5 Amino 1MQ Peptide Txhaj rau Metabolic Health Optimization

Yuav tsum muaj txoj hauv kev tshiab los kho cov teeb meem kev noj qab haus huv hauv metabolic uas tau txais mus rau lub hauv paus ua rau lub zog dysregulation. Nws yog ib txoj hauv kev tshiab kom ceev koj cov metabolism kom tau txais5mq1 uapeptide txhaj tshuaj. Hauv qib cellular, nws hloov pauv li cas lub cev ua haujlwm nrog thiab siv zog. NNMT yog ib qho enzyme uas tseem ceeb heev rau cov roj metabolism hauv lub cev, lub zog ntawm tes, thiab kev ua haujlwm tag nrho ntawm cov metabolism. Tus txiv neej no- ua cov tshuaj molecule me me mus tom qab NNMT.

Nws tuaj yeem pab kom poob phaus, cuam tshuam nrog cov tsos mob metabolic syndrome, thiab tau txais lub zog ntau dua thaum koj muaj hnub nyoog yog tias koj paub tias cov txheej txheem metabolic ua haujlwm li cas thiab yuav ua li cas kom lawv ua haujlwm zoo dua. Tsis zoo li lwm yam kev kho mob uas tsuas yog zais cov tsos mob, qhov sib xyaw no hloov pauv txoj kev ntawm cov tshuab metabolic ua haujlwm. Qhov no ua rau lub cev muaj zog ntau lawm thiab siv tau zoo nyob rau lub sijhawm ntev.

 

5-Amino-1MQ Peptide Txhaj Tshuaj

1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
(3) Txhaj tshuaj
(4) Capsules
(5) Kua dej
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Internal Code: KP-3-5/002
CAS Nr .: 42464-96-0
Cov mis mos molecular: C10H11N2.I
HS code: N/A
Molecular Luj: 286.11
EINECS tus lej: 464-196-0
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4

Peb muab 5-Amino-1MQ Peptide Txhaj Tshuaj, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.

Khoom siv:https://www.kpeptide.com/peptides-healthy/5-amino-1mq-peptide-injection.html

Lub 5 amino 1mq peptide txhaj tshuaj hloov kev siv zog. Kev txhaj tshuaj hloov pauv metabolism los ntawm tshwj xeeb cuam tshuam rau NNMT enzyme kev ua haujlwm. Lub enzyme NNMT tswj NAD + qib. Ntau cov txheej txheem metabolic hauv lub cev xav tau NAD+. Nicotinamide depleted, thiab NAD + uptake txo nrog NNMT kev ua. Cov metabolism qeeb ua rau nws nyuaj rau cov hlwb los tsim lub zog.

NNMT raug thaiv los ntawm 5 amino 1mq, tab sis nicotinamide tseem tuaj yeem tsim NAD+. NAD+ nce hauv hlwb. Thaum NAD + nce, cov proteins uas ntsiag to, suav nrog SIRT1, uas tswj hwm cov metabolism hauv nruab nrab, qhib. Sirtuins tswj mitochondrial ntau lawm, piam thaj tawg, rog hlawv, thiab circadian atherosclerosis.

Cov qauv tshawb fawb uas ua rau tib neeg rog dhau ntawm cov zaub mov qhia txog cov txheej txheem no hauv lub neej tiag tiag. Cov nas tau muab 50 mg / kg ib hnub rau yim lub lis piam tau hloov pauv metabolic txawv txawv. Lawv muaj 230% ntau NAD + hauv lawv cov rog dawb, tab sis 60% tsawg dua NNMT kev ua. Cov kev hloov pauv hauv metabolic no hloov pauv tib neeg cov tsos. Lawv qhov hnyav poob 18% thiab lawv cov nqaij rog pubic poob qis 35%.

