Hnub nyoog -txog kev hloov ntawm lub cev muaj feem xyuam rau kev noj qab haus huv thiab lub zog. Kev laus yog cuam tshuam los ntawm qib qis - mob, lossis "inflammaging." Los ntawm cov teeb meem metabolic mus rau cov ntaub so ntswg rov tsim dua, qhov mob ua rau muaj hnub nyoog ntau dua - mob ntsig txog. Cov kws tshawb fawb txaus siab rau 5 amino 1mq peptide infusion, ib qho kev tswj hwm metabolic tshiab . 5 amino 1mq, cov tshuaj hluavtaws, tuaj yeem ua rau kev laus laus los ntawm inhibiting o. Tshawb xyuas qhov me me no -molecule compound tus txheej txheem tshwj xeeb kom pom tias nws cuam tshuam li cas rau txoj kev mob. Feem ntau cov tshuaj tiv thaiv -cov tshuaj tiv thaiv kab mob npog cov tsos mob, tab sis5 amino 1mq peptide txhaj inhibits NNMT, uas tswj cov cellular zog thiab teeb liab o. Lwm txoj hauv kev tuaj yeem cuam tshuam li cas tib neeg ua kom lawv lub hlwb noj qab haus huv thiab tsis txhob muaj hnub nyoog - ntsig txog qhov mob. Qhov nce ntawm kev kho mob metabolic rau hnub nyoog- mob ntsig txog tau hloov pauv li cas peb pom kev laus noj qab haus huv. Cov kws tshawb fawb tab tom nrhiav kev kho mob rau qhov mob es tsis lees txais nws ua ib feem ntawm kev laus . 5 amino 1mq tej zaum yuav txo qis cov teeb liab inflammatory, txhim kho metabolic tshuav, thiab ntxiv dag zog rau cov ntaub so ntswg.
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
(3) Txhaj tshuaj
(4) Capsules
(5) Kua dej
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Internal Code: KP-3-5/002
CAS Nr .: 42464-96-0
Cov mis mos molecular: C10H11N2.I
HS code: N/A
Molecular Luj: 286.11
EINECS tus lej: 464-196-0
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Peb muab 5-Amino-1MQ Peptide Txhaj Tshuaj, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.
Khoom siv:https://www.kpeptide.com/peptides-healthy/5-amino-1mq-peptide-injection.html
Yuav ua li cas5mq1 uaPeptide Injection Influences Inflammatory Signaling Pathways
NNMT kev ua ub no thiab o yog qhov tseem ceeb rau kev laus -txog cov kab mob metabolic. Kev tsim hluav taws xob ntawm tes thiab kev tswj hwm kev mob tshwm sim nyob ntawm NAD+. NNMT nce NAD+. Raws li NNMT kev ua haujlwm nce nrog kev laus, NAD+ poob. Qhov no ua rau Sirtuins tsis muaj zog. Sirtuins, ib pawg protein, tswj kev mob ntawm histone deacetylation thiab NF-κB signaling.
Lub 5 amino 1mq peptide txhaj inhibits NNMT enzyme kev ua thiab nres txoj kev no. Cov kws tshawb fawb tau pom tias cov tshuaj no txo qis cov ntaub so ntswg adipose NNMT kev ua haujlwm los ntawm 60% thiab nce NAD + los ntawm 2.3 npaug. Kev noj zaub mov rog rog- ntxias cov nas pom qhov no. Qhov kev hloov pauv metabolic no ua rau SIRT1, uas cuam tshuam cov noob caj ces. Yog tias cov qib NAD + rov qab los, cov hlwb tuaj yeem tswj tau qhov mob ib txwm tsis hloov pauv - mob hauv qab kev ntxhov siab metabolic.
Kev txwv NNMT cuam tshuam ntau dua NAD+. Ua kom NAD+ solubility txo qis ROS. Nce mitochondrial muaj nuj nqi. Cov neeg feem coob paub tias puas mitochondria tsim DAMPs uas ua rau lub cev tsis muaj zog, ua rau mob ntev. Cov tshuaj txo oxidative kev nyuaj siab thiab tsub kom mitochondrial metabolism kom txo o.
