Kev tshawb fawb txog kev noj qab haus huv niaj hnub tsom rau kev noj qab haus huv hauv metabolic, nrhiav pom cov tshuaj tshiab uas yuav cuam tshuam rau lub zog ntawm tes. Cov kev tswj cov metabolism thiab cov cellular aging cov pab pawg tshawb fawb tau txaus siab rau 5 amino 1mq peptide txhaj. Qhov kev sim no -synthesised me me molecule tshuaj pab cov kws tshawb fawb kawm seb ntau yam enzymatic txoj kev cuam tshuam rau cellular zog tshuav nyiaj li cas thiab metabolic kev ua si.
Raws li cov zej zog thoob ntiaj teb tawm tsam nrog kev tswj qhov hnyav, lub zog metabolism, thiab hnub nyoog- cuam tshuam txog kev poob qis, cov txheej txheem metabolic tau dhau los ua qhov tseem ceeb. Lub 5 amino 1mq peptide txhaj tshuaj cuam tshuam tshwj xeeb nrog nicotinamide N-methyltransferase (NNMT), ib qho tseem ceeb enzyme hauv cellular metabolism, ua rau nws yog ib qho kev kawm tshwj xeeb. Cov tshuaj no tau kawm rau kev siv cov tshuaj metabolic los ntawm kws tshuaj, biotechnology, thiab cov kws tshawb fawb kev kawm.
Qhov kev tshuaj xyuas zoo no suav nrog 5 amino 1mq cov qauv ntawm kev ua, kev tshawb fawb, thiab cov ntaub ntawv metabolic thiab cellular. Cov molecule lub hauv paus kev tshawb fawb no muaj txiaj ntsig zoo rau kev tshawb fawb metabolic los ntawm cov kws tshawb fawb tshuaj, cov neeg tsim cov ntawv cog lus, thiab cov tuam txhab biotech nrhiav qib siab - cov tshuaj tshawb fawb zoo.
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
(3) Txhaj tshuaj
(4) Capsules
(5) Kua dej
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Internal Code: KP-3-5/002
CAS Nr .: 42464-96-0
Cov mis mos molecular: C10H11N2.I
HS code: N/A
Molecular Luj: 286.11
EINECS tus lej: 464-196-0
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Dab tsi yog 5 Amino 1MQ Peptide Txhaj Tshuaj thiab Yuav Kawm Li Cas Hauv Kev Tshawb Fawb Txog Metabolism?
Nkag siab txog Molecular Structure thiab Chemical Properties
Ib qho me me molecule inhibitor hu ua 5 amino 1mq yog ib yam dab tsi uas cov kws tshawb fawb ua rau cov kev tshawb fawb metabolic. Tsis zoo li peptides uas ib txwm ua los ntawm lub cev, tus txiv neej no - ua cov tshuaj muaj quinoline- cov qauv nrog cov tshuaj hloov pauv tshwj xeeb uas tso cai rau nws ua haujlwm nrog cov enzymes hauv ib txoj hauv kev. Cov kws tshawb fawb tuaj yeem kawm paub meej NNMT thaiv kev ua tsaug rau kev tsim qauv molecular. Qhov no ua rau nws muaj txiaj ntsig zoo rau cov kev sim tshuaj uas nkag siab txog qee txoj hauv kev metabolic tseem ceeb.
Txhawm rau kom ntseeg tau tias cov txiaj ntsig ntawm kev sim yeej ib txwm zoo ib yam, kev tshawb fawb - qib kev npaj ntawm 5 amino 1mq peptide txhaj tshuaj feem ntau ua tau raws li cov qauv purity nruj, feem ntau mus rau saum toj thiab tshaj 98% purity theem. Rau cov tuam txhab tshuaj thiab cov pab pawg tshawb fawb biotechnology kom paub tseeb tias tus kheej thiab purity ntawm molecules, lawv xav tau ntau cov ntaub ntawv txheeb xyuas.
Qhov no suav nrog siab -kev ua haujlwm ua kua chromatography (HPLC) cov ntaub ntawv, kev pom zoo ntawm huab hwm coj spectrometry, thiab nuclear magnetic resonance (NMR) spectra. Cov qauv zoo no ua kom paub tseeb tias cov txiaj ntsig kev tshawb fawb tuaj yeem rov ua dua hauv ntau qhov chaw sim thiab nrog cov kev sim sib txawv.
Kev Tshawb Fawb Cov Qauv thiab Kev Tshawb Fawb Kev Tshawb Fawb Kev Tshawb Fawb
Cov qauv tsiaj sib txawv yog siv los ntawm cov kws tshawb fawb uas kawm txog kev tswj cov metabolism los saib yuav ua li cas 5 amino 1mq peptide txhaj hloov txoj kev ua haujlwm ntawm cov hlwb. Nyob rau hauv vitro cellular kev tshawb fawb siv adipocyte kab lis kev cai, hepatocytes, los yog fibroblast cell kab kom pom ncaj qha cov metabolism hauv feem ntau yog thawj kauj ruam hauv kev tshawb fawb preclinical. Cov kws tshawb fawb tuaj yeem siv cov chaw tswj hwm no los saib seb NAD + qib, kev ua haujlwm mitochondrial, thiab cov qauv ntawm cov noob hloov pauv tom qab cov khoom sib txuas ntxiv.