Qhov kev hloov ntawm lub cev no ua ntau dua li pab koj poob phaus. Tom qab sawv los, cov piam thaj txo qis 22%, thiab HOMA- tus qhab nia IR, uas ntsuas cov tshuaj insulin tsis kam, nce 40%. Lub cev ua insulin ntau dua -sensitive. Cov kev hloov kho no qhia tias cov hlwb ua haujlwm zoo dua rau cov teeb liab insulin thiab siv cov piam thaj, kho cov teeb meem metabolic es tsis npog lawv.

Txhim kho mitochondrial muaj nuj nqi yog lwm qhov tseem ceeb metabolic reset kauj ruam. Qee cov neeg kho mob muaj 150% ntau dua mitochondrial DNA. Qhov no qhia tau hais tias muaj zog mitochondrial biogenesis. Ncaj qha boosting mitochondria txhim kho lub zog efficiency. Qhov no ua rau cov hlwb ntau ATP los ntawm cov peev txheej thiab cov khoom siv hluav taws xob tsawg dua.

Adipose ntaub so ntswg metabolic hloov

Cov rog khaws lub zog thiab tswj cov tshuaj hormones thiab metabolism. Lub 5 amino 1mq peptide txhaj tshuaj hloov cov noob qoob loo, rov tsim cov nqaij rog. Tig cov noob lipogenic zoo li FAS thiab SCD1 tiv thaiv lawv los ntawm kev ua cov roj ntsha tshiab los ntawm cov calories ntau dhau.

Fatty acid-siv cov noob kuj tau qhib. Qhov no boosts CPT1A, ib qho enzyme uas txav fatty acids mus rau hauv mitochondria rau hlawv. Thawj theem yog fatty acid tawg los ntawm ACOX1. Nws siv li no. Cov ntaub so ntswg adipose tso tseg cov rog thiab pib siv lub zog txav mus thoob plaws lub cev vim qhov hloov pauv ntawm cov qauv no.

Txhua yam ntawm lub cev raug cuam tshuam los ntawm kev hloov pauv tshuaj lom neeg rog. Raws li cov rog rog dhau los ua metabolically active, lawv tsim cov tshuaj inflammatory tsawg thiab ntau cov teeb liab molecules. Vim tias qhov kev hloov pauv no, cov ntaub so ntswg adipose thiab lwm cov kab mob physiological sib txuas lus zoo dua. Nws streamlines lub cev tshuaj cov txheej txheem.

Systemic Glucose Homeostasis Txhim Kho

Systemic glucose homeostasis tau zoo dua nrog5mq1 uapeptide txhaj tshuaj. Ib qho zoo dua metabolism ntawm qabzib yog lwm qhov cim qhia tias koj lub cev metabolism ua haujlwm zoo dua. Cov piam thaj nkag mus rau hauv cov hlwb uas muaj cov insulin tsawg dua thaum lawv nkag siab ntau dua rau insulin. Qhov no ua rau nws yooj yim dua los tswj cov ntshav qab zib thiab txo qis kev ntxhov siab ntawm cov txiav. Txhawm rau ua qhov no zoo dua, muaj ntau cov piam thaj thauj khoom, cov tshuaj insulin receptors uas tuaj yeem sib tham tau zoo dua, thiab lub siab tuaj yeem tswj tau lawv cov qib qabzib zoo dua.

Kev txwv NNMT tshwj xeeb yog qhov zoo rau kev ua haujlwm ntawm lub siab. Qab zib, rog, thiab proteins yog tsim los ntawm lub siab. Nws tseem yog lub luag haujlwm rau cov metabolism. Sirtuins nyob rau hauv daim siab tau qhib thaum NAD + qib nce. Qhov no pab khaws gluconeogenesis hauv kev kuaj xyuas thiab txwv tsis pub lub cev ua cov piam thaj ntau dhau thaum nws tsis noj. Cov lipid metabolism hauv daim siab kuj tau zoo dua, yog li cov roj cholesterol tsawg dua, thiab ntau cov roj fatty acids raug hlawv.

