Ib tus neeg siv khoom los ntawm lub chaw haujlwm txawv teb chaws ntawm Réunion Island, Fabkis, tau sab laj nrog peb lub tuam txhab txog cov khoom peptide. Thaum thawj zaug kev sib cuag, tus neeg siv khoom feem ntau nug txog cov txheej txheem tshwj xeeb, sijhawm sijhawm, thiab kev ruaj ntseg ntawm kev thauj mus los thoob ntiaj teb, thiab tau lees paub tias lawv yuav siv tus lej xov tooj ntawm tes hauv Nyab Laj uas yog txhais tau tias rau kev sib txuas lus tom ntej thiab xaj xaj. Ob peb hnub tom qab, tus neeg siv khoom tau hu rov qab, thov kom meej meej tias peb muab cov lus hais rau cov khoom ua ke ntawmCJC-1295 Tsis muaj DAC (5mg) thiab IPA (Iparomine, 5mg). Thaum tus txheej txheem hais lus, thaum tus neeg siv khoom paub tias tus nqi thauj khoom yog $ 85, lawv pib qhia tias lawv tsis tuaj yeem lees txais, xav tias tus nqi siab dhau lawm. Tom qab ntawd kuv ua siab ntev piav qhia tias tus nqi no tsis yog rau tus nqi thauj khoom xwb, tab sis tus nqi pabcuam uas suav nrog tus nqi ntawm kev ntsuas kub - tswj cov khoom ntim raws li cov qauv thauj khoom lom neeg, cov nqi thauj khoom thoob ntiaj teb huab cua los ntawm Tuam Tshoj mus rau Réunion, thiab cov kev pabcuam tseem ceeb tshaj plaws rau cov chaw xa khoom xa tawm kom raug cai thiab xa khoom raug cai. Tom qab tus neeg siv khoom nkag siab meej txog qhov muaj pes tsawg leeg thiab tus nqi ntawm cov nqi, lawv cov kev tsis txaus siab raug tshem tawm, thiab lawv tus cwj pwm tig mus rau qhov txaus siab txais. Lawv tam sim ua tiav qhov kev txiav txim them nqi, thiab tag nrho cov txheej txheem kev sib txuas lus yog kev tshaj lij thiab du, thaum kawg ua tiav qhov kev sib pauv.
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CJC-1295 Tsis Muaj DAC: Qhov "Hloov" rau Kev Loj Hlob Loj Tshaj Tawm
Core Mechanism
CJC-1295 Yog Tsis Muaj DAC yog ib qho kev sib txuas ntawm kev loj hlob hormone-tso cov tshuaj hormones (GHRH) analogue uas muaj 30 amino acids. Nws cov txheej txheem ntawm kev ua haujlwm yog txhawm rau qhib qhov kev loj hlob hormone- tso tawm receptor nyob rau hauv lub caj pas pituitary anterior pituitary caj pas los ntawm mimicking natural GHRH, yog li txhawb kev tso tawm ntawm endogenous loj hlob hormone (GH). Piv rau ntuj GHRH, cov qauv molecular ntawm CJC-1295 Tsis muaj DAC tau ua kom zoo, nrog nws ib nrab-lub neej txuas ntxiv mus txog 30 feeb (thaum lub ntuj GHRH muaj ib nrab-lub neej ntawm tsuas yog 10-20 feeb), tab sis nws tseem yuav tsum tau txhaj tshuaj 1-3 txhua hnub kom muaj kev ruaj ntseg.
Cov yam ntxwv tseem ceeb
Tsis muaj DAC (Drug Affinity Complex): DAC yog ib qho cuab yeej siv txuas ntxiv ib nrab - lub neej ntawm cov tshuaj los ntawm kev khi rau albumin hauv cov ntshav. CJC-1295 Tsis muaj DAC tsis ntxiv DAC, yog li nws lub sijhawm ua haujlwm yog ze rau lub cev lub cev, ua rau nws tsim nyog rau simulating lub ntuj mem tes tso tawm ntawm GH thaum hmo ntuj.
Molecular Luj thiab qauv: Qhov hnyav molecular yog 3367.897, muaj cov amino acids xws li tyrosine (Tyr), D-alanine (D-Ala), aspartic acid (Asp), thiab lwm yam, thiab cov kab ke yog: Tyr-D-Ala-Asp-Ala-Ile-Ph-Thr-Gl n-Ser-Tyr-Arg-Lys-Val-Leu-Ala{{ 19}}Gln-Leu-Ser-Ala-Arg-Lys-Leu{{26} }Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys
Solubility thiab Cia: Me ntsis soluble hauv dej, ethanol, thiab methanol. Nws yuav tsum tau muab cia rau hauv ib qho chaw inert roj ntawm -20℃los tiv thaiv degradation.
