5 Amino 1MQ Txhaj Tshuaj Ua kom AMPK Zog Txoj Kev

Raws li kev tshawb fawb txog kev noj qab haus huv metabolic tau nce mus, cov kws tshawb fawb tau pom cov txheej txheem tshiab ntawm kev tswj lub zog ntawm tes. 5 amino 1mq peptide txhajtuaj yeem ua haujlwm nrog tib neeg lub zog ntawm tes - tswj txoj hauv kev. Qhov no hluavtaws nanomolecule zoo activates metabolic txoj kev, nrog rau AMPK zog txoj kev.

Cov molecule no nkag siab zoo dua thaum koj nkag siab txog lub zog ntawm tes. Lub zog xav tau los ntawm txhua lub cell kom ua haujlwm, kho, thiab noj qab nyob zoo. Lub zog hloov pauv tau raug kho siv cov sensors tshwj xeeb. Cells siv txoj hauv kev AMPK ua qhov ntsuas roj txhawm rau txheeb xyuas qhov tsis txaus ntawm lub zog thiab teb.

Cov kev tshawb fawb metabolic optimization qhia tau hais tias nce AMPK ua kom nce metabolic yooj, mitochondrial muaj nuj nqi, thiab cellular kuj. Lub molecular biology thiab kev noj qab haus huv daim ntaub ntawv ntawm 5 amino 1mq thiab AMPK ua kom txaus nyiam. Cov tshuaj tshiab no suppresses nicotinamide N-methyltransferase. Qhov no hloov pauv downstream AMPK signaling.

Cov kev daws teeb meem kev noj qab haus huv tau nrov vim tias lub zog ntawm tes metabolism cuam tshuam rau ntau yam kev noj qab haus huv. Kev kho lub zog channel zoo tuaj yeem pab cov neeg mob tswj qhov hnyav thiab kev noj qab haus huv mitochondrial. Cov kws tshawb fawb tab tom tshawb nrhiav AMPK ntau yam haujlwm lom neeg. Cov kws tshawb fawb thiab kws kho mob txaus siab rau txoj hauv kev- ua kom cov tshuaj zoo li 5 amino 1mq.

 

5-Amino-1MQ Peptide Txhaj Tshuaj

1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
(3) Txhaj tshuaj
(4) Capsules
(5) Kua dej
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Internal Code: KP-3-5/002
CAS Nr .: 42464-96-0
Cov mis mos molecular: C10H11N2.I
HS code: N/A
Molecular Luj: 286.11
EINECS tus lej: 464-196-0
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4

Peb muab 5-Amino-1MQ Peptide Txhaj Tshuaj, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.

Khoom siv:https://www.kpeptide.com/peptides-healthy/5-amino-1mq-peptide-injection.html

Kev ua kom AMPK txuas nrog 5 amino 1mq peptide txhaj hauv txoj kev uas tsis yog ncaj qha tab sis muaj zog heev. Tus txiv neej no- ua tshuaj tsis khi rau AMPK ncaj qha; Hloov chaw, nws mus tom qab NNMT, ib qho enzyme uas muaj ntau hauv cov ntaub so ntswg adipose. NNMT yog ib feem tseem ceeb ntawm cov txheej xwm methylation uas siv nicotinamide adenine dinucleotide (NAD+), ib qho tseem ceeb coenzyme uas koom nrog ntau cov txheej txheem metabolic.

Nkag siab txog NNMT-NAD+ Kev Sib Txuas

Nws txhawb kev siv NAD + los ntawm cov txheej txheem methylation thaum NNMT kev ua haujlwm nce. Thaum NAD + qib poob, cov teebmeem metabolic tshwm sim vim nws yog ib qho tseem ceeb cofactor rau ntau cov enzymes uas ua rau lub zog. Cov qib qis ntawm NAD + ua rau nws nyuaj rau cov hlwb los ua lub zog, uas hloov mitochondria ua pa zoo li cas thiab cov metabolism hauv tag nrho ua haujlwm li cas.