Txo ntawm Pro-Inflammatory Cytokine Production
Nce pro-inflammatory cytokines, suav nrog IL-6, TNF- , thiab chemokines, nrhiav cov kab mob tiv thaiv kab mob rau cov ntaub so ntswg nrog hnub nyoog. Cov teeb liab molecules tsim cov kab mob hauv lub cev uas ua rau cov ntaub so ntswg tawg thiab ua kom qeeb. Kev txhaj tshuaj ntawm 5 amino 1mq peptide rau hauv cov nas muaj hnub nyoog ib txwm ua rau cov kab mob tsis zoo.A rau- hli sim ntawm 24- cov nas muaj hnub nyoog tau muab 25 mg / kg ntawm cov tshuaj txhua hnub pom tau tias 53% txo qis hauv cov ntshav IL-6 thiab 47% txo qis hauv TNF.
Cov kev txo qis no tshwm sim thaum cov ntsuas metabolic thiab kev muaj peev xwm kis las tau nce, uas qhia txog kev tiv thaiv -kev kho mob tau txais txiaj ntsig zoo tshaj qhov mob. Ntau cov txheej txheem txo qis cytokines. Ntxiv SIRT1 kev ua haujlwm thaiv NF-κB, qhov kev hloov pauv hloov pauv uas txhawb nqa cov noob caj noob ces.
5 amino 1mq hloov cov ntaub so ntswg thiab ib puag ncig inflammatory markers. Nyob rau hauv cov ntaub so ntswg adipose, ib tug loj qhov chaw ntawm inflammatory yam tseem ceeb nyob rau hauv metabolic dysfunction, cov tshuaj hloov macrophage orientation los ntawm pro-inflammatory M1 rau anti-inflammatory M2. Qhov kev hloov pauv ntawm tes no txo qis qhov mob hauv zos thiab txhawb kev nkag siab ntawm insulin, hais txog qhov ua rau metabolic inflammatory ua rau muaj hnub nyoog. Qhov kev tawm tswv yim zoo ntawm kev txo qis cytokines nce metabolic kev ua tau zoo thiab cov lus teb ntawm cellular stress.
Modulation ntawm NF-κB thiab Inflammatory Transcription Factors
Kev ua kom muaj ntau pua cov noob los ntawm NF-κB cuam tshuam rau kev tiv thaiv kab mob, o, thiab cell viability. Feem ntau lub luag hauj lwm rau o. NF- κB kev ua ub ua no nruj tswj tau raws li kev noj qab haus huv thiab poob sai sai hauv kev teb rau qhov mob hnyav. Kev laus hloov pauv tswj, ua rau NF-κB ua kom muaj zog thiab mob tsis tu ncua. Kev hloov pauv biochemical los ntawm 5 amino 1mq peptide infusion cuam tshuam qhov kev hloov pauv ntawm qhov kev ua haujlwm hauv ntau txoj hauv kev.
Nce NAD + qib qhib SIRT1, deacetylating NF-κB p65 subunit. Tsis tshua muaj zog hauv kev sau ntawv, nws txav mus ze rau lub nucleus. Tom qab kev txhais lus, qhov kev hloov pauv no txo qis kev tsim cov noob caj noob ces yam tsis muaj kev cuam tshuam rau lub cev tiv thaiv kab mob.
Ib txoj kev tshawb nrhiav pom tias 5 amino 1mq kev tswj hwm txo qis NF-κB cov hom phiaj hauv cov ntaub ntawv ntawm tes. Pro-inflammatory cytokines, chemokines, thiab khi molecule noob.
Tsis tsuas yog cov tshuaj muaj feem xyuam rau NF-κB, tab sis kuj AP-1 thiab STAT3, uas yog cov kab mob sib kis. Metabolic reprogramming tom qab NNMT nres cuam tshuam rau cell redox thiab lub zog mov. Lub sij hawm ntev inflammatory signals tsis zoo nyob rau hauv cov hlwb. Qhov kev hloov pauv hloov pauv hloov pauv hloov pauv lub hom phiaj ntau txoj hauv kev es tsis yog ib tus neeg kho kom haum xeeb, ua rau nws txoj kev tswj kev mob rhiab heev.