Kev siv tshuaj kho mob
Txhawb kom cov leeg loj hlob thiab kho:Los ntawm kev nce qib ntawm GH thiab insulin-zoo li kev loj hlob zoo-1 (IGF-1), nws txhim kho cov protein synthesis thiab txhawb kev nce hauv cov leeg nqaij thiab lub zog.
Txo cov rog rog:GH tuaj yeem ua kom muaj roj-decomposing enzymes, ua kom cov roj oxidation metabolism, thiab txo cov roj hauv lub cev.
Txhim kho kev pw tsaug zog zoo:GH secretion muaj feem cuam tshuam nrog kev pw tsaug zog sib sib zog nqus (slow-wave pw tsaug zog), thiab CJC-1295 Tsis muaj DAC tuaj yeem pab tswj kev pw tsaug zog thiab txhim kho kev rov zoo.
Anti-aging muaj peev xwm:Kev siv sij hawm ntev - tuaj yeem txhim kho pob txha ntom ntom, tiv thaiv kev ua haujlwm thiab tawv nqaij elasticity, tab sis xav tau kev tshawb fawb ntxiv kom paub meej qhov no.
Kev npaj siv
Noj ntau npaum:1-3 zaug hauv ib hnub, 100-200 ug (1-2 mg / lis piam). Cov koob tshuaj yuav tsum tau kho raws li tus neeg teb cov lus teb.
Txoj kev txhaj tshuaj:Kev txhaj tshuaj subcutaneous. Cov chaw txhaj tshuaj ntau yog lub plab lossis sab nraud ntawm tus ncej puab.
Cycle Management:Nws raug nquahu kom muaj 3-hli "hormone so" txhua 3-6 lub hlis kom tsis txhob muaj kev cuam tshuam ntawm pituitary muaj nuj nqi.
IPA (Ipamorelin): Ib qho "luv- ua haujlwm catalyst" rau kev ua kom muaj GH
Core mechanism
IPA yog ib qho kev xaiv loj hlob hormone tso tawm cov tshuaj hormones (GHS) uas txhawb nqa GH secretion los ntawm kev ua kom GHSR ntawm lub hypothalamus -pituitary axis. Tsis zoo li CJC-1295 Yog Tsis Muaj DAC, IPA muaj lub sijhawm luv luv ntawm kev ua haujlwm (ib nrab-lub neej kwv yees li 2 teev), tab sis nws yog qhov tshwj xeeb thiab yuav luag tsis muaj kev cuam tshuam rau prolactin, cortisol, thiab lwm yam tshuaj hormones, nrog tsawg dua kev phiv.
Cov yam ntxwv tseem ceeb
Molecular Luj thiab qauv: Qhov hnyav molecular yog 711.86, muaj 5 amino acids, thiab cov kab ke yog: Aib-His-D-2-Nal-D-Phe-Lys-NH2
(Aib stands for -amino isobutyric acid, 2-Nal for 2-naphthylalanine)
Solubility thiab cia: Soluble hauv dej thiab yuav tsum khaws cia ntawm -20 degree.
Kev siv tshuaj kho mob
Synergistic kev ua tau zoo: Thaum siv ua ke nrog CJC-1295 yam tsis muaj DAC, nws tuaj yeem npog qhov "pulse peak" thiab "basal value" ntawm GH secretion, ua tiav kev tso tawm tas li rau 24 teev.
Kev txo qis ntawm cov kev mob tshwm sim: IPA tsis ua rau cov kua qaub ntau ntxiv hauv plab los yog qab los noj mov, ua rau nws haum rau kev siv sijhawm ntev -.
Kev txhim kho kev ua kis las: Los ntawm kev txhim kho GH thiab IGF-1 qib, nws txhim kho lub zog, kev ua siab ntev, thiab rov qab nrawm.
Kev siv raws tu qauv
Noj: 2-3 zaug ib hnub twg, 100-300 ug txhua lub sijhawm (2-6 mg ib lub lis piam), feem ntau yog sib xyaw ntawm 1: 1 piv nrog CJC-1295 Tsis Muaj DAC.
Txoj kev txhaj tshuaj: Kev txhaj tshuaj subcutaneous, tuaj yeem ua haujlwm ntawm tib qhov chaw lossis ntau qhov chaw xws li CJC-1295 Tsis Muaj DAC.
Kev tswj lub voj voog: Tsis muaj "hormone so" yuav tsum tau, tab sis kev saib xyuas tsis tu ncua ntawm GH thiab IGF-1 qib yog qhov tsim nyog kom tsis txhob muaj qhov zais cia ntau dhau.
CJC-1295 Tsis muaj DAC 5mg + IPA 5mg ua ke: Kev sib piv thiab kev sib koom ua ke
Kev sib xyaw kom zoo
Ntev- ua yeeb yam + luv luv- ua yeeb yam: CJC-1295 Tsis muaj DAC muab qhov yooj yim GH tso tawm, thaum IPA ntxiv cov mem tes peak kom ua tiav GH tso tawm txhua hnub.
