Kev tshawb fawb kev laus tau nkag mus rau theem zoo siab uas cov kws tshawb fawb tab tom tshawb nrhiav cov kev cuam tshuam molecular uas tsom rau cov txheej txheem ntawm tes ncaj qha. Ntawm cov khoom sib xyaw uas tshwm sim,5 amino 1mq peptide txhajtau txais kev saib xyuas hauv cov chaw soj nstuam thoob ntiaj teb rau nws txoj hauv kev tshwj xeeb rau kev tswj hwm metabolic thiab kev txuag kev noj qab haus huv ntawm tes. Tsis zoo li cov kev cuam tshuam ib txwm muaj, cov khoom siv hluav taws xob me me no ua haujlwm ntawm qib enzymatic, muab cov kws tshawb fawb txog cov cuab yeej tseem ceeb los tshawb xyuas seb cov cellular zog txoj hauv kev cuam tshuam rau cov txheej txheem kev laus.
Kev nkag siab txog yuav ua li cas cov hlwb tswj tau qhov tseem ceeb hauv lub sijhawm yuav tsum muaj cov qauv kev tshawb fawb thiab cov khoom sib txuas uas tuaj yeem hloov kho cov kev lom neeg tshwj xeeb. Lub 5 amino 1mq peptide txhaj muab cov kws tshawb fawb txog qhov muaj peev xwm ua tau zoo, ua kom muaj kev tshawb fawb ntxaws txog nicotinamide N-methyltransferase (NNMT) inhibition thiab nws cov teebmeem downstream ntawm cellular metabolism. Raws li cov chaw soj ntsuam txuas ntxiv tshawb nrhiav kev tiv thaiv- cov tswv yim kev laus, kev nkag mus rau qib siab - cov kev tshawb fawb zoo tau dhau los ua qhov tseem ceeb rau kev nce qib kev paub txog kev tshawb fawb.
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
(3) Txhaj tshuaj
(4) Capsules
(5) Kua dej
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Internal Code: KP-3-5/002
CAS Nr .: 42464-96-0
Cov mis mos molecular: C10H11N2.I
HS code: N/A
Molecular Luj: 286.11
EINECS tus lej: 464-196-0
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Yog vim li cas5mq1 uaKev txhaj tshuaj Peptide suav nrog hauv Cellular Aging Studies?
Lub hom phiaj Enzymatic Qab Cellular Metabolism Research
Cov kws tshawb fawb tam sim no nyuam qhuav pib nkag siab txog kev hloov pauv biochemical uas tshwm sim hauv cov hlwb thaum lawv muaj hnub nyoog. Cov kws tshawb fawb siv 5 amino 1mq peptide txhaj ntau vim tias nws tshwj xeeb txwv tsis pub NNMT ua haujlwm. NNMT yog ib qho enzyme uas ua haujlwm hauv cov ntaub so ntswg rog thiab pab kom muaj kev sib npaug ntawm lub zog hauv cov hlwb. Vim li no, cov kws tshawb fawb tuaj yeem sib cais thiab kawm txog qee txoj hauv kev metabolic yam tsis muaj kev cuam tshuam rau cov kab mob lom neeg uas tsis txuas nrog cov kev ntawd.
NNMT koom nrog ntau yam sib txawv ntawm kev ua haujlwm ntawm tes. Nws pab nrog kev tsim cov rog, tswj cov epigenetics, thiab cov metabolism hauv lub zog. Thaum cov kws tshawb fawb ntxiv 5 amino 1mq rau cov qauv kuaj, lawv tuaj yeem pom tias qhov txo qis ntawm NNMT kev ua haujlwm hloov pauv li cas NAD + muaj, uas hloov pauv ntau cov txheej txheem ntawm tes uas txuas nrog kev laus. Vim tias qhov sib xyaw ua ke tau meej meej txog nws ua haujlwm li cas, nws txaus siab heev rau cov chaw sim uas tab tom saib rau hauv cov tswv yim cuam tshuam metabolic.