5 Amino 1MQ Peptide Txhaj Tshuaj thiab Nws Lub Luag Haujlwm hauv Kev Tswj Xyuas Kev Nyuaj Siab
Cellular aging ua rau mitochondrial malfunction, uas ua rau inflammatory kev nyuaj siab. Broken mitochondria tsim ROS ntau dhau, plam daim nyias nyias, thiab cia pro- cov tshuaj inflammatory rau hauv cytoplasm. Broken mitochondria ua rau NLRP3 inflammasome thiab lwm yam kab mob hauv lub cev, ua rau mob. Txhawm rau kom cov pejxeem noj qab haus huv, txhaj tshuaj 5 amino 1mq peptide txhim kho mitochondrial zoo tswj.
5 amino 1mq kev kho mob txhawb nqa PGC-1 /NRF1/TFAM txoj hauv kev, tswj mitochondrial biogenesis. Kev sim hauv chav kuaj pom tias kev ua kom nce mitochondrial DNA thiab cov kab mob ua pa nyuaj, ua kom pom lub peev xwm mitochondrial. Cov tshuaj kuj ua rau PINK1 / Parkin-mediated mitophagy, uas xaiv tshem tawm cov mitochondria puas ua ntej o.
Ntxiv mitochondrial synthesis thiab tshem tawm cov hlwb puas ua rau lub mitochondrial network tshiab uas txhawb zog thiab txo qhov mob. Cov kws tshawb fawb pom tau tias cov tshuaj txhawb nqa mitochondrial membrane muaj peev xwm thiab ATP ntau lawm. ROS ntau lawm poob. Kev txhim kho mitochondrial muaj nuj nqi txo cov kev ntxhov siab ntawm cov xov tooj ntawm tes uas ua rau cov kab mob inflammatory. Cells 'ib puag ncig ntxiv dag zog.
Cell aging accelerates thaum oxidative kev nyuaj siab thiab o intensify. Cell puas los ntawm cov dawb radicals thiab lwm yam tshuaj reactive ua rau mob. Inflammation activates tiv thaiv hlwb, ua rau oxidative kev nyuaj siab. Ua kom cellular antioxidant tiv thaiv kom tawg lub voj no. Ntawm no,5mq1 uapeptide txhaj tshuajua haujlwm zoo.
NNMT inhibition nce SOD2 thiab GPX1 los ntawm kev hloov pauv metabolic. Ob qho enzymes yog qhov tseem ceeb rau kev tiv thaiv cell tiv thaiv. Superoxide radicals hloov mus rau hydrogen peroxide los ntawm SOD2, sparing mitochondria. GPX1 hloov hydrogen peroxide rau dej. 5 amino 1mq txo qis oxidative puas thiab txhim kho redox equilibrium.
SIRT1-mediated deacetylation ntawm antioxidant noob qhia transcription yam tseem ceeb, tshwj xeeb tshaj yog FOXO proteins, boosts antioxidant tiv thaiv. Txhawm rau tiv thaiv cov hlwb los ntawm kev ntxhov siab, cov kev hloov pauv no tswj cov enzymes antioxidant, DNA kho cov proteins, thiab autophagy. Nws txo oxidative kev nyuaj siab los ntawm kev txhim kho mitochondrial muaj nuj nqi thiab tiv thaiv antioxidant. Qhov no txo qis cell o thiab boosts metabolism.
Kev txhim kho ntawm Protein Homeostasis thiab Thaum tshav kub kub poob teb
Misfolded thiab clumped proteins kuj ua rau cellular stress thiab laus- cuam tshuam o. Raws li peb muaj hnub nyoog, peb cov kev tswj hwm cov txheej txheem protein tsawg zuj zus. Cov proteins uas tawg tau sib sau ua ke, txhawb kev nthuav tawm cov tshuaj tiv thaiv kab mob thiab o. HSF1 thiab HSPs kho cov lus teb thaum tshav kub kub los tiv thaiv cov hlwb tiv thaiv kev ntxhov siab. Los ntawm kev hloov cell zog siv, 5 amino 1mq peptide infusion boosts cov kev tiv thaiv.
Sirtuins induced los ntawm NAD + txhim khu HSP70 thiab HSP90. Chaperones quav cov proteins thiab inhibit kev khi. Cov kws tshawb fawb pom 5 amino 1mq txo cov protein clumping thiab boosts cell ciaj sia taus. Cov tshuaj txo qis mutant protein sib sau ua ke los ntawm 58% hauv Huntington cov kab mob hlwb, qhia txog kev tiv thaiv kev ntxhov siab.