Kev tshawb fawb siv cov qauv tsiaj muab peb cov ntaub ntawv ntxiv txog seb cov txheej txheem metabolic cuam tshuam rau tag nrho lub cev. Txhawm rau kom paub seb NNMT inhibition cuam tshuam li cas rau cov metabolism hauv lub cev, cov kws tshawb fawb tau siv cov qauv kev noj zaub mov - ua rau rog rog, laus laus, thiab metabolic syndrome. Cov kev tshawb fawb sib txawv siv ntau txoj hauv kev rau kev tswj hwm. Txhawm rau nrhiav qhov zoo tshaj plaws rau kev sim, cov kws tshawb fawb sim tawm cov sijhawm sib txawv ntawm kev siv tshuaj, kev xa khoom, thiab kev kho mob ntev. Cov kev tshawb fawb no muab cov ntaub ntawv tseem ceeb rau peb txog seb cov metabolism ua haujlwm li cas, tswj qhov hnyav, thiab yuav ua li cas kom lub zog sib npaug.
Cov Kev Xav Tau Zoo rau Cov Ntawv Thov Kev Tshawb Fawb
Txhawm rau kom ntseeg tau tias lawv cov kev sim muaj tseeb, cov koom haum uas ua cov kev tshawb fawb metabolic xav tau cov tshuaj uas ua tau raws li cov qauv zoo.
Rau kev kawm yog vim li cas, lub5mq1 uapeptide txhaj tshuajyuav tsum tuaj nrog cov ntaub ntawv qhia meej txog kev tshuaj xyuas uas qhia nws tus kheej, purity, thiab tej yam tsis huv. Kev sib raug zoo los ntawm batch mus rau batch yog qhov tseem ceeb tshwj xeeb rau kev tshawb fawb ntev - qhov chaw ntawm qhov kev sim yuav tsum nyob twj ywm tib yam thaum muaj ntau yam kev sim.
Txhawm rau khaws lawv cov qauv molecular thaum lub sijhawm kawm, kev tshawb fawb - cov ntaub ntawv qib kuj yuav tsum tau muab khaws cia kom zoo thiab muaj cov ntaub ntawv ruaj khov. Cov ntaub ntawv uas qhia txog txoj hauv kev zoo los daws, rov tsim dua, thiab ua kom cov khoom sib txuas ruaj khov nyob rau hauv cov khoom sib txawv cia pab pawg tshawb fawb khaws cov khoom sib xyaw kom zoo txij li lub sijhawm lawv yuav mus txog qhov kev sim ua tiav. Cov teeb meem zoo no muaj qhov cuam tshuam ncaj qha rau cov txiaj ntsig ntawm kev tshawb fawb thiab kev siv tau ntawm kev tshawb pom uas tau luam tawm.
Kev tshawb fawb tseem ceeb ntawm 5 Amino 1MQ Peptide Txhaj Tshuaj hauv Cellular Studies
Tshawb nrhiav kev cai Metabolic Pathway Regulation
Qhov kev tshawb fawb no tshuaj xyuas seb qhov inhibiting NNMT cuam tshuam li cas ntawm cov cell metabolic. Thaum cov kws tshawb fawb qhia txog 5 amino 1mq peptide rau hauv cov qauv ntawm tes, lawv ntsuas qhov nce hauv NAD+. Nce NAD + qib ua rau muaj cov xwm txheej uas cuam tshuam ntau yam txheej txheem metabolic.
NAD + qib siab dua qhib sirtuin tsev neeg cov proteins, tshwj xeeb tshaj yog SIRT1, uas tswj kev siv zog thiab kev ntxhov siab. Cov kws tshawb fawb kawm txog cov protein synthesis, tshuaj lom neeg ua haujlwm, thiab metabolic flux los txiav txim cov qauv ua kom muaj zog. Cov kws tshawb fawb tam sim no nkag siab tias yuav ua li cas inhibiting enzymes ua rau metabolic alterations nyob rau hauv ntau hom ntaub so ntswg thiab cell chaw.
Cov kws tshawb fawb tseem tshuaj xyuas cov roj fatty acid metabolism thaum cov tshuaj xa tuaj. Cov kev tshawb fawb Adipocyte qhia txog kev hloov pauv hauv lipid- tsim thiab - rhuav cov noob.