5 amino 1mq tiv thaiv cellular NAD + khw muag khoom los ntawm kev txwv NNMT kev ua. Cov kev tshawb fawb ua tiav ntawm cov qauv ntawm kev rog rog los ntawm kev noj zaub mov qhia tias thaiv NNMT tuaj yeem nce qib NAD + zoo heev. Ua raws li kev kho mob zoo ib yam, NAD + qib tau nce 2.3 zaug hauv qhov chaw sim, qhia txog kev hloov pauv loj hauv cov peev txheej metabolic ntawm cov hlwb.

NAD + Kev nce qib thiab AMPK Kev Tshaj Tawm

Khaws NAD + ib puag ncig ua rau nws yooj yim dua rau AMPK pib ua haujlwm. AMPK yog lub zog saib xyuas uas tig rau thaum qhov piv ntawm AMP rau ATP nce mus, uas txhais tau hais tias cov hlwb poob zog. Tab sis tus nqi ntawm NAD + kuj cuam tshuam rau txoj hauv kev no los ntawm kev sib txuas lus uas txuas rau ib leeg. Ntau NAD + pab kev ua haujlwm ntawm sirtuin proteins, tshwj xeeb tshaj yog SIRT1, uas ua haujlwm nrog AMPK taw qhia txoj hauv kev.

Cov kws tshawb fawb tau pom tias nce NAD + thiab ua kom AMPK ua haujlwm ua ke los pab cov metabolism. Cov nyhuv ob npaug no ua rau nws yooj yim dua rau cov hlwb ua ATP los ntawm mitochondrial oxidative phosphorylation thiab tseem pab lawv siv roj ntau dua. Cov metabolic reprogramming hloov ntau dua li qhov ua kom lub zog; Nws kuj hloov pauv cov noob tau qhia li cas hauv txoj hauv kev uas cuam tshuam rau kev noj qab haus huv metabolic.

Metabolic Hloov thiab siv roj

Thaum AMPK qhib, qhov hloov pauv metabolic tau ua uas ua rau hlawv rog ntau dua li siv cov piam thaj. Qhov kev hloov pauv no tseem ceeb tshwj xeeb rau cov neeg uas xav txhim kho lawv cov metabolic yooj thiab lub cev qauv. Overactive AMPK cov cim qhia ua rau cov hlwb ua rau muaj kev nthuav qhia ntawm cov noob uas ua rau fatty acid oxidation enzymes xws li ACOX1 thiab CPT1A (3, 4).

Tsiaj thwmsim qhia tau hais tias kev kho tsiaj nrog 5 amino 1mq zoo heev ua rau kev nthuav qhia ntawm cov kab mob metabolic no. Qhov sib xyaw ua ke muaj peev xwm txo qis cov ntaub so ntswg adipose los ntawm 35% hauv kev sim tshuaj preclinical txuas rau nws lub peev xwm ntau dua los hlawv roj. Qhov kev hloov pauv hauv cov metabolism no qhia tau hais tias yuav ua li cas AMPK pab cov hlwb xaiv cov roj zoo raws li lawv lub zog xav tau thiab muaj cov substrates.

Rau cov hlwb kom muaj sia nyob, lawv xav tau cov sensors nyuaj uas niaj hnub kuaj xyuas lub zog thiab cov khoom noj uas lawv tau nkag mus. AMPK yog ib qho ntawm cov laus tshaj plaws thiab ruaj khov lub zog sensors hauv cov khoom muaj sia, thiab nws tuaj yeem pom hauv cov poov xab rau tib neeg. Yog koj paub li cas lub5mq1 uapeptide txhaj tshuajcuam ​​tshuam rau qhov kev tswj hwm yooj yim no, koj tuaj yeem paub seb nws cuam tshuam li cas rau cov metabolism hauv feem ntau.

AMPK Structure thiab Activation Mechanisms

AMPK yog ib qho heterotrimeric complex ua los ntawm kev tswj beta thiab gamma subunits thiab nquag alpha subunits. Lub gamma subunit muaj qhov chaw rau adenine nucleotides los khi, uas cia AMPK ncaj qha ntsuas tus nqi ntawm AMP, ADP, thiab ATP hauv hlwb. Thaum cov nqi hluav taws xob poob qis, AMP-rau-ATP piv nce, uas ua rau muaj kev hloov pauv hauv cov qauv uas tig rau lub enzyme.