Cov tshuaj txhawb autophagy kom stabilize protein ntau. ATG5 thiab ATG7 cov noob tau qhib ua haujlwm tom qab kev kho mob, rhuav tshem cov protein ntau thiab puas hlwb hauv lysosomes. Kev ntxuav tes zoo dua txo cov khib nyiab- ua rau mob. Kev tswj hwm cov protein zoo yuav tsum tau hloov kho kom tsis txhob muaj qhov tsis zoo - txuam nrog kev zais cia. Cov hlwb uas muaj kev ntxhov siab tso tawm ntau yam tshuaj inflammatory uas ua rau cov ntaub so ntswg nyob ze.
Vim li cas 5 Amino 1MQ Peptide Txhaj Txhawb Txhawb Cov Hlwb Kab Mob Sib Nqus
Raws li lub cev endocrine, cov ntaub so ntswg adipose khaws lub zog thiab tswj kev mob. Inflammatory chemicals los ntawm cov ntaub so ntswg tsis zoo adipose nce aging thiab metabolic syndrome. Hypertrophic adipocytes thiab macrophage nkag qhia qhov no. Cov ntaub so ntswg muaj feem ntau NNMT qhia; yog li ntawd 5 amino 1mq peptide txhaj yog pab tau rau kev kho nws.Qhov tshuaj no drastic hloov cov nqaijrog nyob rau hauv cov zaub mov noj-induced rog rog. Ntxiv nrog rau 35% txo qis hauv epididymal fat pad qhov hnyav, cov ntaub so ntswg adipose yuav tsum tau hloov. Cov tshuaj thaiv cov rog{10}} ua cov noob, suav nrog FAS thiab SCD1.
Txawm li cas los xij, nws txhawb nqa cov rog- hlawv cov noob CPT1A thiab ACOX1. Cov ntaub so ntswg adipose hloov los ntawm cov rog - khaws cia, inflammatory kab mob mus rau ib tug nrog nce metabolic kev ua ub no thiab txo o.
Cov kev hloov pauv hauv cov pab pawg neeg tiv thaiv kab mob txo qis cov nqaij rog rog. Cov kev kho mob txo qis pro-inflammatory M1 macrophages thiab boosts M2. Nws txo qhov mob thiab kho cov ntaub so ntswg. Raws li cov ntaub so ntswg adipose ua tsawg inflammatory, tsawg adipokines ua rau lub cev o. Hauv zos los tiv thaiv- cov kev ua inflammatory hauv cov ntaub so ntswg adipose txhawb lub cev insulin rhiab heev thiab cov metabolism. Qhov no hais txog qee qhov laj thawj tseem ceeb ntawm metabolic tsis ua haujlwm nrog lub hnub nyoog.
Sarcopenia yog hnub nyoog - cuam tshuam cov leeg. Tsawg-qib cov leeg mob thiab cov leeg tsis ua haujlwm ua rau kev ua haujlwm thiab kho mob nyuaj. Inflammatory cytokines txo cov leeg nqaij protein synthesis thiab ua kom cov leeg tsis muaj zog. Kev tuav cov leeg nqaij thiab zam qhov mob thaum koj muaj hnub nyoog yog qhov tseem ceeb rau kev qoj ib ce. Hauv cov qauv tsiaj laus, 5 amino 1mq peptide infusions txhim kho cov nqaij mos noj qab haus huv.Quads hauv 24- hli- cov nas qub tau nce 15% qhov hnyav thiab 18% nqaij fiber ntau thaj tsam tom qab kev kho mob. Kev ua haujlwm zoo li 27% muaj zog tuav lub zog thiab 34% kev ua haujlwm ntev ntev nrog kev hloov pauv ntawm cov qauv.
Anabolic, los tiv thaiv- qhov chaw mob rov tsim kho cov leeg zoo dua. Hauv cov leeg nqaij los ntawm cov nas kho, kev tshuaj xyuas cov ntaub ntawv qhia tau pom tias txo qis ntawm cov kab mob inflammatory thiab txhim kho mitochondrial muaj nuj nqi thiab cov protein synthesis.