FAS thiab CPT1A yog cov noob no. Peb tuaj yeem tshuaj xyuas cov teeb meem metabolic los ntawm kev tshawb xyuas cov kev hloov pauv hauv cov qauv ntawm lub zog ntawm tes thaum NNMT raug txwv.
Tshawb nrhiav Cellular Aging Mechanisms
Kawm txog cellular senescence thiab aging mechanisms kuj tseem ceeb . 5 amino 1mq peptide txhaj pab cov kws tshawb fawb tshawb nrhiav seb cov metabolism cuam tshuam li cas ntawm cellular aging. Cov qauv zoo sib xws, uas cov hlwb sib faib ntau zaus, yuav raug siv los tshawb xyuas seb puas muaj kev ua kom zoo ntawm metabolic qeeb lossis ua kom muaj kev laus.
Cov kev tshawb fawb ntawm cov qauv fibroblast senescence qhia tau hais tias cov tshuaj txo cov senescence -sociated beta-galactosidase kev ua. Cell cycle regulatory proteins zoo li p21 thiab p16 nthuav qhia kev hloov pauv uas qhia txog theem kev loj hlob ntawm tes.
Qee cov kws tshawb fawb tseem sib cav txog kev sib raug zoo ntawm cov metabolism thiab kev laus ntawm tes. Cov kev soj ntsuam no txhawb kev sib tham.
Nkag siab txog kev ua haujlwm mitochondrial yog qhov tseem ceeb rau kev tshawb fawb kev laus. Tom qab kev tswj hwm tshuaj, cov kws tshawb fawb tau ntsuas mitochondrial membrane muaj peev xwm, ATP tiam, thiab mitochondrial DNA luam los txiav txim seb cov kev kho mob metabolic cuam tshuam li cas ntawm cell zog. Cov kws tshawb fawb kawm txog kev ua haujlwm mitochondrial poob li cas nrog kev laus pom cov kev ntsuas no muaj txiaj ntsig zoo rau kev nrhiav kev daws teeb meem.
Kev tshuaj xyuas qhov mob rwj teb Modulation
Ntawm ob lub cellular thiab systemic theem, metabolic dysfunction feem ntau txuas rau cov txheej txheem inflammatory . 5 amino 1mq peptide txhaj yog siv los ntawm cov kws tshawb fawb los saib rau hauv cov kev sib txuas ntawm kev tswj cov metabolism thiab cov kev taw qhia uas ua rau mob.
Siv cov qauv los kawm txog kev tsim cov cytokine, tshwj xeeb tshaj yog interleukin -6 (IL-6) thiab qog necrosis factor-alpha (TNF- ), qhia tau hais tias yuav ua li cas thaiv NNMT cuam tshuam rau kev tso tawm cov neeg kho mob inflammatory.
Lub senescence-sociated secretory phenotype (SASP) yog ib qho kev kawm uas cov txheej txheem metabolic thiab mob sib ntsib. Senescent hlwb tso tawm ib tug xov tooj ntawm pro- inflammatory tshuaj uas hloov cov ntaub so ntswg nyob ib ncig ntawm lawv. Cov kev tshawb fawb tshawb xyuas SASP cov cim tom qab kev kho mob sib xyaw pab peb nkag siab yog tias cov kev cuam tshuam hauv metabolic tuaj yeem hloov pauv cov kab mob uas tuaj nrog cov hlwb laus dua. Cov ntawv thov kev tshawb fawb no tshwj xeeb tshaj yog muaj txiaj ntsig zoo rau cov pab pawg uas tab tom nrhiav rau hauv cov kab mob metabolic thiab cov mob inflammatory uas tuaj nrog kev laus.
Yuav ua li cas NNMT Inhibition txhawb nqa lub tshuab ntawm 5 Amino 1MQ Peptide Txhaj Tshuaj
Lub Hom Phiaj Enzymatic thiab Nws Lub Luag Haujlwm Metabolic
Nicotinamide N-methyltransferase yog ib qho enzyme metabolic uas feem ntau pom muaj nyob hauv cov nqaij rog thiab lub siab. Nicotinamide yog methylated los ntawm cov enzyme no, uas hloov nws mus rau N-methylnicotinamide thaum siv S-adenosylmethionine (SAM) ua methyl qhov chaw. Nicotinamide yog lub tsev thaiv rau NAD + ntau lawm los ntawm txoj kev khaws cia, yog li kev ua haujlwm ntawm enzymes muaj qhov cuam tshuam ncaj qha rau cov nyiaj NAD + muaj nyob hauv hlwb. Thaum NNMT kev ua haujlwm nce mus, cov hlwb txav nicotinamide kom deb ntawm kev ua NAD +, uas tuaj yeem txo cov zog uas cov hlwb siv tau.