Qee cov kinases sab sauv, xws li daim siab kinase B1 (LKB1) thiab calcium / calmodulin-nyob ntawm cov protein kinase kinase 2 (CaMKK2), phosphorylate threonine-172 ntawm alpha subunit los pib ua kom cov txheej txheem ua kom muaj zog. Sai li AMPK qhib, nws phosphorylates ntau cov dej hauv qab. Cov no hloov cov metabolism hauv hlwb kom catabolic txoj hauv kev ua ATP thaum txoj kev anabolic siv zog.

Indirect AMPK Activation Los ntawm Metabolic Remodeling

5 amino 1mq hloov cov kev ua ntawm AMPK los ntawm kev hloov cov metabolism hauv es tsis txhob cuam tshuam ncaj qha nrog cov enzyme. Qhov sib xyaw ua ke ua rau cov hlwb ntau dua rau AMPK kom qhib los ntawm kev thaiv NNMT thiab ua kom NAD + qib tsis tu ncua. NAD + qib siab dua ua kom muaj NAD + / NADH ntau dua, uas txuas rau kev ua pa ntawm mitochondrial zoo dua thiab muaj txiaj ntsig ATP ntau lawm.

Cov kws tshawb fawb tau pom tias cov hlwb uas tau kho nrog NNMT inhibitors muaj cov pa oxygen metabolism zoo dua. Tus nqi ntawm cov kab mob ua pa nyuaj thiab cov ntawv theej DNA hauv mitochondria loj hlob, thiab ATP ntau lawm cov nqi txhim kho. Cov kev hloov pauv no qhia tau hais tias metabolic reprogramming ua haujlwm, uas txhais tau hais tias AMPK- tau tsav cov lus teb rau kev tsis txaus ntawm lub zog tsis xav tau ntau npaum li.

Coordinated Metabolic Signaling Networks

AMPK yog ib feem ntawm kev sib txuas lus uas suav nrog sirtuins, peroxisome proliferator-activated receptors (PPARs), thiab lwm yam kev tswj hwm cov metabolism. Nws tsis ua haujlwm ntawm nws tus kheej. NAD+-dependent deacetylase SIRT1 cuam tshuam nrog AMPK hauv txoj hauv kev tseem ceeb heev. SIRT1 tuaj yeem qhib tau los ntawm qib siab NAD +, uas tuaj yeem cuam tshuam ncaj qha rau AMPK los ntawm deacetylate LKB1 thiab ua kom nws ua haujlwm zoo dua li kinase.

Qhov kev sib txuas ntawm cov teeb liab no ua rau muaj kev cuam tshuam loj, uas tshwm sim thaum hloov me me hauv ib feem ntawm txoj kev muaj qhov cuam tshuam loj ntxiv hauv kab. Vim tias 5 amino 1mq tuaj yeem nce NAD +, nws cuam tshuam tsis tsuas yog AMPK ncaj qha tab sis kuj tseem muaj lwm txoj hauv kev uas ua haujlwm ua ke los txhim kho kev ua haujlwm metabolic. Kev tshawb fawb ntawm cov ntaub ntawv pov thawj qhia tau hais tias cov noob muaj feem xyuam rau mitochondrial biogenesis, fatty acid oxidation, thiab tiv thaiv antioxidant yog tag nrho tib lub sijhawm.

Energy Sensing thiab Mitochondrial Quality Control

AMPK ua kom txuas txoj kev hlwb nkag siab lub zog rau cov kev tswj xyuas zoo hauv mitochondria. Txhawm rau kom cov neeg nyob hauv mitochondrial noj qab nyob zoo, kev sib txuas, kev sib txuas, fusion, thiab xaiv autophagy (mitophagy) yuav tsum tau teeb tsa. PGC-1 (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) yog tus tswv tswj hwm ntawm mitochondrial noob qhia uas ua thaum AMPK ua haujlwm.

Cov kws tshawb fawb uas tau saib mus rau hauv yuav ua li cas 5 amino 1mq cuam tshuam rau mitochondrial tsis tau pom tias lawv ua qhov sib txawv loj hauv kev noj qab haus huv ntawm mitochondria. Lub peev xwm ntawm daim nyias nyias nyob twj ywm zoo ib yam, kev tsim cov pa oxygen reactive poob qis, thiab muaj peev xwm ua pa tau zoo dua. Cov kev hloov pauv no qhia tau tias lub zog-sensing signals thiab mitochondrial zoo tswj systems tau ua tiav ua ke, nrog rau AMPK kev ua si ua ib feem.