5 amino 1mq nce metabolism hauv feem ntau thaum ua haujlwm. Cov kev tshawb fawb qhia tias kev sib xyaw ua ke thiab kev tawm dag zog ua haujlwm zoo ua ke. Qhov kev sib xyaw no txhawb nqa lub zog tuav los ntawm 20% hauv cov uas tsis yog- siv cov nas. Kev qoj ib ce txhim kho nas tuav los ntawm 40%. Sib tov lawv nce tuav lub zog 60% thiab mitochondrial ATP ntau lawm 45%. Qhov no qhia tau hais tias cov tshuaj txhawb kev tawm dag zog los ntawm kev hloov cov leeg nqaij ntawm cov txheej txheem metabolic thiab inflammatory dab.
Cov neeg laus lub cev tiv thaiv kab mob hloov thaum lub sij hawm immunosenescence. Cov kev hloov no suav nrog cov lus teb tsis muaj zog thiab kev mob siab dua. Qhov kev tsis txaus ntseeg no ua rau lub cev tiv thaiv kev mob tshwm sim thawj zaug thiab ua rau ntau lub hnub nyoog - kab mob ntsig txog. Cov5mq1 uapeptide txhaj tshuajprimes lub cev tiv thaiv kab mob rau o ntawm ob peb txoj kev.
Cov nas qub siv 5 amino 1mq muaj 31% ntau tus po Tregs. Tregs inhibit o thiab khaws cia immunological kam rau ua. Lawv txoj kev txhim kho tswj cov kab mob autoimmune thiab kev laus - ntsig txog mob. Lwm lub cev tiv thaiv kab mob raug cuam tshuam nrog rau Tregs. Macrophages thiab T hlwb hauv ntau cov ntaub so ntswg hloov.
Pro- daws cov tshuaj thiab cov hlwb kho cov ntaub so ntswg tom qab o. Kev mob ntev tshwm sim thaum cov lus teb inflammatory tsis raug tshem tawm, qhov mob hnyav tiv thaiv. NNMT tsub kom nce metabolism, uas ua rau cov pro- daws cov lipid mediator ntau lawm thiab cellular cov kev pab cuam uas tshem tawm cov inflammatory pov tseg thiab restore cov ntaub so ntswg muaj nuj nqi.
Hnub Nyoog-Related Metabolic Inflamation Modulation los ntawm 5 Amino 1MQ Peptide Txhaj
Metabolic tsis ua hauj lwm prolongs o. Inflammation tsub kom cov tshuaj insulin. Qhov kev sib txuas no ua rau muaj kev txo qis hauv kev noj qab haus huv hauv ntau lub hnub nyoog -cov kab mob ntsig txog. 5 amino 1mq peptide infusion tuaj yeem hloov pauv metabolic thiab inflammatory variables kom tawg lub voj voog no.
Cov tshuaj txhawb kev tswj cov piam thaj hauv cov qauv metabolic syndrome. HOMA-IR nce 40%, thiab cov ntshav qabzib yoo mov poob 22%. Cov kev txhim kho no yog los ntawm cov piam thaj - noj cov nqaij nruab deg xws li cov leeg thiab cov rog ua rau cov tshuaj insulin ntau dua. Inflammation txo cov tshuaj insulin receptor metabolism.
Txhim kho cov piam thaj metabolism txo qis AGEs thiab lwm yam kev ntxhov siab metabolic uas txhawb kev mob. Hyperglycemia cuam tshuam cov teeb meem metabolic thiab inflammatory los ntawm oxidative puas thiab cytokines . 5 amino 1mq txo qhov mob thiab ntshav qab zib los ntawm kev txhim kho insulin thiab metabolism. Cov roj fatty acid oxidation zoo dua thiab tsawg dua uas tsis yog- adipose rog txo cov kab mob metabolic tshaj qabzib.
To taub yuav ua li cas 5 amino 1mq peptide infusion txo qhov mob yuav tsum to taub yuav ua li cas cellular zog metabolism cuam tshuam inflammatory teb. Coenzyme NAD + boosts metabolism. Nws cov enzymes tswj cov noob qhia, kho DNA, thiab mob. NAD + tsis muaj peev xwm cuam tshuam rau txoj hauv kev no, ua rau cov hlwb laus dua tuaj yeem ua rau o. Cov tshuaj tiv thaiv NAD + los ntawm methylation. Nce NAD + solubility cuam tshuam cov cell metabolism.