5mq1 uapeptide txhaj tshuajua haujlwm los ntawm kev sib tw sib tw rau NNMT enzyme thiab txwv tsis pub nws los ntawm kev rhuav tshem nicotinamide substrates. Qhov kev thaiv no khaws cov nicotinamide rau kev ua NAD +, uas ua rau muaj ntau dua ntawm NAD + hauv cov hlwb. Cov kws tshawb fawb tau lees paub cov kev hloov pauv biochemical no los ntawm kev ntsuas ncaj qha NAD + hauv cov ntaub so ntswg kho thiab cov qauv ntawm tes.
Qhov no teeb tsa cov txheej txheem yooj yim uas ua rau cov teebmeem metabolic uas ua raws.
Downstream Signaling Cascade Activation
Cov nyiaj ntau ntawm NAD + tig rau cov enzymes uas tso siab rau NAD +, feem ntau yog cov hauv tsev neeg cov protein sirtuin. Sirtuins tswj ntau yam hauv cov hlwb, zoo li cov noob tau nthuav tawm li cas, mitochondria ua haujlwm li cas, thiab cov hlwb cuam tshuam li cas nrog kev ntxhov siab. Thaum SIRT1 qhib, nws hloov txoj hauv kev cov noob caj noob ces tswj los ntawm deacetylates histones thiab hloov pauv yam hloov pauv. PPAR- acetylation lub xeev kev tshawb fawb qhia tau hais tias yuav ua li cas 5 amino 1mq peptide txhaj cuam tshuam rau adipogenic noob qhia cov kev pab cuam ncaj qha los ntawm txoj kev taw qhia.
Txoj kev AMP-activated protein kinase (AMPK) kuj cuam tshuam rau kev hloov pauv hauv cov metabolism los ntawm kev thaiv NNMT. AMPK yog tus saib xyuas lub zog ntawm tes uas tig thaum lub zog hloov pauv. Cov kev tshawb fawb uas tshawb xyuas lub xeev ntawm
AMPK phosphorylation thiab ua kom lub hom phiaj nqes qis qhia tau tias cov kev cuam tshuam hauv metabolic ua rau muaj kev sib koom tes ntawm tes uas cuam tshuam rau ntau lub zog- cov txheej txheem cuam tshuam tib lub sijhawm. Cov kws tshawb fawb tuaj yeem nkag siab zoo dua qhov cuam tshuam ntawm lub cev loj dua uas pom nyob rau hauv tag nrho -tsiaj kev tshawb fawb nrog kev pab los ntawm cov txheej txheem kev xav.
Epigenetic Regulation Los ntawm Metabolic Intermediates
Txoj kev tshawb fawb tshiab tau qhia txog kev sib txuas ntawm kev thaiv cov enzymes digestive thiab kev hloov pauv hauv epigenetics. NNMT txoj kev siv SAM hloov lub peev xwm ntawm cov hlwb rau methylate, uas hloov cov qauv ntawm methylation hauv histones thiab DNA. Thaum 5 amino 1mq peptide txhaj tshuaj txo qis NNMT kev ua haujlwm, SAM cov nyiaj yuav hloov pauv hauv cov hlwb, uas tuaj yeem cuam tshuam li cas epigenetics tswj cov noob. Pab pawg ntawm cov kws tshawb fawb saib mus rau hauv cov kev sib txuas no saib cov qauv methylation thoob ntiaj teb, kev hloov kho histone tshwj xeeb, thiab cov kev hloov pauv hauv cov noob caj noob ces kom paub seb cov kev ua metabolic tau ntev npaum li cas - cuam tshuam rau cov hlwb.
Tshawb xyuas Lub Zog Sib Nqus thiab Metabolic Txoj Kev Nrog 5 Amino 1MQ Peptide Txhaj
Adipose ntaub so ntswg Metabolism thiab Fat Storage Regulation
Cov kev hloov pauv metabolic tseem ceeb tau pom hauv cov kev tshawb fawb uas saib seb cov ntaub so ntswg adipose reacts rau 5 amino 1mq peptide txhaj. Hauv kev tshawb fawb siv kev noj zaub mov- ua rau cov qauv rog rog, muab cov khoom sib txuas ua rau poob phaus thiab poob ntawm cov nqaij rog rog. Txhawm rau txheeb xyuas qhov cuam tshuam loj npaum li cas, cov kws tshawb fawb ntsuas qhov hnyav ntawm cov ntaub so ntswg adipose, tus nqi ntawm cov roj ntsha epididymal, thiab qhov loj ntawm cov hlwb adipocytes. Cov kev hloov pauv uas tau pom yog txuas nrog kev hloov pauv hauv kev qhia ntawm cov noob uas tswj kev tsim khoom thiab khaws cia lipids. Qhov no qhia tau hais tias muaj kev hloov pauv loj hauv cov metabolism hauv cov rog rog.
Kev tshuaj ntsuam xyuas molecular ntawm cov ntaub so ntswg kho tau pom tias cov lipogenic enzymes zoo li fatty acid synthase thiab stearoyl -CoA desaturase-1 (SCD1) tau qhia tsawg dua.