Metabolic zog signaling tswj kev siv roj, cia, thiab kev sib txuas ntawm tes los ntawm kev sib txuas lus nyuaj. Cov5 amino 1mq peptide txhajhloov cov kev taw qhia txoj hauv kev dhau ntawm kev ua kom AMPK. Qhov no hloov cov metabolism hauv ntau dua.

Adipose ntaub so ntswg metabolic reprogramming

NNMT feem ntau muaj nyob rau hauv cov ntaub so ntswg adipose dawb, ua rau nws yog 5 amino 1mq lub hom phiaj. Adipocytes khaws lub zog thiab tso tawm cov tshuaj hormones- zoo li cov tshuaj uas tswj lub cev metabolism. Cov rog ntau dhau, tshwj xeeb tshaj yog cov rog rog, ua rau muaj teeb meem metabolic, suav nrog insulin insensitivity.

Metabolic reprogramming pib nrog 5 amino 1mq hauv cov ntaub so ntswg adipose. Thaiv NNMT txo cov lipogenic noob uas tsim fatty acid synthase (FAS) thiab stearoyl-CoA desaturase-1 (SCD1). Kev nthuav qhia ntawm cov noob roj hlawv kuj nce ntxiv. Qhov no converts adipocytes los ntawm cov roj khaws cia rau cov neeg siv rog.

Hauv kev noj haus-cov qauv kev rog rog, cov nqaij rog rog poob sai sai tom qab kho. Epididymal fat pad hnyav tau txo 35% hauv cov tsiaj kho mob piv rau kev tswj. Qhov no qhia tau hais tias tsis zoo adipose depot zog tshuav nyiaj li cas. Nws zoo nkaus li tias kev rov pib metabolic tshwm sim hauv cov ntaub so ntswg tshwj xeeb thiab tsis yog vim txo calories xwb.

Insulin Sensitivity thiab Glucose Homeostasis

Glucose homeostasis thiab insulin rhiab heev yog qhov tseem ceeb rau kev noj qab haus huv hauv metabolic. Kev ua kom AMPK txhim kho kev ua haujlwm mitochondrial, glucose transporter translocation, thiab o, ua rau insulin ua tau zoo. Glucose metabolism qhia qhia 5 amino 1mq cov teebmeem.

Hauv cov qauv metabolic syndrome, kev kho mob txo cov ntshav qabzib los ntawm 22% thaum tsis noj. HOMA- IR tus qhab nia, uas ntsuas cov tshuaj insulin tsis kam, nce 40%, qhia tias muaj kev nkag siab ntawm insulin ntau ntxiv. Cov kev nce no tshwm sim txawm tias thaum koj tsis noj zaub mov, qhia tias lawv muaj cov txiaj ntsig metabolic tshaj li calorie tshuav.

Muaj ntau yam ua kom muaj kev nkag siab zoo ntawm insulin. Kev ua tau zoo ntawm mitochondrial pab cov hlwb hlawv cov piam thaj thiab fatty acids, txo cov tshuaj insulin- cov ntaub so ntswg rhiab heev. AMPK hloov cov piam thaj mus rau -4 (GLUT4) mus rau cov cell membranes, ua kom cov piam thaj nqus tau yooj yim dua. Cov qib qis ntawm IL-6 thiab TNF- qhia tias muaj kev mob tsawg dua, uas cuam tshuam cov teeb liab insulin.

Hla -Tissue Metabolic Communication

Cov nqaij rog, cov nqaij pob txha, lub siab, thiab lub hlwb yuav tsum txuas rau kev noj qab haus huv hauv metabolic. AMPK txuas cov ntaub so ntswg 'zog qib zog rau lub cev metabolic xav tau raws li qhov chaw taw qhia . 5 amino 1mq's systemic actions hloov cov ntaub so ntswg kev sib txuas lus.