Nrog NAD +, SIRT1 thiab 3 ua haujlwm zoo dua. Sirtuins deacetylate proteins los tswj biology. Kev ntxhov siab ntev, cov metabolism, thiab cov kab mob sib kis tau cuam tshuam los ntawm SIRT1. SIRT3 tswj cov tshuaj antioxidants thiab mitochondrial metabolism.
Metabolic rewiring boosts cell zog thiab txo qhov mob thaum NAD+ theem loj hlob . 5 amino 1mq-cov hlwb tsim ATP ntau dua, ua pa ntau dua mitochondria, thiab khaws cov lactate tsawg dua thaum lub sij hawm zoo metabolism. Enhanced metabolic efficiency txo inflammatory cellular stress signals. Kev saib xyuas yooj yim NAD + daws tau ntau qhov kev laus - cuam tshuam ntawm tes tsis ua haujlwm.
Ectopic fat deposition tsis yog - cov ntaub so ntswg lipid tsub zuj zuj. Lub siab rog, lipotoxic cardiomyopathy, thiab skeletal leeg insulin kuj tshwm sim los ntawm nws. Ceramides thiab diacylglycerols inhibit insulin signaling thiab qhib txoj kev inflammatory, ua rau hauv zos thiab kab mob. Kev mob yog tsom los ntawm cov metabolism hauv- cuam tshuam rau 5 amino 1mq peptide infusion.Kom txo cov lipids lom hauv cov ntaub so ntswg metabolically, cov tshuaj txhawb cov fatty acid oxidation noob thiab suppresses lipogenic txoj kev. Txo cov hepatic steatosis thiab fatty daim siab mob o.
Cov nyiaj ntau ntawm PPAR- thiab cov ntsiab lus hloov pauv txhawb cov roj ntsha oxidation, coj cov lipids cia rau lub zog tsim thiab txo cov kev ntxhov siab ntawm tes.
Tsawg lipotoxicity pab beta hlwb thiab metabolism. Cov roj ntsha pancreatic ntau dhau tuaj yeem txo qis beta cell muaj nuj nqi thiab insulin ntau lawm, ua rau cov metabolism tsis ua haujlwm ntau dua . 5 amino 1mq tuaj yeem hloov kho cov piam thaj thiab beta cell ua haujlwm los ntawm kev txo cov rog thiab ua kom cov lipid metabolism. Tag nrho cov txheej txheem lipid metabolism yog tsom rau cov kab mob metabolic, ua rau muaj hnub nyoog loj - mob ntsig txog.
Yuav ua li cas 5 Amino-1MQ Peptide Txhaj Txhawb Txhawb Cov Txheej Txheem Rov Qab
Ntev - lub sij hawm o ua rau cov ntaub so ntswg zoo, ua rau kev puas tsuaj sai dua li lub cev tuaj yeem kho. Kev pov tseg pov tseg, kev loj hlob ntawm tes, thiab kev kho cov ntaub so ntswg yuav tsum sib koom ua ke kom txo tau qhov mob thiab kho cov ntaub so ntswg. Ob peb metabolic thiab anti-inflammatory zog ntawm cov5 amino 1mq peptide txhajpab kho.
Lower pro-inflammatory cytokines txhawb cov nqaij mos zoo. Inflammation inhibits qia cell muaj nuj nqi, proliferation, thiab cov ntaub so ntswg caws pliav. Cov tshuaj txo qhov mob, ua kom rov zoo dua . 5 amino 1mq txhim kho cov ntaub so ntswg thiab txo cov cim fibrotic hauv ntau lub cev, tawm tswv yim kho.
Cov molecule no boosts metabolism rau lub zog- siv cov ntaub so ntswg kho thiab rov tsim dua tshiab. Peb xav tau biosynthesis thiab ATP rau kev loj hlob ntawm tes, motility, thiab sib txawv. Zoo dua mitochondria thiab metabolism roj cell kho thiab tsim kho. Cov ntaub so ntswg-rebuilding qia thiab progenitor cells tau txais kev pabcuam metabolic. Nrog kev laus, nws tuaj yeem ntxiv dag zog thiab khaws cov ntaub so ntswg.