Cov noob uas pab zom cov roj fatty acids, xws li CPT1A thiab acyl-CoA oxidase 1 (ACOX1), tau nthuav tawm ntau dua. Cov qauv ntawm cov noob no qhia tau hais tias cov metabolism hloov pauv, raws li lub zog- khaws cov txheej txheem qeeb thiab lub zog- siv cov txheej txheem nrawm. Cov kws tshawb fawb uas kawm txog cov kab mob metabolic xav tias cov kev hloov pauv ntawm qib molecular yog qhov tseem ceeb heev rau kev txheeb xyuas txoj hauv kev los kho cov kab mob no.
Glucose Metabolism thiab Insulin Sensitivity Research
Lwm thaj chaw ntawm kev kawm qhov twg 5 amino 1mq peptide txhaj yog pab tau rau kev sim yog cov piam thaj sib npaug. Txhawm rau pom tias cov txiaj ntsig metabolic ua haujlwm li cas, kev ceev cov ntshav qabzib, kev ntsuas ntshav qabzib siab, thiab cov qhab-nees rhiab heev ntawm insulin raug ntsuas hauv cov kev tshawb fawb ua ntej. Cov kev tshawb fawb pom tau tias cov qauv tsiaj kho tau zoo dua ntawm kev tuav cov piam thaj thiab muaj kev nkag siab ntau dua rau insulin, uas qhia tias cov teebmeem no zoo rau kev tswj cov piam thaj metabolism.
Cov kws tshawb nrhiav tuaj yeem tau txais cov kev ntsuas meej ntawm kev hloov pauv ntawm insulin rhiab heev los ntawm homeostatic qauv kev ntsuas ntawm insulin tsis kam (HOMA-IR). Cov kev tshawb fawb uas qhia tias HOMA- qib IR poob qis tom qab kev kho mob sib xyaw ua ke qhia tias cov txiaj ntsig zoo ntawm cov metabolism yog qhov tiag. Cov koom haum uas kawm txog cov kab mob metabolic yuav pom cov kev ntsuas no tshwj xeeb tshaj yog muaj txiaj ntsig, vim insulin tsis kam yog qhov tseem ceeb ntawm tus kab mob no uas xav tau kev kho mob.
Mitochondrial Biogenesis thiab Energy Production Enhancement
Kev ua haujlwm ntawm mitochondria tseem ceeb heev rau kev ua lub zog hauv cov hlwb thiab ua kom cov metabolism hauv kev kuaj xyuas. Cov kws tshawb fawb uas tau kawm yuav ua li cas mitochondria hnov mob rau 5 amino 1mq peptide txhaj tshuaj pom tias cov ntawv luam ntawm mitochondrial DNA tau nce, thiab kev qhia ntawm cov cim rau mitochondrial biogenesis nce.
Raws li tus tswv tswj hwm ntawm mitochondrial biogenesis, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) tau pom tias tau tsa hauv kev sim tom qab kev kho mob sib xyaw.
Siv Seahorse thev naus laus zis lossis kev ntsuas pa oxygen los ntsuas mitochondrial ua pa muaj peev xwm qhia tau tias kho cov hlwb thiab cov ntaub so ntswg muaj peev xwm oxidative phosphorylation ntau dua. Ib yam li ntawd, tus nqi ntawm ATP ntau lawm nce, uas txhais tau hais tias cov hlwb tuaj yeem ua kom muaj zog ntau dua. Cov txiaj ntsig no rov qab rau lub tswv yim tias kev kho mob metabolic uas lub hom phiaj NNMT tuaj yeem txhim kho cellular zog metabolism los ntawm kev txhim kho kev ua haujlwm ntawm mitochondria. Cov qauv kev sim no yog siv los ntawm pab pawg tshawb fawb saib mus rau cov kab mob ntawm lub voj voog lub zog los sim ntau txoj hauv kev los pab tib neeg.
Kev Tshawb Fawb Yav Tom Ntej rau5mq1 uaDaim ntawv thov kev txhaj tshuaj Peptide
Nthuav kev nkag siab txog cov ntaub so ntswg -Kev cuam tshuam Metabolic tshwj xeeb
Tam sim no, kev tshawb fawb feem ntau yog tsom rau cov ntaub so ntswg adipose thiab lub siab metabolism. Txawm li cas los xij, cov kev tshawb fawb tshiab tau pib saib seb cov khoom no cuam tshuam li cas rau ntau hom ntaub so ntswg.5mq1 uapeptide txhaj tshuajtuaj yeem pab cov kws tshawb fawb kawm paub ntau ntxiv txog seb cov leeg nqaij pob txha ua haujlwm li cas, cov ntaub so ntswg lub plawv siv zog li cas, thiab lub hlwb tswj cov metabolism. Cov ntaub so ntswg sib txawv muaj ntau qhov sib txawv ntawm NNMT thiab cov yam ntxwv ntawm biochemical sib txawv, uas qhia tias kev thaiv cov teebmeem yuav txawv ntawm cov kabmob.