Cov nqaij ntshiv skeletal dominate lub zog siv nyiaj thiab metabolic yooj. AMPK hauv cov leeg nqaij pab lub cev nqus cov piam thaj, hlawv rog, thiab tsim mitochondria. Cov kws tshawb fawb pom muaj ntau dua mitochondria, muaj peev xwm oxidative ntau dua, thiab cov metabolism hauv cov noob hauv cov nqaij tsiaj kho. Koj cov metabolism thiab qoj ib ce txhim kho nrog cov kev hloov kho no.

Lub siab metabolism cuam tshuam los ntawm AMPK signaling. Lub siab tswj cov piam thaj, lipids, thiab ketone lub cev raws li qib zog. Thaum AMPK qhib rau hauv hepatocytes, qabzib thiab rog synthesis qeeb, thiab fatty acid ntau lawm. Txawm hais tias muaj kev tshawb fawb ntxiv ntawm 5 amino 1mq qhov cuam tshuam ncaj qha rau daim siab, kev txhim kho hauv lub cev metabolism qhia tau zoo rau daim siab metabolic hloov pauv.

Thaiv NNMT boosts metabolism los ntawm activating AMPK txoj kev. Cov tshuaj stimulating lub cev yog ncaj qha AMPK activators. Txawm li cas los xij, 5 amino 1mq peptide txhaj tshuaj hloov cell NAD + qib nce mus. Qhov no tsim cov xwm txheej metabolic uas qhib AMPK.

Sustained Metabolic teebmeem

Kev thaiv NNMT tsis ncaj qha ua rau AMPK, uas muaj - cov teebmeem metabolic ntev. Direct AMPK activators ua rau luv luv -cov lus teb uas tsis muaj zog nyob rau lub sijhawm vim muaj kev ntxhov siab hloov pauv. Txawm li cas los xij, nres NNMT thiab tswj NAD + qib txhim kho cov metabolism yam tsis muaj kev txo qis.

Ntev -kev sim kho lub sij hawm qhia tau hais tias cov teebmeem metabolic nyiaj tau los. Lub yim-lub lim tiam- kho tsiaj tau nthuav tawm cov kab mob metabolic zoo dua thiab tsis pom kev zam. Kev hloov pauv hauv metabolic, suav nrog kev txo qis, kev nkag siab ntawm insulin, thiab kev ua haujlwm mitochondrial khaws cia, qhia tias lawv tsis muaj kev phiv tshuaj.

Lub sij hawm ntev - cuam tshuam tej zaum yuav yog vim rov qab kho cov metabolism ntau dua li nias nws nyuaj dua . 5 amino 1mq boosts cell zog tiam yam tsis muaj kev pab sab nraud. Ua rau NAD + tuaj yeem siv tau dua. Cov tswv yim no siv lub cev cov txheej txheem tswj hwm hauv lub cev, txo cov kev hloov pauv hormonal los ntawm cov txheej txheem ntau dua.

Kev sib koom ua ke nrog kev cuam tshuam kev ua neej

Kev noj qab haus huv metabolic feem ntau suav nrog kev noj zaub mov zoo dua thiab tawm dag zog ntau dua. AMPK txoj kev txhim kho nrog 5 amino 1mq ua haujlwm zoo dua nrog kev cob qhia kev tawm dag zog, kev tshawb fawb qhia. Kev tawm dag zog ib txwm ua rau AMPK, nce AMP synthesis thiab calcium signaling. Inhibiting NNMT muaj lwm yam cuam tshuam.

Cov ntaub ntawv pov thawj piv rau cov tsiaj uas tsis tau tawm dag zog, tawm dag zog, thiab tau txais kev kho mob ob qho tib si qhia tau hais tias muaj txiaj ntsig zoo ntawm hierarchical . 5 amino 1mq txhawb kev tuav ntawm cov tsiaj nyob ruaj ruaj los ntawm 20%. Kev tawm dag zog ib leeg txhim kho 40%. Nws 60% nce qhia tau hais tias kev sib koom ua ke, tsis yog qhov zoo ntxiv.