Translational Potential nyob rau hauv Metabolic Research Models
Hauv kev tshawb fawb hauv lab siv kev noj zaub mov- ua rau cov qauv rog rog, cov tshuaj no tau pom tias muaj cov txiaj ntsig ntsuas tau.
Cov kws tshawb fawb tuaj yeem khaws cov kev hloov pauv hauv cov cim metabolic, cov ntaub so ntswg pleev, thiab cov tshuaj biochemical los ntawm kev ua raws li cov txheej txheem nruj uas yuav tsum tau ua raws li cov kev npaj ua haujlwm ntev. Cov kev tshawb fawb tswj tau muab cov neeg tshawb nrhiav cov ntaub ntawv yooj yim uas pab lawv txheeb xyuas seb qhov kev ua haujlwm metabolic yuav tshwm sim li cas thaum tib neeg muaj hnub nyoog.
Vim tias qhov sib xyaw ua ke tuaj yeem cuam tshuam ntau txoj hauv kev hauv qab tib lub sijhawm, nws muab kev pom tshwj xeeb rau hauv kev hloov pauv hauv metabolic cuam tshuam rau pawg ntawm cov hlwb uas txuas rau ib leeg. Hauv tib qhov chaw sim, cov kws tshawb fawb tuaj yeem taug qab cov kev hloov pauv hauv cov cim rau insulin rhiab heev, kev ua haujlwm mitochondrial, thiab o. Qhov no tso cai rau lawv tsim cov ntaub ntawv loj uas qhia tau tias yuav ua li cas metabolic cuam tshuam rau kev noj qab haus huv ntawm tes.
Tshawb xyuas Cellular Energy Preservation Research Nrog 5 Amino 1MQ Peptide Txhaj
NAD + Dynamics thiab Kev Tshawb Fawb Daim Ntawv Thov
Cov kws tshawb fawb kawm txog cov metabolism hauv lub zog tau pom tias NAD + yog ib qho tseem ceeb hauv kev laus ntawm cov hlwb. Cov5 amino 1mq peptide txhajhloov cov khoom noj tseem ceeb no los ntawm kev thaiv NNMT, uas hloov txoj hauv kev uas ua rau nicotinamide. Thaum NNMT kev ua haujlwm poob qis, cov hlwb muaj ntau qhov sib txawv ntawm nicotinamide muaj, uas tuaj yeem ua rau NAD + biosynthesis mus nrawm dua los ntawm txoj kev khaws cia.
Cov qauv kev tshawb fawb qhia tau hais tias kev hloov pauv hauv NAD + qib yog txuas nrog ntau cov txheej txheem ntawm tes, xws li kev ua sirtuin, mitochondrial ua pa, thiab muaj peev xwm kho DNA. Cov khoom sib xyaw uas tuaj yeem hloov pauv qhov kev hloov pauv ntawm NAD + hauv txoj kev kwv yees pab cov kws tshawb fawb uas kawm txog cov kev sib raug zoo no. Cov txheej txheem kuaj mob uas siv cov tshuaj no feem ntau suav nrog kev nyeem tag nrho ntawm NAD + / NADH piv nrog rau kev sim ua haujlwm ntawm NAD+-nyob ntawm cov enzymes. Qhov no tsim cov txheej txheem metabolic zoo uas pab peb kawm ntxiv txog seb cov hlwb tswj lawv cov qib zog li cas.
Metabolic Flexibility nyob rau hauv Test Conditions
Ua kom metabolic yooj yooj yim- muaj peev xwm hloov pauv ntawm cov roj sib txawv tau zoo raws li qhov muaj nyob hauv- yog ib feem tseem ceeb ntawm kev ua kom lub zog ntawm tes. Cov kws tshawb fawb tau siv 5 amino 1mq peptide txhaj tshuaj los saib seb qhov thaiv NNMT hloov pauv li cas substrates siv rau ntau hom ntaub so ntswg. Cov kev tshawb fawb qhia txog kev hloov pauv ntawm cov noob caj noob ces uas txuas nrog kev hlawv cov roj fatty acids, rhuav tshem cov piam thaj, thiab ua mitochondria.