Txhawm rau kawm paub ntxiv txog seb cov teebmeem metabolic hauv zos ua haujlwm li cas, pab pawg tshawb fawb tau ua haujlwm ntawm cov qauv kev txiav txim siab thiab cov ntaub so ntswg-txoj kev xa khoom tshwj xeeb.
Cov kws tshawb fawb yuav tuaj yeem qhia tau yog tias kev tswj hwm lub cev muaj qhov cuam tshuam uas muaj kev xav thoob plaws hauv lub cev lossis yog tias muaj cov lus teb tshwj xeeb rau cov ntaub so ntswg sib txawv siv cov kev sim siab heev. Nws yog ib qho tseem ceeb kom nkag siab txog qhov sib txawv no txhawm rau los nrog cov phiaj xwm kho mob tshwj xeeb thiab kwv yees siv dab tsi uas lawv yuav muaj nyob rau hauv cov xwm txheej metabolic sib txawv.
Tshawb nrhiav kev sib xyaw ua ke nrog lwm yam kev cuam tshuam metabolic
Cov kws tshawb fawb paub tias kev tswj cov metabolism hauv muaj ntau cov txheej txheem ua haujlwm ua ke. Qhov no txhais tau hais tias siv ntau tshaj ib txoj kev yuav muaj txiaj ntsig zoo. Nrhiav seb yuav ua li cas 5 amino 1mq peptide txhaj tshuaj tiv thaiv nrog kev tawm dag zog, hloov pauv cov zaub mov, lossis lwm yam tshuaj metabolic yog qhov muaj txiaj ntsig zoo rau kev tuaj nrog txoj hauv kev zoo tshaj plaws los pab tib neeg.
Cov kev tshawb fawb uas muab cov sib xyaw ua ke thiab kev cob qhia kev ua siab ntev qhia tau zoo dua cov txiaj ntsig metabolic dua li kev tshawb fawb uas tsuas yog ua ib qho ntawm ob. Qhov no qhia tau hais tias ob leeg yuav ua hauj lwm ua ke nyob rau hauv additive los yog synergistic txoj kev. Raws li cov kauj ruam tom ntej hauv kev tshawb fawb, peb tuaj yeem saib cov kev sib xyaw ua ke uas suav nrog NAD + cov khoom noj ua ntej, cov tshuaj tua kab mob antioxidants uas tsom mitochondria, lossis lwm yam kev hloov pauv hauv metabolic. Txhawm rau qhia qhov txawv ntawm tus kheej cov teebmeem thiab kev sib tham sib cuam tshuam, cov kev tshawb fawb no xav tau qhov zoo -xav- tawm kev sim tsim, nrog rau ntau txoj kev tshuaj xyuas thiab cov qauv loj dua.
Cov koom haum tshawb fawb cog lus thiab cov tuam txhab muag tshuaj uas tab tom ua cov kev tshawb fawb nyuaj no xav tau kev ntseeg siab, siab - cov khoom siv sib xyaw ua ke kom paub tseeb tias cov kev sim no siv tau rau lub sijhawm tshawb fawb ntev.
Ua kom nkag siab txog Ntev -Lub Sij Hawm Metabolic thiab Kev Nyab Xeeb Profiles
luv-cov kev tshawb fawb txog metabolic muab peb cov ntaub ntawv yooj yim, tab sis nws yog ib qho tseem ceeb kom paub tias yuav muaj dab tsi tshwm sim dhau sij hawm yog tias peb xav ua cov tshuaj tshiab. Ntev- cov kev tshawb fawb ntev nrog cov tsiaj uas saib cov kab mob 5 amino 1mq peptide txhaj tshuaj yuav pab cov kws tshawb fawb pom tias cov txiaj ntsig metabolic nyob rau lub sijhawm thiab yog tias muaj cov txheej txheem uas pab lub cev hloov pauv. Cov kev tshawb fawb no tseem muab cov ntaub ntawv tseem ceeb txog kev nyab xeeb rau peb txog qhov muaj feem cuam tshuam tsis zoo ntawm - lub sij hawm NNMT thaiv.
Cov kws tshawb fawb tau ua haujlwm ntawm kev ua biomarker panels uas ntse dua kom cov metabolism hauv kev noj qab haus huv tuaj yeem taug qab hauv txoj kev ua tiav ntau dua nyob rau lub sijhawm kho mob ntev dua. Txhawm rau kom paub tseeb tias muaj kev tshuaj xyuas tag nrho, cov tshuaj ntsuam no kuaj lub siab ua haujlwm, lub raum ua haujlwm, cov cim ntawm lub plawv, thiab cov tshuaj hormonal. Cov tuam txhab ua cov kev tshawb fawb qib siab no xav tau cov khoom siv tshuaj lom neeg uas tau lees paub GMP- ntawv pov thawj thiab tuaj nrog tag nrho cov ntaub ntawv lawv xav tau los txhawb cov ntawv thov kev tswj hwm thiab cov txheej txheem kev lees paub zoo.