Skeletal Muscle Metabolic Capacity

Skeletal leeg lub peev xwm los hlawv rog yog txhim kho. Qhov loj tshaj insulin- cov ntaub so ntswg rhiab heev hauv lub cev yog cov leeg, uas kuj yog qhov chaw uas feem ntau ntawm lub cev cov piam thaj khaws cia. Kev txhim kho metabolic hauv cov leeg nqaij hloov pauv li cas lub cev siv cov piam thaj thiab lub zog hauv txoj kev loj. Cov kws tshawb fawb tau tshawb pom tias kev kho cov leeg nqaij nrog 5 amino 1mq nce cov mitochondria thiab cov pa oxygen uas lawv siv tau. Qhov no ua rau nws yooj yim dua rau cov fibers los hloov cov piam thaj thiab fatty acids rau hauv lub zog.

Muaj qhov tshwj xeeb zoo kawg nkaus rau cov leeg nqaij hauv cov qauv uas tau laus dua. Tus ntoo khaub lig- ntu ntu ntawm cov leeg nqaij loj hlob 18%, tus nqi ntawm oxidative hom I nqaij fibers sawv, thiab cov leeg tau txais 15% loj dua tom qab rau lub hlis ntawm kev kho mob. Nrog rau cov kev hloov pauv no rau cov qauv, kuj tseem muaj kev txhim kho rau nws ua haujlwm li cas. Piv txwv li, koj tau txais 27% muaj zog nyob rau hauv koj tuav thiab 34% muaj zog ntawm lub treadmill. Cov kev txhim kho no tshwm sim vim tias mitochondria ua rau ATP ntau dua, thiab cov substrates tau hloov tau ntau dua.

Zog Substrate Siv Flexibility

Koj yuav tsum ntiav cov khoom noj sib txawv raws li koj lub cev xav tau kom muaj kev noj qab haus huv metabolism. Thaum tag nrho, lub cev noj qab haus huv hlawv cov piam thaj thiab khaws lub zog hauv glycogen thiab rog. Thaum yoo mov lossis ua haujlwm tawm, koj lub cev yuav tsum tau yooj yim hloov mus rau kev siv cov roj ntsha uas khaws cia rau lub zog thaum tseem muab cov piam thaj rau cov hlwb.

Tsis muaj peev xwm hloov cov substrates yog qhov ua tsis tiav ntawm cov metabolism. Kev zom cov roj fatty acid yog qhov nyuaj hauv cov tshuaj insulin- cov neeg mob tiv taus. Qhov no ua rau cov lipids sib sau hauv daim siab thiab cov leeg tsis muaj rog. Cov rog ntau ua rau cov tshuaj insulin tsis zoo thiab cov metabolism hauv qabzib. Qhov no pib lub voj voog tsis tu ncua metabolic.

Los ntawm txhaj 5 amino 1mq, mitochondrial oxidative muaj peev xwm nce. Kev ua haujlwm zoo ntawm cov tshuaj insulin restores substrate yooj. Cov cell tam sim no tuaj yeem zom cov piam thaj thiab cov rog yooj yim dua, tiv thaiv cov kab mob metabolic thiab cov lipids tsis zoo. Cov kev tshawb fawb ntawm noob caj noob ces qhia tias glycolysis thiab beta - oxidation enzymes ua haujlwm ntau dua.

Inflammatory Pathway Modulation

Ntev -lub sij hawm qis- qib o yog txuas rau metabolic syndrome, insulin tsis kam, thiab kev laus sai dua. Thaum cov nqaij rog yog mob, pro- cov kab mob cytokines raug tso tawm, thiab cov macrophages txav mus rau hauv. Qhov no muaj kev cuam tshuam ncaj qha rau cov teeb liab insulin thiab kev ua haujlwm metabolic. Ib lub xeev ntawm o ua rau oxidative kev nyuaj siab thiab cell puas tsuaj thiab ua kom metabolic poob.