Cov kev soj ntsuam no muab cov ntaub ntawv tseem ceeb rau peb txog yuav ua li cas hloov cov enzymes metabolic cuam tshuam rau txoj kev hloov ntawm cov hlwb. Cov kws tshawb fawb tuaj yeem saib cov ntaub ntawv sau tseg los ntawm ua ntej thiab tom qab qhov sib xyaw ua ke kom pom cov kev hloov pauv ntawm cov metabolism hauv feem ntau thaum NNMT raug thaiv. Cov ntaub ntawv zoo li no yuav pab peb kawm paub ntau ntxiv txog yuav ua li cas cov hlwb ua kom lawv lub zog ruaj khov hauv ntau lub cev thiab qhov peev xwm hloov pauv li cas thaum peb muaj hnub nyoog.
Yuav ua li cas NAD + Cov Txheej Txheem Txuas Nrog 5 Amino 1MQ Peptide Txhaj
Ib qho tseem ceeb heev ntawm kev tshawb fawb txog kev laus yog qhov sib txuas ntawm kev thaiv NNMT thiab NAD + metabolism. Hauv cov chaw tswj hwm, cov kws tshawb fawb muab 5 amino 1mq peptide txhaj tshuaj thiab saib raws li cov saw ntawm cov xwm txheej tshwm sim. Cov xwm txheej no pib nrog hloov nicotinamide metabolism thiab kis mus rau ntau NAD+- cov txheej txheem ntawm tes.
NNMT feem ntau ntxiv cov methyl pawg rau nicotinamide, hloov nws mus rau N-methylnicotinamide thiab ua rau nws tsis tshua muaj kev rov qab los ntawm NAD + los ntawm txoj kev khaws cia. Nws tau xav tias thaiv cov enzyme no yuav ua rau cov khw muag khoom nicotinamide zoo, uas tuaj yeem txhim kho NAD + ntau lawm.
Cov kws tshawb fawb tau pom tias thaum muab cov khoom sib txuas, NAD + qib nce ntxiv nrog rau kev ua sirtuin nce ntxiv. Qhov no yog vim hais tias sirtuins yog ib tsev neeg ntawm cov proteins uas xav tau NAD + los ua lawv txoj haujlwm deacetylase.
Sirtuins cuam tshuam rau ntau cov txheej txheem lom neeg tseem ceeb rau kev kawm txog kev laus, xws li tswj kev ua haujlwm mitochondrial, hloov cov lus teb rau qhov mob, thiab hloov pauv epigenetics. Cov kev tshawb fawb hauv chav kuaj ntsuas NAD + thiab taug qab cov haujlwm sirtuin ua rau peb nkag siab zoo dua ntawm kev hloov pauv biochemical yuav cuam tshuam rau txoj hauv kev uas lub hnub nyoog. Txhawm rau nkag siab tias cov metabolism hauv cofactors thiab cov txheej txheem tswj hwm ua haujlwm ua ke, cov kev tshawb fawb no xav tau cov txheej txheem meej rau kev tswj hwm cov tebchaw thiab cov txheej txheem tshuaj ntsuam xyuas qib siab.
Mitochondrial Function Research Siv 5 Amino 1MQ Peptide Txhaj Qauv
Kev tshawb fawb txog kev laus ntawm cov cellular yog ua raws li kev noj qab haus huv ntawm mitochondria, uas yog cov molecules uas ua rau lub zog rau cov hlwb thiab tseem ua rau cov pa oxygen reactive uas tuaj yeem ua rau lub cev puas tsuaj. Cov kws tshawb fawb tau siv cov txheej txheem uas suav nrog5 amino 1mq peptide txhajlos saib seb qhov thaiv NNMT cuam tshuam li cas rau qhov sib txawv ntawm mitochondrial.