Xaus
Raws li cov kws tshawb fawb nkag siab ntau ntxiv txog cov metabolism thiab kev laus ntawm tes, 5mq1 uapeptide txhaj tshuajkev tshawb fawb hloov. Tus txiv neej no- ua cov tshuaj me me tuaj yeem siv los tshawb fawb NNMT inhibition hauv ntau cov txheej txheem kuaj thiab daim ntawv thov. Los ntawm tib lub hlwb mus rau cov tsiaj loj, cov tshuaj pab cov kws tshawb fawb tshawb fawb txog qhov enzyme txoj hauv kev cuam tshuam lub zog tshuav nyiaj li cas thiab kev noj qab haus huv metabolic.
High -purity, zoo ib yam tshuaj yog xav tau rau kev tshawb fawb metabolic. Raws li kev tshawb fawb daim ntawv thov nce thiab kev sim tsim tau zoo dua, cov khoom siv tshuaj lom neeg muaj kev ntseeg siab nrog cov ntaub ntawv txheeb xyuas meej yog xav tau. Cov kws tshawb fawb ntawm cov ntaub so ntswg adipose metabolism, cellular laus, thiab mitochondrial muaj nuj nqi tau txais txiaj ntsig los ntawm kev tswj hwm, siab - tshuaj zoo.
Cov kws tshawb fawb tab tom tshawb xyuas seb cov kev kho mob twg tuaj yeem pab cov kab mob metabolic thiab kev laus - cuam tshuam txog kev poob qis. Kev tshawb nrhiav metabolic muaj kev cia siab rau yav tom ntej. Txoj kev tshawb no suav nrog 5 amino 1mq peptide txhaj. Cov ntaub ntawv no pab cov kws tshawb fawb nkag siab txog kev tswj cov metabolism hauv cov qib molecular, cellular, thiab cov kab ke.
FAQ
1. Yuav tsum tshawb fawb txog dab tsi ntawm purity - qib 5 amino 1mq peptide txhaj rau kev tshawb fawb metabolic?
Txhawm rau kom paub tseeb tias qhov kev sim ua tau zoo ib yam thiab tuaj yeem rov ua dua, kev tshawb fawb -qib cov ntsiab lus feem ntau yuav tsum muaj tsawg kawg yog 98% ntshiab. Thaum koj siv cov khoom siab tshaj -purity, impurities uas tuaj yeem cuam tshuam cov kev ntsuas metabolic tau khaws cia kom tsawg. Txhawm rau kom paub tseeb tias cov qauv zoo tau ua tiav, kev tshawb fawb- cov ntaub ntawv qib yuav tsum tuaj nrog cov ntaub ntawv txheeb xyuas xws li HPLC chromatograms, cov ntaub ntawv loj spectrometry, thiab daim ntawv pov thawj ntawm kev tshuaj xyuas.
2. Dab tsi ua rau 5 amino 1mq peptide txhaj txawv ntawm cov tshuaj metabolic uas tshwm sim ib txwm muaj?
Lub compound nyob rau hauv nqe lus nug tsis yog ib yam khoom tshwm sim; nws yog ib tug txiv neej- ua molecule me me uas tau tsim los thaiv NNMT. Nyob rau hauv sib piv rau tej yam ntuj tso metabolites los yog peptides ua los ntawm cov kab mob lom, 5 amino 1mq muaj cov qauv tshuaj uas tau ua tib zoo xaiv los ua haujlwm nrog cov enzymes tshwj xeeb. Cov kws tshawb nrhiav tuaj yeem kawm txog cov teebmeem metabolic uas muaj tseeb dua nrog cov khoom siv hluavtaws no ntau dua li qhov sib txawv ntawm cov khoom sib txawv.
3. Yuav ua li cas 5 amino 1mq peptide txhaj tshuaj yuav tsum khaws cia kom ruaj khov rau kev kawm siv?
Rau ntev - khaws cia, cov tshuaj tshawb fawb feem ntau yuav tsum tau khaws cia ntawm qhov ntsuas kub, feem ntau ntawm -20℃thiab -80℃. Piv nrog rau kev npaj ua kua, cov ntaub ntawv lyophilised hmoov yog ruaj khov dua. Txhawm rau khaws cov purity ntawm cov tebchaw thaum lub sijhawm kawm, cov kws tshawb fawb yuav tsum ua raws li cov chaw tsim khoom cov lus qhia rau kev hloov kho, txwv sijhawm cia, thiab tuav kev nyab xeeb. Kev khaws cov ntaub ntawv kom raug ua kom paub tseeb tias cov txiaj ntsig ntawm kev sim tuaj yeem rov ua dua.