Muaj ntau txoj hauv kev uas thaiv NNMT tuaj yeem pab txo qhov mob. SIRT1 tau qhib thaum muaj ntau NAD + nkag tau. Tom ntej no, SIRT1 tshem tawm ib pawg acetyl los ntawm cov khoom siv nuclear-kappa B (NF-κB), uas txwv tsis pub cov noob qoob loo uas ua rau mob. Cov kws tshawb fawb tau pom tias cov cim inflammatory hauv cov ntshav poob los ntawm qhov ntau. Anti-inflammatory IL-6 qib poob los ntawm 53%, thiab TNF- qib poob los ntawm 47% hauv cov nas laus uas tau kho.

Circadian Metabolic Rhythm Coordination

Peb lub cev cov txheej txheem lom neeg ua raws li tus qauv tsis tu ncua ntawm nruab hnub thiab hmo ntuj. Nws yog ib qho yooj yim los npaj yuav ua li cas peb lub cev yuav siv zog, tsim cov tshuaj hormones, thiab zom cov zaub mov thaum lub sij hawm no. Kev laus dua, ua haujlwm hloov pauv, lossis muaj kab mob metabolic tuaj yeem cuam tshuam koj lub suab circadian. Qhov no tuaj yeem ua rau koj lub cev noj qab haus huv thiab ua rau koj muaj mob ntau dua.

Natural changes in NAD+ levels are caused by circadian rhythms. This tells biological processes inside cells what time it is. Since sirtuin activity is tied to NAD+, it also changes with the hours and helps make sure that metabolic gene expression is in sync with the daily cycles. Adding 5 amino 1mq may help improve daily metabolic rhythms by making more NAD+ available. This makes it easier for metabolic processes to work together at the right time.

Mitochondrial Health Preservation

Ib qho laj thawj tseem ceeb vim li cas cov metabolism qeeb qeeb nrog lub hnub nyoog yog tias mitochondria tsis ua haujlwm zoo. Rau mitochondria ua kom muaj ntau cov pa oxygen reactive (ROS) thiab tsis txaus ATP yuav phem. Qhov no ua rau bioenergetics tsis ua haujlwm zoo thiab ua rau oxidative kev nyuaj siab. Txhua lub hlwb hauv lub cev tsis muaj peev xwm ua tau lawv txoj haujlwm vim qhov kev puas tsuaj rau mitochondria.

Thaiv NNMT rau ib lub sij hawm ntev pab mitochondria noj qab nyob zoo nyob rau hauv ib tug xov tooj ntawm txoj kev uas tag nrho cov txuas. Muaj ntau NAD+ tig rau PGC-1, uas yog qhov tseem ceeb uas tswj tau li cas mitochondria ua hluav taws xob. Qhov no pab ua kom cov mitochondria tshiab ua haujlwm. Thaum qhov no tab tom mus, PINK1 / Parkin-mediated mitophagy ua rau cov tshuab uas tswj hwm qhov zoo ntawm mitochondria ua haujlwm zoo dua.

Kev ntsuam xyuas kev kho mob nrog cov5mq1 uapeptide txhaj tshuajuas kav rau rau lub hlis qhia tau hais tias cov cim ntawm mitochondrial muaj nuj nqi ua kom zoo dua. Lub mitochondrial membrane muaj peev xwm nce mus txog 35% hauv cov hlwb uas tau kho piv rau cov hlwb uas tsis kho. Antioxidant tiv thaiv enzymes zoo li superoxide dismutase 2 (SOD2) thiab glutathione peroxidase 1 (GPX1) nyob siab thaum lub sijhawm kho. Qhov no tiv thaiv oxidative kev puas tsuaj los ntawm kev tsim.

Cellular Stress Resistance Enhancement

Resilient cells yog txuas nrog rau kev noj qab haus huv metabolic. Nws txhais tau hais tias cov hlwb tuaj yeem daws thiab rov qab los ntawm cov kev ntxhov siab sib txawv, xws li oxidative puas, protein misfolding, thiab kev hloov pauv hauv cov as-ham. Kev laus thiab teeb meem metabolic ua rau lub hlwb tsis muaj peev xwm los tawm tsam kev ntxhov siab. Qhov no cia kev puas tsuaj tsim nyob rau hauv lub hlwb.