Tom qab muab qhov sib xyaw ua ke, cov kev hloov pauv tau pom nyob rau hauv cov ntawv luam ntawm mitochondrial DNA, kev ua haujlwm ntawm cov kab mob ua pa nyuaj, thiab lub peev xwm ntawm daim nyias nyias. Cov kev ntsuas no pab cov kws tshawb fawb pom tias yog tias hloov pauv cov enzymes tuaj yeem cuam tshuam rau mitochondrial biogenesis, uas yog cov txheej txheem los ntawm cov hlwb ua mitochondria tshiab.
Upregulation ntawm cov noob koom nrog hauv kev tsim mitochondrial, xws li PGC-1, NRF1, thiab TFAM, tau pom nyob rau hauv cov kev tshawb fawb. Qhov no qhia tias thaiv NNMT tuaj yeem tso tawm cov txheej txheem them nyiaj uas ua rau muaj peev xwm mitochondrial siab dua.
Dhau li ntawm biogenesis, peb yuav tsum tau saib rau hauv cov txheej txheem tswj kom zoo hauv mitochondria. Cov kws tshawb fawb tau saib seb puas yog 5 amino 1mq hloov qhov sib npaug ntawm fusion thiab fission txheej txheem uas ua kom cov mitochondrial tes hauj lwm noj qab nyob zoo. Cov kev tshawb fawb kuj tseem saib cov txheej txheem autophagy uas tshem tawm cov mitochondria puas lawm kom pom tias kev kho mob sib xyaw hloov cov hlwb ntxuav lawv tus kheej, uas ua rau tsis zoo thaum peb muaj hnub nyoog.
Kev nce qib tsis ntev los no hauv 5 Amino 1MQ Peptide Txhaj Tshuaj Cellular Tshawb Fawb
Niaj hnub no, kev tshawb fawb siv qhov sib xyaw no tau dhau mus dhau qhov kev saib xyuas cov kab mob metabolic kom saib ntau yam ntawm cov ntsuas kev noj qab haus huv ntawm tes. Cov kws tshawb fawb tsis ntev los no tau saib mus rau hauv yuav ua li cas thaiv NNMT cuam tshuam cov protein homeostasis, uas dhau los ntawm whack raws li cov neeg muaj hnub nyoog. Cov kev hloov pauv hauv kev qhia tawm ntawm cov protein thiab cov autophagy txaus tau kawm. Qhov no qhia tias tej zaum yuav muaj kev sib txuas ntawm kev tswj cov metabolism thiab ua kom cov hlwb noj qab nyob zoo.
Kev tshawb fawb Epigenetic yog lwm thaj chaw ntawm kev txiav ntug qhov twg 5 amino 1mq peptide txhaj tuaj yeem pab tau rau kev tshawb fawb. Vim tias NAD + yog lub substrate rau cov enzymes uas hloov DNA methylation thiab hloov histone, cov tshuaj uas hloov qhov muaj ntawm NAD + yuav hloov epigenetic toj roob hauv pes. Cov kws tshawb fawb tab tom saib seb qhov kev ntsuas metabolic puas tuaj yeem tiv thaiv cov kab mob epigenetic uas los nrog kev laus.
Epigenetic drift yog qhov hloov pauv qeeb hauv cov qauv qhia cov noob uas ua rau lub sijhawm. Kev tswj qhov mob kuj yog ib qho tseem ceeb ntawm txoj kev kawm, tshwj xeeb tshaj yog thaum nws los txog rau kev laus -sociated secretory phenotype (SASP). Cov hlwb uas laus zuj zus feem ntau tso cov tshuaj uas ua rau mob thiab ua rau cov ntaub so ntswg nyob ib puag ncig lawv. Cov kws tshawb fawb hauv chav kuaj sim tau siv cov qauv los saib seb puas muaj kev hloov pauv hauv metabolic cuam tshuam rau qhov profile no. Lawv tau pom cov kev hloov pauv ntawm cov qauv ntawm cytokine tso tawm thiab kev ua haujlwm ntawm cov kab mob inflammatory kab mob tom qab muab cov tshuaj sib txuas.