Kev txo qis ntawm cov kev mob tshwm sim: Qhov tshwj xeeb ntawm IPA tuaj yeem tiv thaiv qhov nce hauv prolactin lossis edema tshwm sim los ntawm CJC-1295 Tsis muaj DAC.
Kev yooj yim ntawm kev siv: Lub pre- sib xyaw 5mg formulation ua kom yooj yim rau cov txheej txheem faib thiab txo qhov kev pheej hmoo ntawm kev sib kis.
Cov ntaub ntawv kho mob txhawb nqa
GH thiab IGF-1 qib: Txoj kev tshawb no qhia tau hais tias kev siv ua ke tuaj yeem nce GH concentration los ntawm 10 zaug hauv 6 hnub thiab IGF-1 qib 3 zaug hauv 9-11 hnub.
Kev txhim kho hauv lub cev muaj pes tsawg leeg: Qhov nruab nrab lub cev rog feem pua ntawm cov neeg kawm tau txo qis los ntawm 5%, lean lub cev hnyav nce los ntawm 3%, thiab cov leeg nqaij muaj zog nce los ntawm 10-15%.
Kev nyab xeeb: Cov kev mob tshwm sim feem ntau suav nrog qhov chaw txhaj tshuaj (mob, liab, o) thiab dej ntws tawm mus ib ntus. Qhov tshwm sim ntawm qhov tshwm sim tsis zoo (xws li carpal tunnel syndrome, insulin tsis kam) tsawg dua 1%.
Cov pej xeem siv tau
Cov neeg ncaws pob thiab cov neeg nyiam kev qoj ib ce: tsom rau cov leeg nqaij, txo cov rog, thiab rov qab sai.
Anti-cov neeg nrhiav kev laus: vam tias yuav txhim kho kev pw tsaug zog, pob txha ceev, thiab tawv nqaij mob.
Cov neeg mob uas tsis muaj GH: raws li kev kho mob ntxiv (xws li kws kho mob cov lus qhia).
Cov kev ceev faj
Contraindications: Txwv tsis pub rau cov neeg tsis haum rau cov khoom xyaw, cov neeg mob uas muaj mob qog noj ntshav, thiab cov neeg mob plawv lossis raum tsis ua haujlwm.
Kev sib cuam tshuam tshuaj: Tsis txhob siv ua ke nrog glucocorticoids, insulin, lossis tshuaj hypoglycemic ntawm qhov ncauj.
Kev soj ntsuam cov ntsuas: tsis tu ncua kuaj ntshav qab zib, ntshav lipids, thyroid ua haujlwm, thiab ua pituitary MRI (rau cov neeg siv sijhawm ntev -).
Risks thiab Controversies: Qhov tseem ceeb rau kev siv Scientific
Pituitary suppression: Ntev - siv lub sij hawm ntev ntawm cov koob tshuaj ntau yuav inhibit lub cev GH secretion function.
Cov kab mob metabolic: Hauv qee kis, nws tuaj yeem ua rau hyperglycemia lossis qib lipid txawv txav.
Kev pheej hmoo raug cai: Hauv ntau lub tebchaws, CJC-1295 Yog Tsis Muaj DAC thiab IPA tsis tau pom zoo rau tib neeg siv thiab tsuas yog siv rau kev tshawb fawb.
Optimize siv cov tswv yim
Dose individualization: Pib nrog ib koob tshuaj tsawg (xws li 1mg ib hnub) thiab maj mam hloov mus rau qhov kev zam.
Kev txhawb nqa kev noj haus ua ke: Ntxiv nrog cov protein, zinc, thiab vitamin D txhawm rau txhim kho cov nyhuv ntawm GH.
Lub voj voog tsim: Txais cov qauv "3 lub hlis ntawm kev siv + 3 lub hlis so" kom sib npaug cov txiaj ntsig thiab kev pheej hmoo.
Xaus
Saib lub peev xwm ntawm peptide kev sib txuas rationally
Kev sib xyaw ua ke ntawm CJC-1295 yam tsis muaj DAC (5mg) + IPA (5mg) muab cov pov thawj tshawb fawb rau cov leeg loj hlob, txo cov rog, thiab tiv thaiv- kev laus los ntawm kev sib koom ua ke ntawm kev ua haujlwm ntev - ua yeeb yam thiab luv - ua yeeb yam. Txawm li cas los xij, nws txoj kev siv yuav tsum tau ua raws li kev coj ua nruj me ntsis rau cov lus qhia noj tshuaj thiab kev ntsuam xyuas zoo ntawm tus neeg mob. Nyob rau hauv lub neej yav tom ntej, nrog rau kev nthuav dav ntawm kev tshawb fawb soj ntsuam ntau ntxiv, qhov kev sib xyaw no yuav tsum ua lub luag haujlwm ntau dua hauv kev kho mob, tab sis tam sim no, yuav tsum tau ceev faj tus cwj pwm kom tsis txhob muaj kev tsim txom lossis kev cia siab dhau.