Kev sib koom cov txheej txheem metabolic qhib ib txhij, ua rau muaj kev sib koom ua ke. Kev tawm dag zog thiab NNMT thaiv kev txhawb nqa kev loj hlob ntawm mitochondrial los ntawm kev ua kom PGC-1 . Nws ua rau cov rog hlawv yooj yim dua thiab cov metabolism hloov pauv. Thaum sib xyaw ua ke, kev cuam tshuam ua rau muaj txiaj ntsig zoo txhim kho, thiab cov txiaj ntsig tau zoo dua li thaum txhua tus txheej txheem ua haujlwm ib leeg.

Metabolic Resilience thiab Stress Adaptation

AMPK tuaj yeem qhib tau rau ntau txoj hauv kev los pab cov hlwb hauv kev tswj kev ntxhov siab. Cov enzyme ua rau kom muaj kev tiv thaiv antioxidant, tswj cov protein zoo, thiab ua kom autophagy. Cov dej num no cia cov hlwb tiv thaiv cov kev ntxhov siab xws li kev noj zaub mov hloov pauv, kev puas tsuaj oxidative, thiab kev sib sau cov protein.

NNMT inhibitors pab hlwb zam kev ntxhov siab thiab ua haujlwm, raws li kev tshawb fawb. Thaum cov metabolism raug thawb, mitochondrial membrane tej zaum tseem zoo ib yam, thiab reactive oxygen hom tsim txo qis, qhia txog kev tswj kev ntxhov siab. Ntxiv protein aggregation kuj txo cov misfolded protein ntau nyob rau hauv cov qauv mob.

Kev ntxhov siab tsis kam muaj cov kev siv tswv yim sab nraud ntawm cov chaw sim. Kev ua kom cov metabolism zoo dua tuaj yeem pab cov tib neeg hloov mus rau kev hloov pauv kev noj haus, rov qab sai dua ntawm kev tawm dag zog, thiab tswj cov metabolism hauv cov txheej txheem lom neeg. Ntau yam ntawm kev tiv thaiv qhia tau hais tias qhov tseem ceeb AMPK yog li cas rau kev hloov kho ntawm tes thiab kev ciaj sia.

Lub zog sib npaug yog qhov sib npaug ntawm kev siv zog, kev siv, thiab kev cia. Lub cev xav tau cov txheej txheem kev tswj hwm nyuaj uas xav txog cov teeb meem los ntawm ntau qhov chaw, xws li kev noj haus, qib tshuaj hormones, thiab cov ntaub so ntswg xav tau lub zog, kom tswj tau qhov sib npaug. Cov5 amino 1mq peptide txhajinfluences zog tshuav nyob rau hauv ntau txoj kev uas muaj feem xyuam.

Thermogenesis thiab Energy Expenditure

Lub zog yog siv los ntawm kev hloov pauv thermogenesis, basal metabolic tus nqi, thiab kev ua si lub cev. AMPK- tswj kev hloov pauv thermogenesis, tshwj xeeb tshaj yog tsis yog -shivering thermogenesis hauv xim av thiab beige adipose cov ntaub so ntswg, tswj lub zog poob.

Ntau cov nqaij adipose xim av mitochondria nthuav qhia UCP1. Hloov chaw ntawm kev tsim ATP, UCP1 rhuav tshem cov khoom siv hluav taws xob thauj cov saw hlau proton gradient nrog cua sov. Uncoupling khib nyiab tsis muaj txiaj ntsig cov hlwb. Dawb adipose cov ntaub so ntswg tuaj yeem ua xim av thiab ua beige adipocytes uas hlawv roj thaum AMPK qhib.

Tom qab kho cov ntaub so ntswg rog nrog 5 amino 1mq, cov kws tshawb fawb tau qhia txog kev txhim kho thermogenic muaj peev xwm. Raws li tus lej mitochondrial nce, oxidative noob qhia nce, thiab cov ntaub so ntswg metabolism txhim kho. Cov kev hloov pauv no qhia tau tias inhibiting NNMT tuaj yeem cuam tshuam kev siv hluav taws xob los ntawm kev hloov pauv cov ntaub so ntswg adipose thermogenesis. Kev tshawb nrhiav calorimetry ncaj qha yuav tsum tau tsim kom pom seb qhov no ua rau lub cev siv zog ntxiv.