Koom Tes Nrog BLOOM TECH raws li koj qhov kev ntseeg siab 5 Amino 1MQ Peptide Txhaj Muag Khoom
BLOOM TECH yog lub tuam txhab uas koj tuaj yeem ntseeg tau muab rau koj siab -cov kev tshawb fawb zoo uas pab nrog cov kev tshawb fawb txog metabolic. Peb tau ua cov organic tebchaw thiab tshuaj intermediates rau ntau tshaj 12 xyoo. Peb muab kev tshawb fawb-qib5mq1 uapeptide txhaj tshuajuas ua tau raws li cov qauv nruj zoo ntawm cov tuam txhab biotechnology, cov tuam txhab tshuaj, thiab cov chaw tshawb fawb cog lus thoob plaws ntiaj teb. Peb GMP- cov chaw tsim khoom tau lees paub tau raug tshuaj xyuas los ntawm Asmeskas -FDA, CFDA, PMDA, thiab EU cov cai tswj hwm, yog li koj tuaj yeem paub tseeb tias cov tshuaj lawv ua tau raws li cov qauv zoo tshaj plaws.
Peb paub tias kev ua tiav ntawm kev tshawb fawb yog nyob ntawm kev sib koom ua ke, kev tshuaj xyuas zoo, thiab kev tswj xyuas cov khoom siv tau zoo. Peb cov txheej txheem kev lees paub zoo suav nrog peb hom kev sim: kev tshuaj xyuas ntawm qib Hoobkas, tshuaj xyuas los ntawm peb tus kheej QA / QC chav haujlwm, thiab ntawv pov thawj los ntawm cov chaw ua haujlwm tsom xam. Txoj kev nruj no ua kom paub tseeb tias txhua pawg tau txais qee theem ntawm purity thiab tuaj nrog tag nrho cov ntaub ntawv txheeb xyuas koj xav tau ua raws li koj cov txheej txheem kawm. Peb yog cov chaw muab kev pom zoo rau 24 ntawm lub ntiaj teb cov kws kho mob loj tshaj plaws thiab cov tuam txhab tshawb fawb. Rau kev tshawb fawb txog kev siv metabolic siab heev, peb muab cov khoom sib txuas nrog cov ntaub ntawv tsim nyog, cov ntaub ntawv ruaj khov, thiab kev txhawb nqa kev tswj hwm.
Bloom Tech muaj cov kev pabcuam tus kheej, tus nqi meej, thiab kev xa khoom sai rau kev tshawb fawb-qib cov ntaub ntawv siv hauv kev tshawb fawb txog cellular metabolism, kev sim kev loj hlob, lossis pab pawg tshawb fawb cov haujlwm. Tham nrog peb pab neeg ua haujlwm txog koj qhov kev xav tau kev tshawb fawb tshwj xeeb thiab nrhiav seb peb qhov kev paub dhau los ua tus muab 5 amino 1mq peptide txhaj tuaj yeem pab koj ncav cuag koj cov hom phiaj tshawb fawb metabolic sai dua. Email rau peb ntawmSales@bloomtechz.comtam sim no kom tau txais cov lus qhia rau koj qhov kev tshawb fawb tom ntej, nug txog kev txheeb xyuas tshwj xeeb, lossis tham txog cov kev cai sib xyaw ua ke.
Cov ntaub ntawv
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2. Kraus, D., Yang, Q., Kong, D., Banks, AS, Zhang, L., Rodgers, JT, & Guarente, L. (2014). "Nicotinamide N-methyltransferase knockdown tiv thaiv kev noj zaub mov- ntxias rog." Xwm, 508(7495), 258-262.
3. Ulanovskaya, OA, Zuhl, AM, & Cravatt, BF (2013). "NNMT txhawb nqa kev hloov kho epigenetic hauv kev mob qog noj ntshav los ntawm kev tsim cov tshuaj metabolic methylation dab dej." Nature Chemical Biology, 9(5), 300-306.
4. Hong, S., Moreno-Navarrete, JM, Wei, X., Kikukawa, Y., Tzameli, I., Prasad, D., & Kahn, CR (2015). "Nicotinamide N-methyltransferase tswj cov metabolism hauv hepatic nutrient los ntawm Sirt1 protein stabilization." Nature Medicine, 21(8), 887-894.
5. Neelakantan, H., Vance, V., Wetzel, MD, Wang, HY, McHardy, SF, Finnerty, CC, & Hommel, JD (2018). "Kev xaiv thiab daim nyias nyias-permeable me me molecule inhibitors ntawm nicotinamide N-methyltransferase thim rov qab cov zaub mov muaj roj ntau{17}}ua rau rog rog hauv cov nas." Biochemical Pharmacology, 147, 141-152.
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