Rau cov lus teb kev ntxhov siab kom ua haujlwm tau zoo, txoj hauv kev uas nyob ntawm NAD + tseem ceeb heev. Kev ua kom sov cov proteins, pib ntawm autophagy, thiab kho DNA yog txhua yam tswj los ntawm sirtuins. Los ntawm kev ua kom NAD + qib siab, 5 amino 1mq tshuaj pab cov txheej txheem tiv thaiv no ua haujlwm zoo dua. Thaum qhov hluav taws kub poob siab qhov tseem ceeb 1 (HSF1) yog qhib, nws ua rau cov khoom ntawm molecular chaperones (HSP70 thiab HSP90). Qhov no pab cov protein ntau yooj yim dua thiab txwv tsis pub cov protein ntau txaus ntshai los ntawm kev tsim.

Ib txoj hauv kev los ua kom cov hlwb tiv taus ntau dua rau kev ntxhov siab yog txhawm rau txhawb kev ntws ntawm autophagy. Thaum kho, gene qhia txog autophagy (ATG5, ATG7) nce mus. Qhov no pab rhuav tshem thiab rov siv cov khoom puas ntawm tes. Qhov no zoo dua ntxuav hauv cov hlwb nres kev tsim cov qauv tawg thiab cov proteins uas ua rau cov metabolism thiab ua rau mob.

Epigenetic Stability Maintenance

Kev hloov pauv hauv epigenetics, xws li DNA methylation thiab kev hloov kho histone, cuam tshuam li cas cov noob tau tsim. Kev laus thiab kev ntxhov siab hauv metabolic ua rau txoj hlab pas, qhov twg cov kev hloov pauv tau tawm ntawm tes dhau sijhawm. Cov noob thiab cov hlwb yuav tsis ua haujlwm zoo vim qhov no. Sirtuins thiab PARPs yog ob qho piv txwv ntawm cov enzymes uas xav tau NAD + ua haujlwm. Lawv ncaj qha hloov histones thiab tswj DNA methylation qauv.

Vim tias SIRT1 pab histone H3K9 deacetylate, cov qauv heterochromatin nyob ruaj khov, thiab cov noob uas tsis ua haujlwm raug raug muab tso tseg. Los ntawm kev txwv NNMT, uas nce tus nqi ntawm NAD + muaj, cov txheej txheem kev saib xyuas epigenetic ua haujlwm zoo dua. Cov qauv ntawm kev laus sai heev yog siv hauv kev tshawb fawb los qhia tias epigenetic stabilization ua haujlwm li cas hauv lub neej tiag tiag.

Nws tau pom tias 5 amino 1mq txo qis ntawm cov cheeb tsam chromatin txawv txav los ntawm 41% thiab ib nrab kho cov qauv qhia cov qauv thaum nws siv. Tus naj npawb ntawm gamma-H2AX qhov chaw thiab lwm yam cim ntawm DNA puas poob los ntawm 54%. Qhov no txhais tau hais tias kev ruaj ntseg ntawm caj ces tau khaws cia zoo dua.

ATP Production Efficiency Enhancement

Txhua lub hlwb khaws lub zog ntawm ATP. Nws powers feem ntau cov txheej txheem, los ntawm cov leeg nqaij ua kom muaj protein ntau. Feem ntau ATP yog tsim los ntawm mitochondrial oxidative phosphorylation. Cov txheej txheem no txuas nrog cov khoom noj oxidation ntawm electron thauj. ATP ntau lawm nyuaj dua yam tsis muaj mitochondria.

Thaiv NNMT txhim kho cov saw hlau thauj hluav taws xob thiab mitochondria, tso cai rau kev tsim cov ATP sai dua. Cov kev tshawb fawb qhia tias5mq1 uapeptide txhaj tshuajthiab kev tawm dag zog nce mitochondrial ATP ntau lawm los ntawm 45%. Txhim khu kev sib txuas ua haujlwm kom tsim tau ntau lub zog.

