cuam tshuam txog NNMT inhibition rau qhov muaj peev xwm ntawm cov hlwb kom hlawv cov roj uas khaws cia rau lub zog.

Gene Expression Hloov hauv Lipid Metabolism

Inhibition ntawm NNMT tuaj yeem rov-txoj haujlwm lipid metabolism ntawm qib ntawm cov noob qhia. Muaj kev qhia ntau ntxiv ntawm lipolytic thiab oxidative noob thiab txo qis ntawm cov lipogenic noob, qhia txog kev hloov pauv ntawm cov rog rog. Cov kev soj ntsuam rov tsim dua tshiab no hauv cov qauv ntawm tes thiab tsiaj txhu muab pov thawj rau kev tswj hwm kev hloov pauv ntawm NAD+- txoj hauv kev, txawm tias tag nrho cov txheej txheem tseem tab tom tshawb nrhiav.

Kev siv hluav taws xob thiab Thermogenic Potential

Ntxiv nrog rau inducing lipolysis thiab rog oxidation, NNMT inhibition yuav cuam tshuam rau tag nrho cov kev siv hluav taws xob. Cov txiaj ntsig sib txawv tab sis kev tshawb fawb nrog 5 amino 1mq qhia txog kev nthuav tawm ntawm mitochondrial thiab oxidative noob, thiab kev siv zog me me. Cov kev tshawb fawb ntxiv yuav tsum tau ua kom paub meej nws cov teebmeem thermogenic thiab lub cev - cov txheej txheem metabolic tshwj xeeb.

Lub Metabolic Push-Pull of Lipid Balance

Qhov sib piv ntawm lipids yog txiav txim los ntawm kev sib cuam tshuam ntawm lipogenesis, lipolysis thiab oxidation. Lub zog xav tau tsav cov rog rog, thaum lub zog siab ua rau muaj roj cia. Kev tshawb fawb qhia tau hais tias NNMT inhibition los ntawm 5 amino 1mq ib txhij tuaj yeem nce oxidative txoj hauv kev thiab txo cov kev ua lipogenic, ua rau muaj kev sib koom ua ke metabolic uas yuav ua tau zoo dua hauv kev txo cov ntaub so ntswg adipose.

Insulin Sensitivity thiab Metabolic Flexibility

Kev rog rog -kev sib koom ua ke ntawm insulin tsis kam cuam tshuam cov metabolic yooj los ntawm kev txo qis insulin lub peev xwm los tswj lipolysis thiab txhim kho cov roj fatty acid tso tawm thiab txo cov rog. Cov kev tshawb fawb tau pom tias NNMT inhibition los ntawm 5 amino 1mq tuaj yeem txhim kho cov piam thaj hauv siab thiab insulin rhiab heev, txawm tias los ntawm kev txo qis adipose lipolysis thiab o.5 amino 1mq peptide. Cov kev tshawb fawb ntxiv yuav tsum tau piav qhia txog qhov cuam tshuam ntawm daim siab thiab cov leeg.

Inflammatory Signaling thiab Metabolic Dysfunction

Kev rog rog yog txuas rau adipocyte hypertrophy, uas txhawb kev mob, cytokine secretion, macrophage infiltration thiab insulin tsis kam, yog li cuam tshuam rau cov roj metabolism.

Qhov inhibition ntawm NNMT los ntawm 5 amino 1mq tau pom tias yuav txo qis adipose o thiab inflammatory signaling thiab tej zaum yuav txhim khu lipolysis. Cov teebmeem metabolic ntawm NNMT yuav tsum nkag siab los ntawm kev sib cuam tshuam ntawm NNMT, NAD + metabolism thiab txoj hauv kev inflammatory.