Circadian Metabolic Rhythm

Circadian rhythms tswj lub zog sib npaug, uas ua ke nrog kev noj mov, txav mus los, thiab so. AMPK cov qib kev ua ub no hloov pauv nrog lwm cov kev tswj hwm cov metabolism hauv ib hnub los tswj cov metabolism. NAD + theem hloov pauv txhua hnub thiab cuam tshuam los ntawm NAMPT.

Kev sib raug zoo ntawm NNMT kev ua haujlwm thiab circadian metabolism yog raug kawm. Qhov muaj NAD + thiab cov cim metabolic tom qab hnub tuaj yeem nyob ntawm NNMT qhia qib. 5 amino 1mq tuaj yeem hloov pauv cov metabolism hauv circadian los ntawm inhibiting NNMT. Qhov no tuaj yeem txhim kho cov metabolism hauv kev hloov pauv rau kev noj mov thiab kev yoo mov.

Teeb meem nrog circadian rhythms yuav ua rau rog rog, insulin tsis kam, thiab metabolic syndrome. Kev kho mob tuaj yeem suav nrog kev hloov pauv ntawm lub cev uas rov ua kom circadian metabolic rhythms. Qhov twg NNMT inhibition, NAD + metabolism, thiab circadian kev tswj ua ke, ntau yam tsis paub. Cov kev tshawb fawb ntau ntxiv tuaj yeem piav qhia txog qhov cuam tshuam metabolic no.

Hypothalamic zog Sensing

Los ntawm kev tswj cov khoom noj thiab lub zog noj, lub hypothalamus tswj lub zog sib npaug. Nws ua tiav qhov no los ntawm kev sib xyaw cov cim ntawm tes xws li leptin, insulin, thiab khoom noj khoom haus. AMPK muaj ntau yam haujlwm hauv lub zog homeostasis hauv hypothalamus. Ntau hom neurones ua kom sib txawv, cuam tshuam rau kev noj zaub mov thiab metabolism.

Hauv pro-opiomelanocortin (POMC) neurones, AMPK ua kom txo qis qab los noj mov thiab nce kev siv hluav taws xob, hos hauv AgRP neurones, nws ua qhov thim rov qab. Cov kev kho mob hloov kho lub hypothalamus lub zog tswj nyob ntawm seb cov neurones cuam tshuam dab tsi thiab yuav ua li cas peripheral metabolism cuam tshuam rau lub hlwb.

Tus nqi ntawm cov khoom noj tsiaj kho nrog 5 amino 1mq noj tsis hloov, tab sis nws tau cuam tshuam rau lawv cov metabolism. Qhov no qhia tias cov tshuaj cuam tshuam rau peripheral metabolism es tsis yog tswj kev tshaib kev nqhis. Qhov hnyav txo thaum tswj kev noj zaub mov qhia txog kev txhim kho metabolic, tsis txwv calorie.

Tig rau AMPK zog txoj hauv kev nrog a5 amino 1mq peptide txhajtuaj yeem txhawb cov metabolism. Tus txiv neej no- ua tshuaj txhim kho AMPK teeb liab los ntawm kev tsom NNMT thiab khaws cia cov cellular NAD+ reserves. Cov txiaj ntsig metabolic suav nrog kev txhim kho cov tshuaj insulin, kev ua haujlwm mitochondrial, kev siv roj, thiab lub zog sib npaug.

Ntau cov kev tshawb fawb qhia txog cov txiaj ntsig tseem ceeb hauv metabolic hauv ntau yam tsiaj sim. Kev ua kom cov metabolism hauv kev ua kom tiav ua rau txo qhov hnyav, rog poob, txhim kho cov piam thaj hauv cov metabolism, thiab muaj peev xwm tawm dag zog. NNMT inhibition thiab kev tawm dag zog ua haujlwm tau zoo ua ke, qhia tias lawv tuaj yeem ua haujlwm hauv cov kev pabcuam kev noj qab haus huv metabolic.

Nkag siab li cas NNMT kev tawm tsam, NAD + kev tuav pov hwm, thiab AMPK kev sib cuam tshuam qhia tau tias cov hlwb tswj hwm lub zog li cas. Kev sib koom ua ke ntawm cov txheej txheem tswj cov txheej txheem metabolic yog tshwm sim los ntawm kev cuam tshuam ntawm kev taw qhia txoj hauv kev xws li sirtuins, PGC-1, thiab metabolic gene qhia. Qhov kev nkag siab no txhawb kev kawm ntau dua rau kev txhim kho metabolic noj qab haus huv siv lawv li cas.