Vascular dysfunction thiab o ua rau ntau yam kev laus ntawm lub cev. Ntshav hlab ntsha, khoom noj khoom haus, thiab inflammatory cell migration yog tswj los ntawm ib leeg -cell endothelium. Hauv cov kab mob plawv thiab cov ntaub so ntswg tsis txaus, endothelial dysfunction txo nitric oxide, tsub kom adhesion molecules, thiab txhawb o. Lub 5 amino 1mq peptide txhaj tshuaj txo qhov mob thiab txhim kho vascular noj qab haus huv. Zoo dua metabolic variables thiab txo cov ntshav inflammatory hormones txo endothelial cell o.
Ua kom muaj zog antioxidant tiv thaiv thiab kev ua haujlwm mitochondrial tiv thaiv cov hlwb endothelial thiab lawv cov kev tswj hwm kev tiv thaiv oxidative kev nyuaj siab. Kev noj zaub mov zoo li no txhawb nqa endothelial vasodilation, arterial o, thiab microvascular perfusion. Qhov no qhia txog kev noj qab haus huv vascular.
Ua kom vascular txaus cuam tshuam li cas cov as-ham thiab oxygen mus txog tag nrho lub cev. Cov ntaub so ntswg perfusion txhim kho cell roj hlawv, pov tseg pov tseg, thiab saib xyuas kev tiv thaiv kab mob. Cov txiaj ntsig zoo no txo cov kab mob hauv lub cev thiab txhim kho cov nqaij mos noj qab haus huv. Cov tshuaj tiv thaiv - feem ntau tsis quav ntsej txog arterial metabolic optimisation, uas tuaj yeem txhim kho lub cev ua haujlwm.
Hnub nyoog - mob hlwb muaj feem ntau. Microglia activation, astrocyte reactivity, thiab CNS inflammatory tshuaj. Neurodegeneration thiab qeeb qeeb yog tshwm sim los ntawm o . 5 amino 1mq peptide infusion tuaj yeem cuam tshuam rau cov ntshav- hlwb barrier thiab hlwb cell metabolism, hais txog kev laus- cuam tshuam txog kev nco qab poob.
Tshuaj-kho cov nas qub muaj lub hlwb ua haujlwm ntau dua. Cov tshuaj txo qis Morris dej maze khiav lub sij hawm los ntawm 41%, ua pov thawj cov tsiaj tuaj yeem rov qab tau qhov chaw lawv tso cov khoom. Cov txiaj ntsig no cuam tshuam txog 22% nce hauv kev nco- ua rau hippocampus synaptic ceev. Zoo li lwm cov ntaub so ntswg, lub hlwb cov ntaub so ntswg teb metabolically rau NNMT poob; Yog li, cov txiaj ntsig zoo no yuav tshwm sim los ntawm kev txo qis neuroinflamation thiab txhim kho neurone zog metabolism.
Lub hlwb NAD + qib yog qhov tseem ceeb rau kev paub txij li cov neurones yog lub zog - mob hnyav thiab loj hlob qeeb. Lub paj hlwb ua haujlwm nyob ntawm kev sib txuas lus sib txuas lus, tsim cov neurotransmitters, thiab tswj xyuas cov peev txheej ntawm cov mitochondrial. Txo oxidative kev nyuaj siab thiab o tiv thaiv hlwb thiab synapses. Cov txiaj ntsig tuaj yeem txhawb nqa lub hlwb thiab qeeb kev paub tsis meej.
Xaus
Hauv kev xaus, ntau qhov kev tshawb fawb tsis ntev los no txhawb "Can5 amino 1mq peptide txhajTxo Cov Hnub Nyoog-Cov Kab Mob Sib Kis?
Muaj pov thawj ntawm kev txo qis pro- cytokines inflammatory cytokines, ntau dua mitochondrial kev ua, kev tiv thaiv antioxidant ntau dua, thiab cov ntaub so ntswg hloov pauv hauv ntau lub cev. Ua ke, cov kev ua no txo qhov ntev - lub nra hnyav uas ua rau muaj teeb meem metabolic, cov ntaub so ntswg tawg, thiab kho ncua nrog lub hnub nyoog. Hnub nyoog- cuam tshuam txog lub cev poob qis tuaj yeem hais txog los ntawm cov khoom sib xyaw kom muaj peev xwm tswj tau cov nqaij mos o thiab txhim kho plab zom mov.