Xaus
Cov5mq1 uapeptide txhaj tshuajyog ib qho cuab yeej tseem ceeb rau kev kawm kev laus niaj hnub no vim tias nws cia cov kws tshawb fawb saib mus rau hauv cellular metabolic txoj hauv kev nrog ib theem ntawm kev nthuav dav uas tsis tau pom dua ua ntej. Cov kws tshawb fawb tuaj yeem nrhiav kev sib txuas ntawm kev tsim hluav taws xob, kev ua haujlwm mitochondrial, thiab ua kom cov hlwb noj qab haus huv los ntawm kev thaiv NNMT. Raws li cov chaw sim thoob ntiaj teb txuas ntxiv mus saib txoj hauv kev kom txo qis kev laus, kev nkag mus rau cov tshuaj tshawb fawb ntseeg tau dhau los ua qhov tseem ceeb dua rau kev kawm txuj ci.
Kev siv cov kev tshawb fawb ntau los ntawm cov kev tshawb fawb thev naus laus zis uas saib yuav ua li cas NAD + ua haujlwm rau hauv - kev tshawb fawb tob uas saib seb cov kev hloov pauv hauv metabolic cuam tshuam li cas rau ntau lub xov tooj ntawm tes tib lub sijhawm. Kev nkag siab meej txog yuav ua li cas cov tshuaj ua haujlwm ua rau kev xav -tsim kev kawm ua tau, uas ntxiv rau peb qhov kev nkag siab tag nrho ntawm cov hlwb hnub nyoog li cas. Thaum kawg, cov kev tshawb fawb no pab cov kws tshawb fawb kawm paub ntau ntxiv txog qhov kev tswj hwm cov metabolism cuam tshuam li cas rau kev noj qab haus huv thiab cellular tseem ceeb hauv lub neej ntawm tib neeg lub neej.
FAQ
1. Vim li cas 5 amino 1mq peptide txhaj tshuaj tseem ceeb rau kev kawm seb cov hlwb ua haujlwm li cas?
Qhov sib xyaw no muab cov kws tshawb fawb txog txoj hauv kev tshwj xeeb los nres NNMT enzyme los ntawm kev ua haujlwm. Qhov no cia lawv kawm seb txoj kev metabolic no cuam tshuam li cas ntawm NAD + thiab cov txheej txheem txuas ntxiv hauv kab hauv hlwb. Vim tias nws cov txheej txheem tau nkag siab zoo, nws tuaj yeem tsim cov kev sim tswj uas cais cov teebmeem metabolic los ntawm kev hloov pauv uas yuav ua rau tsis meej pem.
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2. Cov chaw kuaj mob feem ntau khaws thiab tswj cov tshuaj no li cas?
Txhawm rau kom lawv ruaj khov thiab ua haujlwm, kev tshawb fawb -qib cov ntsiab lus yuav tsum tau muab khaws cia rau hauv txoj kev. Cov ntaub ntawv hmoov feem ntau yog khaws cia hauv chav kuaj hauv cov rooj plaub ntawm qhov kub thiab txias, thiab cov kev daws teeb meem tshiab ua haujlwm tau ua raws li cov cai ntawm kev sim. Daim ntawv pov thawj ntawm cov ntaub ntawv txheeb xyuas los ntawm cov neeg muag khoom tsim nyog yuav tsum tuaj nrog cov lus qhia ntxaws ntxaws.