Txoj kev kho no txo ​​mitochondrial proton to. Qhov no boosts zaub mov oxidation thiab ATP tiam. Txij li qhov no tau kho, cov hlwb yuav tsim ntau lub zog nrog tib cov roj. Muaj pes tsawg oxygen siv los tsim ATP tiv thaiv tshav kub?

Cellular Redox Balance Optimization

Vim mitochondrial respiration thiab lwm yam oxidative kev ua ub no, hlwb yeej ib txwm muaj reactive oxygen hom. ROS muab cov lus thaum tsis txaus, tab sis ntau dhau ua rau DNA, proteins, thiab lipids. Vim muaj teeb meem metabolic thiab kev laus, cov tshuaj tiv thaiv antioxidant tsis tuaj yeem tshem tawm ROS ntau dhau, ua rau muaj kev ntxhov siab oxidative.

Ntau yam cuam tshuam rau NAD + ntau lawm thiab redox equilibrium. NADH thiab NADPH enzymes xav tau NAD+. Cov no txo ​​cov hwj chim antioxidants. Glutathione kho thiab txo thioredoxin nrog ntau NAD + pab cov hlwb hauv kev tawm tsam dawb radicals.

ROS tiam txo qis thaum lub tshuab xa hluav taws xob thauj khoom ua haujlwm zoo dua vim tias mitochondria tuaj yeem tswj tau zoo dua. Nce mitochondrial autophagy tshem tawm mitochondria puas uas tsim ROS, thaum mitochondrial biogenesis tsim kev ua haujlwm, ua pa - chained mitochondria. Qhov kev sib xyaw no txhim kho ROS signaling thiab txo cov oxidative kev nyuaj siab.

Metabolic Signaling Pathway Coordination

Zoo -cov teeb liab sib koom tes saib xyuas cov cell metabolism hauv kev loj hlob, lub zog, thiab kev noj haus. Cov tes hauj lwm no kho metabolic txaus raws li. Cov ntsuas biochemical tseem ceeb suav nrog mTOR, sirtuin proteins, thiab AMPK. Metabolic tsis ua hauj lwm cuam tshuam cov teeb liab tes hauj lwm. Qhov no cuam tshuam lub cev teb.

Ntau NAD + ntxiv dag zog rau AMPK taw qhia ncaj qha thiab tsis ncaj. AMPK ua kom cov cell -degrading cov txheej txheem xws li fatty acid oxidation thiab autophagy. Protein synthesis thiab lipogenesis qeeb qeeb. Qhov kev hloov kho metabolic no tiv thaiv cov tshuaj lom thiab sib npaug zog.

Kev cob qhia kev tawm dag zog thiab inhibiting NNMT ua kom pom kev sib cuam tshuam ntawm txoj hauv kev. Ob qho kev cuam tshuam ua haujlwm zoo ua ke dua li sib cais. Piv txwv li, tuav lub zog nce 60% thaum kev tawm dag zog thiab kev kho mob siv ua ke, tab sis tsuas yog 40% lossis 20% thaum siv ib leeg. Txoj kev AMPK/PGC-1 tau txhawb ntxiv los ntawm kev sib xyaw ua ke no.

Cov5mq1 uapeptide txhaj tshuajyog ib txoj hauv kev zoo los txhim kho kev noj qab haus huv hauv metabolic vim nws ua haujlwm ntawm cov hlwb 'txoj kev lub zog yooj yim. Qhov sib xyaw no thaiv NNMT tshwj xeeb, uas ua rau ntau NAD + muaj. Qhov no hloov mus rau sirtuins thiab txhim kho cov piam thaj homeostasis, mitochondrial muaj nuj nqi, cov metabolism hauv cov ntaub so ntswg adipose, thiab lub peev xwm ntawm cov hlwb los daws kev ntxhov siab. Cov cim kab mob ua rau poob qis, lub cev lub cev tau zoo dua, kev nkag siab ntawm insulin tau zoo dua, cov leeg nqaij thiab kev ua haujlwm nce mus, thiab muaj ntau yam txiaj ntsig uas kev tshawb fawb tau pom. Metabolic rewiring tuaj yeem ua tau ntau yam, los ntawm kev muab cov hlwb lub zog los tswj cov metabolism hauv lub cev. Los ntawm kev kho qhov ua rau metabolic tsis ua haujlwm es tsis yog cov cim qhia xwb, qhov no pab tau. Ntau thiab ntau tus neeg thoob ntiaj teb muaj teeb meem nrog lawv cov metabolism. Nws zoo li kev kho mob uas tsom mus rau cov txheej txheem tswj hwm tseem ceeb yuav pab txhim kho kev noj qab haus huv hauv metabolic hauv txoj hauv kev uas kav ntev.