Kev sim cov qauv thiab kev tshawb fawb txoj kev

Hauv kev tshawb fawb metabolic, lipid metabolism yog kawm ntawm ntau qib lom neeg siv hauv vitro, tsiaj txhu thiab ex vivo qauv. Adipocyte kab lis kev cai tso cai rau kev kawm txog noob caj noob ces, metabolic flux, lipolysis, signaling thiab enzyme kev ua haujlwm raws li kev tswj hwm. Cov qauv tsiaj ntsuas cuam tshuam rau tag nrho cov kab mob thaum cov ntaub so ntswg explants khaws kev sib cuam tshuam ntawm cov hlwb thiab kuaj cov lipolysis tsim los ntawm cov tshuaj lossis cov tshuaj hormones.

koob tshuaj -Kev Sib Raug Zoo thiab Kev Kho Mob Ntev

Kev tshuaj xyuas koob tshuaj yog ua nyob rau hauv NNMT inhibitor kev tshawb fawb kom pom cov koob tshuaj zoo thiab taug qab cov tshuaj lom. Qhov ncauj thiab intraperitoneal ntau npaum li cas los ntawm milligrammes mus rau kaum milligrammes ib kilogram thiab kho los ntawm ib koob mus rau ntau lub lis piam tau siv nyob rau hauv kev tshawb nrhiav tsiaj. Cov kev cuam tshuam luv luv - lub sij hawm yuav ua rau ntev dua - lub sij hawm hloov pauv hauv cov rog rog thiab kev noj qab haus huv hauv metabolic.

Kev txiav txim siab txog kev txhais lus thiab tshawb nrhiav qhov khoob

NNMT inhibition muaj txiaj ntsig zoo metabolic hauv cov tsiaj kuaj, txawm li cas los xij cov tsiaj sib txawv tuaj yeem txwv kev txhais lus rau tib neeg. Qhov tsis sib xws tseem ceeb yog cov txheej txheem, kev siv kho mob tsim nyog, kev nyab xeeb mus sij hawm ntev thiab cov lus teb rau tus kheej. Ntau tus tib neeg- kev tshawb fawb ntsig txog, ua tib zoo kuaj thiab ntsuas kev pheej hmoo, thiab kev tswj hwm yog xav tau ua ntej siv kho mob.

Cov kws tshawb fawb tau kawm txog5 amino 1mq peptidethiab pom qee qhov kev sib txuas nthuav dav ntawm kev txwv NNMT thiab qhov sib txawv ntawm cov hlwb siv cov rog li cas. Cov kev sim tau pom tias thaiv cov enzyme no tuaj yeem hloov qhov sib npaug ntawm seb cov roj khaws cia lossis txav mus los. Qhov no tuaj yeem tshwm sim los ntawm kev hloov pauv NAD + uas nkag mus tau, txoj kev mitochondria ua haujlwm, txoj kev cov noob tau nthuav tawm, lossis cov teeb liab uas ua rau mob. Hauv cov qauv tsiaj, kev tshawb fawb tau pom tias NNMT inhibitors tsa qhov kev qhia ntawm cov noob uas zom cov rog, ua kom cov rog hlawv, thiab txo qis cov rog rog.

Vim tias cov txiaj ntsig no, tam sim no peptide tuaj yeem siv los kawm txog kev tswj cov metabolism thiab kev noj qab haus huv ntawm cov nqaijrog. Nws tau pom tias cov teebmeem hloov ntau theem ntawm kev tswj hwm, los ntawm kev ua haujlwm ntawm cov enzymes thiab cov teeb liab ntawm cov hlwb mus rau cov kev pabcuam transcriptional thiab lub cev tag nrho lub zog sib npaug. Qhov no qhia tau hais tias yuav ua li cas intricate lub webs uas tswj cov roj metabolism. Raws li kev tshawb fawb mus ntxiv, nws yuav ua tau kom tau txais lub tswv yim zoo ntawm cov khoom ua haujlwm li cas, cov xwm txheej zoo tshaj plaws rau kev sim, thiab yog tias lawv tuaj yeem siv rau lwm qhov xwm txheej.