Cov txheej txheem metabolic no tuaj yeem pab cov neeg mob txo qhov hnyav, txhim kho metabolic yooj, thiab ua kom lub zog ntawm tes. Cov kws tshawb fawb thiab kws kho mob yuav zoo li yuav tau them nyiaj ntau dua rau cov tshuaj xws li 5 amino 1mq uas lub hom phiaj tseem ceeb ntawm kev tswj hwm lub zog thaum lawv kawm paub ntau ntxiv txog lawv qhov zoo thiab kev siv zoo.

BLOOM TECH sawv ua tus tsim nyog5 amino 1mq peptide txhajtus neeg muag khoom nrog ntau tshaj 12 xyoos ntawm kev txawj ntse hauv cov organic synthesis thiab tshuaj intermediates. Peb GMP-cov chaw tsim khoom tau ntawv pov thawj raws li cov qauv thoob ntiaj teb suav nrog US-FDA, EU-GMP, thiab PMDA ntawv pov thawj, ua kom cov kws tshuaj- qib zoo rau kev tshawb fawb thiab kev tsim kho daim ntawv thov. Peb muab cov ntaub ntawv txheeb xyuas dav dav, cov khoom sib xws, thiab kev txhawb nqa kev pabcuam rau cov tuam txhab tshuaj, cov koom haum biotechnology, CDMOs, thiab cov chaw tshawb fawb.

Peb qhov kev cog lus rau kev ua tau zoo suav nrog peb npaug - txheej txheem pov thawj los ntawm kev kuaj lub Hoobkas, QA / QC departments sab hauv, thiab thib peb- cov koom haum tswj hwm. Peb muab cov nqi sib tw nrog cov qauv pob tshab, txhim khu kev qha cov saw hlau ruaj khov, thiab cov kws tshaj lij - ntawm - ib qho kev pabcuam los txhawb koj cov haujlwm tshawb fawb metabolic. Txawm hais tias koj xav tau kev tshawb fawb-qib ntau lossis ntau lub peev xwm tsim khoom, BLOOM TECH muab qhov zoo, kev ntseeg siab, thiab kev tswj hwm raws li koj daim ntawv thov xav tau.

Hu rau peb pab neeg hnub no los tham txog koj 5 amino 1mq peptide txhaj tshuaj thiab nrhiav seb peb cov kws tshaj lij tuaj yeem ua kom koj cov hom phiaj tshawb fawb. Hu rau peb ntawmSales@bloomtechz.comrau cov ncauj lus kom ntxaws cov khoom specifications, analytical daim ntawv pov thawj, thiab customized kev daws teeb meem raws li koj qhov project xav tau.

1. Kraus D, Yang Q, Kong D, et al. Nicotinamide N-methyltransferase knockdown tiv thaiv kev noj haus- ntxias rog rog. Xwm . 2014;508(7495):258-262.

2. Ulanovskaya OA, Zuhl AM, Cravatt BF. NNMT txhawb nqa kev hloov kho epigenetic hauv kev mob qog noj ntshav los ntawm kev tsim cov metabolic methylation dab dej. Nature Chemical Biology. 2013;9(5):300-306.

3. Hardie DG, Ross FA, Hawley SA. AMPK: cov khoom noj khoom haus thiab lub zog sensor uas tswj lub zog homeostasis. Nature Reviews Molecular Cell Biology. 2012;13(4):251-262.

4. Cantó C, Auwerx J. AMP-activated protein kinase thiab nws txoj hauv kev hauv qab nqes mus. Cellular thiab Molecular Life Sciences. 2010;67(20):3407-3423.

5. Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin tsis kam, thiab metabolic syndrome. Phau ntawv Journal of Clinical Investigation. 2013;123(7):2764-2772.

6. Hong S, Moreno-Navarrete JM, Wei X, et al. Nicotinamide N-methyltransferase tswj cov metabolism hauv hepatic nutrient los ntawm Sirt1 protein stabilization. Tshuaj kho mob xwm txheej . 2015;21(8):887-894.