3. Cov ntaub ntawv tshawb fawb hom twg yuav tsum tuaj nrog cov tshuaj uas siv hauv kev tshawb fawb?
High -cov ntaub ntawv kawm zoo yuav tsum tuaj nrog tag nrho cov ntawv pov thawj ntawm kev tshuaj xyuas uas teev cov qib purity uas tau kuaj xyuas siv HPLC, cov qauv uas tau lees paub tias siv cov spectrometry loj lossis NMR, thiab cov ntaub ntawv tswj xyuas zoo uas yog tshwj xeeb rau txhua pawg. Cov neeg muag khoom ntseeg tau muab cov kws tshawb fawb pom tseeb cov ntaub ntawv txheeb xyuas uas tso cai rau lawv tshawb xyuas qhov sib xyaw ua ke thiab qhov zoo ua ntej siv nws hauv kev sim.
Vim li cas thiaj xaiv BLOOM TECH li Koj Trusted 5 Amino 1MQ Peptide Txhaj Muag Khoom?
Bloom Tech sawv ua tus tsim nyog5 amino 1mq peptide txhajtus neeg muag khoom uas muaj ntau yam kev txawj ntse uas tuaj yeem pab koj ncav cuag koj cov hom phiaj tshawb fawb. Peb 100,000-square-meter ntau lawm cov nroj tsuag yog GMP- ntawv pov thawj thiab khaws lawv cov ntawv pov thawj los ntawm US-FDA, EU-GMP, PMDA, thiab CFDA. Qhov no ua kom paub tseeb tias qhov zoo yog ib txwm ua raws li cov qauv txawv teb chaws. Peb tau ua cov organic tebchaw thiab tshuaj intermediates rau ntau tshaj 12 xyoo, thiab peb muaj peev xwm muab koj cov kev tshawb fawb-qib tebchaw nrog tag nrho cov ntaub ntawv txheeb xyuas, xws li HPLC thiab cov ntaub ntawv loj spectrometry.
Peb mob siab rau ntau tshaj li muab cov khoom lag luam; peb muab cov kev pabcuam tiav uas suav nrog tus nqi meej, lub sijhawm ua haujlwm raug kaw hauv peb lub ERP platform, thiab cov kws tshaj lij kev pabcuam los ntawm peb pab pawg R & D. Peb cov saw hlau muab tau yooj yim txaus los ua kom tau raws li qhov xav tau ntawm txhua qhov haujlwm, txawm tias koj xav tau gram- teev cov nqi rau cov kev tshawb fawb yooj yim lossis cov lej loj rau cov kev tshawb fawb loj. Hu rau pebSales@bloomtechz.compab neeg los tham txog koj cov kev xav tau kev tshawb fawb thiab nrhiav seb peb txoj kev lees paub zoo thiab cov neeg siv khoom li cas -cov qauv kev pabcuam tsom tuaj yeem pab koj cov kev tshawb fawb txog kev laus ntawm tes.
Cov ntaub ntawv
1. Kraus D, Yang Q, Kong D, et al. Nicotinamide N-methyltransferase knockdown tiv thaiv kev noj haus- ntxias rog rog. Xwm . 2014;508(7495):258-262.
2. Katsyuba E, Romani M, Hofer D, Auwerx J. NAD+ homeostasis hauv kev noj qab haus huv thiab kab mob. Nature Metabolism. 2020;2(1:9-31.
3. Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. Los ntawm kev tshawb nrhiav kev laus mus rau kev kho mob rau kev laus laus. Xwm . 2019;571(7764):183-192.
4. Yoshino J, Baur JA, Imai SI. NAD + intermediates: biology thiab kho muaj peev xwm ntawm NMN thiab NR. Cell Metabolism. 2018;27(3):513-528.
5. Lpez-López-Otín, Blasco MA, Partridge L, Serrano M, Kroemer G. Cov cim ntawm kev laus. Cell . 2013; 153(6): 1194-1217.
6. CantC, Menzies KJ, Auwerx J. NAD + metabolism thiab tswj lub zog homeostasis: ib qho kev sib npaug ntawm mitochondria thiab cov nucleus. Cell Metabolism. 2015;22(1:31-53.