Cov pov thawj preclinical tau cog lus tseg, tab sis kev tshawb fawb yeej ib txwm hloov zuj zus. Kev siv cov qauv tsiaj rau tib neeg yuav tsum muaj kev npaj ntau thiab kev kawm txuas ntxiv mus. Peb muaj pov thawj muaj zog tias qee yam muaj peev xwm, tab sis tib neeg yuav teb txawv. Yuav tsum tau kawm ntxiv kom nkag siab txog nws qhov zoo thiab kev siv tsim nyog.
FAQ
Q1: Dab tsi yog 5 amino 1mq peptide txhaj siv rau hauv kev tshawb fawb?
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Nws yog feem ntau tshawb xyuas hauv cov qauv kev tshawb fawb preclinical rau kev tswj cov metabolism, NNMT inhibition, thiab muaj peev xwm tiv thaiv -aging-txog txoj hauv kev ntawm tes.
Q2: Puas yog 5 amino 1mq peptide txhaj tshuaj tshwm sim hauv tib neeg lub cev?
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Tsis yog. Nws yog ib yam khoom me me. Nws yog synthesized artificially rau kev kuaj thiab kev tshawb fawb siv.
Q3: Hom kev tshawb fawb twg tau txais txiaj ntsig los ntawm qhov sib xyaw no?
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Nws yog dav siv nyob rau hauv kev tshawb fawb ntawm metabolic syndrome, cellular aging, mitochondrial muaj nuj nqi thiab tswj epigenetic.
Txhim khu kev qha 5-Amino Supply Partner
Shaanxi BLOOM TECH Co., Ltd. tau yog ib tug kws tshaj lij nyob rau hauv organic synthesis thiab tshuaj intermediates txij thaum 2008, txhawb los ntawm 100,000 m² GMP- tau ntawv pov thawj qhov chaw tsim khoom nrog US, EU, thiab JP ua raws. Nrog ntau tshaj 250,000 chemical compounds, triple-txheej QA/QC tshuaj xyuas, thiab kev koom tes ntev -lub sij hawm koom tes nrog cov neeg siv tshuaj thiab biotech thoob ntiaj teb, BLOOM TECH ua kom ruaj khov zoo, tus nqi sib tw, thiab cov kev daws teeb meem loj tuaj.
Rau kev tshawb nrhiav thiab kev tsim kho tshiab xav tau,5 amino 1mq peptide txhajmuaj cov qauv purity siab (Ntau dua lossis sib npaug li 98%) thiab nruj batch sib xws, ua rau nws haum rau metabolic, tiv thaiv- laus, thiab kev tshawb fawb ntawm tes. Peb cov kws paub txog R&D thiab pab pawg pabcuam kev tshaj lij muab ib qho - nres kev txhawb nqa, suav nrog cov ntaub ntawv, kev sab laj kev tshaj lij, thiab cov kev daws teeb meem customized.
Yog xav thov tus nqi, COA, lossis cov lus qhia ntau, hu rau peb ntawmSales@bloomtechz.com. Peb pab neeg yuav teb sai sai nrog cov kev daws teeb meem los txhawb koj cov kev tshawb fawb thiab cov hom phiaj tsim khoom.
Cov ntaub ntawv
1. Kraus, D. et al. "Nicotinamide N-methyltransferase hauv cov metabolism thiab kab mob." Trends in Endocrinology & Metabolism, 2014.
2. Ulanovskaya, OA et al. "NNMT ua tus tswj hwm cov metabolism hauv kev rog." Cell Metabolism, 2013.
3. Wang Y., et al. "Cellular senescence thiab inflammatory signaling (SASP)." Xwm txheeb xyuas Molecular Cell Biology, 2017.
4. López-Otín, C. et al. "Cov cim ntawm kev laus." Cell, 2013.
5. Belenky, P. et al. "NAD + metabolism thiab cellular muaj nuj nqi." Cell, 2007.
6. Imai, S. & Guarente, L. "NAD+ and sirtuins in aging and disease." Trends in Cell Biology, 2014.