Bloom Tech yog lub tuam txhab tham nrog yog tias koj xav nrhiav cov5mq1 uapeptide txhaj tshuajrau kev kawm, kev loj hlob, lossis muag. Lawv tau ua cov tshuaj molecules thiab tshuaj intermediates rau ntau tshaj 12 xyoo, uas txhais tau tias lawv tuaj yeem pab koj. Peb cov chaw tsim khoom, uas yog 100,000 square metres thiab GMP- ntawv pov thawj, ua tau raws li US-FDA, EU-GMP, PMDA, thiab CFDA cov qauv. Yog tias koj ua li no, koj tuaj yeem paub tseeb tias txhua pawg ua tau raws li cov qauv kev coj dawb huv thiab kev sib haum xeeb rau kev siv tshuaj. CDMOs, cov tuam txhab biotechnology, thiab cov pab pawg tshawb fawb nyob ntawm peb rau peb cov khoom lag luam ruaj khov, cov ntaub ntawv txheeb xyuas tag nrho, thiab pab nrog cov cai. Peb qhov kev lees paub zoo muaj peb theem: kev sim hauv lub Hoobkas, kev tshuaj xyuas los ntawm peb tus kheej QA / QC pab pawg, thiab ntawv pov thawj los ntawm peb tus neeg sab nrauv. Tsis tas yuav txhawj xeeb thaum koj yuav tshuaj los ntawm lwm lub tebchaws los ntawm BLOOM TECH vim tias peb tus nqi yog qhov tseeb, peb lub ERP platform ua raws sijhawm tos kom raug, thiab peb muaj cov pab pawg txhawb nqa kev pabcuam uas muab ib qho - ntawm- ib qho kev pabcuam. Npaj los tham txog yam koj xav tau? Hu rauSales@bloomtechz.com.

1. Komatsu M, Kanda T, Urai H, et al. Kev ua kom NNMT tuaj yeem pab txhawb kev txhim kho cov kab mob rog rog los ntawm kev hloov kho NAD + cov metabolism. Kev Tshaj Tawm Txog Kev Tshawb Fawb . 2018; 8(1): 8637.

2. Kraus D, Yang Q, Kong D, et al. Nicotinamide N-methyltransferase knockdown tiv thaiv kev noj haus- ntxias rog rog. Xwm . 2014;508(7495):258-262.

3. Ulanovskaya OA, Zuhl AM, Cravatt BF. NNMT txhawb nqa kev hloov kho epigenetic hauv cov ntaub so ntswg adipose los ntawm NAD + metabolism. Nature Chemical Biology. 2013;9(5):300-306.

4. Neelakantan H, Vance V, Wetzel MD, et al. Selective thiab daim nyias nyias-permeable me me molecule inhibitors ntawm nicotinamide N-methyltransferase thim rov qab siab- rog noj- ntxias rog rog hauv cov nas. Biochemical Pharmacology. 2018; 147:141-152.

5. Cantó C, Menzies KJ, Auwerx J. NAD + metabolism thiab tswj lub zog homeostasis: ib qho kev ntsuas ntsuas ntawm mitochondria thiab cov nucleus. Cell Metabolism. 2015;22(1:31-53.

6. Yoshino J, Baur JA, Imai SI. NAD + intermediates: biology thiab kho muaj peev xwm ntawm NMN thiab NR. Cell Metabolism. 2018;27(3):513-528.