Peb xav tau ntau ntxiv hauv - kev tshawb fawb tob, ua tib zoo txhais cov txiaj ntsig ntawm kev sim, thiab kev paub txog cov txheej txheem lom neeg nyuaj npaum li cas thiaj li nkag siab txog cov metabolism. Tam sim no peb paub ntau ntxiv txog nws, NNMT zoo li yog qhov txuas nthuav hauv cov tes hauj lwm uas tswj cov metabolism. Hauv chav kuaj, thaiv nws muaj qhov ntsuas tau ntawm lipid metabolism. Qhov no tsuas yog qhov pib ntawm peb txoj kev kawm rau hauv cov txheej txheem no thiab lawv yuav txhais li cas rau kev tshawb fawb metabolism.

Cov kws tshawb fawb thiab cov lag luam biotech uas kawm txog cov txheej txheem metabolic thiab adipose cov ntaub so ntswg biology yuav tsum muaj peev xwm mus tas li tau txais lawv txhais tes ntawm siab -cov tshuaj tshawb fawb zoo txhawm rau ua kom muaj kev tshawb fawb. Kpeptide yog ib lub tuam txhab uas tsuas yog ua5 amino 1mq peptides. Lawv muaj keeb kwm ntawm kev ua peptides thiab tshuaj me me. US FDA, EU, Nyiv, thiab Tuam Tshoj tau kuaj xyuas peb 100,000-square-meter GMP-certified chaw tsim khoom thiab pom tias nws ua tau raws li cov qauv zoo. Qhov no ua kom paub tseeb tias txhua pawg ua tau raws li cov kev xav tau nruj rau kev tshawb fawb lub hom phiaj.

Peb tuaj yeem ua ntau hom kev tshawb fawb, xws li NMR pov thawj, HPLC, thiab huab hwm coj spectrometry. Kev lees paub zoo tuaj nyob rau hauv peb daim ntawv: kuaj hauv cov nroj tsuag, tshuaj xyuas los ntawm peb tus kheej QA / QC pab pawg, thiab kev pom zoo los ntawm peb tus neeg sab nrauv. Qhov no yog qhov kev tshawb fawb metabolic xav tau. Peb tuaj yeem muab ntau dua lossis sib npaug rau 98% cov khoom ntshiab, cov ntaub ntawv tag nrho los rov qab koj cov kev sim, thiab ntau yam kev xaiv ntim tau yooj yim uas tau tsim kom haum rau cov kev xav tau ntawm kev tshawb fawb metabolic. Peb pab pawg kws tshaj lij tau ua haujlwm hauv kev tsim cov organic thiab kev tsim tshuaj lom neeg rau ntau tshaj 12 xyoos. Lawv tuaj yeem pab koj npaj cov kev sim thiab muab cov lus qhia rau koj ua haujlwm nrog tshuaj.

24 pawg neeg txawv teb chaws tso siab rau Kpeptide ua tus xa khoom vim nws muaj cov khoom lag luam ruaj khov, tus nqi tsim nyog nrog cov qauv tsim nqi, thiab txias -chain logistics uas ua kom cov khoom sib xyaw kom zoo. Cov kws tshawb fawb tuaj yeem tsom mus rau kev tshawb pom kev tshawb fawb es tsis txhob mus yuav khoom vim tias peb ib qho - nres kev pabcuam ua rau nws yooj yim dua rau kev yuav khoom. Peb tuaj yeem pab koj nrog koj cov kev tshawb fawb txog NNMT inhibition thiab kev tswj cov metabolic, txawm tias koj xav tau me me rau cov kev tshawb fawb yooj yim lossis ntau npaum li cas rau kev sim mus ntev -.

Peb pab neeg tshawb fawb tuaj yeem hu rau ntawmsales@kpeptide.com los tham txog koj cov kev xav tau kev tshawb fawb, thov daim ntawv pov thawj ntawm kev tshuaj xyuas, lossis tau txais cov khoom lag luam tag nrho rau 5 amino 1mq peptide thiab cov kev tshawb fawb txog metabolic.

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